Umkhuba we-CRP ekuhlaziyweni kwegazi legazi

Iprotheyini esebenzayo ka-C (i-CRP noma i-CRP kusuka kuphrotheni ye-C-reactive) ibhekisela kuphrotheni ye-plasma yegazi. I-CRP ekuhlaziyweni kwegazi okwemvelo yiyona ezwela kakhulu, ngokushesha iphendula ngokunyuka kwezinga lokuhlushwa esigabeni esiyinkimbinkimbi senqubo yokuvuvukala eyenzeka emzimbeni.

Lokhu kusabela kudlala indima yokuzivikela. Ngezinhloso zokuxilonga, ukuhlaziywa kwe-CRP ngokufanayo nokulinganisa kwe-ESR kusetshenziswa njengendlela yokukhomba inqubo yokuvuvukala.

Iprotheyini esebenzayo ye-C - iyini

Iprotheyini yathola igama layo ngenxa yekhono layo lokumisa (kusukela kwelesiLatini elithi praecipitatio, ngokwezwi nezwi elisho ukuwa phansi, okungukuthi ukubopha kanye nesimiso). Ibophezela kuma-C-polysaccharides we-pneumococci futhi ngaleyo ndlela ivikela umzimba kusuka ekutheleleni.

I-CRP igqugquzela ukukhiqizwa kwe-leukocytes, okuyizona eziyisivimbela amabhaktheriya nezinye izifo. Futhi, le phrotheni yenza ngcono umsebenzi osebenzayo we-T-lymphocytes, echaphazela i-phagocytosis, i-agglutination kanye ne-precipitation reaction ezenzeka emzimbeni.

Indima ye-CRP emzimbeni

Iyini indima yale phrotheni emzimbeni? I-CRP iyakususa emzimbeni we-fatty acids kanye ne-bioactive lysophospholipids, eyakhiwa ngenxa yomonakalo kumangqamuzana eseli kunoma iyiphi inqubo yokuvuvukala noma i- necrosis yezicubu.

I-Phosphatidylcholine yiyona nto eyinhloko yazo zonke izingqamuzana zamaseli. Ngokuvamile, itholakala engxenyeni yangaphakathi yezinambuzane futhi ayitholakali ebusweni bayo. Noma yisiphi ukuvuvukala, amangqamuzana, futhi ngenxa yalokho, izibilini zabo, zonakalisiwe. I-Phosphatidylcholine ivela engxenyeni yangaphandle yamangqamuzana eseli. Bahlotshiswe nge-phosphatidylserine ne-phosphadidylethanolamine. Lezi phospholipids zithola i-hydrolysis futhi ziguqulwa zibe ngabaxhumanisi abaqine kakhulu bezinqubo zezinto eziphilayo ezivela emzimbeni.

Ngakho-ke, zithuthukisa i-hemolysis (ukubhujiswa) kwama-erythrocyte futhi zenza umonakalo emangqamuzaneni ngokwawo. Le nqubo ibangela ukwakheka kwama-antibodies namanye ama-antigens aveza phezu kweseli futhi abe indawo yokubopha i-CRP kanye nekhanda lensiza elonakele. Ngaphezu kwalokho, ama-macrophage asetshenziselwa, okwenza ukuthi athathe izinsalela zeseli elimele.

Ngakho-ke, i-CRP ekuhlaziyweni kwegazi ngegazi iwuphawu lokulimala kwezicubu kunoma iyiphi inqubo yokuvuvukala, ukuhlukumezeka ne-necrosis.

Izizathu zokwandisa i-DRR

I-CRP ikhiqizwa ngamaseli wesibindi futhi i-glycoprotein. Ukuhlaziywa kwe-CRP - kuyini? Ngaphansi kwethonya labaxhumanisi abaphilayo (baxoxe ngenhla), okungukuthi labo ababhekene ne-hydrolysis ye-phospholipids, ukukhiqizwa kwe-CRP kuyakhuthazwa. Okuqukethwe kwayo kuqala ukuvuka ngemva kwamahora ambalwa. Futhi usuku olulandelayo ngemuva kokuqala kwesifo sokuvuvukala noma esinye isifo se-pathological, amaprotheni e-CRP ekutadisheni kwegazi i-biochemistry ingaba izikhathi ezingaphezu kwezingu-20 eziphakeme kunezivamile. Lokhu kubizwa ikakhulukazi ekutheleleni kwamagciwane.

I-CRP iphakanyisiwe futhi ngezinguquko ze-necrotic emahlakheni ayenzeka ngokuhlukunyezwa, ukushaywa nokubola kwama-tumor. Imiphumela yocwaningo lwezokwelapha yakamuva ibonise ukuthi ukwanda kwale protheyini kuyi- serum kuyisici se-atherosclerosis yemithwalo yegazi. Kutholakale ukuthi ngezinguquko ze-atherosclerotic embhede wamathambo, inqubo encane yokuvuvukala ezindongeni zemithanjeni yegazi yenzeke. Izinto ezibambe iqhaza kulolu shintsho lwezinto eziphilayo zi:

• Ukubhema,
• Ukukhuluphala,
• Sikashukela.

Umphumela we-CRP emzimbeni wesifo senhliziyo

Ngisho nokunyuka okuncane ku-CRP ekuvivinyweni kwegazi kwegazi kungabonisa ukuthi kukhona ukuvuvukala okuncane ezindongeni zezitsha futhi ngaleyo ndlela kube uphawu lwezinguquko ze-atherosclerotic.

Kuyaziwa ukuthi ukwanda kwezinga eliphansi le-lipoprotein (LDL) kuthinta ukwakhiwa kwamapuletiki angenawo ama-atherosclerotic ezinkanyeni zemithambo yegazi. Kodwa izifundo zamuva zibonise ukuthi ezigulini ezinamazinga aphakeme we-CRP egazini nasezingeni elivamile le-LDL, ingozi yokuthuthukisa izifo ze-cardiovascular is higher than those those CRP ehlala evamile, futhi izinga LDL liphuma.

Kulezi ziguli ezinesifo senhliziyo (CHD), kanye nabantu abaye bahlaselwa isifo sokushaya isifo senhliziyo, noma isifo senhliziyo noma esiye sathola inqubo yokudlula isifo se-stenosis ye-coronary arteries, ukuhlaziywa kwe-CRP positive (ngenhla kwesijwayelekile) kuyisibonakaliso sokuhlushwa okubi. Lokhu kungase kubonise ukuthi kungenzeka ukuhlaselwa okuphindaphindiwe noma ukuhlasela kwenhliziyo, njll.

I-biochemistry: i-CRP iphakeme kunejwayelekile. Mayelana nalokho okushoyo

Ukuhlaziywa kwe-DRR - yikuphi lokhu futhi lokhu kungakhuphuka kubonisani? Okokuqala, kufanele kuqashelwe ukuthi ukujwayelekile kwalesi sikhombisi egazini kuvela ku-0 kuya ku-0.5 mg / l. Ukwandisa izinga layo egazini kungathinta izinqubo ezimbili zomzimba, kanye nokuphila. Ake siqale sicabangele ukuthi izibalo ze-pathological zithi ukubaluleka kwe-CRP kunganda.

Izinqubo ezithintekayo ezikhulisa izinga le-CRP

Ngakho-ke, leli xabiso landa emazwini alandelayo:

• Ngemuva kwezinqubo ezithathelwanayo eziyingozi, ikakhulukazi uma zinezinhlobo zebhaktheriya.
• Uma kucindezela izinqubo zokuvuvukala ezithathelwanayo noma ezithathelwanayo, kufaka phakathi izinguquko ze-atherosclerotic ezindongeni zemithambo yegazi.
• Noma yimuphi umonakalo ebucayi bomzimba (ukuhlaselwa yinhliziyo, ukuhlinzwa, ukuhlukunyezwa, isithwathwa, ukushisa, njll).
• Ngokuqhekeka kwezidumbu uma kwenzeka izinqubo zemvelo kanye nokubonakala kwemithambo emisha.
• E-high blood pressure.
• Nge-endocrine pathologies (ukukhuluphala, isifo sikashukela, ukudlula ngokweqile noma ukuntuleka kwama-hormone ocansi, njll).
• Ezimweni zokuphulwa kwamaprotheni umzimba.
• Ngezinguquko ze-atherosclerotic ezitsheni.
• Abantu abahlukumeza ukubhema.

Izimo ezingokwenyama ezithinta i-CRP

Ngaphezu kwalokhu, izimo ezithile zomzimba zingathonya ukuhlaziywa kwezinto eziphilayo ze-CRP. Ngakho, izinga lalo lingakhuphuka ngokuzikhandla okukhulu ngokomzimba, isibonelo:

• Abagijimi ngesikhathi sokuncintisana noma ukuqinisa ukuqeqeshwa.
• Kwabesifazane ngesikhathi sokukhulelwa, ikakhulukazi uma kune-toxicosis.
• Uma uthatha isisu sokubeletha kwe-hormonal noma amanye ama-hormone.
• Ukusebenzisa utshwala noma ukudla okunamafutha ngesikhathi sokunikela ngegazi ukuze kuhlaziywe.
• Ubukhona bokuguquka noma izimila emzimbeni.

Kuziphi izimo i-CRP engaphansi kwesimiso

Ngaphezu kwalokho, ukuhlushwa kwe-CRP ekuhlolweni kwegazi kwegazi kungase kube phansi futhi kube ngaphansi kwesimiso ngemuva kwemithi ethile, ikakhulu uma isiguli sithatha isikhathi eside. Lezi zidakamizwa zifaka:

• I-hormone ye-glucocorticoid.
• Izidakamizwa ezingezona isifo esivimba ukuvuvukala.
• Beta-blockers.

I-CRP: evamile

Ucwaningo lwe-DRR luphawu olubucayi kakhulu. Ukuhlaziywa kwe-CRP kungenziwa ngokusebenzisa izindlela ezihlukahlukene. Ubufakazi bakhe bungahlukana kancane kuye ngokuthi ubuzwe be-reagents ehlukahlukene. Ngakho-ke, ku-laboratory ngayinye eveza ukuhlaziywa kwe-CRP, isimiso siboniswa uma umphumela unikezwa.

Ngakho-ke, ama-laboratories ngabanye abonisa umkhuba we-0 kuya ku-0.5 mg / l. Futhi abanye, ngokusebenzisa izindlela ezahlukene, inothi kwimiphumela ekhishwe yocwaningo ukuthi i-CRP isendlalelo ivela ku-0 kuya ku-0.3 mg / l. Ngakho-ke, uma ufunda umphumela, kufanele uhlale unaka izinga elibekiwe.

Ngokungeziwe, imiphumela yalolu hlaziyo iboniswe ngenombolo nje nje nje. Ngaphambilini, indlela yasendulo yasetshenziswa, eyanikeza imiphumela eseduze. Ukuboniswa kokulinganisa kwalokhu kuhlaziywa kwanikezwa ngeziphambano. Ngakho, umphumela ubhekwa njengokuthi "awunayo" (-). Uma kutholakale imiphumela emihle, ikhishwe ngesimo sengqondo enjalo - "ngokuqinisekile" (+). Emakhonini, inani leziphambano ukusuka komunye kuya kwezine labhalwa.

Inani lokuxilonga le-CRP

Ngaphezu kwezinye izinkomba kanye nezindlela zokuhlola, i-CRP nayo ibalulekile. Ngakho-ke, le prothini iqala ukubhekana nokungena kokutheleleka emzimbeni noma ukuthuthukiswa kwesinye isifo. Ngemuva nje kwamahora ambalwa emva kokuthuthukiswa kwe-infarction ye-myocardial, izinga lenkomba egazini liqala ukukhula. Futhi ngosuku kuphela lungakhula ngezikhathi ezingamashumi.

Ukucwaninga kwalesi sibonakaliso ezinamandla kwenza udokotela ahlulele ukusebenza kwamaqhinga akhethwe ukwelashwa. Ngakho-ke, njengoba ukuqina kwenqubo ye-rheumatic noma enye yokukhubazeka kwehla, izinga le-CRP egazini liyancipha.

Lokhu kuhlaziywa sekuyisikhathi eside kwazisa kakhulu, futhi ngisho nokuthuthukiswa kwezinqubo ezintsha zokucwaninga akukwazi ukuyiqeda.

Indlela yokudlula ukuhlolwa kweprotheyini esebenzayo ka-C

Ukuze kudlule ukuhlaziywa okunjalo, ukuqeqeshwa okukhethekile akudingeki. Kodwa kufanele kukhunjulwe ukuthi zonke izivivinyo zegazi zithathwa ekuseni ngesisu esingenalutho. Emini, ezinye izinkomba zingahluka kancane, isibonelo, i-glucose noma i-leukocyte. Ukuhlolwa kwegazi kuvame ukuphathwa ngendlela eyinkimbinkimbi. Lezi zingase zibe nokuhlolwa kwe-rhumum, zibandakanya isifundo se-CRP, noma ukuhlolwa kwegazi emtholampilo, okuhlola i- ESR. Bonke, kanye nokuhlolwa nokuqoqwa kwe-anamnesis, kubalulekile ekuxilongweni okulungile.

Igazi ku-CRP lithathwe emgqeni ekamelweni lokunakekelwa kwe- polyclinic noma kunoma iyiphi enye indawo yezokwelapha.

Ngaphambi kokunikela ngegazi kulolu cwaningo ukuze uthole umphumela owuthembeke ngokwengeziwe, kubalulekile ukugcina imithetho eminingana elula:

1. Kudla isidlo kusihlwa akufanele kube sekwephuzile kakhulu futhi kuningi.
2. Ngokushesha ngaphambi kokunikela ngegazi akunconywa ukuthatha noma yikuphi ukudla futhi kuphakanyiswa ukuthi angabhemi. Kuvunyelwe ukuphuza amanzi.
3. Usuku ngaphambi kokuba kufanele ugweme ukuthatha noma yikuphi uphuzo oludakayo, itiye elinamandla kakhulu nekhofi.
4. Amahora ambalwa ngaphambi kokuba kuvivinywe ukuhlolwa, akusikiswanga ukuphuza ngokweqile noma, ngokuphambene nalokho, i-overcool. Ngamanye amazwi, awukwazi ukuya esikhwameni segazi ngemva nje kwe-sauna, ukugeza, ibhishi noma i-solarium, noma ukubhukuda emgodini weqhwa.
5. Ngaphambi kwehhovisi, kunconywa ukuhlala nokuphumula imizuzu embalwa.

Kuziphi izifo kukhona ukwanda kwe-CRP

Uma ukuhlolwa kwegazi kwe-CRP kwenziwa, isimiso sifika ku-0.5 mg / l. Uma izinga lale nkhomba liphakeme, ke ngokusho kwezinye izimpawu, isiguli singasolwa ngezifo ezilandelayo:

• I-rheumatic system pathologies (i-rheumatoid arthritis, i-systemic lupus erythematosus, njll).
• Izifo ezithinta amagciwane.
• Izifo ze-fungal.
• Izifo zesigubhu esiswini (isisu sangasese, isisu esiswini noma isilonda se-duodenal, i-ulcerative colitis, njll).
• Ukwehlukaniswa kwesifo esibi esibuhlungu noma imetastasis ngesikhathi sezinhlelo zemvelo.
• I-myeloma eminingi.
• I-infarction ye-myocardial (kakade ngosuku lwesibili ngemuva kokuhlaselwa kwe-CRP ikhuphuka futhi iphelalala kuphela ekupheleni kwamasonto amathathu, uma kwenzeka i-angina le nkomba ihlala evamile).
• Endocarditis.
• Amyloidosis yesibili.
• Isifo sofuba.
• I-Meningitis.
• I-Neutropenia.
• I-Sepsis yezingane ezisanda kuzalwa.
• Izinkinga emva kokuhlinzwa, isibonelo, i-peritonitis noma ukuphuma kwe-postoperative.
• Endabeni yokufakelwa kabusha, ukwanda kwe-CRP kungabonisa ukusabela kokulahlwa.

Ngakho-ke, sithole konke mayelana nokuhlaziywa okunjalo njengocwaningo lwe-CRP - ukuthi yikuphi futhi ngaphansi kweziphi izimo ezingakhula. Ukutadisha kwe-CRP ezinhlobonhlobo ze-pathology ye-cardiovascular is a uhlobo lomaka futhi kuvumela ukubikezela izinkinga ezingenzeka. Lokhu kwenza kube lula ukuthola isikhathi nokuvimbela ukuwohloka kwesimo sesiguli, ukuvimbela izinkinga.

Indlela yokuphatha i-CRP ephakeme

Kumele kuqondwe ukuthi ukwandisa izinga le-CRP kungumpawu nje, hhayi isifo. Ngabe yikuphi kulapha okungenzeka ukuthi lesi sibonakaliso sibonisa, udokotela uyazikhethela. Ukwenza lokhu, udinga ukutadisha ngokucophelela konke okufundwayo, ukuhlola isiguli futhi ukuqoqa kahle ama-anamnesis. Ngemuva kwalokho, ukutholakala kwesifo kuphela kuyomiswa. Ukwelashwa akunikezwa uphawu oluthile, kodwa isifo sisonke.