Umuthi 'Ursodez "- yokusetshenziswa. Tablets "Ursodez": analogs kanye nokubuyekeza

Izidakamizwa "Ursodez" - izidakamizwa hepatoprotective. It has nomuthi choleretic, hypolipidemic, isenzo holeliticheskoe, possesses hypocholesterolemic futhi immunomodulating umphumela azinakwa. izidakamizwa Active - ursodeoxycholic acid. Umuthi ayinayo indlela Isikali "amaphilisi". "Ursodez" ikhiqizwa ngendlela amaphilisi.

indlela umsebenzi

I asebenzayo izidakamizwa izidakamizwa unekhono ziyongeniswa ulwelwesi of hepatocytes, eliletha ukuthula oyiyo. Ngenxa yalokho, amangqamuzana bavikelekile izici ephazamisayo, umsebenzi Bile acid nosawoti. Ngakho-ke, nomphumela oqabulayo zomuthi wabonisa ukwehlisa umphumela cytotoxic. Against isizinda cholestasis oyenza Ca2 + protease engaphansi exocytosis-alpha-inkanuko yobulili. Kusho "Ursodez" (isicelo Umsebenzisi kubonisa ke) kunciphisa kakhulu anobuthi Bile acid (deoxycholic, lithocholic, chenodeoxycholic nabanye) at lokuhlala eziphakeme iziguli pathologies hepatic eqeleni ezingamahlalakhona.

Lapho ethola nemithi imakwe ukwehla cholesterol zamagama futhi uketshezi, okusithiyayo of ukumuncwa yayo emathunjini. Ngenxa yalokhu, kunciphisa saturation Bile nale kwakwakhe. Ukulungiswa unekhono ngokuncintisana wehlise absorbability of acid lipophilic emathunjini, okwandisa wamaqhuzu inzuzo inhlabathi ekujikelezeni kwazo enterohepatic. Imithi kuvusa excretion of acid anobuthi, kukhuphuke ndima.

Lo mshini wezenzo zomuthi lusekelwe futhi ukuhlolwa nonpolar Bile acid. Ngenxa yalokhu micelles anobuthi okuxubile. Kusho siba mandla ngo ohlelweni biliary, le solubility cholesterol, usimamise ukukhiqizwa futhi uketshezi of Bile. Umuthi futhi kunciphisa lithogenicity yayo, kwandisa lokuhlushwa acid, ngaleyo ndlela ingqondo ukwanda umsebenzi uketshezi pancreatic kanye esiswini.

Lapho ethola amaphilisi kwadingeka nokonakala okuphelele noma okuyingxenye zamatshe. Ngokunciphisa Bile cholesterol ukugcwaliswa sithuthukiswe ukugqugquzela amatshe. umsebenzi Immunomodulatory ichonywe ngenxa ithonya indlela abasabela ngayo abafanele yi isibindi. Umuthi kunciphisa ukubonakaliswa eziningi histocompatibility antigen. I nomuthi kuyalithinta ezingeni T-lymphocyte, inciphise inani eosinophils.

Pharmacokinetics izindlela

Absorption zomuthi "Ursodez" (incwadi yeziyalezo ibonisa ukuthi leli) emathunjini amancane kwenziwa inqubo okusheshayo yekwentiwa. Esusiwe nge mayelana 90% ingxenye esebenzayo. Esikhathini ileum ketshezi is amuncwa ezokuthutha asebenzayo. Okuqukethwe eliphezulu kakhulu ingxenye esebenzayo ifinyelela cishe ihora elilodwa. Egcekeni has a iphesenti eliphezulu amaprotheni ngibopha - 99%. Ursodeoxycholic acid uyakwazi ukungena placenta.

Kusebenta zokwelapha zomuthi incike lokuhlushwa isithako esisebenzayo kule Bile. Ngezinye njalo eyamukelayo ehlelekile lokhu acid Bile iba serum eyinhloko. ursodeoxycholic acid lokuhlushwa imayelana 48%.

Egcekeni is akheka, udabula amaseli isibindi. Ngenxa yalokho, kwakhiwa glycine kanye taurine conjugates. Imikhiqizo kwamazinyo kuthiwa akhishelwa Bile. Mayelana 50-70% wathola umuthi excreted endleni yabantu abanaleli. Inani elincane izidakamizwa is zithutha phakathi ikholoni. Kukhona-ke kuhlukaniswa ngenxa yesenzo amagciwane (7-dehydroxylation).

Lithocholic acid, ezakhiwe le nqubo okuyinto, is sesimeni ukumuncwa olungaphelele emathunjini ezinkulu, kodwa sihamba sulfation esibindini futhi excreted njengoba sulfolitoholiltaurinovogo noma conjugate sulfolitoholilglitsinovogo.

ubufakazi

Medicine "Ursodez" Kunconywa njengendlela yokukwenza lingaze primary isifo sokusha biliary ngaphandle izimpawu decompensation. Ukubonisa indlela ukuncibilikisa aphakathi nendawo kanye amatshe amancane cholesterol, kanye gallbladder asebenzayo. Prescribers nge biliary Reflux kolwelwesi.

Izimo

Kusho "Ursodez" imfundo on isicelo ayivumeli eya endaweni uma izingxenye le rentgenpolozhitelnyh nesineke (emakamu eliphezulu Ca2 +) amatshe atholakala enyongweni ukungabekezelelani nomuthi. Izimo zihlanganisa isifo sokusha ngesinyathelo decompensation uzwakalise iziyaluyalu kwamanyikwe, izinso. izidakamizwa anconyelwe abantu non-isebenze nenyongo sesinye, acute pathologies ukuvuvukala isimo sawo, kanye isifo wamathumbu and Bile imbobo. Musa akunikeze imithi ukuze abakhulelwe nabancelisayo. Kusho contraindicated abadala kanye nezingane enesisindo esingaphansi 34 kg.

side effects

Kwezinye izimo, ukuthuthukisa imiphumela engadingeki ngenkathi ngokuthatha izidakamizwa, "Ursodez". Yokusetshenziswa ukuxwayisa yokwesabela isicanucanu, uhudo, nokuhlanza. Ekwelapheni inhlabathi ungakheka amatshe atholakala enyongweni calcified. Okhulisa isibindi transaminase umsebenzi, ubuhlungu besisu, nokungezwani komzimba nezinto (kuhlanganise urticaria) nazo engathandeki nemiphumela Ukungenisa "Ursodez".

Nobufakazi ukukhombisa tolerability ezinhle. Ngokweyame ezinhlinzekweni kadokotela nemiyalelo side effects cishe. Kwezinye izimo, ngesikhathi ekwelapheni isifo sokusha biliary waphawula decompensation lezivakashi. Njengomthetho, lesi simanga wedwa iphikelela ngemuva ukuqedwa zomuthi.

Izidakamizwa "Ursodez". Inani. imfundo

Kusho ukuthatha kusihlwa. Umthamo wansuku zonke sokuqeda amatshe - isilinganiso 10 mg / kg. Ukuze abantu nesisindo kg 60 siyafana amaphilisi 2nd ngosuku 81 kg- 3-m, 100 kg - 4 ngaphezulu 100 - 5. Ubude besikhathi - ngemva kwezinyanga eziyisithupha kuya ezingu-12. Ngemva Ukuqedwa amatshe ukuvimbela ukwakheka engayitholi entsha letiphakanyisiwe omunye izinyanga eziningana.

Ukwelashwa isifo sokusha biliary eyenziwa umthamo 250 mg / usuku. Isikhathi course - ezinsukwini 10-14. kuze kufinyelele ezinyangeni eziyisithupha. Kwezinye izimo, isikhathi yokwelapha luyanda iminyaka emibili. Ngenxa yokwelashwa lingaze nomuthi iqondiswa 10-15 mg / usuku. Lapho mass 34 kg Kunconywe izindlela ifomu okwesikhashana. Izindleko zomuthi ngefomu capsule - ruble eziyikhulu.

Liyakushintsha kusho "Ursodez" nozakwabo?

Izidakamizwa eziqukethe ketshezi asebenzayo esifanayo, ekhiqizwa impela eningi. Phakathi kwabo kuwufanele kokukhuluma izindlela ezifana "Ursodoksa", "Ursol". Omunye ethandwa kakhulu Isidakamizwa "Ursosan". Izinkomba ukusetshenziswa zomuthi Kuthi ebanzi. Ikakhulukazi, iqondiswa e fibrosis cystic isibindi skleroziluyuschem cholangitis uhlobo ezingamahlalakhona.

Iziguli eziningi unesithakazelo ukulungiselela lokho okungcono "Ursodez" noma "Ursosan". Kumele wathi ukuthi udokotela ukhetsa noma ngezinye izindlela ngokuhambisana imvelo, Yiqiniso zokugula kanye nesineke wakubekezelela izidakamizwa. In izifo kwesibindi, le gallbladder akuyona Kunconywa kwawena. Ngaphambi kokuthatha imithi udinga ukuhlola kanye kokubonisana onguchwepheshe.

Ukuqapha ukuphumelela ukwelashwa kufanele kwenziwe njalo emva kwezinyanga eziyi6. Kule ndaba ke inikezwa ultrasound njalo futhi-X-ray luhlolo onyakeni wokuqala yokwelashwa. Uma ezinyangeni zokuqala eziyisithupha, ekuhlakazekeni amatshe akwenzekanga, kungenzeka phambili Yiqiniso zingenzeki ngenxa nokungasebenzi.

ulwazi olwengeziwe

Ukuqinisekisa nokonakala ngempumelelo amatshe kubalulekile ukuthi amatshe babe cholesterol kuphela, kodwa ubheka ubungako bawo ingeqi 15 noma 20 kwangu. Ngesikhathi esifanayo egcwele esinyeni nenyongo akufanele abantu abangaphezu kwengxenye, futhi leli pheshana biliary kufanele uzitholele ngokuphelele umsebenzi wawo.

Endabeni uya khona nokunwetshiwe ukwelashwa, ngaphezu kwenyanga, kubalulekile ukuba afeze Assay kwamakhemikhali ekuhloleni umsebenzi transaminases esibindini. Ngaphezu kwalokho, kufanele ukulawula lokuhlushwa bilirubin nezinye izingxube zamakhemikhali. ukuyeka ukuphuza "Ursodez" kusho ngenkathi sigcina ukusebenza high. Nokho, ku- lochwepheshe abaningi, akhayo mayelana ukuphumelela izidakamizwa.

isiphetho

Uma kungekho yi kungenziwa abelwe ukuyokhonza kwelinye nomuthi noma isu ukwelashwa olubukeziwe ngokuphelele. Ngaphambi kokusebenzisa umkhiqizo kumele ayejwayele isichasiselo.