Lipid peroxidation (LPO) kuyinto obubalulekile in exchange umzimba. Umsebenzi eziyisisekelo kangakanani ubuyekeze lipids of cell ulwelwesi.
Ngendlela enempilo umuntu lipid peroxidation kulawulwa okuthiwa uhlelo antioxidant elawula umsebenzi isivinini kanye phosphorylation ngu ngibopha izici letsintsa noma iwukudambisa eziningi ezanele of peroxides ukuvimbela i overabundance imikhiqizo ekupheleni umzimba. Okhulisa namachibi nqubo ingase ibe iphuzu kusukela izinqubo pathophysiological abalulekile amanani izifo. Le nqubo ihlanganisa isinyathelo enzymatic futhi autoxidation non-enzymatic.
izinhlobo
Ukuze ushintshe bilayer phospholipid we ulwelwesi cell ubabonisa namachibi enzymatic. Ngaphezu kwalokho, ehilelekile kumiswa izinto eziphila abakhuthele, ngokukhishwa kobuthi egazini, ukusabela umzimba. namachibi Non-enzymatic owenza kuzibonakalisa njengesizathu esinomthelela elimazayo empilweni esitokisini. Ngenxa ukwakheka esiningi radicals khulula futhi peroxides ekuqongeleleni antioxidant liyancipha okwenziwa kwisistimu futhi ngenxa yalokho, kukhona ukubhujiswa umzimba amaseli.
PAUL umjikelezo
Ukuqala lipid peroxidation khona kuyadingeka umoya-mpilo free radicals, kokuba amandla ezingeni ngokwedlulele eyodwa electron ayibhangqiwe. Ngemva nokuvulwa izinhlayiya zomoya-mpilo ekhiqizwa superoxide okuyinto ihlangana ama-athomu ye-hydrogen, kuphenduke i-hydrogen peroxide. Ukuze ukulawula inani superoxide engqamuzaneni khona dismutase superoxide, ukwakha i-hydrogen peroxide kanye catalase, peroxidase iwukudambisa it emanzini. Uma umzimba ophilayo yayivame ionizing emisebeni, isibalo free radicals hydroxyl kuzokhuphula ephawulekayo. Ngaphezu kwalokho i-oksijini hydroxide nezinye izinhlobo zayo esebenzayo Ukuqala inqubo sokuqalisa of peroxidation lipid.
Imikhiqizo ka lipid peroxidation noma umzimba ilahlwe, noma esetshenziselwa synthesis prostaglandins (izinto ezihilelekile ukuvuvukala ukusabela), thromboxanes (kuhlanganisiwe wendlale thrombogenic ukusabela), ama-hormone adrenal.
indawo elawula uhlelo
Kuye cell ulwelwesi isizinda nesakhiwo isivinini, kanye nenani umsebenzi imikhiqizo okuholela namachibi zingahluka. Ngokwesibonelo, umsebenzi lipids peroxidation ngenhla lapho ingxenye odongeni cell ubuswa unsaturated acid okunamafutha, futhi kancane, uma ngesisekelo iCOP kuyinto cholesterol. Ngaphezu kwalokho, isici ukulawula isamba kanye ngesilinganiso kumiswa mpilo radicals, kanye nokusetshenziswa peroxides, kukhona enzyme umzimba. Ngisho e ukusabela lipids peroxidation iqhaza izinto ezithinta cell ulwelwesi lipid ukwakheka kanye ushintsho ngokungenasizathu ngokuhambisana nezidingo umzimba. Lezi zihlanganisa vitamin E kanye K-thyroxine (hormone yegilo), hydrocortisone, cortisone futhi aldosterone (feedback). Angazinzi cell udonga lensimbi ion, amavithamini C no-D
ukwephulwa yenqubo
imikhiqizo umzimba lipid peroxidation angase buthelela ezicutshini futhi uketshezi lomzimba ngaphandle ohlelweni antioxidant akusho bachithe nabo nge velocity kunesidingo. Ngenxa yalokho iphazamiseke ezokuthutha ion yonkana ulwelwesi cell, okuyinto ngokungaqondile ingaba nomthelela Ukwakheka ionic wesabelo ketshezi wegazi, izinga nokwehlukana kanye depolarization we ulwelwesi imisipha cell (aphule conduction Izinzwa amaza, contractility zabo, ngelula kwesikhathi refractory), lula ukungena uketshezi esikhaleni extracellular (edema, amahlule, electrolyte ukungalingani). Ngaphezu kwalokho, imikhiqizo eyinhloko peroxidation lipid, ngemuva kokwanda ukusabela kwamakhemikhali, eziguqulelwa aldehydes, ketones, acid kanye nokunye. Lezi izinto nethonya enobuthi emzimbeni, esizibonakalisa izinga nokwehlisa DNA zamagama, ukwandisa capillary permeability, ukwandisa ingcindezi oncotic, njengoba ngenxa yalokho, kodaka-syndrome.
Izenzo emtholampilo
Njengoba ukwanda komoya-mpilo radicals khulula has imiphumela elimazayo ebodeni cell, futhi imikhiqizo umzimba ukuphazamisa umzimba kanye synthesis acid nucleic futhi ubuthi emzimbeni, zingabantu isici pathophysiologic kakhulu ekuthuthukeni lezimo eziningana zokwelapha. Indima peroxidation lipid e isibindi kuyinto isifo ebalulekile emalungeni, izifo yisinanakazana ezithathelwanayo, iziyaluyalu hemodynamic, izifo oncological, ukuhlukumezeka kanye ukusha. POL ingenye ezingabangela i-atherosclerosis. ezizivelelayo Mahhala oxidize cholesterol kanye ongaphakeme isisindo yamangqamuzana ingxenyenamba yayo ukuze kwakhiwe imikhiqizo kulimaze odongeni semithambo. Lokhu kuqala kubangela ukusabela sokugembula ejwayelekile ukubhekana umonakalo. Lokhu kuphakamisa amahlule, ukunqwabelana amahlule e mafutha anciphisa isikhala esingaphakathi emincane noma ukunamathela izindonga zawo. Ngenxa yokuthi ukuhamba kwegazi kule ndawo kubambezela, njengoba isivele abe inesikhala isitsha. Lokhu kunomthelela ekuqongeleleni okwengeziwe amahlule. I Lesi sifo siphatha kakhulu ushintsho olunjalo esikhathini nemithambo yegazi yenhliziyo, i-aorta, kubonakala izimpawu umtholampilo we isifo senhliziyo zenhliziyo.
izinyathelo
Practitioners Kumelwe ukhumbule ukuthi ngokuziphatha izindlela zokuxilonga nokwelapha kusebenze mshini lipid peroxidation. Lokhu kufanele ubaxwayise isiguli. Ngu ingqondo zici zihlanganisa ukwelashwa ngemisebe (umdlavuza), kwe-ultraviolet (nge yamathambo, Izifo ukuvuvukala we sinuses, elwa namagciwane amagumbi okwelapha), kazibuthe (MRI, CT, ukubhucunga nokunyakazisa umzimba) amaseshini egumbini hyperbaric (e poliomyelitis, engamamitha ukugula).
Izinhlelo ezivimbayo futhi Ukwelashwa
Abasebenzi abasebenza rentgenkabinetom, orderlies nabahlengikazi, ongoti, ukuyifundisa bezintaba, abantu isisindo okweqile udinga ukudla ukudla okwakungenzeka ukuthi aqukethe Antioxidants zemvelo: inhlanzi, ubhekilanga noma amafutha, amakhambi, amaqanda, itiye eliluhlaza. Ngaphezu ekushintsheni Ukudla, izidakamizwa ingasetshenziswa ukuthi bophezela amaqembu athile noma radicals khulula sihlanganise ezisansimbi ka valency onhlobonhlobo. Ngakho they bekezelela mahhala asebenzayo zomoya-mpilo, ukuvimbela nabo kusuka sesibopho ukuthobisa lipid peroxidation yokukhulisa umsindo.
ukuhlola
Ngesikhathi sigaba samanje ukuthuthukiswa zocwaningo laboratory siyakwazi ukubona peroxide lichaza ekwakheni uketshezi begazi emzimbeni womuntu. Ukuze wenze lokhu, afeze fluorescence microscopy. Uma sikubeka kalula, ukukhomba peroxidation lipid. Inani lale kweemboniso alidingi incazelo. Ngempela, isifo esibalulekile okusekelwe umsebenzi ngokweqile peroxidation lipid. Ukuthola lokhu isimo inquma ukwelashwa.
Kusukela ngokombono zomzimba ejwayelekile peroxidation lipid kuyadingeka ukuze kwakhiwe hormone steroid, balamuli ukuvuvukala, cytokines futhi thromboxanes. Kodwa lapho isibalo chemical imikhiqizo ukushintshanisa kwe-data ukusabela idlula ovumelekile value futhi umonakalo peroxide cell organelles, iDNA uphazamise zamagama amaprotheni, empeleni engena ohlelweni antioxidant ukuthi kunciphisa inani mpilo ezizivelelayo ion of izinsimbi kanye valency onhlobonhlobo. Ngaphezu kwalokho, kwandisa synthesis catalase futhi peroxidase mayelana nokulahla peroxides ngokweqile kanye nemikhiqizo lokugayeka kokudla kwabo okwengeziwe.