"Omeprazole" noma "Ultop" - okuyinto engcono? Incazelo izidakamizwa, izinkomba kanye contraindications, amanani

Ukwelashwa nokuvikelwa izilonda emathunjini we mucosa esiswini noma ipheshana wokugaya ukudla ngokuvamile - inqubo eyinkimbinkimbi kanye eside. Lokhu kungenxa nje kuphela yokuthi hydrochloric acid, ingxenye juice esiswini, inyuka kancane mucosa isici kulo, eziswini kwezicubu siqu, kodwa ukuzihlanganisa khona isifo Helicobacter pylori silwanyana. Ukuze avimbele ukunwetshwa isici bese lula ukululama ngokushesha esiguli, odokotela ukunquma "omeprazole" noma "Ultop". Yikuphi okungcono, sizoxoxa ngani kulesi sihloko.

mshini wezenzo

Naphezu kweqiniso lokuthi le mithi igama elehlukile, isithako esebenzayo kuzo into efanayo - omeprazole. Aphulukisayo lokhu imithi?

Ngokwe-izici amakhemikhali yalolu ketshezi kuyinto cishe zingaxazululeki emanzini, kodwa encibilikayo kakhulu Ethanol noma methanol.

Ngo umkhuba emtholampilo, omeprazole isetshenziswa ukubunjwa izidakamizwa eziningi, kuhlanganise inhlanganisela, njengoba ejenti for ekwelapheni izilonda. "Omeprazole" noma "Ultop" - okuyinto engcono? Isikhathi esining impela ngiyazibuza lo mbuzo, iziguli kanye nodokotela.

Lo mshini wezenzo esekelwe okusithiyayo okuthiwa i-proton futha - amaprotheni ezokuthutha ethize elise ulwelwesi cell kwamaseli secretory isisu. Ngokunciphisa yokuvuma hydrogen ion in the cytoplasm amaseli anjalo secretory kwehle kwinani uveza hydrochloric acid asidi we esiswini juice liyancipha, okuholela ukuncipha izicubu ekubhujisweni uthanda ukuphulukiswa esasizosheshisa izilonda.

Pharmacokinetics

Omeprazole ngempumelelo kuvimbela kokubili ukukhiqiza inkanuko yobulili kanye basal we hydrochloric acid, ngesikhathi umthamo ofanayo umphumela nasekuthengeni. Lapho ukuphatha olulodwa ngemlomo ngaloko lokusandza kwenteka 20 mg "omeprazole" noma reception umthamo "Ultop" ukulungiselela - 20 mg, asidi ukwehla siyenzeka lingakapheli ihora lokuqala, njengoba umuthi ngokushesha futhi kahle ugxile kusukela inesikhala emathunjini bese engena kwegazi.

Nakuba nenxenye impilo esebenzayo ejenti ukwakhiwa kuyinto cishe amahora amabili, okusithiyayo ukwenziwa hydrochloric acid siyenzeka zingakapheli izinsuku emva umthamo owodwa.

emizileni Omeprazole oluhlukaniswe ngu sesibindi ipheshana biliary ulwelwesi lwamafinyila we isisu, cishe akusho zingene kusivimbeli gazi ebuchosheni futhi ngokuphelele nakanjani plasma amaprotheni. I degree of ephonsa the yokugcina lingafika ku 90-95%.

Excretion of omeprazole wenziwa ikakhulukazi umchamo, cishe 60-77% is excreted ngesimo metabolites ezifana gidroksiomeprazol futhi carboxylic acid. Iningi conjugates okuholela abonise cishe akukho msebenzi antisecretory, ngaphandle sulfonomeprazola. Asele somzimba we ketshezi izidakamizwa eyethulwe pheshana emathunjini ku Bile futhi indle.

ngokukhethekile kufanele pharmacokinetics ka omeprazole in iziguli esingamahlalakhona hepatic. Ngokunciphisa umzimba izidakamizwa ifinyelela bioavailability esiphezulu nesikhathi isigamu-ukuphila kungapheli amahora amathathu. In iziguli nesifo esingamahlalakhona kwezinso siyehla excretion of metabolites ka omeprazole ngokuvumelana ukuhlanzwa plasma creatinine.

izinkomba

Izidakamizwa "omeprazole" futhi "Ultop" wabonisa ukuze isetshenziswe ekwelapheni izilonda peptic ka ipheshana wokugaya ukudla, hyperacidity uthi (kuhlanganise kolwelwesi), Zollinger-Ellison syndrome, izimo nasezinkingeni ezilandela ngemva kokuhlinzwa yesifo Reflux. Le mithi kungenzeka Kunconywa for ekwelapheni non-isilonda dyspepsia genesis ekwelapheni izinkinga zibangelwa-non-steroidal yokwelapha protivovospalitelnymim izidakamizwa (analgesics, antipyretic), kanye ukwelapha isilungulela ayinzima elivela izikhathi hhayi ningi than 2 ngeliviki.

Naphezu imiyalo ku-izinkomba ukusetshenziswa zomuthi "Omeprazole" ukuthi uphatha umuthi, uyazi nje ukuthi uchwepheshe oqeqeshiwe. Ngakho-ke, uma ungazizwa kahle, kusukela ipheshana emathunjini, kufanele uye emtholampilo hhayi self-medicate.

Izimo

Zonke izinhlobo zomuthi, kuhlanganise nezibhebhe "Omeprazole" is contraindicated ebukhoneni iziguli hypersensitivity kuya izidakamizwa, kanye nezingane. Ukunciphisa secretory umsebenzi esiswini lapho uthi hypoacid futhi kolwelwesi atrophic ubuye contraindication yokuqoka omeprazole.

side effects

Mayelana izidakamizwa "Omeprazole" futhi "Ultop" Izibuyekezo bathi ngokunciphisa umsebenzi acid-ukudalwa esiswini, kusukela ipheshana emathunjini engabangela ukuqunjelwa, ukuvuvukala, ukuqunjelwa, ukuhlanza kanye nobuhlungu esifundeni epigastric,. Akuvamile waphawula candidiasis, nomlomo owomile, noma ukuthuthukiswa atrophic kolwelwesi hypoacid, polyposis emathunjini.

Kusukela isimiso sezinzwa (ukufaka okuphathelene nemizwa), ungase uzizwe ikhanda, ukucobeka, ukukhathazeka kanye nemizwa ukukhathazeka, ukucindezeleka nokuphazamiseka engqondweni. Kungenzeka ukuvela iziyaluyalu umsebenzi ezibukwayo kodwa engase iphenduke unomphela.

ukuphendula iguliswa omeprazole awavamile. Isimo kungadala isifuba, ukulunywa. Nge ongaphakeme imvamisa amanothi gladomyshechnyh bronchial ukuthuthukiswa spasm cell angioedema nge inchubekelembili obengeziwe khambi anaphylactic kanye nokuthuthukiswa ukushaqeka sosotoyaniya. Casuistically waphawula ukuthuthukiswa gynecomastia, ukubukeka ubuhlungu esifubeni.

nokushintsha kokudla nokufakwa

"Omeprazole" ukuthatha esiswini esingenalutho ngamanzi. Ngo uhlobo olukhethekile iziguli zingase zibhekane nenkinga yokugwinya amaphilisi lomuthi. Kulokhu, kutuswa ukuvula capsule nokuqukethwe kusukela slurry ukulungiselela amanzi-based. ukumiswa kufanele uthathe okungenani isigamu sehora ngemva ukupheka. Umthamo nsuku zonke, isilinganiso esisodwa, kanye inkambo yokwelapha izidakamizwa uqoka udokotela.

Izici isicelo lapho ekhulelwa noma ukuncelisa ibele

Idatha ukuphepha omeprazole kwabesifazane abakhulelwe akudingeki. Ingqikithi izidakamizwa singase siboniswe ngenxa yezizathu zempilo. Isigaba imiphumela embungwini ungazange inqunyelwe.

Uma kukhona isidingo ukuqokwa omeprazole ngesikhathi ibele, impatho wale mithandazo kuwukwenqaba, kusukela izidakamizwa ukungena ubisi lwebele.

ekusebenzisaneni izidakamizwa

Njengoba "omeprazole" futhi "Ultop" ukunciphisa bioavailability izidakamizwa, ukumuncwa okuyinto incike asidi of juice esiswini. Futhi kuvimbela ukukhululwa kwezidakamizwa okuyinto umzimba esibindini.
Ulungiselela oyinyumba isixazululo komjovo we omeprazole lingasetshenziswa amahora 12 inqobo ukusetshenziswa bokuphila isixazululo sodium chloride njengoba kuphela futhi amahora ambalwa ngemva ukulungiselela lapho lisetshenziswa njengedivaysi isixazululo dextrose kuphela. Nezinye izixazululo omeprazole ayihambelani.

Nge concomitant ukwelashwa izidakamizwa "Warfarin" kufanele ziqashwe nsuku anticoagulant amazinga e oketshezini olungenambala olusegazini noma ngendlela esifike ngesikhathi ukuqapha isikhathi prothrombin.

ubuthi kanye nokwelashwa ukweqisa izidakamizwa

Symptomatology ukweqisa izidakamizwa omeprazole kubonakala njengoba nomlomo owomile, isiyezi, ubuhlungu bekhanda futhi umbono kahle. Uma ushevu kungenzeka ukudideka, okuvela kuyo ukozela, palpitations, ukuzwa siwasebenzise.

ubuthi ukwelashwa lingaze okuhloswe ngazo indlela ngaphezulu ukuqedwa okusheshayo zomuthi emzimbeni. A yokuvimbela ethize alwaziwa. Ngenxa izinga eliphakeme sesibopho ukuthobisa plasma amaprotheni, ukusebenzisa izindlela zelashwe ngokukhishwa kobuthi egazini engeke asebenze.

Izixwayiso

Njengoba imithi isetshenziswa ukwelapha izilonda emathunjini isisu kanye duodenum, okuyinto umenzeli etiological ka Helicobacter pylori ukutheleleka, kutuswa ukuba wokuqeda nezilwanyana ezincane ekuphathweni concomitant izidakamizwa elwa namagciwane.

Ngaphambi kokuqala ukusebenzisa izidakamizwa isiguli kufanele siphike izifo ebulalayo neoplastic yokusetshenziswa pheshana emathunjini, njengoba aphoyintimenti "omeprazole" kungase kufihle izimpawu lezi zifo futhi kuthiye ekuhlonzweni. Kuyadingeka ukuba kuqedwe izifo yisinanakazana ezithathelwanayo, kanye ukuhlola umthamo nemisebenzi yokusetshenziswa isibindi kanye nezinso.

"Omeprazole" noma "Ultop" - okuyinto engcono?

A impendulo ecacile yalo mbuzo kunzima, ngoba izidakamizwa esebenzayo, futhi kuzo zombili izindawo kuba omeprazole. Ake sibheke indlela ukukhululwa zomuthi "Ultop". Amaphilisi Abonayo ekhiqizwa endaweni umthamo 10, 20 no-40 mg, kanye powder lyophilized (40 mg kwelinye isitsha) ukulungiswa isixazululo umjovo.

"Omeprazole" uvezwa emakethe ezithaka imithi ngesimo amaphilisi 10, 20 no-40 mg omeprazole kwelinye capsule, kanye powder lyophilized (40 mg kwelinye isitsha) ukulungiswa umjovo izixazululo. powder iqhwa-omisiwe ne kuphela iyatholakala in iphasela single. Ngaphezu kwalokho, izidakamizwa angathengwa ngesimo sachets (izikhwama nge powder) ukulungiswa ukumiswa ngomlomo. Akuvamile has "omeprazole" amaphilisi (zithutha) ne okuqukethwe efanayo efana izidakamizwa.

Ngokuqondene Izibuyekezo mayelana lemithi le, zingabantu esihle, njengoba omeprazole kuyinto izidakamizwa ngempumelelo ukuthi kunciphisa umsebenzi secretory isisu. Umuthi iphumelela kakhulu kangangokuba ngisho odokotela abathi: "Yini omeprazole kangcono" Nokho, kunemibono ehlukene phakathi iziguli. Kaningi osale izidakamizwa "Ultop" Izibuyekezo bathi ngemvelaphi ukuqunjelwa ngemva kokungenisa, ubuhlungu bekhanda nesicanucanu.

Izindleko izidakamizwa

Ngokuqinisekile, izindleko izidakamizwa kuzoncika hhayi kuphela kunethiwekhi ekhemisi badayisa lapho kuthiwa, kodwa futhi ibanga kusukela ekhemisi esibhedlela futhi, yebo, kusukela umakhi izidakamizwa. Umuthi 'Ultop' amanani amabanga ruble iphakethe ngalinye 212 360. Izindleko zokugcina kuncike umthamo kanye nenani amaphilisi ibhokisi ngalinye. Umuthi 'Omeprazole "intengo ngokwesilinganiso engama-ruble angu-80 kuya 140. Intengo futhi kuncike umthamo kanye nenani amaphilisi ibhokisi ngalinye.

isiphetho

udokotela kuphela kufanele ubeke "Omeprazole" noma "Ultop". Lokho engcono kakhulu lezi izidakamizwa, uyazi umuntu afaneleke, futhi isinqumo sayo kumele zisekelwe izinkomba kanye isimo lesiguli. Kumele kukhunjulwe ukuthi ngokuvamile okunqumayo enkulu ekukhethweni kuka umuthi izindleko zawo.

Iziguli kufanele sinake "omeprazole", okuyinto intengo aphansi ukwedlula Analogue "ultop". Labo abazimisele ukuba sizinake ngaphezu, sokubheka analogue zomuthi. Naphezu lenani eliphakeme 'Ultop "intengo eziningana izidakamizwa kungenzeka bathethelele degree zokuhlanjululwa zomuthi, kanye kungenzeka eyengeziwe modulating okufakiwe ukulungiselela uqobo.

Kungakhathaliseki ukuthi laliyini njalo kunesidingo ukukhumbula Wegolide: ukwenza akazibekanga medicate. ekuhlonzweni - ukhiye eyinhloko yokwelashwa okuphumelelayo!