Isidakamizwa esithi "Metipred" salokho okumiselwe? "I-Metipred": izinkomba zokusetshenziswa

Ezinye izifo zingenzeka ngokumelene nezidakamizwa, okungukuthi, ungaphenduli ekuphathweni kwezidakamizwa. Ezimweni ezinjalo, njengomthetho, sebenzisa ukusetshenziswa kwe-glucocorticoids. Enye yezidakamizwa ezinjalo i-"Metipred". Iyini injongo yalo muthi futhi ubhekisela kuphi?

Kuyini lokhu kulungiselelwa?

"I-Metipred" ibhekisela eqenjini lezinto zokwenziwa kwe-glucocorticosteroids, okusho ukuthi, i-analogue ye-hormone ehlanganiswa kahle. Unomsebenzi wokulwa nokuvuvukala, unomphumela wokuvimbela, ukhulula ukuvuvukala, okunciphise umsebenzi wokuzivikela, ubuyisela ukukhathazeka komzimba.

Indlela yokwenza kwayo isekelwe ekuphenduleni nge-receptors ethize ezisezintheni eziningi. Ngenxa yokuxhunyaniswa nabo, amaphrotheni akhethekile akhiwa, okuphethwe ukulawulwa kwezinqubo ezibaluleke kakhulu.

Umuthi unomthelela kuzo zonke izinhlobo zezinqubo zamathambo emzimbeni.

Njengoba lesi sidakamizwa singeqembu le-glucocorticosteroids, lihlelwe kuphela ezimweni ezithile, lapho izidakamizwa eziyisisekelo eziboniswa ukwelashwa kwalesi sifo zingasebenzi.

Ngamaphi amacala ongawasebenzisa ngokuthi "Metipred"? Kuyini okushiwo lokhu noma leso sifo?

Izinkomba zokusetshenziswa

Iziphi izifo zidinga izidakamizwa ze-hormonal zokwelapha? Yiziphi izinhlobo zezifo "I-MetiPred" ekhonjisiwe? Iyini isimiso salolu mithi?

Okokuqala, injongo yalesi sidakamizwa iyadingeka ngezifo zesistimu zezicubu ezixhunyiwe. Ngakho-ke ziyi: systemic scleroderma, i-systemic lupus erythematosus, yonke i-vasculitis, i-dermatomyositis. Kulezi zimo, i-hormone isiza ukunciphisa inqubo yokuvuvukala, ubuyisele imetabolism ezintweni eziphathekayo.

I-rheumatology iphinda isetshenziswe kabanzi yi-Metipred. Izimpawu zokusetshenziswa yizifo ezihlangene ezivuvukalayo: isifo samathambo we-gouty ne-psoriatic etiology, i-osteoarthritis, i-bursitis, i-synovitis, isifo sika-Bechterew. Umphumela oyinhloko wesidakamizwa kulezi zifo awuphikisana nokuvuvukala kanye ne-analgesic.

Ungasebenzisa "i-Metipred" ye-asthma ye-bronchial nezifo ezihlukahlukene ezingavamile.

Isilinganiso semithi

Ngamaphi amanani okusetshenziselwa ukusetshenziswa kweMetiredred? Kumele kukhunjulwe ukuthi uma ukubeka lo muthi, njengamanye ama-hormone, udinga ukucabangela izilinganiso zomzimba zomzimba, kanye nomsebenzi we-cortex ephezulu. Umthamo wesiguli ngasinye ukhethwe ngamunye.

Inani le-hormone lansuku zonke lithathwa kakhulu ekuseni (ngokuvamile kuvunyelwe ukuba uphuze umthamo wonke esikhathini esivela ngo-6 kuya ku-8 ekuseni, noma uhlukanise ngamanani amabili ngo-8 no-12 ntambama). Ukuhlolwa okufanayo kufakwa kuzo zonke izidakamizwa ze-hormonal. I-Metizred akuyona into ehlukile.

Amathebulethi athathwa ngokuqondile ngesikhathi noma emva kokudla. Ezinganeni, umthamo ukhethwe ngokuya ngobudala nesisindo somzimba.

Umkhuba wesidakamizwa uvela ku-4 kuya ku-50 mg ngosuku. I-dose ephakeme (kufika ku-1 g) iboniswa kuziguli ezinezifo zesistimu zezicubu ezixhumeneyo eziqine kakhulu. Ukuqapha okukhethekile kufanele kuhokhwe ekuchazeni isidakamizwa ngaphambi kokufakelwa kwesitho somzimba kunomamukeli noma uma kutholakala ukukhulelwa kwe-in vitro.

Imiphumela emibi

Ngokuhlolwa kahle kwesidakamizwa nokuhambisana nayo yonke imiyalelo kadokotela lapho ekwamukelwa, imiphumela emibi cishe ayiphumeli. Noma kunjalo, kufanele kukhunjulwe ukuthi uma izimo zokumamukela ziphulwa, izimo ezinzima ngokwanele zingathuthuka. Yini engayenza ekusebenziseni le mithi?

"I-Metipred" ngokuyinhloko ithonya elibi ohlelweni lwe-endocrine. Kungase kube nokunciphisa ukubekezelelana kwe-glucose, ukuthuthukiswa kwe-Isenko-Cushing syndrome, ukubambezeleka kokuthuthukiswa ngokocansi (lapho kunikwe izingane).

Uhlelo lokugaya lungasabela ekuphathweni kwezidakamizwa ngokuthuthukiswa kwezinambuzane nokuhlanza, izinguquko zesitokisi, ukuphazamiseka kwezidakamizwa, izilonda, kuze kube nokuphuma kwegazi kanye nokukhishwa kwendonga yesisu.

Ithonya leMetrared on system cardiovascular libonakaliswa ngesimo se-arrhythmias, i-bradycardia, ukuwohloka kombuso womzimba ngokuhluleka kwenhliziyo.

Ngokwengxenye yesimiso sezinzwa, isimo sesimo se-delirium sivame ukubonwa, ukuthuthukiswa kwengqondo, i-paranoia, ukulala nokusila.

Ukungafani

Ngabe akufanele yini ukusebenzisa le mithi? "I-Metipred" ingasetshenziswa kuphela isikhathi esifushane. Ngesamukeli eside, uhlu lwezingqinamba luyanwetshwa kakhulu.

Ngokunakekelwa ukusebenzisa umuthi wezifo ezinjalo zegciwane lokugaya, njengezilonda, i-gastritis, i-ulcerative colitis, idlulisele ukusebenza kumgudu wokugaya.

Izifo eziningi ezithathelwanayo zifakwe ohlwini lwazo ezichasene nezihlobo, ngoba aziwa ukuthi izakhi zizobhekana kanjani nokusungulwa kwezidakamizwa ze-hormonal. Esinye isimo esivimbela ukusebenzisa ama-hormone ngumphumela wabo wokuzivivinya umzimba.

Ungasebenzisi izidakamizwa zesifo sikashukela, ukukhuluphala.

Izingane nabesifazane abakhulelwe bangokwesigaba esinokuphikisana ngokuphelele nokusetshenziswa kweMetipred. Ungabela kuphela uma kukhona usongo olukhulu empilweni.

Ukusebenzisana nezinye izidakamizwa

Njengoba kuyaziwa, izidakamizwa eziningi zingathuthukisa, zinciphise noma zinciphise umphumela womunye umuthi. "I-Metipred" isabela kanjani ngombhalo ofanayo wezinye izidakamizwa?

Ukusetshenziswa kwalesi sidakamizwa nge-inducers ye-enzyme ye-hepatic kuholela ekunciphiseni kwemithi esebenzayo egazini (isisindo sayo senyuka).

Uma unquma iMedipred nge-diuretics, ingozi yokuhluleka kwenhliziyo kanye ne-hypokalemia yanda kakhulu.

Ukwelashwa kwe-pulp "Metipredom" nokuqokwa okwenziwe ngesikhathi esisodwa kwe-glycosides yenhliziyo nge-oda lokuphakama kwandisa ingozi ye -extrasystole ye- ventricular.

Akudingekile ukusebenzisa ndawonye i-methylprednisolone kanye ne-anticoagulants, njengoba umphumela wokwelashwa we-last worsens.

Ukuthatha izidakamizwa utshwala kanye nezidakamizwa ezingekho-steroidal kubangela ingozi eyengeziwe yokuthuthukisa izilonda zamathumbu.

"I-Metipred" inciphisa ukusebenza kahle kwe-insulin egayiwe nezidakamizwa ezingenamandla.

Imiyalo yokusetshenziswa

Ngimaphi amafomu okungaba khona okungaba khona "amaMepered"? Iyini injongo ngayinye yazo? Ake sibheke lezi zinkinga ngokuningiliziwe.

"I-Metipred" (amathebulethi) anqunywe ngezinhlobo ezingekho ezinzima zezifo, kanye nokungabikho kokuphikisana nokuphathwa komlomo.

I-Liofilizate - ifomu elikhethekile lesidakamizwa, okungukuthi i-powder ye-dilution kanye nokuphathwa okunamandla. Isetshenziswa ngokuyinhloko ezinhlobonhlobo zesifo, kanye nokuhlinzeka ngosizo oluphuthumayo.

Isixazululo esilandelayo sinconywa ukuthi sisetshenziswe ngokushesha. Uma udinga ukuyilondoloza isikhashana, kufanele ukuthi kwenziwe ngesikhathi sokushisa kwama-degrees angu-15 kuya kwangu-20. Ngezindinganiso eziphansi, ungagcina ukulungiselelwa okulungiselelwe okungaphezu kosuku.

Ukuze uvikele impilo yesiguli, kunconywa ukuthi usebenzise ama-antacids ngokufana (ukuvikela i-membrane ye-mucous).

Ngaphambi kokusebenzisa le mithi, njalo uxhumane nodokotela wakho mayelana nomthamo wezidakamizwa kanye nemvamisa yokuphathwa kwayo.

"I-Metipred" ekwelapheni ukungasebenzi

Ngokwezinkinga zokubeletha, njengokunye kwezinye izindawo zemithi, besebenzisa "I-Metipred." Iyini isimiso salolu mithi?

Ukusetshenziswa okuyinhloko kwezidakamizwa ukucindezelwa kokuzivikela ngesikhathi sokukhulelwa kwe-in vitro.

I-ECO iyinkqubo, okuyisisekelo sokuhlukanisa iqanda elivela kowesifazane, lifake ithubhu yokuhlola elinesilisa sowesilisa bese ufaka i-zygote ephumela esibelethweni.

"I-Metipred" ne-IVF iboniswa ngokunciphisa umzimba. Kunconywa ukusebenzisa izinsuku ezimbalwa emva kokudluliswa kwe-zygote emgodini wesibindi. Lokhu kwenziwa ukuze kungabikho ukuthi kungenzeka ukuthi ukwenqatshwa ngumzimba we "into yangaphandle".

Ngomphumela omuhle, ukufakwa kombungu ku-mutersa we-uterine, ukwakheka kwe-placenta nokukhula kwe-intrauterine kwe-embryo kwenzeka.

"I-Metipred" ne-IVF iboniswa kubo bonke abesifazane. Uma kukhona ukuphikisana nokusetshenziswa kwayo, kungcono ukwenqaba ukufaka umanyolo we-in vitro.

Ezinye izifo zesimiso sokuzala abesifazane zingadinga ukuqashwa kwamahomoni. "I-Metipred" yezinkinga zokubeletha ngezikhathi ezithile isetshenziselwa ukuphatha i-leukoplakia nezinqubo ezithile zokuvuvukala.

Ukwelashwa kwezifo zesistimu

Ngalesi simo, njengomthetho, sebenzisa okuthiwa ukwelashwa kwe-pulse. Okuyinhloko yale ndlela yokwelapha kanje: isikhathi esincane (ngokuvamile izinsuku ezingu-1-2), isiguli sinikezwa umthamo omkhulu wezidakamizwa, bese kuthi ngemva kwamasonto ambalwa (kuye ngokuthi ubuhlungu kanye nohlobo lwesifo) - umthamo wesondlo womuthi.

Isibonelo, ekwelapheni i- vasculitis ye- systemic, lolu hlelo lufana nalokhu: Isidakamizwa esithi "Metipred" kuqala silawulwa ngomthamo we-1000 mg, emva kwalokho isiguli sidluliselwa kokwelashwa kwesondlo (80-100 mg).

Uhlelo olunjalo lusakazeka ngenxa yokusebenza kahle.

Ukwethulwa kwesilinganiso esikhulu kubangela "ukucindezeleka" kwalesi sifo kanye nokuthuthukiswa kokusebenza okungasebenzi komzimba. Kulesi simo, isilwane esithintekile kulula ukubuyisela ukusabela okujwayelekile kunokuba kungabi nomphumela onamandla kangaka. Kanti futhi, ngenani lemali enkulu, kungenzeka ukuba uvimbele amangqamuzana amaningi omzimba omzimba.

Ukwelashwa kwe-pulse kungenziwa ukwesekwa nge-cytostatics ukuze kutholakale umphumela wokuzikhumbuza umzimba.

Kubaluleka kokusebenzisa lesi sidakamizwa

Lo muthi awukwazi nje ukuthengwa ekhemisi. Udokotela oya khona kuphela ongakhipha imithi ye-"Metipred". Izinkomba zokusetshenziswa kufanele zibe namandla (isibonelo, izifo zokuvuvukala zesistimu). Kuphela kuleli cala lo mtholampilo uzokwazi ukukunika izidakamizwa ozidingayo.

Esinye isici semithi ukuthi uma isetshenziswa isikhathi eside, umlutha noma ukuvela kwe-abstinence syndrome kungenzeka.

Ivela kulolu daba lapho "iMetipred" iqokwa isikhathi eside nangamanani amakhulu. Ngokufanayo, kukhona ukucindezeleka kwamahomoni akhiqizwa ezigulini eziyingozi. Kulesi simo, ungawukhansela ngokushesha lesi sidakamizwa. Kutuswa ukunciphisa kancane umthamo esikhathini eside. Ngaphansi kwezimo ezinjalo, ama-hormone ajwayelekile angabuyiselwa.