Umuthi 'Ukrliv ": yokusetshenziswa, incazelo, ukwakheka kanye nokubuyekeza

Kaningana, odokotela zanamuhla izifo ezithize iziguli zabo ukuba linqume izidakamizwa "Ukrliv". Imiyalo le ndlela kuhilela ngempela idatha eningi ewusizo futhi kwabaningi limelela umthombo obalulekile wokwaziswa. Kodwa akupheleli lapho kahle kutsi ebhaliwe lapho, nokuthi nikunikiwe, kuyinto kude uhlu oluphelele ulwazi mayelana nalesi izidakamizwa.

umphumela

Ursodeoksiholievaya acid iningi labantu amacala njalo ingxenye encane e Bile womuntu. Uma sithatha ke ngomlomo, uqala kakhulu ukunciphisa izinga isiyonke saturation Bile ne-cholesterol ngu ingasheshi ukumuncwa ngaphakathi emathunjini amancane kanye ukunciphisa uketshezi yesici ezinikezwe Bile. Kusobala ukuthi ngenxa hlakazwa organic compounds kanye ukwakheka crystal liquid uqala kancane chaza cholesterol cholelithic, okuyinto kunomphumela omuhle isimo jikelele zomzimba womuntu.

Ngokusho ulwazi lwamanje kunenkolelo acid ursodeoksiholievaya uma izifo ezihlukahlukene izifo zesibindi noma cholestatic ingafinyelela umphumela ngenxa esikhundleni isihlobo lipophilic efana insipho anobuthi Bile acid ku hydrophilic non-enobuthi cytoprotective ursodeoksiholievuyu acid, futhi kamuva a ngokuphawulekayo ngcono secretory umsebenzi gepotatsitov nezinqubo ezihlukahlukene immunoregulatory.

Lapho isetshenziswa?

Ngu izidakamizwa "Ukrliv" imfundo kubonisa ukuthi odokotela linqume ngokuvamile iningi kunjalo uma isiguli cholesterol amatshe atholakala enyongweni abakhona kabani ubukhulu akuyona engaphezu kuka-15 mm. Lokhu kusho ezimweni eziningi kunenzuzo iziguli liphele nge isebenze gallbladder elisebenza kungakhathaliseki khona therein eyodwa noma ngaphezulu amatshe atholakala enyongweni. Ikakhulukazi, ukuze lesi sidakamizwa "Ukrliv" manual uthi leli thuluzi ikuvumela ukuncibilikisa ngokuphelele rentgenaktivnye cholesterol amatshe atholakala enyongweni.

Ngaphezu kwalokho, ukusetshenziswa le izidakamizwa ngokuvamile iqondiswa kwanele uma ukwelashwa kudingekile siyefana eyinhloko isifo sokusha biliary, ngokungabi bikho isifo sokusha decompensated.

Pharmacokinetics

Ngemva ngokuthatha izidakamizwa iqala ursodeoksiholievaya acid ngokwanele ngokushesha ugxile emathunjini amancane nasesifundeni engenhla ileum ngokudluliswa yokwenziwa, futhi egumbini yokugcina ileum i ezokuthutha asebenzayo. Ezimweni eziningi, ngezinga elithile kunenzuzo ka ukumuncwa ivela 60% kuya ku-80%, njengoba kufakazelwa izidakamizwa "Ukrliv" imfundiso. Ngemva ukumuncwa ephelele Bile acid kuthintwa sekuyaphela conjugation hepatic nge amino acid taurine kanye glycine, ngaleyo ndlela iqedwe ngokuphelele ne Bile. Kuyaphawuleka yokuthi esiyinhloko imvume nokuwela kwawo Inkomba isibindi ifinyelela 60%.

Ngaphansi kwethonya amagciwane ahlukahlukene emathunjini kwenzeka ukuba nokucekelwa esinqunyiwe kanye lithocholic 7-ketolithocholic acid. Kulokhu, lithocholic acid uba gepototoksicheskogo izidakamizwa futhi kubangele ahlukahlukene umonakalo parenchyma hepatic e uhlobo oluthile isilwane. Kubantu, kuphela ugxile engxenyeni ethile ayinto okuyinto sulfated ngokuphelele esibindini futhi detoxified ngaphambi kokuba excreted endleni yabantu abanaleli futhi Bile.

Indlela yokusebenzisa lesi imithi ngesikhathi sokukhulelwa

Abesifazane abaseseminyakeni yokuthola abantwana, ungasebenzisa izidakamizwa kuphela uma kwenzeka ukuthi zisetshenziselwa izinto zokuvimbela inzalo sasivumela okuthembekile. Ngaphambi ukwelashwa, kubalulekile ukubeka eceleni ngokuphelele kungenzeka yokukhulelwa. Ukuze uqinisekise esiphezulu ukwelashwa ukuphepha noma kunjalo akufanele kwenziwe ngesikhathi senyanga yokuqala sokukhulelwa. Ngu izidakamizwa "Ukrliv" (amaphilisi) La mazwi abonisa ukuthi okungaphandle enikeziwe ngesimo izimo, lapho udokotela ecabanga ukuthi izinzuzo ukusetshenziswa kwezimali idlula izingozi ezingase zibe khona.

Azikho ngqo idatha emitholampilo ephathelene nokusetshenziswa ursodeoksiholievoy acid abesifazane ngesikhathi ibele, futhi ngenxa yalokho ukusetshenziswa kwezimali kwalesi sigaba iziguli is hhayi Kunconywa.

Izimo

Ngu izidakamizwa "Ukrliv" (amaphilisi) isitatimende waphawula eziningana Izimo ezinkulu ukuze ukusetshenziswa kwaleli thuluzi:

• khona ukuvuvukala okukhulu uvule imbobo Bile noma nenyongo sesinye;
• khona isiguli ukuzwela ngokweqile ezintweni ezithile lichaza ekwakheni ukulungiswa;
• Bile imbobo occlusion (lapha lihlanganisa kokubili ezivamile imbobo odla ngisho nezinkinobho ezihlukene ngaphambili ukubekwa uphawu esinyeni);
• isifo sokusha kwesibindi, uhlala decompensated.

Ngaphezu kwalokho, kuyafaneleka yokuthi leli thuluzi akufanele ebekiwe iziguli nenyongo sesinye, okungasekelwe ibukeke besebenzisa amasu radiographic, kanye neziguli kanye contractility kahle kwesinye nenyongo ngamatshe calcified noma labo ukwethula njalo colic biliary , njengoba kufakazelwa izidakamizwa umyalelo (ukumiswa) "Ukrliv". Uphenyo odokotela uqinisekise leli qiniso, ngoba ochwepheshe ayibeki umncele le-ejenti e kulezi zimo ezingenhla.

side effects

Phakathi yokwamukela lokhu izidakamizwa kungabangela imiphumela eminingi engemihle njengezindlela elandelayo:

• semfene ezahlukene pheshana emathunjini;
• ezimweni ezingajwayelekile kakhulu ngesikhathi ekwelapheni eyinhloko biliary iziguli isifo sokusha kwaphakama ngempela eqinile ubuhlungu abdomialnaya ku hypochondrium kwesokudla;
• e izifundo zokwelapha, kwatholakala ukuthi iqembu elithile iziguli kwavela indle okuxekethile noma isifo sohudo ngesikhatsi ukwelashwa usebenzisa ursodeoksiholievoy acid;
• semfene ahlukahlukene esinyeni nenyongo futhi isibindi;
• Nalapha futhi, ezimweni ezingajwayelekile kakhulu ngesikhatsi ukwelashwa nale izidakamizwa calcification of amatshe atholakala enyongweni;
• ngesikhathi yokwelapha ithuthukiswe ngezigaba eyinhloko isifo sokusha biliary, ezimweni ezingavamile, iziguli samanje isifo sokusha decompensated, okuyinto kancane ephindela emva kokwelashwa wayekwa.

Ngaphezu kwalokho, odokotela bavame kuphawulwe ukubuyekeza kwabo ukuthi imiphumela emibi kokuthatha lesi imali ungaboniswa zonke izinhlobo hypersensitivity ukusabela noma ukuqubuka. Abantu ezithandwa komzimba ngokuqapha kufanele lisetshenziswe.

Kanjani ukuyisebenzisa?

Azikho yobudala ku yokuvuma zomuthi alikho, njengoba kufakazelwa izidakamizwa "Ukrliv" imfundo (amaphilisi). Intengo kwaleli thuluzi, ngokulandelana, kuyafana kungakhathaliseki ukuthi iyiphi iqembu iziguli ezidinga ukwelashwa.

Ezigulini kokuba esisindo esingaphansi 47 kg noma ubunzima amaphilisi nokugwinya, kungenzeka usebenzisa lokhu izidakamizwa ngesimo ukumiswa, okuyinto evame odokotela wawubona ngempela. Kuye izinkomba ezithile udokotela ukuba khona inikeza kungenzeka ngokusebenzisa le izidakamizwa kule ngemithamo elandelayo.

Ukuhlakazwa biliary cholesterol amatshe

• Isisindo: 47 kuya ku-60 kg. izibhebhe ezimbili ngosuku.
• Isisindo: 61 kuya ku-80 kg. amaphilisi amathathu ngosuku.
• Isisindo: 81 kuya ku-100 kg. amaphilisi amane ngosuku.
• Isisindo: ngaphezu kuka-100 kg. amaphilisi Five ngosuku.

Tablets kumele kusetshenziswe kanye ngosuku, udinga konjane them lonke aphuze nengcosana ketshezi. Ngu izidakamizwa "Ukrliv" imfundo (amaphilisi) mathupha uthi kungcono ukusebenzisa leli thuluzi kusihlwa ngaphambi kokulala, kuyilapho reception kufanele kube njalo ukuze kuzuzwe nomphumela ofiselekayo.

Izici

Isikhathi esidingekayo kwamakomidi ephelele amatshe atholakala enyongweni, ezimweni eziningi kunenzuzo kusuka ezinyangeni eziyi-6 kuya ku-24. Kuleso simo, uma ukuncipha ubukhulu isiyonke amatshe atholakala enyongweni is hhayi waphawula ngemuva kwezinyanga eziyi-12 reception asebenzayo izimali, ukwelashwa okuqhubekayo Kunconywa.

Ngu izidakamizwa "Ukrliv" (isiraphu) Isitatimende lesi sithi impumelelo ukwelashwa kufanele ihlolwe njalo emva kwezinyanga eziyi6 ngosizo-X-ray noma ultrasound. ucwaningo okuningi kufanele kwenziwe ngalolo akwenzeki uma calcification nesineke zamatshe e imithi oyinikiwe. Uma lokhu kwenzeka, inqubo yokwelapha ke kufanele wayeka ngokuphelele.

ukuphathwa siyefana PBC

Endabeni yesiguli aphansi isifo sokusha biliary isisindo nesineke oluthinta ngqo kangakanani izidakamizwa izosetshenziselwa "Ukrliv". Ukufundiswa uthi kuye isisindo umthamo wansuku zonke zingahluka kusuka amaphilisi 3 kuya ku-7.

Phakathi nezinyanga ezintathu zokuqala okwelashwa, ithebhulethi kumele kusetshenziswe usuku lonke, kuyilapho engayitholi nsuku kufanele basakaza izigaba eziningana. Kuleso simo, uma amagugu isibindi phezu kwalesi sikhathi, kuye kwenziwa ngcono, sizokwazi ukuthatha umthamo wansuku zonke kanye kuphela kusihlwa.

Tablets kufanele kugwinywe lonke, badinga ukuphuza uketshezi, futhi ngesikhathi esifanayo kuleli cala futhi kubalulekile ukugcina njalo. Kufanele kuqashelwe ukuthi lesi sidakamizwa "Ukrliv" (Ukumiswa) imfundo manual uthi ukusetshenziswa kwalo uma kwenzeka isiguli aphansi isifo sokusha biliary inikezwe isikhathi eside, uma kudingeka ngesikhatsi ukwelashwa.

Izici

Kuyaphawuleka yokuthi iziguli nale Ihlahlubo okokuqala, ezimweni ezingajwayelekile kungenzeka Ukuwohloka izimpawu zokwelashwa, futhi, ngokukhethekile, abanye ukulunywa anda kwenzeka. Njengoba kufakazelwa lesi sidakamizwa "Ukrliv" imfundo, ukumiswa noma amaphilisi e Kulokhu kuyakuba ingasetshenziswa lapha, kodwa kufanele kuncishiswe umthamo wansuku zonke, ngemva kwalokho isikhathi liyakhula kancane kancane nenani oyifunayo. Ngakho, kubalulekile isonto ngalinye ukwandisa umthamo wansuku zonke kuze kube okwamanje kuze oyifunayo umthamo lwemithi abayifunayo.

ukweqisa izidakamizwa

ingozi kakhulu eliphansi ukweqisa izidakamizwa avuse yimiphi imiphumela emibi. Ikakhulukazi, ukuthi kungenzeka nesenzakalo yesifo sohudo, lapho kakhulu Kunconywa ukuba ngezikhathi ukuqapha izinkomba main umsebenzi sesibindi. Uma uhudo uzodinga ukunciphisa umthamo, futhi uma kungasizi ukuyeka ngokuphelele ukusetshenziswa kwaleli thuluzi, njengoba kufakazelwa izidakamizwa "Ukrliv" imfundo manual. Intengo imishini (ruble 460., Kuye uhlobo lomkhiqizo) evumela cishe noma ubani ukuyisebenzisa umthamo efanele.

Ayikho zokumelana ethize kulokhu kungadingeki, futhi imiphumela sohudo kufanele aphathwe symptomatically kuphela, ngenkathi kuhlonishwa ngokucophelela kokusele electrolyte nasoketshezini. Lokhu kubalulekile ngempela ukuze kuzuzwe umphumela esiphezulu ngezinga konke okusemandleni zokuphepha.