Amathebulethi "Valvir": imiyalelo yokusetshenziswa, ukubuyekezwa

Umthamo we-"Virvir "unqunywe ngamuphi umthamo? Imiyalo yokusetshenziswa kwezidakamizwa kanye nomthamo wayo ishiwo ngezansi. Futhi ezintweni ezikulesi sihloko ungathola ulwazi mayelana nezinkomba zomuthi, imiphumela yaso emibi kanye nokuphikisana.

Ukwakhiwa, ifomu kanye nokupakishwa kwemithi

Iluphi uhlobo ukulungiselela "Valvir" okuthengisiwe? Imiyalelo yokusetshenziswa ifakwe emakhadibhodi okupakishwa kanye namaphilisi amhlophe ama-oval ne-biconvex (nge-blisters), agcoke ngesigxobo sefilimu.

Isithako esisebenzayo sale mithi i-valaciclovir hydrochloride hydrate. Ngokuqondene nezithako ezengeziwe, abakhiqizi basebenzisa i-povidone ne-microcrystalline cellulose njengezithako zabo.

Izakhiwo zomzimba

Umuthi "Valvir" iyinhlangano ye-antiviral. Ngemuva kokuba into esebenzayo ingena emzimbeni ngaphansi kwesenzo se-valacyclovirhydrolase, ivele ihluke ibe yi-acyclovir ne-L-valine.

Lo muthi uvimbela umsebenzi we-varicella, i-herpes simplex ne-cytomegalovirus.

Amaphilisi e-"Valvir", imiyalo yawo evezwa ngezansi, wehlisa ukuqala kwe-DNA egazini. Ngamanye amazwi, ingxenye ephathekayo yalesi sidakamizwa yakhiwa yi-DNA yamagciwane, bese iphula ububanzi bayo futhi ivimba ukuphindaphindiwe.

Imingcele ye-Pharmacokinetic

Ukubanjwa kuka-Valvir kuphi? Imiyalelo yokusetshenziswa ikhombisa ukuthi le mithi igxila kwi-systemic bloodstream ukusuka kumgudu wokugaya. Emva kokuthatha umthamo owodwa ngesamba kuze kufike ku-2 g, ukuhlushwa okuphezulu kwesidakamizwa kufinyelelwa egazini ngemuva kwamahora amabili. Ukutholakala kwezidakamizwa akuxhomeke ekutheni ukudla futhi kungu-54%.

Ukubambisana kwezidakamizwa ezisebenzayo ezinamaprotheni e-plasma kuncane kakhulu (cishe ngo-15%). Noma kunjalo, zisakazwa ngokushesha ngokushesha kuzo zonke izicubu zomzimba. I-Acyclovir itholakala emisipha, isibindi, amaphaphu nezinso. Ngaphezu kwalokho, ingena kwi-vesicles ehlanzekile, i-cerebrospinal fluid kanye nemfihlo yesifazane.

Ukuphila kwengxenye yalo muthi amahora amathathu. Ukususwa kwalo emzimbeni kwenziwa kanye nomchamo.

Yini ayetshenziselwa?

Ngisiphi isibonakaliso iziguli ezibekwe imithi efana ne-Valvir (500 mg)? Imfundo iyazisa ukuthi lokhu kusho ukuthi kuyasebenza uma:

• Herpes zoster;
• I-herpes ye-Labial;
• Ukubuyiselwa kwesikhumba kanye ne-mucous membrane infections (esetshenziselwa kokubili prophylaxis kanye nokwelashwa) eyabangelwa i-herpes (esanda kutholakala futhi ibuyela kabusha i-herpes yobulili);
• Ukutheleleka kwe-Cytomegalovirus (njenge-prophylaxis), eyakhiwa ngesikhathi sokufakelwa komzimba.

Ngaphezu kwalokhu okungenhla, lesi sidakamizwa sisetshenziselwa ukunciphisa amathuba okutheleleka komlingani ophilile (ngokubambisana nekhondomu).

Ukungafani kokusetshenziswa

Isidakamizwa esithi "Valvir" ngesikhathi sokukhulelwa asikhuthazwa. Futhi amaphilisi akwazi ukuphathwa uma:

• Ukufakelwa kwe-bone marrow;
• Ebusheni;
• Ukuvezwa ngokomzimba ngesimo sokutheleleka nge-HIV;
• Ukufakelwa kwezinso;
• Ukuziphendulela ngokwezinto ezidakamizwa.

Ngokucophelela le mithi inqunyelwe iziguli ezinokuphefumula okungenangqondo nokuqeda amandla, kanye nokubeletha.

Ukulungiselela "Valvir": imiyalo yokusetshenziswa

Amathebulethi akhethe noma akhethe ngaphakathi. Ukulinganisa kwabo kuncike ekutheni luhlobo olunjani nesifo.

• Nge- herpes zoster , i-1000 mg yemithi inqunywe kathathu ngosuku ngesonto.
• With herpes labial, umuthi unikezwa isiguli 2 g kabili ngosuku. Umthamo wesibili kufanele uthathwe ngemva kwamahora angu-12.
• Nge-herpes elula, odokotela batusa ukusebenzisa imithi engu-500 imithi kabili ngosuku. Uma ubuyela emuva, inkambo yokwelapha kufanele ibe izinsuku ezingu-3-5, futhi isigaba esiyinhloko - cishe izinsuku ezingu-10.

• Ekuvimbeleni ukutheleleka kwe- cytomegalovirus kubantu abangaphezu kweminyaka engu-12 ubudala, kubalulekile ukusebenzisa u-2 g wezidakamizwa izikhathi ezine ngosuku. Isikhathi sokwelapha sisezinsuku ezingu-90.
• Uma kuvinjelwa ukuphindaphinda kwezifo ezibangelwa igciwane le-herpes simplex, abantu abane-immune ejwayelekile banqunywe ama-500 mg wemithi kanye ngosuku, iziguli ezikhulile ezine-immunodeficiency - 500 mg kabili ngosuku, futhi ziphindaphinda njalo - 250 mg ngesilinganiso esifanayo. Isikhathi sokwelashwa sinyanga ezingu-7-12.

Amacala okudlula ngokweqile

Iziphi izibonakaliso zokudlula ngokweqile okwenzekayo uma uthatha amazinga aphezulu we-Valvir kusuka ku-herpes? Ukuphawula kochwepheshe kubhekisela kulezi zibonakaliso ezilandelayo: i-hallucinations, i-nausea, i-agitation, i-confusion, ikhanda, ukuhlanza, i-coma, ukuhluleka kwezinso, ukuxubana, ukwanda kwe-creatinine (serum) egazini.

Uma izimo ezinjalo zenzeka, kufanele uthintane nodokotela ngokushesha. Uma kwenzeka ukudlula ngokweqile, iziguli kufanele zihlale zihlonishwa ochwepheshe ukuze zibonise izimpawu zemiphumela enobuthi.

Ukuqhutshwa kwe-hemodialysis kuvumela ukususa ngokuphelele i-acyclovir emzimbeni wesisulu.

Amaphilisi e-Valvir: imiphumela emibi

Uma uthatha i-Valvir, iziguli zivame ukukhononda ngokuthinta okunzima njengokuphathwa kwekhanda nokuhlukunyezwa. Ngaphezu kwalokho, imithi ngokuvamile idala izimo ezimbi kakhulu ezinokuhluleka okukhulu kwezinyosi, i-thrombocytopenic purpura ye-thrombotic, izifo ze-neurological kanye ne-hemolytic-uremic syndrome.

Kumele kuqashelwe ukuthi kwezinye izimo, iziguli zingathola imiphumela elandelayo engathandeki (ngokumelene nesizinda sokuthatha lesi sidakamizwa):

• Ukuphazamiseka esiswini;
• Dyspnoea;
• I-Leukopenia ne-thrombocytopenia;
• Umsebenzi wezinso ongasebenzi kahle;
• Anaphylaxis;
• Umbono ongenakwenzeka;
• Ama-hallucinations, ukufutheka, izimpawu ze-psychotic, isizungu, ukucindezeleka, ukukhathazeka, ukudideka, ukucindezeleka, ukucindezeleka, ukunciphisa amakhono engqondo;
• I-Erythema multiform;
• Ukuhlambalaza esikhumbeni, i-photosensitivity kanye nokushaya;
• Hypercreatininaemia, ukwehlisa i-hemoglobin;
• I-Angioedema ne-urticaria;
• I-Thrombocytopenic thrombotic purpura, i-neutropenia, i-anemia ye-inslastic ne-vasculitis ye-leukoplastic;
• I-Dysmenorrhea, izifo zokuphefumula, umkhuhlane, i-tachycardia, ukuphela kwamanzi, i-arthralgia, i-nasopharyngitis, ukukhathala, ukuvuvukala ubuso, ukucindezela okwandayo kanye ne-rhinorrhea.

Izincomo zokuthatha imithi

Ngokusho kochwepheshe, ukutholakala kwe-bioavailability yalesi sidakamizwa akuxhomeke ekutheni ukudla. Kulokhu, ungathatha iphilisi futhi ngesikhathi sokudla, nangemva kwalokho. Kulesi simo, kunconywa ukuba ugcine isikhathi esilinganayo phakathi kwamanani athathwayo.

Abantu asebekhulile akudingeki balungise izilinganiso. Ukukodwa yilokho kuphela amacala lapho iziguli zinezinkinga zokungasebenzi ngokweqile.

Okuhlangenwe nakho kokusetshenziswa kwezidakamizwa ezinganeni ezingaphansi kweminyaka eyi-12 engekho. Ngakho-ke, ukummisa kule minyaka akufanele kube.

Ukuphawula kweziguli ngesidakamizwa

Iziguli zithini ngomuthi onjenge- "Valvir" (kusuka ku-herpes)? Ubufakazi balabo abaye basebenzisa le mithi bathi lesi siluleko senza kube lula ukuqeda zonke izimpukane ezomile (embranini, ama-genitalia, njll).

Ngaphezu kwalokho, lesi sidakamizwa sithuthukisa kakhulu isimo senhlalakahle nengokomzimba yesiguli.

Kumele kuqashelwe ukuthi i-ejenti ecutshungulwayo ingabhalwa kuphela ukwelashwa kwegciwane le-herpes, kodwa futhi nokuvimbela kwayo. Inani elikhulu leziguli liphikisana ngokuthi ukudla okulawulwa kwalesi mithi kunganciphisa izigameko ze-bubble uhlaselwa okungenani. Umuntu akanakusiza ukusho ukuthi ukusetshenziswa kwezidakamizwa eziphakanyisiwe zezidakamizwa kubantu cishe akubange kubangele imiphumela emibi.

Kanye nezimpendulo eziqondile mayelana namaphilisi "Valvir", zibuye zenzeke. Njengomthetho, zixhunyaniswe nentengo ye-overestimated yalo muthi. Namuhla, amaphilisi angu-10 alo muthi angathengwa ngamaruble angu-630-680.