Umuthi 'Hydroxyzine ": yokusetshenziswa, analogs kanye nokubuyekeza

Diphenylmethane nemikhiqizo efana kuyindlela yokuthola "Hydroxyzine". isicelo Umsebenzisi uthi ayinto kuyinto powder emhlophe enhle, oncibilikayo emanzini futhi ayinaphunga. 374,9 amagremu imvukuzane ngayinye yiyona isisindo yamangqamuzana kwakwakhe.

iqembu Clinico-kwemithi

Umuthi has sine umphumela anxiolytic. Lokhu kuchaza umphumela inhibitory umsebenzi izakhiwo ezithile subcortical we isimiso sezinzwa esiyinhloko kanye isenzo Ukuvinjwa phezu emaphakathi H_1-histamine futhi receptor m-cholinergic.

"Hydroxyzine" analogue izidakamizwa abe ukupholisa liphinyiselwe nomsebenzi omnene anxiolytic. Have kumqhubezela ku amakhono lolwazi, kwenza amehlo futhi inkumbulo. kwencika Psychic nokuluthwa yizidakamizwa ingekho emva ukusetshenziswa isikhathi eside lesi sifo ningagcini. Bubonakala anticholinergic, antihistamine, isenzo antispasmodic. "Hydroxyzine" aqede izinhlungu zibe of imisipha abushelelezi, kanjalo okubangela bronchodilatory nemiphumela analgesic, possesses isinyathelo antiemetic futhi ubungozi ngokulinganisela inhibitory ku uketshezi esiswini. . Isifuba, dermatitis, eczema, ukulunywa, njll incipha ngesikhathi yokwelapha kusho "Atarax" (hydroxyzine - ketshezi esebenzayo).
Umhlahlandlela uthi ukupholisa kufinyelelwa, ngokujwayelekile phakathi nemizuzu engu-10 kuya ku-45 ngemva ukungenisa (kuncike uhlobo izidakamizwa), anti-histamine - ihora elilodwa emva ukungenisa. Ngo iziguli isifo sesibindi, umphumela antihistaminic kungalindeleka kungakapheli amahora 96.

Hhayi imakwe isinyathelo mutagenic futhi umdlavuza zomuthi.

Pharmacokinetics

Lapho udle isidakamizwa ngokushesha ugxile kusukela ipheshana emathunjini, C_max khona ngamahora amabili. Ukulungiselela "Hydroxyzine" idlule placenta futhi gazi ebuchosheni (degree of lokuhlushwa emisipheni fetus kunelawo kwezicubu komama). Ngo inqubo umzimba hepatic cetirizine kwakhiwa - the metabolite ezinkulu. Inani T_1 / 2 kungakhathaliseki ubudala isiguli kanye kungaba 7 amahora eyenzelwe izingane ezineminyaka engu eminyakeni 2-10, 20 amahora abadala, 29 amahora asebekhulile kanye nabantu asebekhulile; in iziguli isifo sesibindi kungase kukhule ku amahora 37. Ukuqedwa Kwenziwa ingxenye enkulu yi-izinso (0.8% njengoba injalo yasekuqaleni).

izinkomba

"Hydroxyzine Hydrochloride" isetshenziselwa:

• ukususa nokukhathazeka hyperexcitability isimiso sezinzwa;
• ngesikhathi ukuhoxiswa e abantu abaphethwe sokuncika utshwala;
• yokwelapha izifo psychoneurotic;
• njengengxenye yokwelashwa esibanzi esikhathini nasezinkingeni ezilandela ngemva kokuhlinzwa emva ezinye ukulimala;
• premedication;
• ukunciphisa ukucindezeleka yangaphakathi, ukukhathazeka generalized, izinqubo ukulungiswa yokutakula, ekwelapheni izifo letindzala;
• ukuqeda izimpawu eczema, dermatosis silume, urticaria, dermatitis atopic;
• sokuthatha isinyathelo antiemetic kuboniswe.

Izimo lesi sidakamizwa "Hydroxyzine Canon"

Izibuyekezo lodokotela abonisa ukuthi izidakamizwa is hhayi Kunconywa ukuba wamukele:

• iziguli glaucoma;
• wendlala hypertrophy (wendlala);
• iziguli okukuyo luyanda umsebenzi kokuwa;
• iziguli ezine myasthenia gravis;
• ezigulini sebethole kwezinso futhi ukwehluleka hepatic;
• iziguli komqondo.

Umuthi is contraindicated ku:

• kwabesifazane abakhulelwe;
• iziguli ezine-porphyria;
• isikhathi ibele (kwesikhathi yokwelashwa kufanele uhlukane nale ubisi ibele likamama);
• ukubonakaliswa iguliswa akha isithako (njengoba kulezo zimo lapho hypersensitivity imakwe ngaphambili kwamanye cetirizine esuselwe, aminophylline, piperazine noma ethylene diamine);
• nalapho bebeletha.

Mayelana neminye imiphumela emibi

Iziguli bangase bahlupheke ukozela, gubha ubuthakathaka jikelele, isiyezi kanye ikhanda ekuqaleni ukwelashwa "Hydroxyzine". Izibuyekezo iziguli ziphathwe ngale ejenti, usho nemiphumela engemihle elandelayo:

• komzimba, palpitations, isicanucanu;
• nokugcinwa urinary, futhi ukuqunjelwa;
• kome nolwelwesi ebonakalayo lwamafinyila, ukujuluka owandiswayo;
• angaboni kahle (mhlawumbe ukuhlukumeza kuhlala);
• ukwehlisa umfutho wegazi, bandisa inkonzo isibindi enzyme;
• bangezwa bronchospasm.

Kakhulu ezingavamile ukubonakaliswa sokuwa eliqhaqhazelayo futhi disorientation, ataxia, ukukhuthazwa nakuba bese ukhulisa motor umsebenzi e ukusetshenziswa amathuluzi.

ukweqisa izidakamizwa

Priority ngokuthi reflex Gag noma esiswini sihlanzwe ukweqisa izidakamizwa zomuthi "Hydroxyzine". Yokusetshenziswa yazisa ukuthi kwezinye izimo kubalulekile ukuqapha imisebenzi lesiguli esibalulekile, ukwethulwa sodium benzoate, i-caffeine, norepinephrine, ngisho igazi esikhundleni, abazenzi zonke izinyathelo ezidingekayo ekusebenzeni kahle emzimbeni. sinqobe Specific ithuluzi has, hemodialysis kalungisiswa.

Ngokuvamile, lezi nemiphumela awushintsheki noma izimpawu zabo zinyamalale emva umthamo wansuku zonke zokubuyekeza.

Isikali

Umuthi iqondiswa ngomlomo noma ujove esicutshini. Umthamo kuncike nosologies, ubudala isiguli kwindlela izidakamizwa ikhishwe "Hydroxyzine".

Yokusetshenziswa kusikisela ukuthi ukwelashwa lingaze ukudala ukukhathazeka syndrome, omdala Kunconywa engayitholi mg 25 kuya ku-100 we ketshezi abamelwe emini. Elivame ukusetshenziswa kakhulu umthamo 12.5 mg ekuseni emini futhi 25 - kusihlwa.
Ngo ebuntwaneni, preoperatively zisebenzisa ukuba 1 mg ngayinye kg esisindo ngosuku kusihlwa ngaphambi namaminithi 60 ngaphambi inqubo.

Ngenjongo premedication iqondiswa kubantu abadala "Hydroxyzine" at umthamo 50-200 mg izidakamizwa ngomlomo noma ngesimo imijovo esicutshini ka 1.5-2.5 mg ngayinye kg isisindo nesineke iqondiswa ihora elilodwa ngaphambi kokuba sihlinzwe.

Ngenjongo esiqoshiwe Ukulunywa umthamo ngempumelelo ivela 25 kuya ku-100 mg e 3-4 ngemithamo ahlukaniswe.

Izingane kusukela kwabaneminyaka engamashumi unyaka owodwa ukuze 6 umthamo ingeqi 1-2.5 mg ngayinye kg esisindo ngosuku ngemithamo ehlukene ngokwenkolo.

Esikhathini esifanayo nokushintsha kokudla nokufakwa lwemithi izingane ezingaphansi kweminyaka eyi-6 sabelwe 1-2 mg ngayinye kg esisindo emini.

umthamo sangemihla kubhekwe ukuba 300 mg. Maximum umthamo owodwa - 200 mg.

Ukuqalwa Asebekhulile yokwelapha etuswa Isikali nengxenye.

Isibindi kanye nokwehluleka ukusebenza kwezinso zidinga ukulungiswa umthamo lesi sidakamizwa "Hydroxyzine".

Umhlahlandlela uxwayisa ngokuthi ukuze kuzuzwe esiphezulu nomphumela oqabulayo isixazululo okusheshayo iqondiswa intramuscularly, ezijulile 50-100 mg ngayinye umthamo owodwa. It Kunconywa amasu izidakamizwa ekuphathweni amahora 4-6.

Ngo wezifo zengqondo, imithi isetshenziswa endaweni umthamo mg 300 izinsuku. Isikhathi salesi kwelashwa amaviki 4.

Endabeni ka ukubonakaliswa komzimba okufana ubuthakathaka, ukozela, akagcini ezinsukwini ezimbalwa, umthamo kumele kungancipha.

izinyathelo zokuqapha

Nakuba ukwethulwa "Hydroxyzine" kusukela "Adrenaline" kuhlale ayisasebenzi.

Umuthi kunomphumela yokugcizelela ku umphumela okulalisayo of isidakamizwa analgesics chungechunge, utshwala, zinhlungu, barbiturates, izidakamizwa esetshenziswa ngenhloso izidakamizwa okuyiluthayo nezinye ezikucindezelayo CNS umsebenzi.

Akunconyelwe isicelo ahlangene into noma holinoblokatorami nge Mao inhibitor.

Lapho kuhlangene indlela ukuthatha phenytoin umphumela anticonvulsant incipha kusukela reception lakamuva.

isicelo engathandeki kanyekanye zomuthi nge cholinesterase blocker.

Ngenxa yalo okwandisa emakamu plasma zomuthi bangaphakela isicelo yayo nge inhibitor enzyme isibindi.

ukwelashwa kanye kanye nama ejenti ethu okuyinto zivimbela umsebenzi CNS, noma nge holinoblokatorami zidinga Isikali ukulungiswa.

Ngokunakekela okukhulu okumele lunqunywe iziguli kokuba propensity ngoba fibrillation noma ukufaka isicelo antiarrhythmics, kanye yalezo ziguli beyizidlova ukubonakaliswa convulsive. Therapy kuyinto contraindication kuya ukusebenzisa uphuzo oludakayo. Uma kudingekile, nokwenza izivivinyo ku komzimba reception "Hydroxyzine" ukukhansela kufikela kuzinsuku ezingu-5 ngaphambi luhlolo okuhleliwe. Kudingeka ukuqapha uma usebenzisa izidakamizwa kanti ukulawula imoto period abashayeli kanye neziguli, ubuchwepheshe ezidinga emakamu eliphezulu.

Kumele kukhunjulwe ukuthi ukusetshenziswa injectables kuphela kungenzeka nge ujove esicutshini. Umjovo ongama imoto noma Ukungena wale mithandazo ezitsheni ezinkulu kungabangela umonakalo izicubu.

Ukwelashwa leli thuluzi kungaba vyzyvavt Imiphumela zamanga test kwabathinta.

Imigomo nemibandela yokusetshenziswa futhi isitoreji

Kuyadingeka ukuba khona oyisibopho amaphilisi lesi sidakamizwa "Hydroxyzine".

Yokusetshenziswa uthi amafomu ngomlomo izidakamizwa ingangeni egcinwe iminyaka engaphezu kuka-5.

"Hydroxyzine". nobufakazi

Ezinganeni, ukusetshenziswa kwezimali ngaphansi hyperactivity, ziyancipha isikhathi eside kusiza ingane yakho ukuba izethembe, ugxile futhi anake, aqede lokhu kushintshashintsha kwemizwa. Ngesikhathi esifanayo ekwelapheni izidakamizwa "Atarax" ( "Hydroxyzine") yokusetshenziswa liyasiqinisekisa ukuthi umsebenzi nangamandla wengane akukashintshi. ukungaphathwa kahle imithi kuba ezingavamile.

Ngokusho izitatimende iziguli, ekusebenziseni ezimweni ezithile "Hydroxyzine" (analogue zomuthi), kusobala ukuthi uzolile futhi ukuzethemba ngokwezinga elikhulu kunamanye izidakamizwa eziningi. uvalo nokuqwasha ketshezi ikhuthaza kangcono ngilale ubuthongo umsindo. Nokho, ukususwa zomuthi izinsuku zokuqala ezimbalwa nzima kakhulu inqubo ngilale, kodwa, isimiso, umphumela ukwelashwa kuyakhuthaza kakhulu.

I inani lentengo lomuthi

Thenga izidakamizwa "Hydroxyzine" kumakhophi, njengengxenye equkethe hydroxyzine, kungaba ekhemisi on kadokotela. Intengo ruble 270-300 ngamunye izibhebhe 25 mg 25.

"Hydroxyzine". Synonyms

Synonyms of "Hydroxyzine" yilezi: "Hydroxyzine Canon", "Atarax", "Masmoram", "Ateraks", "Hydroxyzine", "Hydroxyzine Hydrochloride", "Alamon", "Duraks".