Inhibitor Aromatase: kuzibuyekezo, izintengo. inhibitor Aromatase sawo esiningi

inhibitor Aromatase, noma ukuvimba, - uhlobo amathuluzi asetshenziswayo ukunciphisa okuhlushwa estrogen egazini futhi ukwandisa ezingeni ephulukisa gonadotropins ne-testosterone. Lezi izinto nazo asetshenziswa ukwelapha kanye nokuvinjelwa gynecomastia besilisa.

inhibitor Aromatase sawo esiningi avame ukusetshenziswa ngesikhathi Yiqiniso kwezidakamizwa Anabolic ukuze:

• ukuthuthukisa ukusebenza hormone Anabolic egazini;
• zokuvimbela gynecomastia;
• ukuvimbela nomfutho wegazi ophezulu;
• ukwandisa Bump (ususe umphumela ongemuhle estrogens);
• ekunciphiseni izinga le-estrogen ekubhujisweni-eksisi amasende-pituitary-ngxenye, okuholela ukwakhiwa kabusha ngokushesha.

Ukwakha Yiqiniso, kumelwe sizilungiselele ukubhekana nezingozi iqiniso lokuthi ukunambitheka lungekho ngaphansi zonke Ama-anabolic steroid. Sebenzisa ulungisiswa lapho ukusetshenziswa imikhiqizo efana methandrostenolone, methyltestosterone, testosterone nemikhiqizo yalo. Kancane enongiwe Halotestin, boldenone.

ukusebenza

I kunazo ayethanda futhi iyatholakala inhibitor aromatase (i ezinezithelo cishe efanayo):

Kufanele kuqashelwe ukuthi lokuhlushwa ngokulinganisela estrogen kuyasiza kwemisipha ukukhula, imithamo Nokho yokuvimbela wabonisa eziningi ezithinta kulondolozwe izinga physiologically edingekayo of estrogens besilisa.

Ukusebenzisa Yiqiniso

Iningi abasubathi yasekhaya usebenzisa aromatase inhibitor, sebenzisa amaqhinga alandelayo: asetshenziselwa izidakamizwa kuphela uma izimpawu zokuqala gynecomastia (ukulunywa we izingono, ukuvuvukala, ububomvu). Ngeshwa, le ndlela akakwazi ngokuthi elilungile.

Isixazululo okunengqondo kakhulu kubhekwa estradiol ihlolwe kwezinsuku eziyishumi, ukusetshenziswa kwezidakamizwa Anabolic nge short isigamu-nokuphila ( "Methandrostenolone", "testosterone propionate") noma amaviki amathathu noma amane kwesicelo we ester side ( "Sustanon", "enanthate," "cypionate"). Ngaphezu kwalokho ebekiwe ingxenye isilinganiso "Anastrozole" - 0.5 mg Njalo ngemva kosuku olulodwa. Ngemva kwezinsuku eziyishumi, aphethwe ukuhlaziya ukulawula estradiol nesilinganiso is ivunyelaniswe imiphumela.

Ukuhlehla ukusebenzisa servings ongaphakeme uphinde ungamele "Anastrozole" igxile okuvelayo siqu. Uma emva ukwelashwa okunjalo kuba ecindezelekile, ukuphazamiseka Erectile umsebenzi, libido iconsi ke udinga ukwehlisa umthamo.

ucwaningo

Ukuvela brand "letrazole" umphakathi Nilethé lo mkhiqizo ku phambili. Kunezindlela ezihlukahlukene izivivinyo ukufakazela ukusebenza eliphezulu leli thuluzi ezingabantu. Ukwethulwa izinto ephelezelwa ukwanda okuphawulekayo gonadotropin (LH). Isikali Sizuzise evela 0.02 mg (zokwelapha ngezansi izikhathi 100): kungenzeka nge yesithathu aphansi i-estrogen okuhlushwa. 50% "letrozole" aphume emzimbeni zingakapheli izinsuku 2-4, ukuvumela wamphuzisa ngosuku. I ethile eyisisekelo ubhekwa ikhono layo emazingeni aphansi i-estrogen, ngisho ngemithamo emincane.

"Anastrozole" ethandwa sawo esiningi, emangalisayo bahlola ku amadoda njengendlela yokuthola ekunciphiseni estradiol. Empirically ke waboniswa ukuthi umthamo 1-0.5 mg estradiol ezingeni kungehlisa izinga cishe 50%. Abathengisi Lo mkhiqizo angathengwa kuze kube ezishibhile ekhemisi izikhathi eziyishumi. Ngo megacities ihlangabezana ezishibhile "Anastrozole Kabi."

Encwadini yakhe, uDkt Mauro G. De Pascal wabhala: "Kusolwa ukuthi estrogens ukuthi akhiwa ngenxa aromatization kwe-testosterone noma ezinye Ama-anabolic steroid eminyangweni of hypothalamus nobuchopho, ukunciphisa uketshezi of luteinizing ama-hormone, kanye, ngenxa yalokho, ukukhiqizwa kwe-testosterone." Gilman futhi Goodman unolwazi ukuthi impendulo icushiwe kunalokho zemali-estrogen, kunokuba testosterone. Ngale ndlela, it is wachaza ukuthi inhibitor aromatase kungaba ngokuphawulekayo ukunciphisa umphumela inhibitory ejenti Anabolic ukwaba hormone ocansini siqu.

imiphumela engemihle

I aromatase inhibitor ziyingozi amadoda? Siyazi ukuthi izinga le-estrogen ngemithamo ongaphakeme nethonya elihle emzimbeni wesilisa. hormone estrogen ukwandisa futhi ukukala ukusebenza kanye nozwela androgen receptor. Ngaphezu kwalokho, bona ngokwabo nethonya zokuzivikela futhi Anabolic.

Okusho imisipha estrogen yokwamukela kahle kuchazwe Anna Wiik ngokuningiliziwe. Empeleni blocker iyamangalisa ngempela umthamo kungase ngokungadingekile ukunciphisa izinga estrogen, okuyinto enomthelela ukuvela komzimba okufana:

• okusithiyayo kwemisipha ukukhula;
• ubuhlungu bamalunga (arthralgia);
• Ukuwohloka ezempilo ukwehla libido;
• nokucindezeleka;
• ukuphazamiseka igazi lipid Iphrofayela (i-cholesterol ukwanda);
• wehlise kuqinise amathambo.

Subjectively, izidakamizwa bubekezelelwa ungcono "Tamoxifen".

inhibitor yemvelo

Ingabe lokhu okulandelayo:

• caffeine;
• resveratrol;
• zinc;
• i-nicotine;
• apigenin;
• catechins;
• eriodiktiol.

Ukusetshenziswa "Anastrozole"

Angaphezu kuka ezinhle aromatase inhibitor? le mithi kabanzi sawo esiningi. Ngokwesibonelo, "Anastrozole" edingekayo zokulondoloza amanzi emzimbeni womuntu kanye nokuvimbela okuvela gynecomastia (ngokuvamile lihambisana androgens testosterone futhi Dianabol uhlobo noma lihambisana finasteride). Kodwa kule ndaba, lo msubathi sizwana nale eziyinkimbinkimbi umxhwele kwezidakamizwa sinqatshiwe kusukela "uhlu izidakamizwa ezenqatshelwe kanye nezindlela", ngaphandle kokuba uhla yayo siqu yemiphumela yesibili.

Ukusetshenziswa engalawuliwe "Anastrozole" abasubathi, kwenziwe mayelana, ikakhulukazi, sawo esiningi kungabangela arthralgia, asthenia, noma ukwehlisa ukuhamba amalunga, ikhanda elibuhlungu, somnolence. Yiqiniso, ngezinye izikhathi kubonakale izinkinga thromboembolic nokuthuthukisa imivimbo.

On "Anastrozole" Kuningi okuye kwabhalwa izincwadi kubagijimi njengoba isidakamizwa esingenangozi kakhulu. Kodwa imiphumela kude futhi ngokushesha kwi reception yayo angaba kakhulu futhi ebuhlungu. Ngempela, uma nje ukuthatha esinye isibhebhe sibonisa (1 mg) nsuku zonke, ingalungiswa liphinyiselwe i-hormone yokwanda. By endleleni, lokhu mkhuba ubizwa ebonwe ezingaphezu kuka-80% abantu esetshenziswa umkhiqizo.

Ngokuvamile, inhibitor aromatase - izidakamizwa ngokwanele. odala lwesithathu amasampula blocker "Anastrozole", futhi kamuva "vorozole" futhi
'Letrozole', zadalwa njengoba imikhiqizo imigqa yokuqala neyesibili ngokuphulukisa ehlakazekile yokwamukela-HIV umdlavuza webele.

"Krizin"

Ukuze weightlifters kwemithi emakethe futhi inikeza 5.7-digidroksiflavon ( "Krizin"), abasubathi ukusebenzisa ebulilini kakhulu. It has izakhiwo antiaromatazatnymi futhi kukhiqizwa amafomu amabili - MRM-Chrysin kuhlaliswe 500 mg ngayinye capsule krizina nasici futhi SciFit-Chrysin ES, ehlalisa isigamu ketshezi asebenzayo.

imiphumela emibi Onjiniyela akazange ukudalula, kodwa kufanele sikhumbule ukuthi zonke izinto futhi amalungiselelo kokuba antiaromatazatnym isinyathelo, abangela umonakalo emzimbeni nomsubathi umxhwele. Ngaphezu kwalokho, bona "Uhlu izinto kungavunyelwe nezindlela."

Izibuyekezo

bodybuilders abaningi bathi, osekelwe kokuhlangenwe nakho ne "letrozole" ( "Femara"), baphetha: Lo mkhiqizo, ngokuxazulula inkinga eyodwa (inkomba okusezingeni eliphezulu estrogen), ikhuthaza ukuvela ezinye izinkinga eziningi. Yiqiniso, aromatase inhibitor kubalulekile amadoda. Phela, umzimba (madoda ikakhulu) isebenzisa i-estrogen ukulondoloza impilo kwesimiso somzimba sokuzivikela ezifweni, ubuchopho, amazinga evamile cholesterol, amalunga omzimba abe nempilo, nemisipha, nokunye.

Abasubathi bathi estrogen icuphe indlela umzimba sika kwemisipha ukukhula. Ukuthatha 2.5 mg "letrozole" ngosuku abaqala uzizwe kungadaleka ingozi embi kakhulu amalunga omzimba articular nemisipha, futhi babe sengozini yezifo ezithathelwanayo kanye ezibangelwa amagciwane.

abasubathi abaningi bakholelwa ukuthi kungenzeka 'Letrozole' ingasetshenziswa bodybuilders professional belungiselela uhlanga. Siyabonga kuye, ukuqeda uketshezi olunqwabelene emzimbeni (bezempilo ngoba ukunqoba akuyona sorry). Kuyabajabulisa ukuthwala inhibitor aromatase. Intengo wabo banelisekile nje impela.

Abanye abasubathi bathi umphumela 'Letrozole' omuhle umzimba ngisho at umthamo we 0.1-0.5 mg. Bayabika ukuthi akusiyo sibi kakhulu kunalokho okuboniswa nethonya ezincane nezinye inhibitor, kanye nendinganiso kulolu hlobo lwemithi. Zithi subjectively, umkhiqizo ubizwa ngokushesha revolutionizing wamasende ivolumu ukwedlula "Tamoxifen" futhi "Clomid". Futhi bangase baphikise ngokuthi inhibitor aromatase - izidakamizwa ukuthi izindleko ufaneleke izinga.

Abanye abasubathi umbiko engasetshenziswa iyiphi blocker, kodwa zinikezwe umkhiqizo eliphezulu "letrozole" ngemithamo emincane, kuba engabizi kakhulu.

"Anastrozole"

Namuhla "Anastrozole" kuyinto blocker ethandwa kakhulu. Eshibhe kubhekwa "emzini wabantu." Ezinye inhibitor aromatase kule ekhemisi ezingajwayelekile, isibonelo, "Anastrozole Kabi."

Abantu abaningi ungasindisi empilweni yabo bese ukhetha izinga.

Thatha "Anastrozole" ngokuhambisana ezingeni layo estradiol. amazinga estradiol Ngakho kuqala ihlolwe ulungise esekelwe ingxenye ukuhlaziywa. Isikali Isilinganiso classical kuyinto 0.5 mg ngosuku.

Ezinsukwini eziyishumi kamuva, kudingeka ukuthi uhlolwe futhi. Uma lizinga estradiol indinganiso, kungenzeka ukunciphisa umthamo 0.5 mg kabili ngesonto. Uma namanje okusezingeni eliphezulu, yokwamukela kufanele kuqhutshwe. Futhi ngakho-ke kufanele kube sisebenza kuze amazinga alulame ngokugcwele estradiol.