Umuthi 'Baraklyud ": yokusetshenziswa, incazelo, ukwakheka kanye nokubuyekeza

"Baraklyud" libhekisela izidakamizwa anti-retroviral, ingxenye iqembu nucleoside analogue. Ezinqunyelwe ekwelapheni ezingamahlalakhona-HBV-ukutheleleka. Isithako asebenzayo we entecavir izidakamizwa ngokushesha suppresses ukufanisana viral zokusha kwesibindi.

Kumelwe nakanjani kube isichasiselo wafunda ngaphambi kokuthatha lesi sidakamizwa. Njengoba kuboniswa yokusetshenziswa? "Baraklyud" (Baraclud) - umuthi okuhloswe ukuqala backflow izinqubo fibrotic in iziguli isibindi sibe sesomile.

isidakamizwa

Umuthi itholakala ongakhetha ezimbili Isikali - 0.5 kanye no-1 mg ingxenye entecavir asebenzayo zibukeke zehlukene udayi umbala (omhlophe noma pink, ngokulandelana).

Ukulungiswa futhi kuhlanganisa:

• polysorbate;
• magnesium stearate;
• monohydrate lactose;
• Valium;
• povidone;
• colorant Opadry.

imiphumela kwemithi

Isithako esebenzayo entecavir okuyinto kuyinto analogue of the guanosine nucleoside, ikhulumelani umsebenzi abakhethayo ukuba ukusha kwesibindi kohlobo B.

Entecavir is phosphorylated i triphosphate iyasebenza nge uhhafu-ukuphila amahora angaba ngu-15, okuqukethwe intracellular zazo ihlobene lokuhlushwa entecavir amaseli ngaphandle. Uma lokhu ningagcini ekuqongeleleni appreciable lomcebo asebenzayo emzimbeni. Medicine "Baraklyud" yokusetshenziswa okhombisa kahle yaso ephezulu, suppresses umsebenzi polymerase viral, nomthelela kanyekanye ezicini ezintathu:

• kwezici Strand omuhle ka-DNA-HBV;
• ukuhlanekezela umbhalo wentambo negative mRNA pregenomic;
• I-HBV iyatholakala priming enzyme.

Triphosphate akuyona retarders eqinile enzyme-DNA yeselula, ngisho ne wokuqukethwe enkulu akunamthelela mitochondrial DNA zamagama.

umphumela we izidakamizwa

I asebenzayo izidakamizwa izidakamizwa uyakwazi isikhathi esifushane ugxile kusukela lomgudu wokugaya ukudla bese ifinyelela esiphezulu saba of wo contents kumaminithi 30-90 emva ngokuthatha amaphilisi.

ukwanda sokuboshwa e Cmax kanye indices AUC kwenzeka lisetshenziswa alandelayo 0.1-1 mg nomuthi "Baraklyud". Yokusetshenziswa ukhuluma ngani nokufeza ukulingana ngosuku 6-10-th isilinganiso esisodwa zomuthi ngosuku. Ukusetshenziswa ukudla okunamafutha kakhulu inkimbinkimbi entecavir ukumuncwa inqubo, nekususa amakhodi Cmax kanye AUC ngu 45% no 20% ngokulandelana.

Umuthi ngokushesha ugxile izicubu futhi ngo-13% eboshiwe plasma amaprotheni. I asebenzayo izidakamizwa ingxenye ingasebenzi kuzo substrates, enzyme inhibitor noma inducers ka P450 uhlelo. It uyakwazi buthelela emzimbeni futhi okukhipha ngohlelo kwezinso ngu filtration glomerular kokukhwehlela ijabulise.

izinkomba

Nomuthi "Baraklyud" Kunconywa ukuthatha ekwelashweni eyinkimbinkimbi ukusha kwesibindi kohlobo B:

• Nge izimpawu samanje ukufanisana ezibangelwa amagciwane kanye nokwenyuka degree of umsebenzi transaminases ku serum, phambi ukubonakaliswa histological ukuvuvukala okuqhubekayo kwesibindi.
• izilonda isibindi Unrecovered.

impumuzo abalulekile isibindi izimpawu isifo okuyokwenzeka ngemva izidakamizwa isimiso sokuqondisa 'Baraklyud ". Tablets imfundo manual incoma ukuthi iziguli kwesibindi kohlobo B okungamahlalakhona, isifo sesibindi nzima lokhu okulandelayo:

• elise decompensated;
• isimo sokugembula sesibindi esingelapheki kubantu abangamaphesenti isinyathelo isinxephezelo uma efakwe ukubonakaliswa ukufanisana viral kutholakala ukuthi uphethwe yini ka isibindi cystic nge AST anda no-ALT.

Izimo

Umuthi 'Baraklyud "has Izimo ezilandelayo:

• anda ezifweni ukuze entecavir kanye nezinye izinto kufakwe Ukwakheka izidakamizwa;
• lezinceku lactose ukungabekezelelani, zikashukela-galactose malabsorption, ukuntula noma ukungabi emzimbeni we lactase enzyme ;
• yobudala engaphansi kuka-18 ubudala.

Abantu nge nokwehluleka ukusebenza kwezinso kudingeke uthathe isidakamizwa kadokotela futhi ngaphansi kweso lwezokwelapha njalo.

Reception "Baraklyuda" ngesikhathi sokukhulelwa is hhayi Kunconywa ngesikhathi yokwelapha Kudingeka uyeke ukuncelisa ibele.

side effects

Kungase kube ezihlukahlukene iziyaluyalu wokugaya ukudla ngesikhathi ukwelashwa izidakamizwa "Baraklyud". Yokusetshenziswa zibonakala ngokucacile kuchaziwe imiphumela emibi:

• iziyaluyalu wokugaya ukudla;
• isifo sohudo,
• isicanucanu nokuhlanza;
• dyspepsia.

Ungase uthole nokuthi uba ikhanda, ukuqwasha noma ukozela, ukungakuthandi ukudla, nokungezwani komzimba.

Ukusebenzisa imithi njenge-ejenti yedwa zokwelapha noma lihambisana namanye antiretroviral kungabangela hepatomegaly ezinzima nge steatosis, okungase kubangele ukufa lesiguli.

In iziguli nombono decompensated laktatsiadoz izilonda kungenzeka isibindi, esibonakala by:

• jikelele ukuba buthakathaka kwezicubu;
• ukuphefumula okusheshayo futhi ukubukeka iphika;
• isicanucanu;
• ukunciphisa abalulekile esisindo;
• ubuhlungu peritoneum, epigastric.

Futhi, izidakamizwa kungabangela ukusabela ezahlukene futhi umzimba:

• enanini eliphakeme transaminases hepatic;
• ukuqubuka kwesikhumba;
• ukuphendula anaphylactoid.

Iziguli futhi ukuhlupheka decompensated isifo sesibindi, ngaphezu, ukusabela okunjalo kukhona umzimba kubonakala:

• ukwehluleka kwezinso (ezimweni ezingajwayelekile);
• anda okuqukethwe bilirubin egazini;
• . Ukwehlisa platelet ukubala izinkulungwane 50 / mm ³ noma ngaphansi;
• nokwehlisa Bicarbonate egazini;
• nesanda ALT;
• ezingaphezu kuka ukwanda emithathu ngeshumi umsebenzi lipase;
• yehlise amazinga-albumin.

Nomuthi "Baraklyud": Isikali kanye nokuphathwa

Umuthi kumele kuthathwe esiswini esingenalutho, isikhathi kusuka esidlweni sokugcina ngaphambi kokudla nokufakwa kufanele kube amahora angaphezu kwamabili.

Lapho ihlawulelwa ukulimala kwesibindi reception Kunconywa "Baraklyuda" 0.5 mg nsuku zonke. Ekukhombeni ukumelana lamivudine Isikali kumele kabili.

Iziguli izilonda isibindi unrepaired ebekiwe engayitholi nsuku zonke 1 mg. Ukuze asebekhulile kanye neziguli kanye esingamahlalakhona kwezinso, umthamo kumele kushintshwe kuye ngokuthi ezingeni CK (creatinine lokuhlushwa) egazini.

ukweqisa izidakamizwa

Ulwazi amacala izidakamizwa ukweqisa izidakamizwa akwanele.

Amavolontiya, okwakubekelwa emtholampilo ihlolwe, wathola umthamo wansuku zonke 20 mg amasonto amabili banikezwa iphilisi elilodwa le ephakeme - 40 mg izidakamizwa "Baraklyud". Iziyalezo yokusetshenziswa uthi imiphumela emibi zitholiwe.

Ezinconyiwe ukwelashwa posindromnoe ngaphansi kokuqondisa ukubonakaliswa emtholampilo.

Ukuxhumana nezinye izidakamizwa

Ngenxa yokuthi esebenzayo ingxenye entecavir is excreted ngokuyinhloko ngokusebenzisa uhlelo kwezinso, ukwelashwa eziyinkimbinkimbi lihambisana namanye izidakamizwa ezinikeza imiphumela eqondile noma engaqondile ku nokusebenza kwezinso futhi kuthinte uketshezi ijabulise, kungaholela ukwanda emzimbeni entecavir kanye izinto asebenzayo we izidakamizwa.

Ukuxhumana "Baraklyuda" nge adenovirom, i-tenofovir, i-lamivudine awazange eqoshiwe.

izinyathelo zokuqapha

Ukwemukelwa iziguli engazweli ukuba lamivudine kuholela ingozi yokuba ukumelana.

Futhi, kunobufakazi okuvela exacerbations ka-hepatitis B emva ukuqedwa lesi sidakamizwa "Baraklyud". Yokusetshenziswa uchaza ngempumuzo exacerbations ngaphandle kokwelashwa ezengeziwe.

Izixwayiso

Reception "Baraklyuda" kohlaka monotherapy nokwelashwa kuhlangene nezinye ejenti ngezidambisigciwane, kungabangela lactic acidosis, hepatomegaly nge steatosis. Kulokhu, kukhona ingozi yokufa.

Engozini iziguli zihlanganisa lezi zinhlobo ezilandelayo:

• abaphethwe hepatomegaly;
• baphathwe ukusetshenziswa nucleoside analogue;
• kokuba ukhuluphele;
• iziguli zesifazane.

Yokusetshenziswa zomuthi "Baraklyud" kuphawula kungenzeka kumiswa ukumelana zamagciwane ezibangelwa amagciwane. Active isithako entecavir izidakamizwa is hhayi Kunconywa for ekwelapheni human immunodeficiency virus ngenxa nokusebenza ngendlela kulesi siqondiso ungazange okwamanje wafunda ngokugcwele.

Esikhathini nokwelashwa kweziguli zokugula kohlelo kwezinso, kuyadingeka ukuze ulungise umthamo.

Ukuphepha kanye nempumelelo ngokusebenzisa "Baraklyuda" ekwelapheni iziguli emva isibindi ukufakelwa Awaziwa futhi zidinga ekhethekile ukunakekelwa ukuhambisana izinyathelo.

izimo Isitoreji kanye nezindleko

Ukugcinwa Kwazo Ngenjongo ukuthuthwa zithutha kufanele kwenziwe uhla lokushisa 15-25 ° C. Ukulungiswa ofanele ukusetshenziswa iminyaka emibili kusukela usuku ukwakhiwa.

Umuthi likhona iqembu elihlukile semithi ebalulekile, futhi ngoba izigaba ethile yezakhamuzi setha ukulethwa khulula zomuthi "Baraklyud". Yokusetshenziswa ithumba leli qiniso.

Inani izindlela eMoscow Pharmacy iqala kusukela ayizinkulungwane 12. Ruble.

Ukubukwa iziguli

Ikhombisa kusebenta okusezingeni eliphezulu zomuthi "Baraklyud" imfundo manual. Inani, ukubuyekezwa zazo wabonisa ukuthi kwakungelula yeningi, uma kulinganiswa nokwenu analogue zomuthi, uyahluka 12-17 ayizinkulungwane iphakethe ngalinye, lapho 30 zithutha. Lokhu kwenza bomuthi ukuthi zithandwa kakhulu futhi ziphoqa iziguli ukwelapha ukusha kwesibindi kohlobo B.

Esikhathini impendulo engeyinhle ikakhulu okubhekiselwe proitvopokazaniya futhi side effects zomuthi, ezifana ukuqwasha nesicanucanu.