Umuthi 'Aspekard ": yokusetshenziswa, analogs, ukubuyekezwa

Acetylsalicylic acid (ASA), libhekisela izidakamizwa ngemiphumela antipyretic, eqeda ukuvuvukala kanye antiplatelet. Zokwelapha isetshenziswa eminyakeni engaphezu kuka-125, ngoba ingenye izidakamizwa okucwaningwa ngawo kakhulu. Kulokhu ASA isiyatholakala njengendlela kardioformy ukunciphisa ingozi yenhliziyo Umthambo thrombosis, okuyinto ebambezela ukuthuthukiswa isilethikusebenza. Isibonelo esivamile ukulungiswa "Aspekard" equkethe acetylsalicylic acid endaweni elilungile umthamo antiplatelet umphumela.

Imininingwane kwifomu ukukhululwa kanye Umkhiqizi

Umenzi zomuthi yinkampani Ukrainian "Stirolbiopharm". Ngakho, ubuchwepheshe yokukhiqiza esetshenziswa, akhiqizwa amafomu ifomu zheludochnorastvorimoy at umthamo mg 100 iphilisi ngalinye. Izindlela ezibhebheni isakhiwo:

• ibhokisi amaphilisi 120 (amabhamuza 10 kuya 12 ithebhu.);
• isiqukathi polymeric amaphilisi 100.

I-Tablet "Aspekard" iqukethe mg 100 ASA, microcrystalline cellulose, sodium croscarmellose, colloidal Silicon dioxide, stearic acid.

Izincomo aphoyintimenti

Lapho belungela ukuya khona "Aspekard" isicelo lincane ngokwanele, nakuba siqukethe imiyalo ephathelene nezincomo ukuze kwelashwe izifo eziningi, kuhlanganise nezifo rheumatism. Umkhiqizi Kunconywa "Aspekard" futhi njenge-agent antipyretic noma analgesic. Empeleni, umthamo acetylsalicylic acid imithi kungenziwa wayisebenzisa kuphela njengoba izidakamizwa evimbela platelet wokuhlanganisa.

Izinkomba "Aspekard"

On the ukulungiselela "Aspekard" imfundo on isicelo, izibuyekezo emitholampilo ucwaningo ochwepheshe futhi unike eningi ukwaziswa okuhlobene antiplatelet yokwelapha. It is kuboniswe ngayo ezimweni ezilandelayo:

• lapho (ACS), sibi syndrome senhliziyo (at isinyathelo kokuphakama acute esivimba amanzi infarction, ukucindezeleka noma yayinjalo ST ingxenye indawo, e angina engazinzile);
• unhlangothi (stroke ischemic noma lezivakashi kuhlasela ischemic);
• uma kungase kutholakale ukuxhumelela imithambo yenhliziyo isifo njengendlela yokuthola nokuvinjelwa sibi syndrome senhliziyo kanye nesifo sohlangothi;
• ekuvimbeleni iziqephu yansukuzonke of sibi syndrome senhliziyo kanye nesifo sohlangothi;
• nokuba khona varicose emithanjeni;
• njenge-ejenti ukukhalima, a thrombosis isixwayiso shunt ngemva CABG;
• nge nomfutho wegazi ophezulu esimweni ingozi eliphezulu zenhliziyo.

ingozi High zenhliziyo kuyinto umqondo aggregate ebandakanya khona target umonakalo isitho nomfutho wegazi ophezulu kanye nezifo ezihlobene: ngifundise ngesifo sikashukela, yenhliziyo Umthambo isifo, TSVB.

Izici Isikali zemithi Kunconywa ngumkhiqizi

Lapho belungela ukuya khona "Aspekard" imfundo umkhiqizi akuyona ubuholi eyinhloko yokwelashwa lesiguli. Liqukethe ulwazi mayelana nokuphathwa izidakamizwa ezimweni ezahlukene zokwelapha ezisukela nokuvimbela izenzakalo atherothrombotic e CHD futhi TSVB ziphethe iziyaluyalu okukhulu kwegazi cerebral futhi inhliziyo. Lokhu ukungenzi kubhekwa isimo sengqondo sokungakunaki futhi ngokomsebenzi engiwenzayo nempikiswano izidakamizwa ohambisana zabo ulwazi izinto. Iphinde kudala preconditions ukushicilelwa mass izihloko lapho imithamo Kunconywa kuhluke.

Sokuphuzisa zemithi ngesisekelo izincomo ngamazwe

Ngesisekelo yiziqondiso zomhlaba wonke akhiwa European Community of nezenhliziyo (ESC) futhi-American Heart Association (AHA) futhi iguqulwe ngu-Ministry of Health, tindlela kwesicelo acetylsalicylic acid zimi kanje:

• ngesinyathelo eziphuthumayo ngesikhathi sibi syndrome senhliziyo liyadingeka ukunikeza isiguli ukuhlafuna izibhebhe 3 "Aspekard 100". Yokusetshenziswa unganakwa, kanye umthamo owodwa we-300 mg;
• ezingamahlalakhona ischemia inhliziyo (CHD) reception njalo babelwe esinye isibhebhe sibonisa 100 mg kusihlwa ngemva kokudla kwakusihlwa;
• nge nomfutho wegazi ophezulu iziguli enengcuphe enkulu yezinkinga zenhliziyo, kanye varicose emithambo yegazi njalo yamukelwa mg 100 (1 tablet) kusihlwa ngemva kokudla kwakusihlwa.

Ezinye izindlela kwezidakamizwa isimiso sokuqondisa 'Aspekard "imfundo ESC futhi AHA alinikezi. Kubalulekile futhi ukwazi ukuthi umthamo ejwayelekile "Aspekard" 100 mg ASA. Ukuze ekugwemeni izifo ngenhla, ngokuhambisana nemiyalelo ESC futhi AHA, isicelo umthamo 75 mg. Nokho, mg 100 babelwe iziguli emva CABG ukuvimbela thrombosis we shunt. Kwezinye izimo-ke Kunconywa ukusebenzisa 75 mg, isb inani ASA, esinikela eyanele antiplatelet umphumela futhi ubuncane ingozi gastrotoxicity.

Futhi, umenzi alinikezi imininingwane ebalulekile kwi ukuqedwa zomuthi. Ngokusho nezibalo, ukumisa ngokuzumayo imbangela 10.2% imicimbi acute senhliziyo. Futhi betholakala cishe emuva 10.6 izinsuku kusukela ngosuku ukwesulwa ASA. Le nkathi yisilinganiso futhi ikhombisa isikhathi lapho sonke isibalo sabantu kuyehla platelet cyclooxygenase ukusebenza. Ngenxa yalokho, kungenzeka amahlule abuyiselwe. Ngoba izidakamizwa kumele kuthathwe ngokuqhubekayo, kuyilapho ukuqashwa kukaNksz umbangeli antiplatelet esikhundleni "Aspekard" ukubonakala ngenxa yezinkinga pheshana emathunjini liyadingeka.

Izimo "Aspekard" ukulungiselela

Ukuphepha yonke imikhiqizo eyenza imithi lilinganiselwe ngoba inemiphumela ethile engemihle. Ngesikhathi esifanayo babangela ezinye Izimo. Ikakhulukazi:

• in iziyaluyalu kwegazi coagulation (oluhambisana diathesis, hemophilia A no B);
• in iziyaluyalu izici isisu (erosions, izilonda acute isisu kanye duodenum 12);
• ngesikhathi senyanga yokuqala nokukhulelwa kanye lactation;
• e ukungakhuli ezinzima kwezinso noma hepatic;
• lapho komzimba nezinto salicylates;
• kubantfwana labancane kunalabo abaneminyaka engu-18;
• ebukhoneni somoya bronchial;
• ekwelapheni methotrexate.

Lezi Izimo kukhona ngokuphelele, yize isikhathi esithile: lactation, ukukhulelwa, ukuguguleka komhlabathi kanye nezilonda yokusetshenziswa pheshana emathunjini, esewusana. Futhi kukhona iqembu uthi, khona lapho kudinga ukuqapha njalo ngudokotela. Lokhu ukusetshenziswa ngesikhathi esisodwa yokwelapha antiplatelet nge anticoagulants, nokwelashwa kweziguli ngemva yenhliziyo ukuhlinzwa Umthambo dlula. Uma umsebenzi izinso isetshenziswa lesi sidakamizwa "Aspekard" yokusetshenziswa zidinga Isikali zincishiswe noma ukuqedela ukuqedwa kancane kancane izidakamizwa.

imiphumela Joint "Aspekard"

Acetylsalicylic acid enezinto eziningi imiphumela ezithuthukisa noma sicindezeleke isenzo izidakamizwa eziningana. Ikakhulukazi:

• ASA sithuthukisa umphumela iyiphi anticoagulants namanxusa antiplatelet;
• ASA sithuthukisa umphumela antipyretic kanye analgesic of ama-NSAID, icacisa umphumela enqanda ukuhlasela kwesifo samalunga "Meloxicam";
• lapho kuhlangene izidakamizwa cytotoxic ithuthukisa gastrotoxicity zabo;
• lapho kuthathwe ngotshwala ingozi isilonda yezinkinga noma ukopha inyuka;
• glucocorticoids ukwanda gastrotoxicity "Aspekard";
• Ack attenuates umphumela isisu lapho kuhlangene isisu "Furosemide", "torasemide", "spironolactone".
• "Aspekard" buthakathaka umphumela ejenti uricosuric, "Probenecid", "Etamid", "sulfinpirazon";
• nonabsorbable antacids kakhulu ukunciphisa ukumuncwa "Aspekard".

Amathuba ngokweqile futhi izimpawu zaso

Ngokulinganiswa izidakamizwa "Aspekard" imfundo, impendulo kanye nokusebenzisa izibalo ukuqinisekisa izinga eliphezulu ngokwanele sokuphepha edilini lomshado ngokuvumelana izinkomba kanye contraindications ngaphandle. Lokhu kusho ukuthi umthamo onqunyiwe 100 mg zomuthi iphephile ngokwanele, nakuba kokulawula isimo sempilo kuyadingeka. Ngaphezu kwalokho, ngenxa yokuthi welicembu kweziguli kokuzibulala, kanye ingozi ukuthi izibhebhe ASA kuzothatha umntwana, imininingwane edingekayo okungenzeka ukweqisa izidakamizwa futhi izimpawu zaso.

Ezintsha ubuthi salicylates, cuphuluza isicelo ekulungisweni "Aspekard" ngaphandle izimpawu udokotela izincomo kukhona uthi ezilandelayo: isiyezi, ubuhlungu podlozhechkovoy fossa, endaweni enkabeni, ngezinye izikhathi ubuhlungu, ikakhulukazi iziguli isifo sezinso. Endabeni ka ukweqisa izidakamizwa njengoba kukhona ukuqhaqhazela, ukuhlanza, kwesinye isikhathi streaks wezimpi ezalandela. Eyokuqala nge lokungeniswa yokufakelwa of emesis: luningi isiphuzo esibandayo, isebenze namalahle indlela futhi ehnterosorbentov nesineke ukulethwa esibhedlela.

Okubalulekile, ngemithamo anobuthi "Aspekard" imfundo manual alisho. Zihluke isisindo ehlukene kanye nobudala isiguli. Ngokwesibonelo, e omdala womuntu ukweqisa izidakamizwa unezimpawu ezikahle ASA kwenzeke yokuvuma olulodwa mayelana 5-7 amagremu acid. Izingane angasaneli ukweqisa izidakamizwa 1.5 g umthamo owodwa. A ukweqisa izidakamizwa eside kwenzeka uma sisebenzisa 7-9 amagremu abadala nezingane 2-2.5 igremu ASA.

Lokhu degree of izidakamizwa ukweqisa izidakamizwa olwaboniswa iziyaluyalu ngenhla ezihilela imisebenzi yobuchopho. inothi Lost iqala tinnitus ukucabanga kuba udidekile ngenkulumo incoherent. Ukuhlanza ngokuvamile kwenzeka, isiguli ngokushesha ilahlekelwa uketshezi ukuhlanza, ukuphefumula ophilisayo, kukhona acute nokugcinwa urinary, kukhuphuke izinga lokushisa komzimba. Ukusiza isiguli usesimweni esinjalo akunakwenzeka ngokuzimela - ukulethwa iyadingeka Nicu ukulapha ukumnika Bicarbonate, sodium lactate.

Izici yesenzo zokwelapha "Aspekard"

Njengoba unamathele izidakamizwa "Aspekard" ezisebenza imfundo yakhiwa inkomba yokwamukela iphilisi elilodwa ngelanga (100 mg / ngosuku). Lokhu umthamo ASA yanele ukuba zivimbele platelet cyclooxygenase. Umphumela okusithiyayo of synthesis thromboxane A2, okuyinto kuvimbela ngokuphelele ikhono amaseli ukuze platelet wokuhlanganisa. Lokhu kungabi sengxenyeni kungenzeka thrombosis, okuyinto imbangela infarct esivimba amanzi noma palsy.

Ukuhlinzeka umphumela antithrombotic ka acetylsalicylic acid kufanele angena igazi. Nokho, omunye wawo wenza esiswini futhi ezivimbela cyclooxygenase-1 kanye isoforms yayo le mucosa isitho. Waba yini umphumela walesi indlela luluhlangothi umphumela - ikhono encishisiwe muco-zokuzivikela isithiyo carbonate. Lokhu kwandisa izingozi erosions futhi izilonda ze-isisu, ekhuthaza emathunjini-ukopha. ukwakhiwa Enteric bayakwazi ntombazane ukopha, kodwa imvamisa lokhu side effect, banayo elincane kakhulu.

Nokukhulelwa kanye lactation

umbono Isazi, esekelwe kokuhlaziywa izibalo kanye uchungechunge ucwaningo, okukuvumela ukuba abe nokuqonda okucacile isicelo "Aspekard" izidakamizwa ngesikhathi sokukhulelwa. Ikakhulukazi, 1 yokuthathu ukusetshenziswa kwaso akuvunyelwe. Kweyesi-2 no-3 senyanga isicelo avumelekile, kodwa ngemva nokuhlola ukusetshenziswa zayo zokwelapha nokumadanisa izingozi reception. Ngo iningi emitholampilo izimo aphoyintimenti ASA ngokungadingekile, nakuba ezinye ama-NSAID bayakwazi kwandisa ingozi yokungenwa yisisu.

Phakathi lactation, sebenzisa izidakamizwa "Aspekard" analogue kuye, imithi ejwayelekile, kanye yonke imithi nge acetylsalicylic acid ukwakheka akuvunyelwe. Isizathu salokhu kube ukuthi hit izidakamizwa ngobisi lwebele. lihlaba naye isidumbu sengane. Futhi ingozi alo nengozi enkulu yokuba Reye Syndrome - i encephalopathy ogulisa ngokwedlulele hepatic, elibangela ubuchopho ukuvuvukala kanye ukufa kwengane. Ngenxa yesizathu esifanayo, kungavunyelwe ukusetshenziswa kwezidakamizwa ngaphambi kweminyaka eli-16-18.

Imininingwane Izibuyekezo ochwepheshe kanye neziguli

Ngazo izidakamizwa "Aspekard" impendulo nesineke ezimweni eziningi nganhlanye. Bona kahle behlolisise inani lentengo lomuthi, ngoba cishe ephansi phakathi ontanga. Nanyana kunjalo, ukutshwaya eziphathelene ngokoqobo kancane eyabonisa ukungakwazi ukuhlola degree of iziguli kuncishiswe ingozi thrombosis semithambo. Ngamagama amathuba okuba nemiphumela engemihle ibikwe iziguli, umuthi libhekene njengoba ngokwanele ephephile.

Imibono lochwepheshe zicacile: okokuqala, umuthi ngempumelelo ekunciphiseni ingozi thrombosis, futhi okwesibili, iziguli ukunamathela antiplatelet yokuyelapha ephakeme ngenxa ongaphakeme "Aspekard" inani lentengo lomuthi. Analogs we ekilasini ejenti antiplatelet kukhona siphezulu. Domestic ukulungiselela enteric "Atsekardol" ezibizayo ngo-50%, kanti izindleko ukungena ephakeme nge izikhathi 7-10. Kodwa esekelwe ayinayo imiphumela eminingi engemihle ejenti enteric, kanye okutholakele kwezomnotho, kuyatuseka ukuba abeke "Atsekardolu". Izindleko zokwelapha nyangazonke kuyoba ruble angu-20.

Ukungabi umgomo ka kardiopreparata "Aspekard"

Njengoba unamathele izidakamizwa "Aspekard 100" imfundo manual uthi isidakamizwa itholakala amaphilisi. Bangancibilika esiswini ukukhiqiza emakamu eliphezulu. Ukunikeza wendawo gastrotoksichesky umphumela, umuthi ulahlekelwa Safety Okunye izidakamizwa, okungukuthi enteric. esiswini ukopha ingozi uma kusetshenziswa wesibili ingasaphathwa.

Izibonelo izidakamizwa ephephile zimi kanje: ". Aspirin Cardio" "Atsekardol", "Polokard", "Cardiomagnyl", Ngaphezu kwalokho, wathi izindlela futhi siqukethe magnesium hydroxide, bakwazi ukuvikela mucosa ekulimaleni ngu acetylsalicylic acid. Noma kunjalo, lesi sidakamizwa "Aspekard" ingase isetshenziselwe nokuvimbela thrombus ekwakhekeni, siqala nemikhawulo. Nokho, iziguli kokuba ukuguguleka mucosal, isilonda 12 duodenum noma esiswini, ezihlanganisa ezingamahlalakhona, kutuswa ukuthatha enteric kardioformy acetylsalicylic acid.

Vneotraslevoe isicelo kardiopreparata "Aspekard"

Iningi imiyalelo zitholakalele ukusetshenziswa eveza khona antiinflammatory futhi izakhiwo antipyretic izidakamizwa "Aspekard 100". Eqinisweni, ikhambi umnyuziki kunemiphumela zokwelapha iyona izikhathi 5 umthamo owodwa - 500 mg. Umthamo 100 mg siku inhliziyo, futhi umphumela wawo alanele ukunciphisa ngempumelelo lokushisa izifo ezithathelwanayo.

Kardioforma ukulungiselela ekhiqizwa umthamo 100 mg, kufanelekile ubuhlungu nempumuzo imfiva kuphela umthamo owodwa we amaphilisi 5. Ngakho selectivity predominance ngoba cyclooxygenase 1 inquma khona sebuningini ohlangothini ukusabela. Ngakho-ke, njengoba febrifuge "Aspekard" amaphilisi, yebo, afaneleka. Nokho, okwamanje kukhona eziningi izinhlobo eziningi zezidakamizwa ephephile bembonisa selectivity enkulu ngoba cyclooxygenase 2. Baye ayinayo imiphumela eminingi engemihle elihlobene ne-kokunikezwa kwe-ekwandeni epithelium emathunjini.

Ukuphepha ekilasini nozakwabo "Aspekard" izidakamizwa

A mkhuba efanayo kwaphawuleka ekwelapheni izifo rheumatism. Futhi exhunywe izidakamizwa "Aspekard 'ukufundisa ukusetshenziswa liqukethe ulwazi mayelana nokwelashwa kwazo. Nokho, umthamo watusa kuyinto komyalelo wokungabi 5-8 amagremu ngosuku.

Lokhu nenani acetylsalicylic acid libonisa gastrotoxicity engenakuqhathaniswa namandla umphumela kunangesikhathi "meloxicam" Imithi, "celecoxib", "Roferoksib" nabanye. Futhi njengoba antipyretic ekilasini eyigugu kakhulu Analogue kuyinto "ibuprofen".