Isidakamizwa esithi "Doxycycline", ama-analogues nesenzo sabo.

"I-Doxycycline" ibhekisela kuma-antimicrobial for use systemic. Njengo-Doxycycline ngokwawo, izifanekiselo zalesi sidakamizwa ziyingxenye yeqembu le-tetracycline. Zinezinto eziningi ezenzelwe ukulwa nama-microbes.

Ama-analogues adume kakhulu omuthi "Doxycycline" angama-"Unidox solute", "Doxycycline gidlochloride", "Doxibene", "Doxycycline-darnitsa" nabanye abanye. Ngokuvamile ungabona indlela umuntu angabaza ngayo lokho okungazithenga, "Doxycycline" noma "Unidox", isibonelo. Kumele kuqashelwe ukuthi i-pharmacodynamics yale mithi iyafana. Ngakho-ke, konke kusebenza ngokumelene ne-Gram-positive (Stamphylococcus spp., Streptococcus spp., Actinomyces Israel, Clostridium spp., Listeria monocytogens, Bacillus anthracis) kanye ne-Gram-negative (i-Neisseria gonorrhoeae, i- Vibrio cholerae, i- Bordetella pertussis, i-Yersinia spp., I-Enterobacter spp. Klebsiella spp., Escherichia coli, Salmonella spp., Shigella spp.) Yamagciwane amakhulu. Uzwela ku-Doxycycline kanye nezifanekiselo zayo i-Mycoplasma spp., URickettsia spp., Treponema spp., Borrelia burgdorferi, uClamydia spp., Amanye ama-protozoa (afaka i-Entamoeba histolytica, i-Plasmodium falciparum). Izwe elizwela kakhulu kunezilinganiso ze-"Doxycycline" i-Haemophilus influenza (91-96%) nama-pathogens we-intracellular.

Iminingwane ewodwa ephawulekayo, ehluke emilenzeni ye "Doxycycline" - ukuthi ingaphansi kwamanye ama-tetracycline ayingozi kakhulu emathunjini emathunjini, futhi anesikhathi eside eside sokusebenza nokumuncwa okuphelele. Ama-antibiotic avela ku-tetracycline amaningana angene esitokisini futhi agweme ukukhiqizwa kwezifo eziphilayo ezikhona lapho. Ngokwesilinganiso sokusebenza kwamagciwane, isidakamizwa esithi "i-Doxycycline hydrochloride" sidlula zonke ezinye i-tetracyclines, kuhlanganise nemvelo.

Njengesidakamizwa esithi "i-Doxycycline," ama-analogs awo anemigomo elandelayo yokusetshenziswa:

- izitho ze-ENT ezithathelwanayo;

- ukutheleleka kwepheshana lokuphefumula;

- ukutheleleka kwesistimu ye-genitourinary ;

- ukutheleleka kwezicubu ezithambile nesikhumba;

- ukutheleleka kwegciwane lesibhilidi kanye nomzila wamathunjini;

- i-osteomyelitis, i-brucellosis, ukukhwehlela okukhwehlela;

- i-syphilis, i-yersiniosis, i-malaria, i-yaws, i-ky fever, i-legionellosis, i-typhus, i-rickettsiosis, isifo se-Lyme, i- chlamydia yezindawo ezihlukile, i-bacillary ne-amoebic yamathumbu, ikholera, i-tularemia, i-actinomycosis;

- ekwelapheni jikelele - granulocyte erlichiosis, leptospirosis, psittacosis, trachoma, ornithosis;

- subacute endocarditis septic, sepsis, peritonitis.

Inqatshelwe ukusebenzisa "i-Doxycycline" ngokuzwela okukhulu kwe-tetracyclines, ukuhluleka kwesibindi esikhulu, i-porphyria, ngesikhathi sokukhulelwa, i-lactation (isikhathi sokuthatha isidakamizwa ekunceliseni ibele kufanele ishiywe), lapho uneminyaka engaphansi kweminyaka engu-12 ubudala. Ngokuqapha kufanele uthathe lesi sidakamizwa kubantu abaphuke isibindi, i-leukopenia.

Isidakamizwa esithi "i-Doxycycline" ingaba nemiphumela emibi ku:

- isimiso sezinzwa (isisindo esiyinkimbinkimbi yesimiso sezinzwa, ukucindezela okungahambisani nesimo);

- Ukuzwa izitho (umsindo uvela ezindlebeni);

- uhlelo lokugaya (i-enterocolitis, ukuhlanza nokuhlanza isisu, isifo sohudo noma ukuqothulwa, isisu somzimba, i-dysphagia, i-glossitis, i-esophagitis, ukubonakaliswa kwesisu kanye ne-duodenum);

- kusuka eceleni kwesimiso senhliziyo (i-edema, i-tachycardia);

- hematopoiesis (thrombocytopenia, eosinophilia, i- hemolytic anemia, neutropenia, porphyria);

- ukusabela okubonisa ukuguqulwa komzimba (isikhumba, ukushaywa, ukusabela kwe-anaphylactoid, ukuqhuma kwe-maculopapular, i-Stevens-Johnson syndrome, i-anti-neuropathy edema);

- Okunye (isifo sofuba, i-jaundice, i-myalgia, i-arthralgia, i-photosensitization, i-discoloration eqinile yezinyosi zamazinyo, ukuvuvukala endaweni ye-anogenital, i-candidiasis, i-dysbiosis).

Uma kwenzeka ngokweqile kwe-Doxycycline, ungase uqaphele izimpawu ezilandelayo: i-hepatotoxicity, nemiphumela emibi kakhulu. Kulesi simo, kufanele usebenzise ngokushesha ukwelashwa, ukhansele lesi sidakamizwa bese uqhuba ukwelashwa okuyisimangaliso (njengoba kungekho-antidote ethile), kuyadingeka nokugcina nokulawula ukuthi imisebenzi ebalulekile iqhubeka kanjani.