Preparart "Lucentis": Izimpendulo iziguli nodokotela, yokusetshenziswa

Kulesi sihloko sizoxoxa umkhiqizo zokwelapha "Lucentis". Imiyalelo, ukubuyekezwa, umthamo - konke lokhu nokunye okuningi liyongcweliswa kithi.

"Lucentis" lisetshenziswe zamehlo ukwelapha ezihlobene nokukhula macular ukonakala (neovascular). Iphinde isetshenziselwe for sikashukela macular edema ukubuyisela umbono. Umuthi iqondiswa ngomjovo emzimbeni Vitreous esweni.

Sakhiwo Ukwakheka

Kuyinto esobala noma kancane opalescent isixazululo belungiselela nokuphathwa kweBhange ngaphakathi "Lucentis" (izilinganiso nesineke siliqinisekise).

The main isithako zomuthi kuyinto ranibizumab. Okuqukethwe kwalo e 1st izidakamizwa isitsha kuyinto 2.3 mg. Ngaphezu kwalokho, izingxenye asizayo ezilandelayo zifakwe "Lucentis":

• dihydrate α-trehalose;
• polysorbate;
• L-histidine hydrochloride monohydrate;
• amanzi.

Omunye ibhokisi ne izidakamizwa zihlanganisa:

• ecacile ingilazi ibhodlela, umthamo we 0,23 ml, zomuthi;
• Needle nge okokuhlunga;
• A isipetu luhlanzekile futhi inaliti.

Umuthi ikhishwe Pharmacy ngu kadokotela kuphela.

ubufakazi

Yabela eziningi izifo amehlo "Lucentis". Nobufakazi ngempela kuyadida njengoba ekulenzeni libe namandla - umuntu izidakamizwa kusiza, kuyilapho abanye neze uyalibona ukusebenza kwawo. Noma kunjalo, "Lucentis" lomisiwe izifo elandelayo:

• (Neovascular) ifomu emanzi degeniratsii ezihlobene nokukhula macular;
• angaboni kahle ngenxa ukuthuthukiswa sikashukela macular edema - ukusetshenziswa yesikhathi esisodwa noma kuhlangene laser coagulation ;
• umbono encishisiwe ngenxa edema macular, okuyinto kubangelwa ngwengwzi vein occlusion;
• encishisiwe umbono ngenxa neovascularization choroidal kubangelwa myopia sokugembula.

Izimo

Kunezindlela eziningana Izimo ukuqokwa lesi sidakamizwa "Lucentis". Iziguli amazwana futhi zisikisela ukuthi izidakamizwa ezinqunyiwe alulona olwawo wonke umuntu. Ngakho, lesi sidakamizwa akuvunyelwe ukuba isetshenziswe ezigulini:

• abaphethwe izifo ezithathelwanayo of ocular noma periocular ezithandwa izinqubo ezithathelwanayo kwasendaweni;
• okwatholakala ukuthi une-"ukuvuvukala intraocular";
• nedostrigshim engu-18 ubudala;
• ababonisa hypersensitivity kunoma isithako zomuthi.

Umuthi futhi ayikwazi zaphathwa abesifazane abakhulelwe kanye lactating.

Umuthi isetshenziswa ngokuqapha in iziguli kule mikhakha elandelayo:

• Abantu abanegciwane le-hypersensitivity; uma kukhona ingozi yokushaywa unhlangothi, umuthi iqondiswa kuphela emva ukuhlolwa odokotela ingozi-kusizakale "Lucentis".
• Iziguli DMO ngenxa ngwengwzi vein occlusion noma CNV, okuyinto kubangelwa myopia sokugembula, khona ingqondo ischemia noma unhlangothi - izidakamizwa kungabangela thromboembolism.
• Abantu kakade ukuthatha imithi ukuthi isinyathelo semithambo ukukhula endothelial.

Kwezinye izimo, impatho iphazamisekile

Zikhona nezinye izimo lapho kunesidingo esiphuthumayo uphazamisa yokwelapha kanye akazamanga ukuvuselela:

• izinguquko ingcindezi intraocular ukuze mmHg 30 noma ngaphezulu. Article.
• ehle acuity ezibukwayo ngezincwadi ezingu-30 noma ngaphezulu kuqhathaniswa nesilinganiso zokugcina;
• izinyembezi ngwengwzi;
• subretialnoe ukopha, ezithinta emgodini maphakathi, noma wamshaya phezu 50% endaweni;
• enifeza ukuhlinzwa intraocular.

Isikali

Kuphela ngesimo imijovo Vitreous "Lucentis" lisetshenziswa. Nobufakazi ukukhombisa ukuthi inqubo ngokwalo ngaphandle kobuhlungu.

Okuqukethwe elilodwa ibhodlela izindlela senzelwe kuphela umjovo owodwa. Ngenisa izidakamizwa can kuphela ophthalmologist abanesipiliyoni lezo zinqubo.

Kusukela ndlela yokwelapha ihilela imijovo amaningi, kumelwe kukhunjulwe ukuthi phakathi kwabo kufanele libukwe samahora okungenani inyanga 1. Umthamo watusa "Lucentis" ngoba umjovo owodwa - 0.5 mg. Phakathi ekwelapheni control unomphela phezu nokucija kumele eyenziwe.

Ngo kuqokwa izidakamizwa iziguli abaneminyaka engaphezu kuka-65 umthamo okhethekile udinga ukulungiswa.

"Lucentis": yokusetshenziswa

Ukubuyekeza ku nokulungiselela kanye umsebenzi odokotela bathi isiguli kuyadingeka ukuqapha Amalungiselelo isingeniso yenqubo ukugwema kwamacala.

Ngakho, ngaphambi ukwethulwa izindlela ezidingekayo ukuqinisekisa ukuthi ikhambi ilungile - umbala, ukuthungwa, ukungabi inzika. Lapho kushintshwa ithoni noma khona izinhlayiya zingaxazululeki "Lucentis" kwenqatshelwe ukuyisebenzisa.

Isingeniso ekulungisweni okufanele kwenzeke ngayo ngaphansi kwezimo oyinyumba: izandla sezimo eziphuthumayo kumelwe ngokufanele iphathwe; asetshenziswa amagilavu oyinyumba kuphela, futhi kufanele kube usula oyinyumba isivalo speculum futhi wonke amathuluzi izosetshenziswa.

Ngaphambi nje kokuba ama umjovo Kwenziwa magciwane kwesikhumba ezizungeze amehlo kanye nobudala. Khona-ke idriphu izinzwa yaphinde yaphathwa antimicrobial. Kumele kukhunjulwe ukuthi amanxusa anti-microbial kumele safaka izikhathi 3 ngosuku ngaphambi nangemva inqubo izinsuku ezintathu.

Kuphela ngaphansi kwale mithetho kungase kube yokwelashwa okuphumelelayo ngoba "Lucentis". Izimpendulo ezivela kulabo wawuthabatha, ethi kukhona izikhathi lapho udokotela ifaka izidakamizwa iziguli ezimbili yenaliti efanayo. Leyo akwamukelekile kungaholela ukutheleleka izifo eziningi futhi izifo ezinjengengculaza.

Izidakamizwa uqobo iqondiswa emzimbeni Vitreous guiding ichopho inaliti maphakathi nendawo yeso. imijovo okwalandela kumele kwenziwe nengxenye eyodwa sclera, okwakubekelwa ayithinteki umjovo wokuqala.

Njengoba ihora ngemva kokuhlinzwa, ingcindezi intraocular ongama, kubalulekile ukulawula kanye nokuqapha perfusion we emsipheni optic. Ezimweni ngekucindzetelwa kudingeka ukuba babanikeze ukwelashwa ukwehlisa ingcindezi.

Omunye inqubo uvunyelwe ukungena izidakamizwa kuphela eyodwa iso.

ukweqisa izidakamizwa

ukweqisa izidakamizwa Khona Ngengozi iye yabonakala ngesikhathi zokwelapha. Izimpawu ezivame kakhulu lokhu yilezi:

• ubuhlungu eqinile futhi elibukhali iso;
• waqinisa intraocular.

Uma uqaphela izimpawu ezifana isiguli kumele kube ngaphansi kokuqondisa udokotela futhi ibhekane ukwelashwa kudingekile.

Ukuxhumana nezinye izidakamizwa

Akwaziwa ukuthi nezinye izidakamizwa ekuhlanganyeleni izidakamizwa "Lucentis". Izibuyekezo iziguli (iningi labo) ziholela esiphethweni ukuthi odokotela musa linqume "Lucentis" yimuphi leze nezinye izidakamizwa ngaphandle imithi yokubulala izinzwa anti-infective.

Lokhu kungenxa yokuthi ucwaningo nokuxhumana "Lucentis" nezinye izidakamizwa ungazange sezenziwe. Ngakho-ke, imithi kumele kusetshenziswe ngokuhlanganyela nezinye izixazululo noma izidakamizwa.

Nokukhulelwa kanye lactation

Is contraindicated kubantu besifazane abakhulelwe kanye lactating kwabathinta "Lucentis" (izimpendulo futhi ukuqinisekisa lokhu). Lokhu kungenxa yokuthi i-izidakamizwa ubhekwa omunye izidakamizwa teratogenic futhi embryotoxic, okungukuthi, kudala ukuphazamiseka kwengqondo ukukhula kwe-fetus.

Ukuze abesifazane yokuzala, isikhawu phakathi nesikhathi sokuphela ukwelashwa ekukhulelweni akufanele kube esingaphansi kwezinyanga 3 - ngesikhathi lapho ranibizumab isikhathi alethe ngokugcwele emzimbeni. Kuze kube yileso sikhathi, kufanele basebenzise izinto zokuvimbela inzalo ethembekile.

side effects

Futhi kungase kubangele imiphumela engathandeki lidubuleke esweni ( "Lucentis"). Izibuyekezo iziguli kulokhu ikakhulukazi omuhle - side effects ezingajwayelekile kakhulu. Noma kunjalo, iminyaka emibili izifundo zokwelapha ziye zakhomba imiphumela elandelayo sína engathandeki empilweni emva umjovo:

• endophthalmitis;
• lamabutho ngwengwzi ;
• ngwengwezi;
• waqinisa intraocular;
• ukuvuvukala intraocular.

Ngaphezu kwalokho, saphawula futhi kancane esiyingozi imiphumela usebenzisa "Lucentis" ezihlobene izinhlaka emehlweni:

• ukuvuvukala umzimba Vitreous futhi intraocular;
• lamabutho Vitreous;
• angaboni kahle;
• ukopha ngwengwzi;
• ubuhlungu emehlweni;
• ukopha conjunctival;
• blepharitis;
• ukuluma kwamehlo;
• amehlo zamanzi;
• ezomile iso syndrome;
• iritis;
• uveitis;
• kwehle acuity ezibukwayo;
• Spike iris;
• izinqubo esiwohlozayo kwe-retina;
• ububomvu esweni.

Futhi sihlangabezane side effects elandelayo:

• nasopharyngitis;
• Umkhuhlane;
• ukukhathazeka;
• anaemia;
• ukuphathwa ikhanda;
• unhlangothi;
• ukukhwehlela;
• isicanucanu;
• ukulunywa futhi ukuqubuka;
• arthralgia.

Nokho, le miphumela emibi angaphansi kuka-2% wezindleko amacala kusho "Lucentis" ukusetshenziswa. Ukubuyekeza, ikakhulukazi, ibonisa okuyinto kuqhathaniswa njalo ububomvu nobuhlungu. Nokho, lezi zimpawu zinyamalale kunalokho ngokushesha.

izimo isitoreji

"Lucentis" kufanele ligcinwe ngaso 2 kuya ku-8 degrees Celsius, kodwa noma kunjalo, hhayi kwi freezer. Kusho kunesidingo ukugcina endaweni emnyama futhi omile lapho izingane ayikwazi ukufinyelela. Impilo eshalofini we umuthi iminyaka 3 kusukela usuku ukwakhiwa. Ungayisebenzisi "Lucentis" aphelelwe yisikhathi.

Izixwayiso

Uma usebenzisa "Lucentis" bangase babe nokuphazamiseka kwempilo okubukwayo zibulale ikhono lesiguli ukusebenza izindlela ezahlukene futhi ukulawula imoto. Ngakho-ke, uma lezi zimpawu zisobala, ungatholi beshayela imoto noma lokusizakala indlela kuze kube isikhathi lapho bonke ukuphazamiseka visual zinyamalale.

Futhi hhayi Kunconywa ukuba ashayele imoto ngokushesha emva umjovo, ngisho noma ungazizwa lutho ekuqaleni abazange bakuqaphele. Imiphumela engemihle kungenzeka kamuva, isibonelo emva kokuphela imithi ebulala izinzwa.

'Lucentis': izibuyekezo odokotela

'Lucentis' ngokuvamile Kunconywa futhi ebekwe odokotela ngoba ubhekwa izidakamizwa siyasebenza ngempela. Ngakolunye uhlangothi, akuyena ngaso sonke isikhathi nesineke kungaba ukukhokha lemali edingekayo umjovo: "Lucentis" - ithuluzi kunalokho ezibizayo. Kulezi zimo, odokotela basikisela ukuba esikhundleni sako umfuziselo eshibhile - "Avastin". Nokho, lona wamuva ingakamiswa uphenyo endaweni ngezinga elifanelekile, ngakho isincomo sokuqala odokotela kuyinto "Lucentis" eside ziphumelela. Sekuyisikhathi eside bamehlo wayewazi leli thuluzi, uyazi ukuthi imiphumela esingayilindela futhi bakubone ekulenzeni libe namandla.

nobufakazi

Manje asikhulume ngalokho iziguli ngokwabo ukucabanga mayelana nomkhiqizo zokwelapha "Lucentis". Izibuyekezo zisikisela ukuthi izidakamizwa akusho ngaso sonke isikhathi ibe nomphumela oyifunayo. Noma kunjalo, iningi ezigulini eziye zabhekana, ibonisa ukuthi umbono ziye zathuthuka kakhulu noma saphela ukuncipha. Kuyaqapheleka enjalo eshalofini imiphumela obunjengobuhlungu kanye nesenzakalo yokungenwa yizifo ezithathelwanayo, kodwa kalula babhekane ngemithi elwa namagciwane. Ngaphezu kwalokho, iningi leziguli bayaqiniseka ukuthi miphumela engadingeki zibangelwa.

Nokho, kukhona amacala lapho izidakamizwa wazibonakalisa ayizwakali. Iqiniso lokuthi ukusiza 'Lucentis' hhayi 100% we izimo, bathi, futhi odokotela ngokwabo. Nakuba kusimo esiphawuleka kunazo zonke iziguli bakholelwa ukuthi - izindleko izimali. Akuwona wonke umuntu angakwazi ukukhokhela izifundo ezigcwele umjovo eziningana.

Phakathi izinzuzo abalulekile, ngaphezu kahle, isicelo kobuhlungu ngokuthi "Lucentis" (izibuyekezo kulo magazini uyavumelana). Ububi kuphela iyona kabi ngaphambi sokuqondisa futhi emva. Nokho, abasakwazi ukubekezela, futhi ukugwaza ngokwakhe wazizwa. Ngemva ekunqanyulweni ngokusungula indlela yokubulala izinzwa, kukhona indawo ngeminjunju ezincane.

Noma kunjalo, "Lucentis" kusho ithuluzi kuhle ngempumelelo emva isicelo zazo iziguli batfola ngcono umbono.