ACE inhibitor - izidakamizwa ephumelelayo nezenhliziyo yesimanje

Inhibitors noma ACE angiotensin ukuguqulela isici okuthiwa vasodilators anamandla esetshenziswa nezenhliziyo ukwelapha umfutho ophakeme wegazi. Isenzo yaleli qembu izidakamizwa kungapheli ekuvimbeni adrenal i-hormone angiotensin II - pressor isici esiyinhloko ezithinta ukubaluleka blood pressure. ACE inhibitor avimbela ukuthi kungenzeki ukubhidlika bradykinin, okuyinto sithinta isimo zemikhumbi, futhi ngenxa yalokho on ukuphakama komfutho wegazi. Le mithi basize ukwandisa amazinga igazi vasodilator prostaglandins banciphise izimpawu eziwumphumela wokugula ka ezingamahlalakhona ukumelwa inhliziyo, bavame waphawula in iziguli nomfutho wegazi ophezulu ebalulekile. Ngesikhathi esifanayo, ACE inhibitor, ngokungafani nezinye izidakamizwa ukuthi kunciphise umfutho wegazi azinamphumela ku-glucose ne-lipid umzimba, ukwehlisa urinary amaprotheni nezinso.

ACE inhibitor asetshenziswa iminyaka engaphezu kwengu-40. Elokuqala leli qembu izidakamizwa ngo-1975 waba kwemiqondo captopril, wasebenzisa namuhla. Eminyakeni embalwa kamuva wabekwa etholwe enalapril futhi lisinopril. Bona kwathathelwa indawo ngaphezulu yesimanje ACE inhibitor isizukulwane esisha.

Ngo nezenhliziyo yesimanje ACE inhibitor asetshenziswa njengoba izidakamizwa esiyinhloko ekwelapheni abanomfutho wegazi ophakeme nesifo, ischemic isifo senhliziyo, ezingamahlalakhona yokumelwa yinhliziyo.

ACE inhibitor ngezigaba

Kunezinhlobo eziningana ACE inhibitor, okuncike ukususwa endleleni kwezidakamizwa emzimbeni, kuye ngokuthi iqembu kwamakhemikhali okwenzeka engqamuzaneni uxhumana ACE maphakathi izinyathelo umsebenzi. Ukwahlukaniswa ezivame kakhulu isenzo kwemithi.

Ngokusho isenzo kwemithi ye angiotensin ukuguqulela inhibitor zonke izici zihlukaniswe amaqembu amathathu.

Iqembu sokuqala captopril noma hood, okuyinto kuvimbela ngqo, isb kuvimbela angiotensin mina ukuguqulela umsebenzi hormone ngo lwesigaba okwalandela - angiotensin II. Ukuze silondoloze captopril noma kapoten blood pressure evamile kuthathwe kathathu kuya kwamane ngosuku.

Ukuze iqembu lesibili eyakhe enalapril, ramipril, trandalopril, tsilazipril, fosinopril, quinapril nezinye izidakamizwa ukuthi aguqulwa emzimbeni ku eselaphayo ezinethonya vasodilatory. Le mithi zanele ukuthatha kanye kuphela ngosuku.

Ekugcineni, iqembu lesithathu siqukethe lisinopril Zestril, prinivil, prestarium noma perindopril. ACE inhibitor iqembu lesithathu Kunconywa ukuthatha kanye noma kabili emini.

Imiphumela engemihle ACE inhibitor

Uma uthola leli qembu izidakamizwa kufanele bazazi ukuthuthukiswa kungenzeka nemiphumela engemihle. Kwezinye izimo, ukuthatha ACE inhibitor zingavela isifuba esomile anda amazinga potassium igazi, isiyezi, iguliswa ukuqubuka kwesikhumba, ukukhishwa angioedema. Lezi zinkinga kuyaqedwa ngokuphelele ngemva izidakamizwa zokuqaleka. isifuba esomile lapho livela ngosuku lwesithathu nanhlanu ukwelashwa. Khona kanye ukubukeka kwawo kungenxa sokuzuza amaphaphu bradykinin. Khwehlela ubalekela ngokuphelele ngemva ukuqedwa inhibitor. Ezinye iziguli zingase wehlise esesuthi ziphazamiseke ukunambitheka bezibona.

Omunye Izimo ezinkulu ukuze ukusetshenziswa ACE inhibitor kuyinto zamazwe amabili kwezinso Umthambo constriction. Kulokhu, ingcindezi igazi luyanda ngokuvusa ezingeni renin egazini lapho le mithi azinamphumela.

Kufanele siqaphelisise inikezwe ACE inhibitor e izifo zesibindi nezinso ezingamahlalakhona ekuthuthukiseni izimpawu esingamahlalakhona hepatic futhi kwezinso.