Amaphilisi e-Lopedium: imiyalo yokusetshenziswa, ukubuyekezwa

"Ukulahlekelwa" yisidakamizwa esicindezela i-peristalsis. I-gelatin capsules ngegobolondo elukhuni, eqoshwe kumbala ompunga noma omnyama (aqukethe i-powder ehambisanayo yombala omhlophe) noma amaphilisi amhlophe.

Izakhiwo zomzimba

Amathebulethi "Ukulahlekelwa" (imiyalelo yokusetshenziswa esinikezwe kulesi sihloko) iqukethe into ekwazi ukuxhumana nama-opiate receptors emathumbu. Ngenxa yalokhu kuxhumano, ukukhululwa kwe-acetylcholine ne-prostaglandins kupheliswa. Ngale ndlela i-peristalsis yomsindo incishisiwe futhi isikhathi sokudla kwesidlo sokudla ngendlela yokugaya isanda kakhulu. Futhi, izindonga zamathumbu zithatha uketshezi oluthe xaxa, ziyangena kumsindo we-muscle we-sphincter.

Pharmacokinetics

Iningi le-loperamide, elingene emzimbeni, lithinteka emathunjini, noma kunjalo, ngenxa yesimiso esinamandla sokuqala kwesimiso sokuqala, ukutholakala kwe-systemic bioavailability kungokwesine kuphela kwephesenti.

Ngenxa yocwaningo kwatholakala ukuthi lo muthi usakazwa ngokuhambisana nodonga lwamathumbu, futhi ngesikhathi esifanayo ubophezela ku-receptors kwendwangu yesikhathi eside yegobolondo lemisipha. Ngokuyinhloko, i-loperamide ibopha amaprotheni, ikakhulukazi i-albin.

Amathebulethi "Ukulahlekelwa" (imiyalo yokusetshenziswa ibhekisela kubo njengamalungiselelo aphephile) asondelene ngokuphelele nesibindi, lapho ahlanganiswa khona, agxiliwe futhi agxiliwe emzimbeni nge-bile. Ngenxa yempembelelo enkulu yendima yokuqala yomuthi ngesibindi, ukuhlushwa kwezidakamizwa ngokwayo egazini kunciphisa kakhulu, kusele kakhulu. Isidakamizwa sisuswe ngokuphelele emzimbeni ngemva kwamahora ayishumi nanye noma amane.

Izinkomba zokusetshenziswa

"I-Lediumum" (amaphilisi) imfundo yokusetshenziswa iphakamisa ukuthatha uma kwenzeka isifo sohudo esingapheli nesisindo. Lesi sidakamizwa singathathwa ngabantu abathintekayo ekuhambeni ("isisu sovakashi"). Kulokhu, inkambo yokwelapha kufanele ibe yizinsuku ezimbili. Kodwa-ke, uma igazi litholakala ekunyameni kwezinhlungu, ungasebenzisi imithi kuze kube yilapho imbangela yokugxekwa kukadokotela isungulwe.

Ukungafani

Ungasebenzisi iphilisi uma kwenzeka kukhona ukuzwela okwenyuka ku- loperamide hydrochloride noma yiziphi ezinye izingxenye zomuthi.

Ukuphikisana okuyinhloko kweziguli:

- i-enterocolitis yebhaktheriya, etholakala ngenxa yomsebenzi wamagciwane ezincane:

- isifo samathambo esiyingozi, sihambisana nesifo sohudo nesifo somkhuhlane.

Hlanganisa lesi sidakamizwa nanoma yimaphi ama-antibiotics ngokuqapha okukhulu. Qinisekisa ukuthi utshela udokotela ngalokhu.

Ungasebenzisi amaphilisi e-Lodeium (imiyalo yokusetshenziswa isexwayisa iziguli) uma uqala ukuqotshwa, ukuvinjelwa noma ukuvimbela emathunjini. Gwema kusho uma kwenzeka udinga ukugwema ukucindezelwa kwe-peristalsis.

Ungathatha kanjani i-Lodepin kumaphilisi

Isidakamizwa singasetshenziswa ngabantu abadala nabantwana abangaphezu kweminyaka eyisithupha ubudala. I-capsule (ithebhulethi) kufanele igonywe ngokuphelele, ihlanzwe phansi ngamanzi amancane ahlanzekile.

Ukuze uhudo olungapheli futhi olunzima, umthamo wabantu abadala kufanele ube yi-4 mg yesidakamizwa (ama-pcs amabili). Kubantwana, into eyodwa izanele. Isidakamizwa kufanele sithathwe ngemva kokunyakaza kwamakhemikhali. Isibonelelo esiphezulu sosuku nosuku nabantwana kuba amaphilisi ayisithupha kuya kweziyisishiyagalombili.

Uma izimpawu zesifo sohudo esiphuthumayo singanyamalala zingakapheli amahora amane nesishiyagalombili, isidakamizwa kufanele siphelelwe.

Iziguli ezigugile azidingi ukulungiswa okukhethekile kwesilinganiso samaphilisi. Okufanayo kuya kubantu abahlupheka ngezinkinga zezinso. I-"Lediumum" (amaphilisi) imfundo yezingane ezineminyaka emithathu ubudala ayikhuthazwa.

Izici zohlelo lokusebenza

Ngokuvamile, ukwelashwa kwesifo sohudo kuhlelekile. Uma isiguli sinethuba lokuthola i-etymology yesifo, khona-ke kulesi simo kufanele kubhekane nokwelashwa okuqondile. Kungenzeka ukuthi lo muthi unqunywe odokotela ngenkathi kusetshenziswa ukwelashwa kwama-antibiotic. Ngokufana nokuthatha imithi ye-"Lediumum" (amaphilisi), imfundo yezingane iphakamisa ukwelashwa endaweni esikhundleni sokuvuselelwa kwama-electrolyte kanye ne-liquid. Lokhu kufanele kwenziwe lapho kwenzeka ukungalingani nokuphelelwa amandla kwamanzi we-electrolytes.

Iziguli eziye zazuza i-immunodeficiency syndrome (i-AIDS), enehudo, masinyane uyeke ukuthatha "i-Lopei" uma kuqhuma.

"Ukulahlekelwa" (amathebulethi): imiyalelo yokusetshenziswa ekukhulelweni naseLactation

Odokotela abathongo ukuthi bathathe lesi sidakamizwa kubesifazane abakhulelwe nabalahlayo. Lokhu kungenxa yokuthi inani elincane loperamide lingangena ubisi lwebele. Yingakho abesifazane "esimweni" kufanele baxoxe nodokotela ngaphambi kokuthenga lesi sidakamizwa.

Ukusebenzisana nezinye izidakamizwa

Ososayensi bayazi izimo zokuxhumana nezidakamizwa ezinezici ezifanayo zezokwelapha. Imithi enomthelela ocindezelayo ohlelweni lwezinzwa ezisemaphakathi ayikwazi ukuhlanganiswa ne "Lopezium."

Kuyafaneleka ukucabangela ukuthi i-loperamide ingumgogodla we-P-glycoprotein. Ukusebenzisa ngesikhathi esisodwa "i-Lopezium", kanye ne-quinidine ne-ritonavir, kungaholela ekunyuseni okukhulu ekuhlungeni komuthi egazini. Umthamo ungase ukwandise izikhathi ezimbili kuya kathathu. Umphumela ofanayo ubonakala ngokusetshenziswa kwe-itraconazole ne-ketaconazole.

Kutholakale ukuthi izidakamizwa ezinamakhemikhali afanayo ezemvelo zingandisa umphumela we-loperamide izikhathi eziningana. Kodwa izidakamizwa ezisheshisa inqubo yokudlulisa okuqukethwe kwendlela yomzimba, ngokuphambene nalokho, ukunciphisa ukusebenza kwayo.

Overdose

Izibhebhe ze-Lopedium (imiyalelo yokusetshenziswa ichaza izimpawu zokudlula ngokweqile) kungaholela ekulahlekelweni kokubambisana, ikhanda, ukulala, ukubambezeleka nokuphuza ukuchama. Uma uthola lezi zimpawu, ungathatha i-Naloxone. Ezimweni ezingavamile, geza isisu uphuze amalahle acushiwe.

Ukuphendula okubi

Esikhunjini singakha ama-rashes, kuhlanganise ne-Stevenson-Johnson syndrome; I-Erythema multiform; I-Edema; Ukunambitheka kanye nemifantu.

Isidakamizwa singasithinta kakhulu isimiso sezinzwa. Iziguli zingase zizwe ukulala, ukungaboni kahle, ukulahlekelwa yocwaningo, ukucindezeleka nokugwedla.

Esikhathini sezinhlelo zokugaya, iziguli zingase zibone umlomo owomile, ukuqothulwa, isicanucanu, flatulence, ukuhlanza, ukuvimbela emathunjini. Iziguli eziningi zathola ukukhathala okusheshayo.

Ngokunakekelwa okukhethekile ukusebenzisa lesi sidakamizwa emotweni yemoto nokusebenza nezinqubo, ngoba lesi sidakamizwa singabangela ukulala.

Ifomu lokukhululwa, ukupakishwa nokubunjwa

I-capsule ngayinye (ithebulethi) iqukethe ama-milligram amabili we-loperamide hydrochloride. Ngaphandle kwesisetshenziswa semithi eyisisekelo, lokulungiswa kuqukethe usizo, okungukuthi: i-talc, i-magnesium stearate, isitashi samabele kanye ne-lactose monohydrate.

Amathebulethi okuthengisa ngamapuleti ezinhlamvu eziyishumi. Ephaketheni ingaba kusuka ku-one kuya kwezingu-5.

Amaphilisi amhlophe embala futhi ajikeleze, adibanisa ngakolunye uhlangothi.

Isidakamizwa kufanele sigcinwe endaweni emnyama, eyomile engekho ekufinyeleleni kwezingane. Ukushisa akufanele kudlule ama-degree angamashumi amabili nanhlanu. Life Shelf - iminyaka emihlanu kusukela ngosuku lokukhiqizwa. Isidakamizwa singathengwa kunoma iyiphi ikhemisi ngaphandle kwemithi kadokotela. Kodwa-ke, ungakhohlwa ukuthi ukuzivocavoca kungabangela imiphumela emibi.