Lactulose: yokusetshenziswa

Lactulose kuyinto eyayenziwe kwemiqondo stereoisomer lactose - ubisi noshukela. Njengaye, i-molecule ye lactulose yakhiwa izinsalela of molecule fructose kanye galactose, kodwa ubunjalo ketshezi ayitholakalanga.

Lactulose, encibilikayo powder emhlophe, u yokuqala eyatholakala lactose ngo-1929, kodwa ngezici zawo zokwelapha avulekele kamuva kakhulu. Imiphumela yayo achazwa ngokokuqala kuphela iminyaka engamashumi amathathu. Okwamanje, imikhiqizo esekelwe yalolu ketshezi ingenye ngempumelelo kakhulu futhi ethandwa laxatives.

Lactulose, yokusetshenziswa zazo incazelo eningiliziwe impahla yayo, kungokwalabo isigaba okuthiwa prebiotics - izinto ufake umzimba ngokudla, kodwa hhayi matasa hhayi ngaphansi ukugaya. Inani labo itholakala lokuthi ukuthi ukwandisa ukukhula emathunjini of microflora ezuzisayo, ngekubamba lichaza ukugaya. Kulesi - umehluko oyinhloko prebiotics ukuba laxatives kakhulu, ukuhlinzeka isinyathelo esifanele ngenxa nomthelela imisipha abushelelezi emathunjini. Okhulisa emathunjini motility lactulose (isicelo Umsebenzisi Ukhulumela ukulungiswa wesenzo) kungenxa anda yayo ingcindezi osmotic. A esihlalweni ngenxa yale nqubo kuba voluminous kakhudlwana futhi woketshezi, lapho ukukhululeka kwenzeka.

Ngaphezu laxative, lactulose kwandisa uketshezi we Bile, kuvusa kwesibindi kanye kusiza izimpawu hepatic lokudakwa. Ngemuva kwesicelo yayo iyehlisa yiliphi igazi ezinobuthi, ikakhulukazi ammonia. Ngokuvamile, basuke neutralized by amaseli isibindi - hepatocytes. Nokho, in iziguli esingamahlalakhona hepatic, kwenzeka, isibonelo, isibindi sibe sesomile, metabolites anobuthi esikuthola kusukela amathumbu kanye nethonya anobuthi ebuchosheni. Ngenxa yalokho, isiguli eba ezingamahlalakhona portal encephalopathy letindzala (PSE) - a eziyinkimbinkimbi Neuro-ngemilingo syndrome. It libhekene iziyaluyalu kwamanyuroni zokukhukhumala, iziyaluyalu yokuziphatha futhi ukwazi. Lactulose (umsebenzisi ku ekuphathweni izidakamizwa ibonisa ukuthi leli) Isidakamizwa kwaphumelela kakhulu, okuvumela ukuba zehlise isimo lesiguli at PSE: linikeza imvume okusheshayo ammonia emzimbeni futhi kuvimbela ukumuncwa yayo lingene egazini.

Isenzo lactulose phezu microflora emathunjini efana umphumela wezokudla fibre, ngokwesiko asetshenziselwa ukwelapha ukuqunjelwa. Ucwaningo luye lwabonisa ukuthi ngenxa isebenza esiswini kakhulu kwandisa isibalo lactobacilli ehilelekile ukugaya ukudla. Ngaphezu kwalokho, isetshenziswa amafomu ayinzima izifo emathunjini: nokuncipha inani pathogenic esiswini amagciwane - omunye imiphumela izidakamizwa "Lactulose". esebenzisa kwesicelo inhlukano lithi kuvimbela ukwanda kwe-Salmonella nangokuthi amanxusa e uhudo - Shigella. Ngenxa yalezi izakhiwo, lactulose isetshenziswa ekwelapheni dysbiosis.

Kuze kube manje, umhlaba ukhiqiza amashumi amaningana amalungiselelo ngesisekelo lactulose "Duphalac", "Normase", "Livolak", "Laktofiltrum", "Laktusan" nabanye. Lactulose, yokusetshenziswa okuyinto likuchaza ngokuningiliziwe imiphumela engemihle engase zomuthi, kuyinto laxative kahle abantwana abancane, abesifazane abadala, abakhulelwe kanye lactating. Isebenza kahle, kahle, cishe ngaphandle kokudala ukungakhululeki. Phakathi imiphumela engemihle engase - ubuhlungu besisu futhi ukuvuvukala. Ngezinye izikhathi lapho isicanucanu nokuhlanza ngokujwayelekile ohambisana nesifanekiso ukungabekezelelani ngakunye izidakamizwa. Kulokhu, kubalulekile ukuba ayeke reception.

Inkambo yokwelashwa nge lactulose kuyinto, ngokwesilinganiso, cishe izinyanga ezimbili. Ukuze ekwelapheni ukuqunjelwa lactulose (umsebenzisi uyasho ngokunembile umthamo Kunconywa) kuqala sisetshenziswa 15-45 ml ngosuku (umthamo kushintshwe ngamunye). ukudlula Ezinsukwini ezimbalwa ukuze umthamo yesondlo - ke izoke kancane. Izingane isiraphu ye lactulose (amaphuzu umsebenzisi ke) kunconywa ukuthola umthamo 5 ml ngosuku. Lapho PSE ekuqaleni ukwelashwa, ancibilikisa izinhlayiyana ngamanzi iqondiswa rectally 3-4 izikhathi ngosuku. Ngemva sinjalo isiguli izidakamizwa esithathwayo ngomlomo umthamo ebekwe udokotela.