"DioCore 160": yokusetshenziswa, nozakwabo yangempela. "DioCore solo 160": yokusetshenziswa, ngempela

Inani labantu ngezikhathi uhlushwa-high blood pressure. Nokho, isimo sokugembula ezinjalo hhayi kuphela kuletha ukungakhululeki abalulekile isiguli, kodwa futhi esabisa ukuphila kwakhe. Ngakho-ke, ngo-Kwimakethe ezithaka imithi kukhona imikhiqizo eminingi anomthelela ukwehlisa wegazi.

Ethandwa kakhulu phakathi kwalabo bantu ababelwela njalo uhlushwa umfutho wegazi ophakeme, isebenzisa isidakamizwa ngokuthi "DioCore 160". Yokusetshenziswa, analogue lomutsi, kanye nokubuyekezwa ngakho, izici izakhiwo izokwethulwa ngemva kwesikhashana.

Ukwakheka, incazelo, emabhokisini futhi ukuma

Medicine "DioCore 160", isitatimende kuqukethwe ebhokisini elenziwe amakhadibhodi, enziwa ngendlela amaphilisi. Ziyakwazi ifilimu-camera futhi unezithako ezifana esebenzayo njengoba valsartan futhi hydrochlorothiazide. Futhi indlela yokubika kuhlanganisa microcrystalline cellulose, sodium lauryl sulfate, amazambane isitashi, talc, corn isitashi, sodium croscarmellose, magnesium stearate, colloidal Silica anhydrous futhi opadry II Orange.

Asinakusho ukuthi umuthi onjalo, futhi zingatholakala ku ukudayiswa ngokuthi "DioCore Solo 160". Kusukela esandulele ke uyahluka ngokuthi isithako yayo asebenzayo izenzo valsartan kuphela.

Umgomo we operation ye nomuthi

Uyini izidakamizwa "DioCore 160"? Iziyalezo imibiko ukusetshenziswa ukuthi lokhu ejenti antihypertensive, okuyinto yakhiwa isisu thiazide kanye angiotensin II yokwamukela isitha.

Leli thuluzi has anhlobonhlobo imiphumela bokuphila okuyinto zithathwa njengengxenye engaqondile neqondile wegazi isiqondiso. Angiotensin II vasoconstrictor ejenti enamandla okubangwa oqondile pressor umphumela. Iphinde kubambezela sodium ne kuvusa uketshezi of aldosterone.

Valsartan ngokuthi asebenzayo futhi ethize angiotensin II yokwamukela isitha. It yenzelwe ekuphathweni temlomo na ngokukhetha uthatha isinyathelo AT1 yokwamukela subtype ukuthi banesibopho imithelela angiotensin II. Kwengxenye agonist umsebenzi ngesikhathi AT1 yokwamukela subtype, lesi sici alibonisi.

Futhi valsartan hhayi zivimbela ACE, oguqula angiotensin mina ukuba angiotensin II, bradykinin echithayo. Ningagcini futhi side effects kubangelwa bradykinin.

Ngo abantu umfutho wegazi ophakeme, izidakamizwa kubangela ukwehla komfutho wegazi. Kulokhu, it akunamthelela kwenhliziyo.

Iziguli eziningi ngemva umthamo owodwa we isihloko izidakamizwa ekuqaleni umsebenzi antihypertensive waphawula ngaphakathi 2 amahora, futhi wegazi ukunciphisa phezu amahora 6.

I inciphise umfutho wegazi ophakeme zomuthi iqhubeka isikhathi esingaphezu kosuku. Ngezinye iphilisi njalo esiphezulu nomphumela oqabulayo kufinyelelwa emasontweni amane futhi zigcinwe phakathi nayo yonke yokwelapha eside.

Pharmacokinetics

Yiziphi izindawo esingokwemvelo kinetic we nomuthi "DioCore 160"? Yokusetshenziswa (amaphilisi kufanele libekwe udokotela kuphela) uthi ngemuva kokuthatha izidakamizwa ngaphakathi ukumuncwa hydrochlorothiazide futhi valsartan kuyashesha kakhulu. Isilinganiso bioavailability eliphelele le-ejenti kwaba 23%.

I kinetics ka valsartan kukhona komugqa. Ukulisebenzisa ngokuphindaphindiwe igama izidakamizwa ongathwali noma yiziphi izinguquko. Nge iphilisi elilodwa wayenemfuyo sabo azinakwa.

Valsartan nakanjani plasma amaprotheni at 94-98%. excretion wayo wenziwa kanye indle kanye nomchamo. Lapho kuthathwe kanye AUC ka valsartan ukudla kuyehla 48%.

Emva kokuthola amaphilisi ngaphakathi hydrochlorothiazide ukumuncwa kwenzeka msinyana (mayelana 2 amahora). Ngaphezu kwalokho, bioavailability salo 60-80%. Ibonisa ke umchamo.

Nge inhlanganisela valsartan futhi hydrochlorothiazide bioavailability letindzala wale mithandazo kuyehla cishe 30%.

amaphilisi izinkomba

Kungaphansi kwaziphi izimo kungenzeka isiguli esimisiwe izidakamizwa "DioCore 160"? Yokusetshenziswa, odokotela real ukubika ukuthi leli thuluzi kahle uqobo wabonakaliswa esikhathini umfutho wegazi ophakeme, kanye nokuntuleka ukuphumelela kwalesi sifo kuphela.

Izimo ukuba ngamukele izibhebhe

Bewazi yini ukuthi kwezinye izimo, amaphilisi engamiswanga "DioCore 160"? Manual ithi imithi enjalo is contraindicated kokungabekezelelani ngazinye izithako zako.

Ngaphezu kwalokho, akuvunyelwe ukusetshenziswa in iziguli cholestasis, ezinzima isibindi ukungakhuli, futhi isifo sokusha biliary. Futhi, akukashicilelwa kubantu abaphethwe noma yiluphi uhlobo ukungasebenzi ngokulinganisela ezinzima futhi kwezinso, uphawu anuria, encishisiwe sodium ne-potassium amazinga egazini, hypercalcemia futhi hyperuricemia.

Tablets "DioCore 160": yokusetshenziswa

Njengoba ojwayelekile, ukuqeda-high blood pressure ekhaya iziguli ukutusa ukusetshenziswa iphilisi elilodwa "DioCore 80" kanye ngosuku. Ngokuqondene 'DioCore 160 "zomuthi, it is kunqunyiwe esibhedlela. Kulokhu, isiguli kufanele kwenziwe ngaphansi kokuqondisa njalo udokotela.

Njengoba umkhuba ubonisa, ubungane umphumela lubonakale at umfutho wegazi ophakeme eqinile waphawula ngemva kwamasonto 2-3 Ukuqalwa yokwelapha.

Kubantu abanalesi ukungakhuli hepatic noma kwezinso emaphakathi noma enkulu liyadingeka ukuze afeze ukulungiswa ledzingekako umthamo ububanzi (ngamunye).

Ubude yokwelashwa nale imithi kufanele azimisele kuphela udokotela ukuba khona.

side effects

Hlobo luni side effects isiguli kufanele bazazi ngaphambi kokusebenzisa umuthi "DioCore Solo 160"? Iziyalezo yokusetshenziswa lithi kubhekwe imithi ayivamile ukubangela izigigaba ezingezinhle ukuthi abe nohlamvu engazinzile futhi waphathwa echaziwe.

Cishe 1% eziguli ngenkathi kokuthatha lesi izidakamizwa bavele bekhanda ababuthakathaka, iqolo, ukukhathala, ukukhwehlela, isiyezi kanye nasopharyngitis.

Ngaphansi kuka 1% bakhalaza ubuhlungu besisu, ukukhathazeka, ukungakhululeki entanyeni nasesifubeni, ukukhathala, ukuqaqamba kwamalunga omzimba, ukucinana kwemigudu yokuphefumula serous, ukozela, laryngitis, iphika, uhudo neziyaluyalu, ukwakhiwa encishisiwe, wehlise amathe, hypotension, Gastroenteritis, paresthesia, anda ukujuluka, kwehle ukuzwela, imisipha amajaqamba, ukuqwasha, edema neuropathy, isicanucanu, indlebe izifo, ukuminyana acinene futhi ukwenyuka okuncane kwezinga lokushisa komzimba. Ngezinye izikhathi isiguli uye kahle umbono, tachycardia engazinzile futhi tinnitus. Kufanele kuqashelwe ukuthi ubuhlobo ngqo okuvela zindlela zokusabela kanye izidakamizwa engakaze isungulwe.

Yiziphi ezinye imiphumela emibi kungabangela imithi "DioCore Solo 160"? Imiyalelo isicelo ubonisa ukuthi uma usebenzisa leli thuluzi, kwaba nezigameko elingalodwa ukuqala amawala, ukulunywa futhi kwezinye izimpawu, ukubona umzimba uxabane nawo, kuhlanganise vasculitis, futhi serum ukugula. Ngaphezu kwalokho, iziguli ngezinye izikhathi ukuthuthukisa myalgias futhi nefralnaya ukungasebenzi.

ifomu kakhulu ezingavamile amathuba okuba nemiphumela engemihle uma nithatha "DioCore 160" mkhiqizo i-edema lula non-cardiogenic ukuthi lihlotshaniswa ukungabekezelelani ngazinye hydrochlorothiazide.

Ucwaningo luye lwabonisa ukuthi kwezinye iziguli ziphathwe leli thuluzi, kwehle potassium igazi, ebeka creatinine kanye urea, kanye ekukhombeni neutropenia omnene.

Izimpawu ze-ukweqisa izidakamizwa

Ziyini izimpawu "DioCore Solo 160" nge ebulilini izidakamizwa? Manual ithi Ezimweni ezinjalo awaziwa ngalesi sikhathi.

Isibonakaliso eyinhloko umthamo lenyuke imithi kungaba hypotension ezinzima. Uma izidakamizwa kwavunyelwana esanda kutholakala, isisulu liyadingeka eyayenziwe ntombazane ukuhlanza. Futhi kungenzeka hypotension ukulwa eyenziwa abaphathi emthanjeni of nosawoti evamile.

Kufanele kukhunjulwe ukuthi akunakwenzeka baphethe izidakamizwa kubhekwa kusukela umzimba by hemodialysis. Lokhu kungenxa yokuthi valsartin, kufakwe ngezithako zawo, ke ixubana amaprotheni oketshezi olungenambala olusegazini. Nokho, kufanele kuphawulwe ukuthi hydrochlorothiazide siqedwa ngale ndlela ngempela ngempumelelo.

Izidakamizwa ekusebenzisaneni neminye imithi

Kungenzeka yini ukuba zihlangana kanjani nezinye izindlela "DioCore 160"? Ukufundiswa uthi inhlanganisela lokhu izidakamizwa nezinye izidakamizwa antihypertensive iqembu anganikela ukuthuthukisa umphumela ukwehlisa wegazi.

Ukusetshenziswa ngesikhathi esisodwa nomuthi nge izithasiselo potassium-equkethe, isisu omnene, solezamenitelyami futhi izinto ukwandisa okuqukethwe potassium emzimbeni, kudinga ukuhlolwa njalo lokuhlushwa potassium igazi serum.

Lapho ukuphatha kanyekanye "DioCore" nge-ACE inhibitor sezihlonziwe ukwanda esethola e lokuhlushwa lithium egazini.

Imiphi imithi angasebenzisa ngokuphepha lesi sidakamizwa "DioCore 160"? Umhlahlandlela ibika ukuthi monotherapy nomfutho wegazi ophezulu leli thuluzi awuzange waphawula iyiphi ukuxhumana "glibenclamide", "amlodipine", "warfarin", "cimetidine", "Digoxin", "furosemide", "indomethacin" Atenolol ".

Kusukela izidakamizwa e ukwakheka ngaphansi ukucatshangelwa kuhlanganisa thiazide isisu iqembu, ekuxhumaneni yayo kungenzeka ezilandelayo:

• wehlise empeleni isisu zomuthi uma isetshenziswa kanye NSAID (isib salicylates noma "Indomethacin");
• potentiation kwemisipha relaxants.

Yini okunye ukuxhumana izidakamizwa odinga ukukwazi ngaphambi kokuthatha "DioCore 160"? Imiyalelo, ukubuyekezwa abonisa ukuthi ngenkathi usebenzisa leli thuluzi nalawo kaliynesberegayuschimi isisu, salicylates, ACTH, amphotericin karbenokslolonom futhi mhlawumbe ukwehla elibukhali lokuhlushwa potassium igazi.

Lapho esetshenziswa komjovo futhi ngomlomo izidakamizwa antidiabetic kufanele sigcwaliswe ngamunye ulungise umthamo wabo.

It is hhayi Kunconywa ukusebenzisa nomuthi kubhekwe kanye isisu iqembu thiazide, njengoba lokhu angakhulisa oshiwo ngenhla side effects izidakamizwa futhi abangele hypersensitivity ukusabela.

Lapho isicelo kanyekanye ne methyldopa hydrochlorothiazide kungenzeka baba nesifo sokuntuleka kwegazi hemolytic.

Lapho izidakamizwa kuhlanganiswe "DioCore 160" nge kolestiraminom incipha bioavailability yayo kanye ukumuncwa.

Ngaphambi kwangathi izidakamizwa ne-vitamin D kakhulu egazini calcium lokuhlushwa zandiswe iziguli.

Akuvunyelwe ukuthatha "DioCore" nge cyclosporine, njengoba lokhu kungabangela izimpawu isimo podagropodobnye giperurikekii.

izincomo Specific ku iphilisi

Yini odinga ukuyazi ngaphambi kokuba usebenzise izidakamizwa "DioCore Solo 160"? Yokusetshenziswa, ukubuyekezwa bathi ngesikhatsi ukwelashwa nale ejenti e isiguli kufanele kube zokuqapha njalo amazinga serum of electrolyte egazini.

Nge ukuthuthukiswa kwe-hypotension abathintekayo kumele iguqulwe ibe yindawo evundlile. Uma kudingeka, afeze ukumnika emthanjeni of nosawoti evamile. Ngemva eliletha ukuthula ukuphathwa kwengcindezi kungenzeka waqhubeka.

Abantu ne sohlangothi olulodwa noma zamazwe amabili kwezinso Umthambo stenosis eyamukelayo valsartan kungadala ukwanda serum creatinine noma igazi urea.

Lapho sabele nomuthi iziguli izinso kahle umsebenzi umthamo udinga ukulungiswa, kodwa kudinga ukuqapha ngezikhathi creatinine futhi uric acid, kanye potassium okuqukethwe igazi.

Kunobufakazi bokuthi isisu thiazide kungayibhebhethekisa omzimba izicubu erythematosus. nabo ukushintsha ukubekezelelana glucose isiguli, ukwandisa lokuhlushwa cholesterol, futhi uric acid kule triglyceride igazi. Kule ndaba, iziguli sikashukela kungadinga ukulungisa umthamo we temlomo ejenti hypoglycemic noma nge-insulini.

In iziguli ngokulinganisela nezincane isibindi ukungakhuli ngaphandle cholestasis ukulungisa umthamo liyadingeka. Kodwa ngaphansi kwalezi zimo izidakamizwa okufanele zithathwe ngokucophelela okukhulu.

Kukhona imibiko photosensitivity ngesikhatsi ukwelashwa nge isisu thiazide. Uma ngokuhamba yokwelapha nale kusho kukhona ukusabela photosensitivity, ukwelashwa kufanele inqanyulwe.

Uma kudingekile, abaphathi okuphindiwe isisu Kunconywa ukuvikela izingxenye ezisengozini kwezindlela yelanga noma ilanga.

izidakamizwa analogue

Yini ibhekwe esikhundleni izindlela zethu? Ngokusho onekhono izakhiwo efanayo yizidakamizwa ezifana "Air kolwandle", "Dentokind", "Intsena", "Cinnabsin", "Softovak", "Medotsef" "Vinblastine-Teva".

Izibuyekezo sokulungiselela

Manje ngoba sewuyazi ukuthi indlela ukusebenzisa izidakamizwa "DioCore 160". Yokusetshenziswa lomutsi iye yachazwa ezinhlwini ezingu imininingwane ngenhla.

Leli thuluzi bemthanda iziguli nodokotela. Ochwepheshe ukubika ukuthi ngempumelelo kuzibonakalisa khona ezinzima lwemithambo Hyperplasia. Abathengi uvumelana ngokugcwele nalo. Ngokusho izimpendulo zabo, ukuthatha esinye isibhebhe sibonisa ikhuthaza sokubuyiselwa wegazi, kanye lula isimo sabo.

Akunakwenzeka ukuba uqaphele iqiniso lokuthi izidakamizwa has a ifomu elula ukukhululwa kanye umthamo. Noma kunjalo, ukwamukela umthamo ephakeme zomuthi kufanele kuphela esibhedlela, ngaphansi kokuqondisa kukadokotela.