"Simvastatin": ukubuyekezwa, izinkomba ukusetshenziswa, intengo kanye analogue

Kungani ngidinga imithi "Simvastatin" ukwenzani? Nobufakazi mayelana izidakamizwa izokwethulwa kancane okunye. Siphinde ukunitshela ngaloNkulunkulu izidakamizwa itholakala ifomu okuyinto anakho izinkomba, side effects kanye contraindications kumakhophi, ukuthi kubiza malini, indlela kufanele Kwafaneleka nokunye. D.

Okufakiwe, ifomu yomkhiqizo kanye nokusungulwa

Izidakamizwa "Simvastatin" kuqhubeka ukudayiswa ngesimo amaphilisi. Banezinhliziyo round biconvex Umumo uphawu kulolu hlangothi, kanye nomhlophe. amaphilisi Camera, izibhebhe ezinjalo aqukethe 10 mg simvastatin. Futhi nomuthi kuhlanganisa izingxenye asizayo njengoba butylhydroxyanisole, i-lactose, magnesium stearate, isitashi prozhelatinizirovannogo, talc, futhi microcrystalline cellulose.

Ngo iphakheji, ungathenga imithi "Simvastatin"? Izinkomba ukusetshenziswa kwezimali elicacisiwe imiyalelo, okuyinto kuqukethwe iphakethe amakhadibhodi. Kukhona futhi abekwa shashaza ezimbili amaphilisi (izingcezu 10).

imiphumela kwemithi

Kanjani lesi sidakamizwa "Simvastatin"? ochwepheshe lezivakashi ibonisa ukuthi lokhu lipid-ukwehlisa izidakamizwa. It ikhiqizwa synthetically.

ejenti kubhekwe kuyinto lactone esingasebenzi. Kubantu, kuba hydrolyzed, futhi kamuva wakha esuselwe hydroxy-acid.

Ukusebenzisa izidakamizwa akakubangeli ekuqongeleleni ubuthi. It is ngokushesha akheka futhi ehilelekile izinqubo eziningi Kuhlanganisa.

I izakhiwo zomuthi

Yini property imithi "Simvastatin"? Izibuyekezo asho ukuthi leli thuluzi kusiza ukunciphisa amazinga plasma triglyceride, cholesterol inani ephansi kwabantu Esilula.

Umthelela zokwelapha ngemva kokuqala ukuthatha izidakamizwa kwenzeka kungakapheli amasonto amabili. Isenzo zomuthi lihlala lisesilinganisweni isikhathi ukwelashwa. Ngemva ukwesulwa amaphilisi cholesterol kancane kancane abuyele ukusebenza kokuqala.

Pharmacokinetics

izidakamizwa "Simvastatin" Kuyoze esikuthola? ochwepheshe lezivakashi bathi ukumuncwa izimali iphezulu kakhulu. Lapho ethola nemithi emakamu yayo eliphakeme egazini kufinyelelwe ngemuva kwamahora 1.5-3 futhi ancipha 90% ngemuva kwamahora angaba ngu-12. Ukuxhumana ne-plasma cishe 95%.

Umzimba izidakamizwa esibindini. Isigamu-ukuphila we metabolites kuyinto cishe amahora amabili.

nomuthi ziboniswe indle kanye ngokusebenzisa nezinso.

Izidakamizwa "Simvastatin": izinkomba ukusetshenziswa

Kulaba izimali Kunconywa ukuba isetshenziswe hypercholesterolemia, nesifo senhliziyo nemithambo yayo. Linqume imithi enjalo kufanele kuphela udokotela emva ngihlolwa.

Ngakho kunoma isiphi isimo ungathatha izibhebhe "Simvastatin"? Kusukela ukuthi kusho inikezwa? Ngokusho imiyalelo, umuthi Kunconywa lapho:

• hypercholesterolemia eyinhloko;
• ukwehluleka Ukudla nge ongaphakeme cholesterol ekudleni kanye nalokunye kungenelela non-izidakamizwa (kwesisindo, umsebenzi ngokomzimba) in iziguli isifo sokuqina kwemithambo yegazi yenhliziyo;
• hypertriglyceridemia ehlanganisiwe hypercholesterolemia, okungasekelwe ukulungiswa imithwalo nokudla okukhethekile.

Yiziphi ezinye izimo ebekiwe imithi "Simvastatin"? Izinkomba ukusetshenziswa kwaleli thuluzi cabanga njengamanje:

• nokuvinjelwa esivimba amanzi infarction;
• ukunciphisa ingozi iziyaluyalu inhliziyo (isib, lezivakashi kuhlasela ischemic noma unhlangothi);
• retardation ka-atherosclerosis ezitsheni yenhliziyo.

Izimo

Manje ngoba sewuyazi ukuthi yini imithi enqunyiwe "Simvastatin". Izinkomba for ukusetshenziswa ithuluzi ziye ethulwa ngenhla. Nokho, lokhu izidakamizwa kukhona Izimo. Isimo ezilandelayo ziqondise kubo:

• Lesi isifo esikhubaza imisipha (noma okuthiwa myopathy);
• isifo sesibindi okwenzeka esigabeni esebenzayo;
• kweminyaka eyi-18;
• kokuphakama eziphikelelayo enzyme isibindi (kuhlanganise omsakazo engaziwa);
• hypersensitivity kuya izidakamizwa noma izingxenye zayo ngazinye (kuhlanganise zokungezwani ne-lactose);
• hypersensitivity kuya ezinye izindlela statin chungechunge.

Qaphela ukulungiselela reception

Nomuthi "Simvastatin", intengo oboniswe ngezansi, ngokunakekela ethile inikezwa iziguli ababusebenzisa kabi utshwala, kanye nabantu abalandelayo isitho ukufakelwa (elashwe immunosuppressive).

Ngaphezu kwalokho, isihloko kusho ngokunakekela ezithathwe izimo okuholela ukuthuthukiswa ukwehluleka kwezinso (isib hypotension, izifo ngokujulile ubunjalo ezithathelwanayo, encishisiwe noma, kunalokho, i tonus anda kwemisipha izicubu, uzwakalise umzimba kanye endocrine iziyaluyalu, isifo sokuwa, electrolyte ibhalansi thuthuva, ukuhlinzwa, kuhlanganise zamazinyo kanye nokwethuka).

Izidakamizwa "Simvastatin": ukusetshenziswa kanye umthamo

Kubhekwe indawo ngaphambi kokuba kuqalwe ukwelashwa kusho isiguli kumelwe ibhekane indinganiso Ukudla hypolipidemic. Phela, kufanele ilandelwe kulo imithi oyinikiwe.

"Simvastatin" ithebhulethi iqondiswa kanye nsuku zonke kusihlwa. Nakuba kokuthatha lesi imithi akufanele kuhambisane ukudliwa kokudla.

Umthamo Kunconywa for ekwelapheni izidakamizwa hypercholesterolemia kuyinto 10-80 mg ngosuku.

izinguquko umthamo kumele kwenziwe njalo ngezikhathi ngenyanga. Okokuqala, isiguli kufanele uthathe 10 mg ke 20, 30 nokunye. D. Ezimweni eziningi umphumela elilungile zokwelapha eyatholakala lapho ithola 20 mg zomuthi.

Umthamo zomuthi incike yobudala lesiguli, nesimo salo nokunye. Kule ndaba, ikhambi elinjalo kufanele aqoke udokotela, ngemva kokuhlola isiguli ngihlolwa.

ukusabela ezingezinhle

Njenganoma iyiphi izidakamizwa, nomuthi "simvastatin" Ubuye engemihle. Phakathi ezivamile yilezi ezilandelayo:

• Besisu ubuhlungu, isifo sokusha kwesibindi, ukuqunjelwa, pancreatitis, ukubuyisa, ukuhlanza, ama-enzyme isibindi iyokhushulwa, uhudo kanye nesicanucanu.
• Asthenic syndrome, umuzwa kahle zokunambitha, ikhanda, angaboni kahle, isiyezi, peripheral neuropathy, ukuqwasha, paresthesia, imisipha amajaqamba.
• Angioedema, eosinophilia, polymyalgia rheumatica, urticaria, i-lupus-like syndrome, vasculitis, dyspnea, thrombocytopenia, ukushisa komzimba, kukhuphuke erythrocyte sedimentation isilinganiso, siwasebenzise kwesikhumba, imfiva, photosensitivity, Arthritis.
• Ukuqubuka kwesikhumba, ukukhishwa Alopecia, dermatomyositis, ukulunywa.
• Myopathy, rhabdomyolysis, myalgia, ubuthakathaka, imisipha amajaqamba.
• Isifo sokulahlekelwa yigazi, potency encishisiwe, inhliziyo, ukwehluleka kwezinso (acute).

imiyalelo Special ukuthola nomuthi

Ngaphambi kokusebenzisa umkhiqizo kumelwe ufunde imiyalelo ngokucophelela. Lithi:

• ngaphambi kokuqala ukwelashwa kuyadingeka azokuqhubela isifundo kwesibindi;
• izidakamizwa "Simvastatin" akufanele athathwe uma kwenzeka ukwehluleka kwezinso futhi babe sengozini enkulu yokufa rhabdomyolysis;
• imithi kungaba nemiphumela emibi embungwini;
• it is hhayi Kunconywa ukuthatha amaphilisi nabesifazane asebeneminyaka efanele yobudala yokuzala abangafuni basebenzise izinto zokuvimbela inzalo;
• ngesikhatsi ukwelashwa akufanele yayiphuza ngokweqile;
• ngesikhathi yokwelapha, isiguli kumele athobele Ukudla hypolipidemic;
• reception ngesikhathi esisodwa ubhamubhamu juice kungayandisa degree of kobukhulu ohlangothini ukusabela;
• ukulungiselela kungase kuphumelele njengoba monotherapy, futhi kanye nokusetshenziswa Bile acid sequestrants.

Analogs futhi izindleko zomuthi

Manje uyazi ukuthi kuyinto izidakamizwa "Simvastatin". Analogue, intengo yaleli imithi uzonikezwa manje.

Uma kuwukuthi isicelo kungenzeki lokhu izindlela ungayithola enye nezinye izidakamizwa ezifana "Simvakard", "Avestatin", "Holvasim", "Aktalipid", "Sinkard", "Aterostat", "Simplakor", "Vasilip", "Simli" "Vero -Simvastatin "," Simgal "," Zovatin "," Simvor "," Zocor "," Simvastol "," Zorstat "," Simvalimit "," Ovenkor "," Simvakol "," Simvageksal "futhi t. d.

Inani izidakamizwa "Simvastatin" akuyona eliphezulu kakhulu futhi imayelana 240 ruble amaphilisi 20.

Uphenyo nomuthi

Iziguli eziningi wake "Simvastatin" amaphilisi, uqaphele kahle yaso ephezulu. I umuthi ngokushesha kwehlisa cholesterol, ekuvimbeleni ukukhumuzeka izifo ezihlukahlukene.

Nokho, ezinye iziguli abangajabule ladabula emva kokwelashwa cholesterol liphuma futhi ivamile lekufa.