Umuthi 'Manini': yokusetshenziswa

Ukulungiselela "Mannino" imfundo manual uchaza kahle izidakamizwa antidiabetic ukuthi ebhukwini INN (International Nonproprietary Amagama) gama "Glibenclamide". Le into ungamandla oqavile kwenye incwadi ukulungiselela, okuyinto kuveza abakhiqizi ngesimo amaphilisi, enesisindo 1.75 mg noma 3.5 mg. Ukwakheka izidakamizwa njengoba compounds asizayo nazo zihlanganisa monohydrate lactose, Silica, ukudla okufakiwe E 124 - cochineal udayi, amazambane isitashi, gimetelloza.

I izakhiwo pharmacokinetic zomuthi inqobo glibenclamide - ketshezi asebenzayo main - kuqukethwe ekwakhiweni ngefomu micronized. Lokhu kwenza kube nokwenzeka ukwandisa izinga Ukungena umuthi namaphesenti ukwandisa endaweni ukuncela yayo. Futhi, ukumuncwa ngempumelelo ngaphezulu yezingxenye izidakamizwa kunomthelela methylhydroxyethylcellulose, oyingxenye ukulungiswa "Mannino".

Yokusetshenziswa uzokwazisa ukuthi okufakiwe kwadingeka cishe akunamthelela isimo umzimba, kodwa, nokho, kwenza kube nokwenzeka kakhulu ngempela kwandisa isikhathi sokuhlala yezingxenye zomuthi esigabeni abahlakazekile bengaba, ukuyedlula ngezenzo zakhe. Phakathi nalesi sigaba lokuhlushwa izidakamizwa e izingxenye plasma kwandisa izikhathi ezintathu kuya kwezinhlanu, ngaleyo ndlela kukhona ukwehliswa okukhulu ngenani glucose.

Nomuthi "Mannino" ephawula kokubili Umhlahlandlela kusho kokuba impahla ngokushesha ugxile kusukela pheshana emathunjini bese injalo micronized ka glibenclamide lusenza ngokuphelele ukhululeka compounds asizayo emzimbeni imizuzu emihlanu. Lo mphumela wenza sikwazi ukuthatha izidakamizwa nje ngaphambi kokudla, ngoba 5 - emaminithi 10 ngaphambili. Ubuningi isiqongo kwenzeka ukulungiselela ngaphambili, futhi ukusebenza kwawo, ngakho-ke, kuba bokuphila. Nakuba leso simiso reception kanyekanye ukudla akanawo nomphumela kakhulu isenzo izidakamizwa. Ukulungiselela "Mannino" has a level of 100% bioavailability. isigamu-ukuphila kwalo umzimba yisilinganiso sesifundo esisodwa nengxenye amahora amathathu nesigamu.

Isikhathi esitebeleni umphumela hypoglycemic ka glibenclamide inakekelwa usuku lonke.

I izakhiwo pharmacodynamic zomuthi, "Manini" imfundo manual uchaza ngale ndlela. Medikamet Lokhu kungase ngcono uketshezi we-insulin lapho ukuncela kusuka beta amaseli kwamanyikwe, kanye izidakamizwa ithuthukisa insulini ukuzwela, okuyinto ibangelwa ukukhuthazwa yokwamukela insulini.

Ngaphezu kwalokho, glibenclamide uyakwazi ukwehlisa isenzo platelet ukuvimbela ischemia esivimba amanzi. Umuthi Ubuye izinyathelo zokunqanda ngokumelene arrhythmias inhliziyo.

Njengoba Sekutholakele, umuthi ngaleyo ndlela sinciphise izingozi izinkinga zesifo sikashukela (uhlobo 2), okuhlanganisa zenhliziyo sikashukela, nephropathy futhi retinopathy. Medicine "Mannino" imfundo manual uchaza njengendlela yokuthola ekunciphiseni izinga phambili yokufa yizifo ezihlobene nokungabikho sikashukela.

I izinkomba esiyinhloko ukusetshenziswa glibenclamide - sikashukela uhlobo lwesibili, lapho ukwelashwa Ukudla babonisa umphumela abanelisi. Tablets "Manin" ingasetshenziswa njengenhlangano agent ezimele zokwelapha, futhi njengengxenye ukwelashwa neminye imithi eqeda sikashukela.

Kumele kukhunjulwe ukuthi isikhathi imithi umthamo ukubaluleka kunqunywa udokotela esekelwe ndlela ngamunye isiguli. Ngesikhathi besanda kuqala ukwelashwa usethe amazinga okukhishwa ezincane kwezidakamizwa abaphathi. Khona-ke, imodi ukulungiswa kwesicelo, kanye ukulungiswa yokudla. Imininingwane umthamo lwemithi ezichazwe yokusetshenziswa zomuthi.

Umbandela esiyinhloko umthamo ukulungiswa kuyinto ezingeni glucose.

Ukuthola glibenclamide kungadala imiphumela emibi, esikhulunywa abantu abaningi okuyinto kahle kungakhuphula izinga likashukela. Izimpawu zayo kukhona ukujuluka okungazelelwe, liqhaqhazela, ikhanda elibuhlungu, iziyaluyalu esithinta izinzwa, kanye nabanye.

Izimo kwezokuphatha zomuthi kukhona hypersensitivity kuya izingxenye ukungasebenzi ukwelashwa yesibili nge "Mannino", ketoacidosis, iziyaluyalu ukusebenza nezinso isibindi.

Akukho lwazi esanele ukusetshenziswa kwezidakamizwa izingane, ogama yobudala ingeqi iminyaka engu-18.

Ungayisebenzisi imithi ngenkathi besancelisa ngesikhathi sokukhulelwa.

Gcina izidakamizwa kumele kube ezingeni lokushisa hhayi ngaphezu kuka-25 C. izimo wesitoreji eshalofini yokuphila zomuthi kuyinto engu-3.