Prodrug "Parnavel": yokusetshenziswa

Ukulungiselela "Parnavel" imfundo manual uchaza njengendlela prodrug, okuyinto i inhibitor ACE futhi kunomphumela ophawulekayo antihypertensive. Ukusebenza leli thuluzi le okusithiyayo ukuncintisana umsebenzi ACE, kamuva okuholela ukwehla lokuhlushwa angiotensin II. Ngokuthatha imithi "Parnavel" (yokusetshenziswa ke kuqinisekisa) Layisha encishisiwe, afterload (OPSS), kanye ukumelana in imithambo yegazi yamaphaphu, futhi kwandisa ukucindezeleka ukubekezelelana. Ngokuqondene izakhiwo pharmacokinetic we-ejenti, wabe esesho siqala imakwe umphumela hypotensive phakathi nezinsuku zokuqala imizuzu ayisithupha ngemva kokuphathwa, ukufinyelela esiphezulu yayo ngemva kwamahora amane okushaya noma eziyisishiyagalombili futhi ephikelela ekwephuleni usuku lonke.

izidakamizwa Iyatholakala "Parnavel", intengo zazo kuhluka amabili namashumi ayisihlanu ruble ezingamakhulu amathathu, ngesimo ezivamile round amaphilisi. Ukwakheka iphilisi elilodwa njengoba element esebenzayo eyinhloko ifakiwe okungaphansi kwenkululeko perindopril erbumine angu ezine.

Thatha imithi "Parnavel" imfundo manual incoma ukuthi sisetshenziselwe ekwelapheni amafomu ezingamahlalakhona ephethwe yisifo senhliziyo noma umfutho wegazi ophakeme. Umthamo kokuqala zomuthi, ngokuvamile phakathi no angu amabili ngosuku ngesikhathi, kanye nokugcinwa - emibili kuya kwemine angu ngosuku.

Sebenzisa ithebhulethi "Parnavel" ochwepheshe batusa kakhulu ukuthi abantu ukungabekezelelani ngazinye perindopril erbumine kanye nabo bonke labo babe nezici ezithile ukuze ukuthuthukiswa angioedema. Ngaphezu kwalokho, uhlu Izimo ngqo ukusetshenziswa zihlanganisa ukukhulelwa futhi engu-nesishiyagalombili. Isikhathi lactation kufana kufanele uyeke ukuthatha izidakamizwa "Parnavel". Yokusetshenziswa Amanothi kanye undesirability yokusetshenziswa kwawo esimweni wegazi vele ophakeme kakhulu noma eqalwe ukwehluleka kwezinso. Abantu abaphethwe kusilela uketshezi kanye sodium, ngaphambi kokuqala Yiqiniso yokwelapha kufanele kube impoqo ukwenza ukulungiswa lokho okubizwa ngomlobokazi amanzi electrolyte ukungalingani.

Ngaphezu kwalokho, udinga ukusebenzisa ngokucophelela ithebhulethi "Parnavel" kanyekanye baphuza imithi kungabangela nokwanda okuphawulekayo ezingeni potassium.

Ekuphetheni, kufanele ishiwo kungenzeka ukusabela ezingezinhle ukuthi kungase kubangelwe ngokuthatha lo izidakamizwa. Ngokwesibonelo, izazi uqaphele ingozi kahle eliphezulu of isifuba esomile ikhanda, isiyezi, ukuphazamiseka zokunambitha nomlomo owomile. Ngaphezu kwalokho, kungase kube izinguquko njalo kwemizwa, nezinkinga zobulili, ukuqubuka kwesikhumba, ukukhishwa angioedema, ukuquleka, erythema, isikhumba ububomvu, ukulunywa futhi isifuba. Ngaphezu kwalokho, kungenzeka ukuncipha-hemoglobin Inkomba futhi ukwandisa ezingeni uric acid kanye creatinine ngenxa Ukungenisa "Parnavel".