Isidakamizwa esithi "Bidop": izinkomba zokusetshenziswa, izifaniso nezibuyekezo

Ukucindezela okwenyuka akugcini nje ukukhathazeka okubonakalayo kwesiguli, kodwa futhi kuyingozi kakhulu ekuphileni. Ukuze kuqinisekiswe isimo sabo, abantu abaningi kakhulu basebenzisa izindlela zokwelapha. Kodwa-ke, ochwepheshe babonisa ukuthi kulula kakhulu ukwandisa umfutho wegazi ophansi ekhaya, kunokuba wehlise umfutho wegazi ophakeme. Ngakho-ke, batusa ukusebenzisa izidakamizwa ezenzelwe lezi zinhloso.

Enye yezindlela ezithandwa kakhulu futhi eziphumelelayo ze-hypertension imithi, njenge "Bidop". Izinkomba zokusetshenziswa, izifaniso kanye nezimpendulo zabathengi kulo muthi zizoxoxwa ngokuqhubekayo. Futhi, uzofunda ukuthi ungayisebenzisa kanjani kahle lo muthi, kungakhathaliseki ukuthi unemiphumela emibi kanye nokuphikisana.

Incazelo, ukwakha, ukupakisha nokubunjwa kwemithi

Isidakamizwa esithi "Bidop", okufana nazo ezidayiswa kuwo wonke ama-pharmacy, sitholakala ngesibhakabhaka esibhakabhaka esibhakabhaka esinamabala aluhlaza okwesibhakabhaka kanye nekhanda lefilimu. Ifomu le-round, le-biconcave limakwe "B1" ngenhla engozini futhi inombolo "5" ("10") ngaphansi kwayo.

Isithako esisebenzayo salesi sidakamizwa yi-bisoprolol hemifumarate. Ngokuphathelene nezinsiza ezisizayo, i-lactose monohydrate, i-magnesium stearate, i-cellulose microcrystalline, i-crospovidone ne-yellow pigment PB 22812 (13% iron iron oxide futhi 87% i-lactose monohydrate) isetshenziselwa izinsimbi ezisizayo.

Ukuze uthenge amaphilisi "Bidop", ukusetshenziswa okudingekayo kubantu abanomfutho wegazi ophezulu, kungenzeka ngamabhansela kanye namaphakethe wekhadibhodi, ngokulandelana.

Imingcele ye-Pharmacodynamic yomuthi

Iyini imithi "Bidop"? Izinkomba zokusetshenziswa kwalolu remedy zibangelwa isenzo saso semithi. Lesi sidakamizwa i-β1-adrenoblocker ekhethiwe. Ayinayo imiphumela ye-sympathomimetic, futhi ayinayo umthelela wokulondoloza isikhumba.

Isidakamizwa esibuzwayo singanciphisa umsebenzi we-renin, sinciphise isidingo se-carbohydrate e-oksijini futhi sinciphise isivumelwano sakhe.

"Bidop" - isidakamizwa esinamakhemikhali e-antianginal, antiarrhythmic and hypotensive. Ngokunciphisa i-β1-adrenergic receptors ye-myocardial (ngamanani amancane), kunciphisa ukuhamba kwe-intracellular ye-calcium ions, kunciphisa ukuhlanganiswa kwe -AMP kusuka ku-ATP (okuvuselelwe ama-catecholamines), kunemiphumela emibi ye-chrono, i-batmo-, i-dromo- ne-inotropic imiphumela, futhi iyanciphisa ukuqhuba nokuzijabulisa.

Uma izidakamizwa zokwelapha zidlulile, umuthi ubonisa umphumela wokuvimbela i-β2-adrenergic.

Ekuqaleni kokwelashwa (ezinsukwini zokuqala), ukuphikiswa komzimba wezindonga zamasongo kuyathuthukiswa. Ngemuva kwezinsuku ezingu-3 kufinyelela ku-original, kodwa emva kokwelashwa okwesikhathi eside iyanciphisa ngokuphawulekayo.

Izakhiwo zomkhiqizo wokwelapha

Iziphi izakhiwo ezifakwe emthini "Bidop"? Umphumela wezamakhemikhali walesi sidakamizwa ngenxa yokwakhiwa kwawo.

Umphumela we-hypotensive wezidakamizwa uhlotshaniswa nokunciphisa emgodini wegazi wamaminithi, ukuvuselela ukuzwelana kwezintambo zezintambo ze-peripheral, kanye nokubuthakathaka komsebenzi wesistimu ye-renin-angiotensin, umphumela ohlelweni lwezinzwa, nokubuyisela impendulo ephendula ekunciphiseni kwengcindezi.

Ngomfutho wegazi ophakeme, umphumela wokwelapha wezidakamizwa uqala zingakapheli izinsuku ezinhlanu. Isenzo sakhe sokuqiniseka siza emva kwezinyanga ezimbili.

Yini ebangela umphumela we-antianginal wale mithi? Incazelo yesidakamizwa "i-Bidop" iyazisa ukuthi isenzo esinjalo sibangelwa ukwehla kwezidingo zamathambo omzimba we-oxygen. Lokhu kungenxa yokunciphisa kwenhliziyo, ukunciphisa inzalo, ukunciphisa i-diastole nokuthuthukisa igazi. Ngenxa yokwanda kwengcindezi ye-diastolic ema-ventricles kanye nokwelula kwezicubu zabo zomzimba, isidingo somoya-mpilo singakhula.

Ngokuqondene nezakhiwo ezithinta izidakamizwa zesidakamizwa esibuzwayo, kungenxa yokuqedwa kwezinto ezibangela ukuguquka (ukusebenza kwesistimu enozwela, i-tachycardia, isifo somfutho wegazi ophakeme, ukwanda kwenkampanini ye -AMP). Futhi, lesi sidakamizwa sivimbela i-AV-conductivity futhi sinciphisa izinga lokuzijabulisa kwabakhubazekile.

Yiziphi ezinye izici ezitholakala emithi "Bidop"? Imfundo yokusetshenziswa, incazelo, ukubuyekezwa kochwepheshe bathi uma uthatha imithi ehlotshisiwe, lo muthi, ngokungafani nokukhetha okungabonisi i-β-blockers, unethonya elincane ezingxenyeni ezine-β2-adrenergic receptors (i-pancreas, i-muscle musterature, i-peripheral musterature , Isibeletho kanye ne-bronchi), kanye nokushintshaniswa kwama-carbohydrate. Ngaphezu kwalokho, izidakamizwa ezibuzwayo azigcini i-sodium ions, futhi amandla esenzo saso esingafani ne-propranolol.

Imingcele ye-kinetic yokulungiselela

Ziyini izakhiwo ze-kinetic ze-Bidop? Impendulo evela kubaguli ngeke iphendule lo mbuzo. Iqukethe kuphela imiyalelo. Ngokusho kwakhe, ngemuva kokuthatha imithi, ubambe iqhaza kusukela ekugayeni okugaya ngo-80-90%. Ukusetshenziswa kokudla akuthinti inqubo nganoma iyiphi indlela.

Ukuhlushwa okuphezulu kwesakhi esisebenzayo egazini kulungiswe emva kwamahora angu-2-3. Lesi sidakamizwa sihlangana nama-protein ase-plasma ngo-30-32%. Idlula kunalokho kabi ngokusebenzisa umkhawulo wegazi-ubuchopho kanye ne-placenta.

Cishe u-50% wezidakamizwa uguqulwa ube isibindi. Kulesi simo, kwakhiwa ama-metabolite angasebenzi.

Ukuphila kwengxenye yesidakamizwa kufinyelela emahoreni angu-12. Cishe u-2% wezidakamizwa zixutshwe ndawonye ne-bile futhi cishe ngo-98% - ngezinso.

Izinkomba zokusetshenziswa

"I-Bidop" akuyona nje isidakamizwa esinamandla, kodwa futhi i-anti-anginal futhi anti-arrhythmic. Ngakho-ke, kunqunyelwe ukuqeda ukucindezeleka komzimba nokuvimbela ukuhlaselwa kokunyuka kwama-angina azinzile.

Ukuqhathaniswa kwe-drug antihypertensive

Manje uyazi ukuthi kungani udinga umuthi onjengeBivop. Izinkomba zokusetshenziswa zinikezwe ngenhla. Noma kunjalo, izidakamizwa ezibuzwayo zivinjelwe ngokweqile ekunqumeni:

• Shock;
• Hamba;
• Ukuhluleka kwenhliziyo enzima;
• I-edema yepulmonary;
• Ukuvinjelwa kwe-sinoatrial ;
• Ukuvinjwa kwe-AV kwezinga lesibili noma lesithathu (ngaphandle kwe-electrostimulator);
• I-syndrome yobuthakathaka besici se-sinus;
• Bradycardia enamandla;
• Ukwehluleka kwenhliziyo okungapheli, okudinga ukwelashwa kwe-inotropic;
• Isifo sikaRaynaud ;
• Ukuziphendulela kwamagciwane;
• I-metabolic acidosis ;
• Ukuphathwa ngesikhathi esisodwa kwe-MAO inhibitors (ngaphandle kohlobo lwe-MAO B);
• I-Cardiomagaly (ngaphandle kokuhluleka kwenhliziyo);
• I-asthma ye-bronchial ne-COPD enamandla;
• Izinguquko ekujikelezeni kwe-peripheral, ikakhulukazi ngezigaba kamuva;
• I-Pheochromocytoma (ngaphandle kokuthatha i-alpha-blockers);
• Ukukwazisa izinto ezidakamizwa noma ezinye izithiyo ze-beta-blockers;
• Ukungabekezelelani ne-lactose, i-malabsorption ye-galactose / i-glucose nokuntuleka kwe-lactase;
• Ngesikhathi esincane.

Ukuqokwa ngokucophelela

Izimpawu zokusetshenziswa kwe- "Bidop" zihlelwe emibhalweni enamathiselwe. Ithi futhi ngokunakekelwa okhethekile lesi sidakamizwa sinqunywe isifo sikashukela, ukuxhaphaza noma ukungafinyeleli kahle kwe-type engapheliyo, i-myasthenia gravis, i-psoriasis, i-thyrotoxicosis, i-AV yokuvinjelwa kwezinga lokuqala, i-Prinzmetal angina, ukucindezeleka, ukungezwani komlando emlandweni, ukudla okuqinile nabantu asebekhulile Ubudala.

Indlela yokuthatha nokulinganisa imithi

Iyini injongo yokuqokwa kanye nendlela yokusebenzisa lesi sidakamizwa "Bidop"? Izinkomba zokusetshenziswa, imiyalo yalo muthi ihanjiswa kule ngxenye.

Thatha amaphilisi omlomo okungcono ekuseni, ngesisu esingenalutho. Ngeke zihlolwe, ngaphandle kwalokho uzolimaza igobolondo lefilimu.

Umthamo walomkhiqizo ukhethwe ngamunye. Ukwenza lokhu, kufanele uxhumane nodokotela ngaso sonke isikhathi.

Ngakho kufanele uthathe kanjani umuthi "Bidop"? Izimpawu zokusetshenziswa, noma kunalokho - ukutholakala kwazo - lokhu kuyimfuneko ebalulekile yokuqokwa kwale mithi.

Ukuze kuvimbele ukuhlaselwa okunamandla kwe-angina eqinile futhi lapho kukhona ukucindezeleka komzimba, iziguli zinikezwa umthamo wokuqala we-5 mg. Kuthathwa nsuku zonke, kanye.

Uma kudingekile, lesi samba senyuke sibe ngu-10 mg. Kule nkinga, ukuphindwa kokumaketha kugcinwa.

Isilinganiso esiphakeme nsuku zonke semithi "Bidop" singama-20 mg.

Kubantu abanokukhubazeka ngokweqile, kanye nezifo ezinzima zesibindi, isilinganiso esiphezulu ngu-10 mg ngosuku.

Lungisa inani elichaziwe lemithi kubantu asebekhulile akudingeki.

Imiphumela engathandeki

Imiphi imiphumela emibi ingayenza imithi "ye-Bidop"? Imibono yeziguli ibonisa ukuthi kungenzeka ukuthi kwenzeke yini imiphumela ethile engathandeki. Lezi yizi:

• Amehlo anomile, umbono okhubazekile, wehlile u-salivation, conjunctivitis.
• I-Orthostatic hypotension, ukuvinjelwa kwe-AV, ukucindezeleka okukhulu kwengcindezi, ukunciphisa ukwelashwa kwe-myocardial, i-sinus bradycardia, ukukhubazeka komzimba we-myocardial tissue, arrhythmia, izimpawu zokuntuleka komzimba (okungapheliyo), i-angiospasm, ubuhlungu besifuba.
• I-Asthenia, ubuthakathaka, ukukhathala, ukuphazamiseka kokulala, ukudideka, i-myasthenia gravis, isizungu, amaphupho angena ebusuku, i-paresthesia emaphethelweni, ukucindezeleka, ukukhathazeka, ikhanda, ukuthuthumela, ukucabangela, ukuxuba.
• Ukungqubuzana kwe-nasal, ukuphefumula kanzima lapho uthatha izidakamizwa ngamanani aphakeme noma kubantu abanezici ezihambisana ne-bronchospasm ne-laryngospasm.
• I-nausea, i-hepatitis, owomile we-mucosa yomlomo, ukunambitheka ukunambitheka, ukuhlanza, ukuphazamiseka kwesibindi, ukuqothulwa, i-hypertriglyceridemia, ubuhlungu besisu, isifo sohudo, i-hyperbilirubinemia, ukunyuka kwama-enzyme yesibindi.
• Ukukhushulwa kwe-psoriasis, ukusabela kwe-psoriasis-like, i-hypermia yesikhumba, i-exanthema, ukujuluka kwe-sweat, i-alopecia.
• I-Hyperglycemia, isimo se-hypothyroid, i-hypoglycemia (kubantu abasebenzisa i-insulin).
• I-Thrombocytopenia, i-agranulocytosis, i-leukopenia.
• I-Arthralgia, yehla i-potency, i-litumbul, iyanciphisa i-libido, i-thoracalgia, i-withdrawal syndrome.
• I-Hives, itching, i-rash.
• I-Bradycardia, ukuphuza ukukhula kwe-intrauterine.

Izimpawu zokudlula ngokweqile

Imiphi imiphumela emibi ebonakalayo uma uthatha amanani aphezulu we-Bidop? Izimpawu zokusetshenziswa kwalesi thuluzi zide kakhulu nezimo zokusetshenziswa kwazo. Kubaluleke kakhulu ukugcina zonke izilinganiso zomuthi, okwakunconywa udokotela oya khona. Uma lesi seluleko singanakiwe, isiguli singase sibe nezibonakaliso zokudlula ngokweqile njenge-bradycardia, i-extrasystole ye-ventricular, i-cyanosis yezandla, i-arrhythmia, i-bronchospasm, i-AV yokuvimbela, isizungu, ukucindezeleka okukhulu kwengcindezi, ukuphelelwa yisikhathi, ukwehluleka kwenhliziyo, ukuxubha, ukuphefumula nobunzima Hypoglycemia.

Ukuqeda izimo ezinjalo, isiguli sihlanzwa ngesisu, sinikezwe ama-enterosorbents futhi senza ukwelashwa okuphawulekayo.

Ukusebenzisana kwezidakamizwa

Ingabe "i-Bidop" (izidakamizwa) iyahambisana nezinye izidakamizwa? Lokho umuthi osetshenziselwa, sithole. Nokho, ngokuhambisana neminye imithi, kufanele ilawulwe ngokuqapha okukhulu.

Ngenxa yokuphathwa okunamandla kwesidakamizwa esithi "Phenytoin", kanye nokusetshenziswa kwezimali ze-inhalation anesthesia, umphumela we-cardiodepressive we-"Bidop" ukwanda.

Izidakamizwa ezinama-iodine ezinama-iodine zokuphatha ngendlela eningi zandisa ingozi yokuphendula kwe-anaphylactic.

"I-Bidop" ivamise ukufaka izimpawu zokuthuthukisa i-hypoglycemia. Futhi kwandisa ukuhlushwa kwe-xanthines ne-lidocaine egazini.

I-Sympatholytics, i-diuretics, i- "Clonidine", "i-Nifedipine", "i-Hydralazine" nezinye izidakamizwa eziphikisayo uma zihlangene ne "Bidop" ziholela ekunciphiseni okukhulu ekucindezelekeni.

I-Tetracyclic ne- tricyclic antidepressants, kanye ne-ethanol, i-hypnotics, i-sedative kanye ne-antipsychotics, yandisa ukucindezeleka kwe-CNS.

Izincomo Ezikhethekile

Yini okufanele isiguli siyazi ngaphambi kokuthatha amaphilisi e-Bidop? Ukubuyekezwa kodokotela kusho ukuthi ekuqaleni kwalashwa iziguli kufanele uqaphele futhi uqaphele ngenkathi ushayela.

Ukulawulwa kwabantu abathwala izidakamizwa okucatshangelwayo kubandakanya ukulinganisa izici zokucindezela nokucindezela, kanye nokunquma izinga leshukela legazi nokuqhuba i-electrocardiogram. Abantu asebekhulile badinga ukuqapha uhlelo lwezinso.

Ngaphambi kokuqala ukwelashwa kuyadingeka ukuxilonga umsebenzi wokuphefumula ezigulini ezinomlando we-embolism ye-pulmonary.

Lapho ukwelapha abantu nge-pheochromocytoma, kunengozi yokuthuthukisa ukucindezeleka okubangelwa yi-arterial hypertension.

Kubantu ababhema, ukusebenza kwe-beta-blockers kuncishisiwe.

Uma ukuhlinzwa okuhleliwe okuhleliwe kuyadingeka, imithi kufanele ikhanseliwe izinsuku ezimbili ngaphambi kwe-anesthesia jikelele.

Ngokuthuthukiswa kokucindezeleka, ukwelashwa kufanele kumiswe.

Kuvinjelwe ukuphazamisa ukwelashwa ngokushesha ngenxa yengozi eyengeziwe yokwelashwa kwe-myocardial noma ama-arrhythmias aqinile. Imithi ikhanselwa kancane kancane, ukunciphisa umthamo wamasonto amabili noma ngaphezulu.

Amathebulethi "Bidop": ama-analogues nezindleko

Uma kunesidingo, ukulungiswa okubuzwayo kungashintshwa yizindlela ezifana ne "Bisocard", "Aritel Kor", "Tirez", "Aritel", "Niperten", "Bidop Kor", "Cordinorm", "Biprol", "Coronal", "Biol "," Corbis "," Bisogamma "," Concor "," i-Bisoprolol ", i-" Concor Cor, "" i-Bisomor "," i-Bisoprolol-OBL ", i-" Bisoprolol-Teva. "

Izindleko zale mithi antianginal, antiarrhythmic kanye antihypertensive cishe ngama-ruble angu-250-300 (amaphilisi angu-28).

Ukubuyekeza mayelana nomuthi

Manje uyazi ukuthi yini engakunqunywa kumuthi onjengale "Bidop". Izimpawu zokusetshenziswa, impendulo yabathengi kule mithi inikezwa ezintweni ezikulesi sihloko.

Imibiko yeziguli ibonisa ukuthi umphumela we-ejenti okucatshangelwayo usebenza kakhulu. Amathebulethi "Bidop" masinyane anciphise ukucindezela futhi avele avele zonke izimpawu zesifo senhliziyo ischemic.

Noma kunjalo, kufanele kuqashelwe ukuthi lesi sidakamizwa ngokuvamile siba nemiphumela emibi. Bangabonakaliswa yiziphi izitho nezinhlelo.

Kufanele kuphawulwe ukuthi kubantu abangama-20% abane-angina pectoris, le remedy ayiphumeli. Odokotela bachaza lokhu ngenxa yokuqina kwe-coronary atherosclerosis, kanye nomthamo we-diastolic owandayo we-ventricle kwesokunxele.

Uma kungekho mthelela, isiguli kufanele sixoxe nodokotela olunye ukwelashwa.