"Nimid" (amaphilisi): Yokusetshenziswa nempendulo

Abantu abaphethwe izifo amathambo, amalunga nemisipha njengoba odokotela ukwelashwa lingaze ngokuvamile ukunquma "Nimid" (amaphilisi). Yokusetshenziswa liqukethe ulwazi ukuthi izidakamizwa kususa ubuhlungu nje kuphela, kodwa futhi unalo isinyathelo eqeda ukuvuvukala. Ake sizame ukuba uhlole ukusebenza umkhiqizo kabanzi futhi uthole lapho izimo uyakwazi ukusiza.

ifomu kwezidakamizwa kanye nokusungulwa

Ngokuphathelene izinhlobo zomuthi ke namuhla Pharmacy Ungathenga i-tablet, ukumiswa, elimbudumbudu kanye gel. The main isithako okukukho nimesulide. I-Tablet ekwakhiweni izidakamizwa eyakhishwa ngo 10 izingcezu amabhamuza. Omunye sibhebhe sinamaphutha 100 mg nimesulide, futhi njengoba izingxenye asizayo esetshenziswa kunodokotela microcrystalline cellulose, sodium stearate, sodium croscarmellose futhi Aerosil 200. Lokho iqukethe ulwazi ezifana mayelana nokubunjwa "Nimid" ukulungiselela (amaphilisi) yokusetshenziswa.

I powder kukhicite sachets umthamo. Leli fomu zomuthi ewusizo for ekwelapheni izingane. Ngempela, ukwakheka, ngaphandle nimesulide, povidone K-30, tabletozy 80 Aerosil 200 iqukethe excipients ezifana sodium saccharin, citric acid, futhi flavorings. Ayindlala ujabule ukuthi uphuze okumnandi okuphekiwe abazali bakhe zokwelapha "cocktail".

Ngo 1 ml ukumiswa, futhi 1 g gel iqukethe 100 mg nimesulide. Njengoba ikhomponethi asizayo kulezi amafomu amabili asetshenziswa propylene glycol, sodium gidroskid, carbomer 940, disodium edelat, aromotizator, amanzi ahlanzekile kanye methylparaben.

Isenzo kwemithi zomuthi

Nimesulide, okuyinto isithako esebenzayo ye nomuthi kungokwalabo iqembu nonsteroidal anti-sulfonanilides. Once in the umzimba womuntu, ngokukhetha kuvimbela Cox-2 futhi kuvimbela synthesis prostaglandins e Locus ukuvuvukala. Analgesic, antipyretic nomphumela eqeda ukuvuvukala kufinyelelwa ngemva "Nimid" Tablets olulodwa. Yokusetshenziswa iqukethe ukwaziswa okwengeziwe mayelana imithi umthamo.

Ngaphezu okungenhla, umuthi uyakwazi zivimbela ukukhululwa kwe-oksijini khulula ezizivelelayo zivimbela ukukhululwa kwe myeloperoxidase, nge akunamthelela chemotaxis futhi phagocytosis izinqubo.

Kepha isenzo eqeda ukuvuvukala zomuthi, ke ibangelwa ikhono nimesulide ekuvimbeleni ukuba balamuli ukuvuvukala futhi kuncishiswe isimila necrosis izici. Ngu ezivimbela synthesis-interleukin-6 futhi urokinase ukulungiselela "Nimid" (incwadi yeziyalezo kuyalifakazela iqinisweli) kuvimbela nokwehliswa kwesithunzi proteoglycans collagen uqwanga. Ngaphezu kwalokho, nimesulide ubambe amabhlogo ngoba nociceptive ubuhlungu amaza uhlelo.

Uma sicabangela indlela ye analgesic isinyathelo, ihlobene okusithiyayo of histamine ukukhululwa inqubo insika amaseli eziningi kanye nethonya kwakwakhe esebenzayo ngayinye receptor glucocorticosteroid.

Uma udokotela wakho okunqunyiwe "Nimid" (amaphilisi), ukuze yokusetshenziswa kufanele kucatjangwe ngako ngekucophelela ngaphambi kokuthatha imithi. Phela, le dokhumenti iqukethe izincomo ukuthi kumele kunakwe phakathi ukwelashwa.

Pharmacokinetics

Ngemva kokuthola lo umthamo watusa zomuthi ngenkuthalo ugxile kusukela pheshana emathunjini. Futhi ngemva kwamahora angu-1.5-2.5 wabonisa lokuhlushwa esiphezulu isithako esisebenzayo e oketshezini olungenambala lwegazi. Isici nobuntu ukulungiswa yikhono okusezingeni eliphezulu ukuze uxhumane amaprotheni, kanye Ukungena umgoqo igazi ebuchosheni futhi gematoplatsentarny. Ngezinye lokuhlala eliphezulu nimesulide likalwa ezingeni a Locus ukuvuvukala, futhi uketshezi lwamalunga.

izidakamizwa umzimba kwenzeka esibindini, njll, esikhathini esiningi ngefomu ingashintshiwe metabolites asebenzayo, siqedwa nge izinso (e umchamo), at - indle. Ingxenye-ukuphila we ketshezi esebenzayo kufezwa ngokusebenzisa amahora 3.5-5. Liqukethe idatha olucacile pharmacokinetic "Nimid" imiyalelo ukulungiselela ukusetshenziswa.

ubufakazi

Ngokuphumelelayo nomuthi ngoba imfiva obuhambisana yezifo engenhla ipheshana zokuphefumula bese engenhla ipheshana zokuphefumula. Kaningi linqume izidakamizwa kubantu abaphethwe i-rheumatoid arthritis, myalgia, i-osteoarthritis, bursitis, tendonitis nakwezinye iziyaluyalu imisipha, amathambo kanye ngokuhlanganyela, ephelezelwa ubuhlungu syndrome. Esikhathini umkhuba yamazinyo izifo zabesifazane ngenxa yobuhlungu nasezinkingeni ezilandela ngemva kokuhlinzwa postrevmaticheskih futhi wasebenzisa igama elithi "Nimid" nomuthi. Yokusetshenziswa ezimweni ezinjalo kungcono ukuthenga ithebhulethi, powder noma granules.

Mayelana izidakamizwa ngefomu ijeli, ukuthi senzelwe ukusetshenziswa nezokusigcoba nezicubu elikhanyayo (esithambile) okuyinto zibangelwa ezibuhlungu ezihlukahlukene. Ngokuphumelelayo kusho futhi izinqubo ukuvuvukala kanye nokuguliswa esiwohlozayo of the system zemisipha, i-osteoarthritis, ankylosing spondylitis , nabanye. Liqukethe uhlu enwetshiwe izinkomba ngoba ukusetshenziswa kwezimali "Nimid" yokusetshenziswa nomakhi.

izimo reception nomthamo ophezulu wemithi uhlelo

Uma kuziwa ukuphuza imithi ngesimo amaphilisi, ukumiswa, kubalulekile ukuyisebenzisa kuphela emva kokudla. Kuyinto efiselekayo zidlulile imizuzu okungenani 20 ngemva kokungenisa, ngaphandle kwalokho umphumela pharmacokinetic ka nimesulide siyehla. Ngokuphathelene esebenzisa nokushintsha kokudla nokufakwa kanye nesikhathi sokwelashwa, ukuthi le mibuzo kufanele baphendule ngqo udokotela ukuba khona ikhumbula izici ngamunye isiguli kanye degree of isifo zaba namandla kakhulu. Ngakho-ke, sicabanga izincomo jikelele kuphela, equkethe ulwazi mayelana imithi "Nimid" imfundo manual.

Tablets babelwa kubantu abadala kungamaphesenti kabili ngosuku ngesikhathi mg 100. Ngo amafomu ezinzima zalesi sifo zingase umthamo wansuku zonke kube kabili. Izingane Ezisathomba iminyaka engu-12 kuya ku-18 Kunconywa ukubala umthamo izinga izidakamizwa 1.5 mg ngayinye esisindo 1 kg. Uma impatho idingwa ingane eneminyaka engaphansi kwengu-nambili, isisindo sawo idlula 40 kg, it is ebekiwe mg 100 zomuthi ngelanga sokuhlukanisa izinga ngezigaba ezimbili. Emacaleni angakajayeleki, udokotela angase ukwandisa umthamo watusa.

Kusho ngesimo granules elisetshenziswa izingane ezineminyaka engu-12 kanye nabantu abadala: 1 sachet ekuseni nakusihlwa. Okuqukethwe isikhwama kuthiwa buhlanjululwe in 100 ml amanzi afudumele futhi ukuphuza ngemva kokudla.

Ngokuphathelene ijeli "Nimid", ke - akuyona izikhathi ezingaphezu kuka-4 ngosuku - ungqimba elincanyana (ngaphandle bezihlikihla) engxenyeni umzimba ubuhlungu olunzima. Ngemuva kokusebenzisa imithi, geza izandla zakho ngensipho ngaphansi kwamanzi agelezayo.

Lesi sidakamizwa is contraindicated?

Musa akunikeze imithi ukuze abantu peptic isilonda isifo, okunzima kwesibindi nezinso, kanye ukusabela hepatotoxic kumlando nimesulide. Kakhulu contraindicated izidakamizwa ngesikhathi ukuthambekela ezahlukene ukopha, esingamahlalakhona senhliziyo ebuthaka futhi hypersensitivity elilodwa noma ngaphezulu yezingxenye nomuthi "Nimid Forte". Yokusetshenziswa futhi iqukethe ulwazi ukuvinjelwa ukusetshenziswa kwezimali lihambisana imithi engase hepatotoxic ngoba imfiva, zomkhuhlane uthi futhi wasola zokugula acute kuhlinzwa.

Njengoba for izimali ngendlela ijeli, ke akukashicilelwa iziguli ezingaphansi kweminyaka engu-12 ubudala futhi abantu abanemizimba komzimba. Babhebhethekisa isifo phakathi isicelo nomuthi kungenzeka zingabi, ukulimala dermatitis isikhumba kanye nezifo, kanye isifuba somoya bronchial, okuyinto kubangelwa ASA. Ngakho engamiswanga izindlela "Nimid" ku pathologies ngenhla. Imiyalelo amaphilisi ukusetshenziswa ezimweni ezinjalo, futhi, is hhayi Kunconywa.

Ngingaba ukuthatha imithi ngesikhathi sokukhulelwa?

Ososayensi bathola ukuthi nisumelid ukwazi sinomthelela okuzala. Ngaphezu kwalokho, it kuvimbela synthesis prostaglandins, aziwa ukuba imbangela oligohydramnios, umfutho ophakeme wegazi yamaphaphu, oliguria futhi ukuvaleka nisebancane Batalova imbobo. Kwangathi kwandisa ingozi yokungenwa kuyadamba zomsebenzi, ka edema neuropathy ukopha uma usebenzisa izidakamizwa "Nimid". Yokusetshenziswa, amaphilisi kanye nezinye izinhlobo imithi akuvumelekile kokubili ngesikhathi sokukhulelwa futhi ngesikhathi lactation. Phela, ketshezi asebenzayo nge obisini lwebele angangena umzimba wengane futhi zingaphazamisa ukusebenza izinhlelo zawo ezibalulekile. Kulezo zimo lapho akwenzeki ukwenza ngaphandle imithi, kanye nezinzuzo unina bulingana ingozi ukulinyazwa umntwana, umthamo kanye Inkambo yokwelashwa kunqunywa udokotela.

side effects

Futhi omuhle mass izici kwemithi, ukulungiswa kuphinde kube nohlu umxhwele amathuba okuba nemiphumela engemihle. Ngakho ake sibone ukuthi yini uhlobo ukuphendula engase yenzeke uma usebenzisa "Nimid". Tablets (umyalelo ngesiRashiya kwenza idatha etholakalayo) kungabangela ukulunywa, isifuba ahlukahlukene ukuqubuka kwesikhumba, ukukhishwa angioedema, futhi kwezinye izimo of Stevens-Johnson syndrome ne epidermal necrolysis. GI angabuye, aphendule izidakamizwa kusukela ukuqunjelwa, uhudo, ngezinye izikhathi iziguli ezwe ubuhlungu esiswini, isicanucanu. Kakhulu akuvamile amaphilisi angabangela perforation we isilonda kanye isilonda peptic no 12 isilonda duodenal.

Njengoba inqubo umzimba kwesibindi, futhi unale nkinga. Ngakho-ke, ukusetshenziswa eside imithi kwezinye izimo, zingabangela nezinguquko e transaminases, cholestasis, jaundice ngisho ukusha kwesibindi kohlobo oyingozi. Ezinjalo njengoba ukushayisana kwesibindi akuzona kuphela amaphilisi kanye granules kanye powder, kodwa "Nimid".

Qaphela uchaza ngokuqondile ukusabela kungenzeka kohlelo urogenital e izidakamizwa abaphathi. Kungaba njengoba edema, dysuria, nokugcinwa urinary, futhi oliguria, ukwehluleka oyingozi so-renal, nephritis interstitial. Uhlelo zokuphefumula kungenzeka dyspnea futhi bronchospasm, ukusetshenziswa nokunwetshiwe kungabangela ukuthuthukiswa somoya.

Ngaphezu miphumela, isiguli singase ukuthuthukisa tachycardia, umfutho wegazi ophakeme, hypothermia, ukukhathala kanye nezinye izifo. Cishe zonke ukusabela ezingezinhle Kunconywa ukukhansela imithi futhi afune usizo lwezokwelapha ngokushesha. Ukuze kungabi kulesi simo, kudingeka uhlole ngokucophelela konke ukwaziswa kungenzeka mayelana izidakamizwa bese ukuthatha "Nimid Forte" (amaphilisi). Yokusetshenziswa, okuyinto ngamunye nemithi iphakethe kungasiza.

Overdose kwezidakamizwa kanye nosizo algorithm lokuqala

Uma ngephutha idlule umthamo ovumelekile, kufanele usheshe uye esibhedlela. Phela, ngenxa yephutha enjalo kungaba ukozela, isicanucanu, ukuhlanza, ubuhlungu espigastrii, ukucobeka, kukhuphuke blood pressure. Lena uhlu kuphela ukukhanya ukusabela umthamo ephakeme zomuthi "Nimid". Tablets - inhlukano uxwayisa ngalokhu - ezithathwe isamba yizicucu 2-3 ngaphezu kwesilinganiso esivunyelwe, kungabangela ukopha zangaphakathi kanye kuholele nokwehluleka ukusebenza kwezinso. Zokwelapha, ngisho fixed Ezimweni ezingavamile ukusabela anaphylactoid, ukucindezeleka zokuphefumula kanye ikhoma ngenxa yokweqisa yalesi izidakamizwa.

Uma sifuna umthamo kuvunyelwe weqiwe, ulinde ukubonakaliswa emitholampilo Akufanele uzizwe zinkulu. Kufanele ngokushesha iphume esiswini, thatha laxative osmotic futhi chelators. Ithanda ngemva ezingenhla ukuya esibhedlela, lapho Ochwepheshe uzoqhubeka ukwelashwa lingaze. Kufanele kuqashelwe ukuthi kuze kube manje lingekho ikhambi ethize.

Yini abacabanga mayelana izidakamizwa iziguli?

Yiqiniso, e izifo nobuhlungu acute cishe zonke iziguli isamukele imithi kubhekwe. Bona wazi ukuthi imiphumela kokusetshenziswa kwezidakamizwa kwenzeka angabacwasi ngokushesha, okungakwazi kodwa jabulani. Izimo zethu zihluke kakhulu amanye amazwana ungezwakala lapho isiguli okunikezwe inkambo eside imithi yokwelapha, "Nimid". Tablets (ngesandla incoma ukuthi ukunakekela okukhethekile lokhu impahla kwemithi zomuthi) ekudambiseni ngokushesha ubuhlungu, kodwa ngemva kwezinsuku ezimbalwa reception bazenza side effects ezaziwayo. Eyokuqala iqala zisuse nimesulide pheshana emathunjini, isimiso sezinzwa kamuva (lokhu kuboniswa ukucasuka, ukushintshashintsha kwemizwelo nokuthambekela nokunganaki).

Yiqiniso, sebekubeke bathi izidakamizwa owenza kungalimaza kakhulu kunokuba kusize, akunakwenzeka. Phela, kuyasiza ngempela. Kodwa lapha ukuthatha ngaphandle ubufakazi futhi uya khona Uchwepheshe is hhayi Kunconywa.

Uma ngabe ulwazi olungaphezulu wahlala ungabaza yini noma cha ukuthenga "Nimid" (amaphilisi), imiyalelo, ukubuyekezwa, futhi iseluleko udokotela iziguli kungasiza ukwenza isinqumo esifanele.