PTH anda - njengoba kufakazelwa ukuhlaziywa?

i-hormone Parathyroid (ngenye ngokuthi i-hormone parathyroid, parathyrin) - i-hormone ekhiqizwa yi-parathyroid izicubu (parathyroid) nezindlala, okuyinto zitholakala ohlangothini anterolateral entanyeni. Ziyakwazi emva indlala yegilo, okuyinto eduze eduze kwamanzi ezingemuva zalo Ezansi bobabili share yayo. i-hormone Parathyroid ngokwemvelo yabo zamakhemikhali kuyinto eziyinkimbinkimbi amaprotheni izidakamizwa - polypeptide acid acid nemikhiqizo.

umsebenzi wayo lomkhulu iqhaza nekulawulwa calcium ne phosphorus umzimba emzimbeni. Okuqukethwe kwe-calcium egazini futhi uketshezi hormone parathyroid encike ngqo kusuka komunye nomunye. Hormone kungandisa lokuhlushwa calcium ngokulwa enethambo izicubu, izinso kanye ipheshana emathunjini. I parathyrin ithambo kwandisa logoff Ukuqedwa amaminerali ingxenye by inkanuko zamagama enzyme ethize banesibopho ukubhidlika ithambo impahla. Bone izicubu is phansi ngaphansi kwethonya PTH resorption ne-calcium ion zitholakala egazini. Ndawonye calcium exchange paratgormot esiza ekulawuleni izinga le-phosphate emzimbeni. Ukunciphisa umfutho inqubo yokuqala begazi, ke icacisa ukugeleza yesibili. Ngaphezu kwalokho, i-hormone ehilelekile ekuthuthukiseni synthesis calcitriol emathunjini, ekusizeni i-calcium reabsorption. i-hormone Parathyroid kuthatha ingxenye engaqondile e ukulawulwa imisebenzi yonke enzyme calcium ancike katalirizuemye abasabela ngayo. Ngaphansi ithonya lakhe futhi uthola uhlelo igazi coagulation.

Uma PTH liphakeme ke kwakhiwa izifo ezinzima endocrine ezihlobene ne amathambo ubuqotho ukwephulwa - hyperparathyroidism, kwamathambo. Waba yini umphumela wesibindi enjalo isici bokuphila ngokucijile incipha ngo izinga le-calcium egazini, okuholela anda excitability kwamanyuroni. Comorbidities kulokhu ongakhonza okuqukethwe okusezingeni eliphezulu alikhali emzimbeni kanye nokuthuthukiswa ukwehluleka kwezinso. Ngokunciphisa okuqukethwe calcium lens amehlo cataract kwenzeka.

Amazinga le-hormone of nezindlala parathyroid egazini kuncike a isigqi lomzimba. Izinga basal isethwe cishe 8 ekuseni, ngesikhathi amahora 14-16 kosuku, lapho indoda isezingeni eliphakeme lomsebenzi, i-hormone parathyroid anda. Ukuhlolwa kwegazi Kwenziwa ngenani parathyrin immunohemilyuminestsentsii. Kumelwe wenze esiswini esingenalutho, ne usuku noma ezimbili ngaphambi igazi amasampuli ukuqeda nophuzo oludakayo futhi umsebenzi esindayo amahora ambalwa ngaphambi kokuthi inqubo, ungabhemi.

Ngemva kokuhlaziya hormone parathyroid ezinqunyiwe kuphela uma isiguli okusolwa ukuba khona izifo ezifana hyper- futhi gipokaltsimiya, urolithiasis futhi neurofibromatosis. Futhi izinkomba for ukuhlaziya injongo kungabandakanya: amathambo kwamathambo psevdoperelomy eside, noma iyiphi bokuphila eshintsha ithambo osteosclerosis noma imigwamanda vertebral futhi wasola endocrine amaningi neoplasia uhlobo 1 kanye nohlobo 2 (AMADODA 1.2). On parathormone Izinga omdala kubhekwa 9,5-75 pg / ml. Lokhu kusebenza kokubili amadoda nabesifazane asebeneminyaka efanele yobudala zokuzala. Uma ithole ukuthi lo PTH liphakeme, sinesizathu esizwakalayo ukuphetha ngokuthi isiguli lokuqala, lesibili, hyperparathyroidism ephakeme, pseudohypoparathyreosis noma Zollinger-Ellison syndrome.

Ngaphansi kuhlanganiswe hyperparathyroidism eyinhloko Hyperplasia we ndlala parathyroid, umdlavuza ijwabu wesinye endocrine neoplasia izinhlobo ezimbili. Co. hyperparathyroidism yesibili zihlanganisa nesifo esingamahlalakhona kwezinso, hypervitaminosis D, izilonda emathunjini, yamathambo, isifo Crohn. Uma PTH liphakeme ke ukuhlaziya ngokuvamile kwenziwa ngokuhlanganyela kwencazelo ezingeni le-calcium egazini nasesikhathini esizayo ngokufaniswa izinkomba ezimbili futhi ukukhomba ukuncika.