Umuthi 'Tamoxifen'. Ukufundiswa ukufunda

Umuthi 'Vero Tamoxifen "lisetshenziswa okwesikhathi eside. Lo muthi libhekwa njengoba abakhethayo estrogen yokwamukela modulators. Medicine kokuthola emgudwini wegazi, yasakazwa kulo lonke umzimba.

Ngenxa yokuthi izindlela "Tamoxifen" Umsebenzi azinakwa estrogenic, ke kunomphumela enganamandla kakhulu ukuvuselela ku amaseli. With ikhono ukuvimba ama-receptor khulula phezu isimila cells, umuthi kuvimbela ezishukumisayo hormone neoplasm. Ngakho, i-izidakamizwa livela umphumela antiestrogenic.

Umuthi 'Tamoxifen "Umhlahlandlela uchaza njengendlela yokuthola kwekhethelo izimila kule ndlala mammary kwabesifazane premenopausal. Umuthi esimisiwe abesifazane postmenopausal. Nokho, phakathi nale nkathi nomuthi kangako ngaphandle inhibitor (isinyathelo inhibitory) aromatase (enzyme ethize).

Umuthi 'Tamoxifen "manual uncoma umdlavuza wesinye nowamabele wesilisa, umdlavuza wesikhumba, webele, amaqanda e abesifazane. Umuthi ezinqunyiwe kanye nenzalo zesifazane. Ukulungiselela "Tamoxifen - hexane" is ngaphezu kwalokho ukuboniswa njengenhlangano adjunct emva kokwelashwa kuhlinzwa ka webele carcinoma.

I nomuthi lungasetshenziswa njengoba prophylactic. Ngakho, lesi sidakamizwa "Tamoxifen" uyakwazi ekuvimbeni yokwamukela i-estrogen nomdlavuza wamabele amaseli enempilo. Lokhu kukuvumela ukuba ukwabela izidakamizwa iziguli nezici ezithile okusezingeni eliphezulu umdlavuza, kodwa akusho uhlushwa kubo phambi.

Njengomthetho, isikhathi izidakamizwa isimiso sokuqondisa 'Tamoxifen "- iminyaka emihlanu. Kuyadingeka ukuba uqaphele lapha endabeni ukuqokwa izidakamizwa ekuthuthukisweni metastatic okuba nomdlavuza ngokuphawulekayo, uphuzwe kakhulu ngendlela umphumela wawo ihlala.

Umthamo kusho "Tamoxifen" Umhlahlandlela incoma ukubeka ngamunye. Ngokuvamile engabelwe kona amabili kuya amane angu ngosuku.

Umuthi 'Tamoxifen "imfundo ayivumeli ukuthola ngesikhathi sokukhulelwa.

Ukusetshenziswa imithi kungabangela eziningi nemiphumela engathandeki. Ikakhulukazi, indlela ebangela ukucindezeleka, isiyezi, ukuphazamiseka visual, ukuvuvukala ngemithambo. Kwezinye izimo, kungase kube ikhanda, haemorrhage (isitho sangasese somuntu wesifazane), ukulunywa zangasese, ukuqubuka. Okuvame kakhulu emibi ibandakanya ukucanuzela kwenhliziyo, imfiva, ubuhlungu izilonda bone.

Kufanele kuqashelwe ukuthi ngokuhamba kwesikhathi ukuphumelela izidakamizwa "Tamoxifen" buthakathaka. Ngenxa yalokho, lo muthi akakwazi ukuba nethonya ku amaseli wangaphambili. Kwezinye izimo, umphumela walo sishintshile. Ngamanye amazwi, lo izidakamizwa iqala ukuba enze izinto njengedemoni estrogen futhi sikhuthaze ukuthuthukiswa amaseli, esikhundleni abacindezela kubo. Ngokwezinga elikhulu lo mphumela lihlotshaniswa ikhono estrogen yokwamukela ukushintsha lingakanani, ukuminyana, ukuma noma umsebenzi. Ngaphezu kwalokho, e-umdlavuza webele kungase kuhambisane khona kokubili i-hormone engemihle futhi amaseli i-hormone i-HIV. Kulokhu, lesi sidakamizwa "tamoxifen" ngekuhlobana kuseli eyodwa siyasebenza, futhi maqondana abanye - akukho. Ngenxa yalokho, abanye receptor aphendule, kuyilapho abanye amelana izidakamizwa.

Uma post-menopausal isiguli imithi, futhi ngemva kweminyaka emibili noma emithathu, kuba ingaphumeleli, udokotela ngokuvamile ithatha owesifazane ku aromatase inhibitor.

Kufanele kuqashelwe ukuthi uhlobo oluthile lokwelapha (isb, ama-hormone) abakwazi esikhundleni nezinye izindlela zokwelapha ezivamile. Kuyadingeka ukuba sikhumbule ukuthi ngokuvamile ukubaluleka mode isenzo ngasinye kuxhomeke kakhulu lapho kuhlanganiswe uhlelo lokusebenza.

Kuyo yonke ukwelashwa nge ukusetshenziswa kwezidakamizwa "Tkamoksifen" kufanele ehlelekile ukuqapha igazi isithombe.