Tiotriazolin: imiyalelo yokusetshenziswa

Uyazi umuthi "Tiotriazolin"? Imiyalo yokusetshenziswa kwalo muthi izochazwa ngokuningiliziwe esihlokweni esethuliwe. Ngaphezu kwalokho, sizokutshela ngesimo lapho umuthi udayiswa khona, yiziphi izinkomba, imiphumela emibi kanye nokuphikisana.

Ukwakhiwa, ukupakisha kanye nefomu lokulungiselela

Iyini uhlobo lomuthi "Tiotriazolin"? Imfundo iyazisa ukuthi inamafomu ahlukahlukene. Okuthandwa kakhulu yilokhu okulandelayo:

• Isixazululo esenzelwe umjovo we-intramuscular and intravenous. I-1 ml yalesi se-ejenti iqukethe u-0.025 g we-thiotriazoline. Futhi, imithi inezinsimbi ezisekelayo ezinjengamanzi omjovo. Isidakamizwa singathengwa ngama-ampoules we-4 ml (efakwe ephaketheni lekhadibhodi).
• Amaconsi e-Eye "Tiotriazolin". Imiyalo yokusetshenziswa kwalesi thuluzi ithi u- 5 ml wesidakamizwa uqukethe ama-50 mg we-thiotriazoline, kanye nezinye izinto. Isidakamizwa sithengiswa kwi-polyethylene amabhodlela-droppers, efakwe ebhokisini lekhadibhodi.
• Amathebulethi "iTiotriazolin." Imfundo yale fomu yesidakamizwa ithi ekhoneni elilodwa elimhlophe elimhlophe elinesigcawu esiphezulu line-100 mg ye-morpholinium methyltriazolylthioacetate, noma okuthiwa i-thiotriazoline. Njengoba izingxenye ezengeziwe zalesi sidakamizwa i-potato isitashi, i-microcrystalline cellulose, i-povidone yesisindo sephansi esincane, i-calcium stearate ne-sucrose. Ngokuvamile, ebhokisini lekhadibhodi kukhona amaphilisi angu-50.

Pharmacodynamics

Iyini ithuluzi elifana neTiotriazolin? Imiyalo yokusetshenziswa ithi lesi yisidakamizwa se-antioxidant. Ukusebenza kwawo okuphezulu kubangelwa izindawo zokuvimbela antioxidant, anti-ischemic, immunomodulating kanye ne-membrane-stabilizing.

Lo muthi uvimbela ukushona kwama-hepatocytes, ukhuthaza ukutholakala kwawo, ukunciphisa izinga lokungena kwamanoni, okuholela ekujwayelekile kwiprotheni, i-carbohydrate, i-lipid kanye ne-pigment metabolism, futhi kunciphisa amathuba okuba ne-centrolobular necrosis yesitho esinjengobindi. Ngaphezu kwalokho, lesi sidakamizwa sithuthukisa ukuhlukaniswa kanye nokuhlanganiswa kwe-bile, kuvumela ukuhlanganiswa kwayo (amakhemikhali).

Izakhiwo zomkhiqizo wokwelapha

Yiziphi ezinye izinto okwenziwa ukulungiselela "iTiotriazolin"? Imiyalo yokusetshenziswa kwalo muthi kudingeka ifunde. Ngempela, kuphela kulokho ongathola ukuthi umuthi obuzwayo ususa ukuvimbela izinqubo ze-oxidative emjikelezweni we-Krebs, ukulondoloza isikhwama se-ATP esiyi-intracellular, futhi kuthuthukisa ukusebenza (ukubuyisana) kwe-anaerobic glycolysis.

Kumele kuqashelwe ukuthi emva kokuthatha imithi, isithako esisebenzayo siqala ukusebenza kuhlelo lokulwa ne-antioxidant, ukuvimbela izinqubo ze-oxidative zamafutha ezingxenyeni ze-ischemic zomzimba. Ngaphezu kwalokho, lesi sidakamizwa sithuthukisa izakhiwo (rheological) zegazi ngokusungula uhlelo lwe-fibrinolytic.

Izakhiwo ze-antioxidant zezidakamizwa ziboniswa ngenxa yokuthi kukhona i-iulf sulfur esakhiweni se-tiotrazoline molecule, eyaziwa yi-oxidation kanye nezici zokunciphisa, kanye ne-nitrogen ephakeme, ehlanganisa i-hydrogen ions ephakeme kakhulu.

Kumele kuqashelwe ukuthi ingxenye esebenzayo yomuthi iyakwazi ukusabela nge-lipid radicals kanye namafomu asebenzayo oksijini. Lokhu kubangelwa izakhiwo zokunciphisa ezithiwa zeqembu le-thiol. Ngaphezu kwalokho, imithi ivimbela ukwakheka kwezinhlobo ze-oksijeni esebenzayo, ukuvuselela izinsolo ezinjalo zokulwa nezidakamizwa njenge-catalase, glutathione peroxidase ne-superoxide dismutase.

Pharmacokinetics

Ingabe lesi sidakamizwa "i-Tiotriazolin" sithatha? Lo myalelo uthi isikhathi sokumamatheka komuthi kungamaminithi angu-30, kanti ukutholakala kwemithi kungu-65.5%.

Ukuhlushwa okukhulu kwesidakamizwa egazini kufinyelelwe amahora angu-1.4 emva kokungeniswa. Ukuxhumana nama-protein akudluli ku-10%.

Ngokukhulu kakhulu, imithi ihlanganisa izicubu zesibindi, inhliziyo, i-rectum, i-pleen nezinso, futhi ezincane-emathunjini amancane namaphaphu. I-Tiotriazolin idonswa kakhulu yizinso.

Izinkomba

Uma kukhona okungajwayelekile, amaphilisi, ama-injection kanye namaconsi e-eye "Tiotriazolin" ingabekwa? Imiyalo yokusetshenziswa kwalezi fomu iqukethe izinkomba ezilandelayo:

• I-cirrhosis yesibindi;
• Ukulimala kwesibindi ishukela, utshwala, igciwane lesandulela ngculazi kanye nemithi (isibonelo, emva kokuthatha ama-antibiotics, izidakamizwa ze- antiviral , ama-antituberculosis nama-antitumor agents, izisu zomlomo kanye nezidakamizwa zokuvimbela i-tricyclic);
• I-hepatitis viral chronic;
• Ukusetshenziswa kwesibindi sokuphuza ngokweqile nesimiso esingapheliyo;
• Ukudakwa kwesibindi esinyama.

Izinkomba zokusetshenziswa kwamaconsi:

• Izifo ze-cornea;
• Ukushisa noma ukulimala kweso;
• I-conjunctivitis ye-Viral.

Kungani usebenzise i-ophthalmologic drug "Tiotriazolin"? Imfundo (amaconsi angathengwa kunoma iyiphi ikhemisi) ikwazisa ukuthi le mithi ivame ukushiwo ukuvimbela amehlo omile, i-asthenopia nezinye izifo ezivuthayo ezithombeni ezibukwayo.

Isilinganiso samathebulethi

Kufanele ngisebenzise kanjani amaphilisi e-Tiotriazolin? Imfundo iqukethe ulwazi ukuthi ukulungiswa okunikeziwe kufanele kuthathwe ngaphakathi kuphela. Njengomthetho, i-tiotriazolin inqunyelwe amaphilisi angu-1 noma amabili izikhathi ezine ngosuku ngezinsuku ezingu-25-30.

Isikhathi sokwelapha nalesi sidakamizwa kufanele sithathwe kuphela ngodokotela ngamunye (kuye ngokuthi isimo senkinga nobukhulu besifo esikhona).

Isixazululo semithi "Tiotriazolin": imiyalelo yokusetshenziswa

Izifo ze-"Tiotriazolin" zenziwa nge-intramuscularly noma nge-intravenously. Isilinganiso sabo sinqunywa udokotela (kuxhomeke kulesi sifo). Nge-infarction ye-myocardial ne-hepatitis umuthi ujova kancane kancane ngaphakathi 2 ml izikhathi 2-3 ngosuku. Lapho imishanguzo ye-cirrhosis inikwe i-intramuscularly (2 ml izikhathi ezingu-2-3 ngosuku). Inkambo yokwelashwa yizinsuku ezingu-60.

Amaconsi e-Eye "Tiotriazolin": imiyalelo yokusetshenziswa

Amaconsi amehlo "iTiotriazolin" afakwe esikhwameni se- conjunctival. Ngokujwayelekile, isilinganiso somuntu omdala singama-2 wehla kuze kube izikhathi ezine ngosuku. Ngokuqondene nezingane, inani lemithi lithathwa yilazi zezingane kuphela. Isikhathi sokwelashwa ngamaconsi eso kufanele senziwe kuphela ngudokotela oya khona.

Ngokujwayelekile, isikhathi sokwelapha nalesi sidakamizwa asikho ngaphezu kwamasonto amabili. Kodwa uma ukuthuthukiswa kungabonakali, inkambo ingadluliselwa inyanga.

Uma kwenzeka ukuthi izilonda zezitho ezibukwayo zigcwele futhi zinzulu, ama-injection kuya emaconsi asehlokisiwe amisiwe (okulungiselelwe okunye).

Ukuvimbela ukomiswa kwamagobolondo esiso (ngenkathi usebenza kukhompyutheni), kubalulekile ukusebenzisa imithi yamaconsi amabili phakathi nosuku ngekhefu lamahora amabili.

Imiphumela emibi

Imiphi imiphumela emibi ingabe umuthi "Tiotriazolin" (imijovo) ingabangela? Imfundo yale thuluzi ithi umuthi onikeziwe udluliselwa kahle. Kodwa-ke, ngesidakamizwa esibucayi, ukusabela okungathandeki kusengenzeka.

• Uhlelo lwesimiso esiyinhloko: isizungu, ubuthakathaka jikelele, izintambo.
• Ipheshana lokugaya: umlomo owomile, isiyaluyalu, ukuqhuma.
• Izitsha nenhliziyo: ukwanda kwegazi, tachycardia, arrhythmia, ubuhlungu enhliziyweni.
• Uhlelo lokuphefumula: ukuhlasela kwe-asthma nokuphefumula.
• Ukuphefumula: umkhuhlane, ukusabela kwe-hypersensitivity, angioedema.
• Ukusabela kwendawo: ukubomvu nokukhipha endaweni yokujova.
• Ukusabela kwe-Dermatological: i- hyphenia yesikhumba, itching, imihlathi.

Ngokuqondene namaconsi e-eye, kwakungekho nemiphumela emibi engxenyeni yabo.

Ukusebenzisana kwezidakamizwa

Ngokusho kochwepheshe, umuthi "iTiotriazolin" ungasetshenziswa ngokuhambisana nemithi eyisisekelo ehloselwe ukwelashwa kwesifo senhliziyo. Lokhu kubangelwa ukuthi lo muthi uthe i-agent e-cardioprotective.

Kumele kuqashelwe ukuthi lesi sidakamizwa sivumelekile ukuba sisetshenziswe ngesikhathi esifanayo nezidakamizwa ezibekwe ukwelashwa kwesifo sofuba se-etiology ehambisanayo.

Amaconsi e-Eye "i-Tiotriazolin" inganikwa abesifazane abakhulelwe, kanye nesikhatsi se-lactation. Futhi kufanele kuthiwa uhlobo oluthiwa ludakamizwa luvumelekile ukuthi lusetshenziswe ngesikhathi esifanayo namanye amadivaysi ezokwelapha.

Utshwala nemithi "Tiatriazolin" kuqinisa isenzo somunye nomunye. Kulokhu, ukwamukela kwabo ngesikhathi esisodwa akuvunyelwe.

Imiyalo ekhethekile

Amaphilisi okucatshangelwayo afaka i-sucrose (ngesamba se-2.8 mg kuthebulethi eyodwa). Ngakho-ke, isilinganiso esiphezulu somthamo wansuku zonke somuthi singase sibe no-22.4 mg wezinto. Kubalulekile ukwazi ngaleli qiniso ezigulini ezine-diabetes mellitus.

Izindlela kanye nezikhathi zokugcina

Ngokuqinisekile zonke izinhlobo zezidakamizwa "iTiatriazolin" kufanele zigcinwe endaweni evikelekile ekukhanyeni futhi ezingenakutholakali ezinganeni ekushiseni kwama-degrees angu-14 kuya kwangu-26. Ukuphila kwesilondolozi semithi iminyaka engu-3.