Umuthi 'Ofloxacin ": kobufakazi nesineke. Yokusetshenziswa kwe-antibiotic "Ofloxacin"

Ukulungiselela "Ofloxacin" izilinganiso iziguli okuyinto ikakhulukazi omuhle, limelela ejenti elwa namagciwane kusukela iqembu fluoroquinolones spectrum ezibanzi umsebenzi. Umuthi sithinta gyrase DNA - isinqamu webhaktheriya, ukuhlinzeka supercoiling ngakhoke ukuzinza amagciwane DNA (ngenxa destabilization DNA Strand die).

pharmacodynamics

Kusho "Ofloxacin" - umuthi maqondana nezilwanyana ezincane ezikhiqiza beta-lactamase, kanye elikhula mycobacteria atypical. Emithini, azwela amagciwane kakhulu Gram-negative, kuhlanganise nezilwanyana ezincane amelana methicillin nezinye elwa namagciwane. Streptococci, enterococci, futhi Mycobacterium sofuba zinezikhathi ezifweni engazinzile emuthini "Ofloxacin". Izibuyekezo lodokotela abonisa ukuthi ekwelapheni anaerobic izifo zibangelwa peptostreptokokki, peptokokki nezinye anaerobes, umuthi ngokuvamile lokhu akuphumeleli.

Pharmacokinetics

Ngemva kokuthola lezi nomuthi ku ukumuncwa kuqedile (amaphesenti angu-95) futhi fast. Bioavailability - ezingaphezu kuka amaphesenti angu-96. Ubuhlobobo plasma amaprotheni - amaphesenti 25. Ngemva kwamahora amabili ngemva kokuphathwa ngomlomo okuhlushwa eliphakeme attained. Kuyinto ulapha ancike: ukusetshenziswa elilodwa angu ezingamakhulu amabili, amane noma ayisithupha namashumi kwezidakamizwa lokuhlushwa ngesikhathi ngokulandelana 2.5, 5 noma 6.9 UG / ml.

Ukudla ukusetshenziswa kungathinta ukumuncwa eceleni Ukwehla, kodwa akukho nomphumela enkulu bioavailability. Ukulungiselela "Ofloxacin" - i-antibiotic kokuba umthamo enkulu ukusatshalaliswa (eziyikhulu amalitha), ukuze ukulungiselela iqondiswa cishe inani eligcwele lingena ngokukhululekile ku amaseli. Lamanani aphezulu kakhulu kukhona emisipheni, uketshezi lomzimba kanye nezinhlaka: kumaseli (macrophage alveolar, leukocyte), izicubu zomzimba ezithambile, esikhumbeni, ethanjeni, umgudu wokuphefumula, ingaphakathi okhalo futhi besisu, ngamathe, uketshezi Prostatic, umchamo, Bile. lingena kahle nomuthi lo esinomhlapho futhi gazi ebuchosheni, is ethakwa kusukela ubisi lwebele, futhi cerebrospinal fluid ingena ngesikhathi non-elikhanyayo futhi avuvukele ulwelwesi ubuchopho (14 kuya ku-60 amaphesenti).

Mayelana 5 amaphesenti zomuthi is akheka esibindini ukwakha dimetilofloksatsina futhi N-oxide ka ofloxacin. Kungakhathaliseki umthamo isigamu-ukuphila phakathi ezine nesigamu kuya amahora ayisikhombisa. Lokukhipha izidakamizwa ezingaguquliwe isamba amaphesenti 75-90 of ezinso, e isamba amaphesenti 4 - e-Bile. bangaphansi kwamaphesenti angu-20 ka-imvume extrarenal. Ngemva umthamo owodwa we angu ezingamakhulu amabili ejenti kuyinto selitholakala umchamo amahora 20-24. Endabeni excretion hepatic noma kwezinso kungenzeka kancane. Lapho zelashwe isuswa 10 kuya kwangu-30 imithi.

izinkomba ngoba

Ngo zezifo ezithathelwanayo namakhambi ukuvuvukala okubangelwa nezilwanyana ezincane ezihlukahlukene, kuboniswa nomuthi isicelo "Ofloxacin". Izibuyekezo babike ukuthi muhle kakhulu zokuphefumula ipheshana izifo (pneumonia, ukucinana kwemigudu yokuphefumula), engenhla ipheshana zokuphefumula (otitis abezindaba, sinusitis, laryngitis, pharyngitis). Yabela izidakamizwa e soft izicubu izilonda, amalunga, amathambo, isikhumba, ipheshana biliary, ngomgudu womchamo (urethritis, cystitis), izinso (pyelonephritis), ingaphakathi lesisu, Izitho zangasese (orchitis, colpitis, epididymitis), izitho kwezitho zangasese (salpingitis, prostatitis, cervicitis, endometritis, oophoritis, nemingcele).

Futhi izidakamizwa eliphumelelayo ureaplasmosis, chlamydia, isipatsholo. Yisebenzise nokuvimbela izifo iziguli ezinokuphazamiseka isimo mzimba (kuhlanganise neutropenia).

Ifomu umthamo. isakhiwo

Ukukhululwa nomuthi kuyinto ngesimo camera omhlophe noma awube mhlophe amaphilisi ifilimu-camera biconvex round ukuma. Isiphambano Sectional lubonakale izingqimba ezimbili, enye yazo has a kwe-tint aphuzi. isakhi Active uba ofloxacin. Omunye ithebhulethi eziqukethwe mass 200 noma 400 mg. izithako Minor aziyona primelloza (croscarmellose sodium), microcrystalline cellulose, Aerosil (colloidal Silicon dioxide), Silica titania, povidone, methylcellulose hydroxypropyl (hypromellose), talc, magnesium stearate, polyethylene glycol 4000 (macrogol). A inzuzo enkulu zomuthi "Ofloxacin" - intengo. Tablets equkethe 200 mg lomcebo ephilayo okuyisilinganiso sabangu-ruble 16-20 ngamunye izingcezu 10, nalabo eziqukethe angu 400 ofloxacin, izobiza ruble mayelana 50-55 ngamunye izingcezu 10.

"Ofloxacin" imithi. Yokusetshenziswa

Tablets kufanele baphuze ngaphambi noma ngemva kokudla. Bayobizwa kugwinywe wonke, ngaphandle ukuhlafuna, uphuze namanzi izinto eziningi ezincane. I Isikali kumele akhethwe ngamunye kuncike ngobucayi isifo, kwasendaweni nesifo, isimo jikelele isiguli, umsebenzi izinso, isibindi, namagciwane ukuzwela.

Njengomthetho, ukwelapha "ofloxacin" senziwa izinsuku eziyisikhombisa kuya kweziyishumi. Adult nsuku ebekiwe edonsa ezingamakhulu amabili, angu angamakhulu ayisithupha okungenani kabili ngosuku. Umthamo kungase kukhule ku angu eziyisishiyagalombili esimweni igciwane sina, noma uma isiguli sifuna ukhuluphele. A umthamo angu ezine zingafundwa ngesikhathi esisodwa, mhlawumbe ekuseni.

Iziguli kahle umsebenzi so-renal kanye awukwazi ukuthatha angu engaphezu kwamakhulu amabili kwezidakamizwa, umthamo sangemihla e ukungakhuli hepatic - angu anamakhulu mane. Ngemva ukunyamalala izimpawu kanye ukuzinza lokushisa, ngisho izinsuku ezimbili noma ezintathu kufanele uqhubeke yokwelapha.

Imiphumela engemihle. nobufakazi

Akubona bonke iziguli lesi sidakamizwa "Ofloxacin 'ebekezelele ngokubhekakade kahle. Uphenyo abanye abantu aqukethe ulwazi ukuthi izidakamizwa kubangela ikhanda elibuhlungu, isicanucanu, ukuhlanza, ukukhishwa isisu, ukundindizela, ukungabi namizwa emikhawulweni. On the yesimiso zokugaya zingase ukuthuthukisa njengoba ubuhlungu besisu, gastralgia, ukuvuvukala, jaundice cholestatic, ukudla, ukudla hyperbilirubinemia, enterocolitis pseudomembranous, futhi isimiso sezinzwa - yokuntuleka ukunyakaza, amajaqamba, amaphupho okukhulu, ukusabela zengqondo, ukuyaluza, ukukhathazeka, ukudideka, zokwesaba, ukusangana, ukucindezeleka.

Ngaphezu kwalokho, kukhona ingozi ukwephulwa ohlelweni motor (arthralgia, tendonitis, myalgias), izinzwa (ukunambitheka neziyaluyalu, imibala, ukuzwa, ibhalansi, iphunga), isimiso semithambo yegazi futhi inhliziyo (ukunciphisa umfutho wabo wegazi, tachycardia), isikhumba (dermatitis, iphuzu ukopha, ukuqubuka papular), ka hematopoiesis (thrombocytopenia, ukuntuleka kwegazi emzimbeni, leukopenia). Emva kokuthola "Ofloxacin" izidakamizwa (izibuyekezo uqinisekise lesi), kwezinye izimo kubonakala silume isikhumba, bronchospasm, urticaria.

Izimo

Ukuthola nomuthi sinqatshiwe ukungabekezelelani ofloxacin nezinye nemikhiqizo fluoroquinolone, esimweni ukuntula glucose-6-phosphate dehydrogenase, isifo sokuwa, izilonda imisipha, ekunciphiseni kokuquleka embundwini. Ngaphezu kwalokho, awukwazi ukuthatha lesi sidakamizwa "Ofloxacin" kwabesifazane abakhulelwe kanye lactating, izingane ezingaphansi kweminyaka engu-nesishiyagalombili. Ngokulungiselela ngokucophelela ezinqunyiwe iziyaluyalu kwegazi ebuchosheni, i-cerebral atherosclerosis semithambo, ukwehluleka kwezinso e CNS ezingamahlalakhona izilonda nemvelo eziphilayo.

Nomuthi "Ofloxacin" ngesikhathi ureaplasma. Izibuyekezo

Into esemqoka ukuthi abantu bethi, ukusebenzisa umkhiqizo - kungcono umphumela wakhe ngokushesha. Iziguli ukubika ukuthi umphumela uba obonakalayo kakade ngosuku lesithathu noma lesine. Kodwa kubalulekile ukuba baxwayisa ngokuthi lokhu akusho ukuqala ukwelashwa. Labo iziguli abaye bayeka ukuphuza amaphilisi, ngaphandle kokudabula uze uwaqede, bese futhi uphethwe ureaplasmosis, ngoba ama-bacterium ungazange sekususiwe ngokuphelele.

Izixwayiso

Lapho i-pneumonia cuphuluza pneumococcus, umuthi ayizwakali. Futhi, aluboniswa ukwelapha namathansela oyingozi. Kuyadingeka ukuba ayeke izidakamizwa uma ku isizinda wavuma ukuzwa ukusabela iguliswa, le CNS disorder, nesifo pseudomembranous. Abesifazane ekusebenziseni izindlela "Ofloxacin", it is hhayi Kunconywa ukusebenzisa tampons, ngoba kulesi simo kukhona sengozini enkulu yokuba thrush.