Kuyini eosinophilic cationic amaprotheni? Norma eosinophil cationic amaprotheni ezinganeni nakubantu abadala

Ngaphambi sikhuluma ngezinto ezinzima, udinga ukubhekana elula. Kulokhu, kufanele ungaqali ne eziyinkimbinkimbi amaprotheni izakhiwo, injongo abaningi - nje kweqembu izincwadi, futhi iyunithi enembile kwamangqamuzana egazi. Uhlelo Ihlangano, uma singakubeka kanjalo.

igazi ukwakheka

Wonke umuntu uyazi ukuthi igazi siqukethe ingxenye ewuketshezi nezinhlayiyana okuqinile - amaseli. Plasma yisisombululo of electrolyte, amaprotheni namavithamini. Iningi ke - amanzi (mayelana 95%). Ngaphezu kwalokho, kukhona ama-enzyme, imikhiqizo umzimba, izinto wezinto ezingaphili adingwa umzimba ukuze isekele ukuphila.

egazi

Manje ingxenye yeseli. Umuntu omdala kuze cishe uhhafu wezindleko igazi ivolumu matasa ngokwakha izakhi. Basuke emelelwa abomvu egazi, izinhlayiya zegazi kanye leukocyte.

1. Erythrocyte. Kubo kangangobana banikela ngegazi lethu abomvu. Lokhu biconcave amaseli zingenalo ifomu ovuthiwe-nucleus. Kodwa kufanele elithwala umoya-mpilo, okuvumela ukuba athwala umoya-mpilo ziyoncibilika plasma ezicutshini zomzimba.
2. Ama-platelet I - ipuleti encane emhlophe. Zinikeza igazi ekunqandeni, uxhumana plasma amaprotheni. Lapho umkhumbi lilimele, beqala ukophula bayigubungele isilonda, ekuqedeni umonakalo. Matter uqine kangakanani uzakwenza lokhu isithiyo ukopha, ukuphila komuntu ngezinye izikhathi kuncike.
3. Leukocyte - ithole emhlophe. Kodwa lokhu akulona uhlobo olufanayo amaseli, iqembu yabo yonke. Umsebenzi wawo oyinhloko - ukuvikela umzimba kusuka ejenti angaphandle. It sika uhlobo amaphoyisa uhlale ezingenakuguquleka isikhundla. Abakwazi ukubona futhi ukubulala konke ezingalimaza. Nokho, abanye ukusabela stereotypy kwamakhemikhali kungaholela ukuphazamiseka ukuzivikela komzimba futhi ukulimala amangqamuzana omzimba siqu.

leukocyte

Kulesi sihloko sinesithakazelo kuphela amangqamuzana amhlophe igazi ngeqhaza ababenalo empilweni yomuntu. Njengoba kushiwo ngenhla, amhlophe egazi - yigama elididiyelayo okunikezwe iqembu lamaseli. Kukhona yesimanje egazi ngezigaba okukhulunywa ezifana:

1. luyimbudumbudu noma granulocytes. Ngemva staining umaka kuzo kungabonwa core esikhulu ihlukene futhi inani elikhulu inclusions encane. Uma kungenzeka, thatha udayi amangqamuzana amhlophe egazi zihlukaniswe eosinophils (pink), basophils (blue) kanye neutrophil (zipendwe ngemibala emibili).

2. Nezernistye noma agranulocytes. Yiba core elula, zingenalo inclusions ku cytoplasm. Lezi zihlanganisa i-lymphocyte futhi monocytes.

Igazi ukuhlola kubonisa ngokuphelele inani leukocyte nesibalo salabamnyama ngamunye ingxenyenamba njengoba amaphesenti.

eosinophils

Lapha sesiqala esiyikho nesithakazelo. Lokhu egazi obhekene ukusabela ukuvuvukala. Sinenkosi ukwenza inombolo yezici ezenziwa imvelo. Phakathi yokugcina kungaba ikhono ovelele ku amoeboid ukunyakaza, okusho ukunyakaza ezimele izitsha nezicubu, kungakhathaliseki ukugeleza kwegazi ..; ithuba zingene udonga semithambo, seeping phakathi amaseli bese ufaka ezicutshini futhi izitho, okwandisa ukuvuvukala. Ngaphezu kwalokho, sibangela eosinophils chemotaxis (ukunyakaza siqondiswe umthombo chemical).

Enye impahla ezithakazelisayo kula maseli kuyinto phagocytosis, ukuba ngqo - mikrofagotsitoz. Bayakwazi ukuncela izinhlayiya ezincane noma izingxenyana amaseli. Kodwa isici esiyinhloko kuba ummeli wakhe. Ngenxa umzimba wakhe ithumba ngokunembile ejenti angaphandle futhi ukhiqiza immunoglobulin E bawabulale yabo.

Ukuncela nokukhululwa histamine kwenza eosinophils esisemqoka ukuvuvukala. Nokho, inani elikhulu kakhulu babo kungabangela ukuthuthukiswa anaphylaxis futhi ukushaqeka - isimo esibulalayo. Noma yimuphi yokungezwani komzimba kuphakamisa ukwanda kwenani lolu hlobo ezimhlophe cell segazi. Lena ngenye yama-izici zokuxilonga.

EKB (EBU)

ECP - eosinophilic amaprotheni cationic. Futhi ungamangali ukuthi ezinye isifinyezo namagama ngamazwe zilotshiwe ikakhulu ngesiNgisi.

Ukwazi manje kuyini eosinophils, kungaba lula ukuba aqonde futhi amukele ibinzana ukuthi eosinophilic amaprotheni cationic - lokhu ingenye yezingxenye elimbudumbudu kulezi egazi. Yena - omunye amaprotheni ukuthi zikhishwa ngesikhathi ukuvuvukala ukusabela kanye nomthelela oluzungezile izicubu kanye izitho. Njengoba ukusabela umzimba ikakhulukazi stereotyped, amaphrotheyini kungase ngokunenzuzo kuthinte ukuqinisela imvelo yangaphakathi noma kubuqede. Umsebenzi we chemical kungahlanganiswa helminthiasis, isifuba somoya bronchial, dermatitis, rhinitis, isifo sokuhlasela kwamasosha omzimba, komzimba okungamahlalakhona.

Ezinkulu eosinophil cationic amaprotheni kwezine kuyinkomba ebaluleke kakhulu ukuqapha umsebenzi ukuvuvukala.

isakhiwo

The ECB iqukethe esibalulekile arginine, lokhu kuvumela namabala udayi kakhulu esidi ukunikeza iseli pink umbala. Ukulandelana acid acid eyinqaba bakwazi ukuhlukanisa ke lonke ngokusebenzisa omzimba monoclonal. Ngaphezu kwalokho, amaprotheni ngokuphelele ethize, ukuze imiphumela yocwaningo ukubonisa 100% iqiniso.

I izakhiwo ezishukumisayo isizukulwane ECB uketshezi amangqamuzana goblet ze- bronchi, okusithiyayo of T-lymphocyte ayanda, a heparin ngibopha futhi okusithiyayo of coagulation. Liveza izindawo enobuthi ngokumelene eziwuhlupho, kodwa ngesikhathi esifanayo futhi kungalimaza amangqamuzana omzimba: kwemizwa, EPITHELIAL, inhliziyo (kwemisipha).

anda

Ngokuvamile, eosinophil cationic iphrotheni esegazini kumelwe ibe ngaphansi kuka-7 micrograms ilitha. sici kwesifo: iziguli somoya bronchial liyophuma ukuba 15-20 micrograms ilitha; uma inkomba ngenhla kuyinsakavukela aphindwa izikhathi eziyishumi noma ngaphezulu - a bot noma exacerbation of dermatitis. Izinga eliphakeme - kuze kufinyelele micrograms 200 ilitha - zingase zibe Indlela myeloproliferative umdlavuza wegazi.

Akufanele yini ngokushesha netwetwe uma ubona ukuhlolwa igazi ukuthi aphakeme eosinophil cationic amaprotheni. Izimbangela kulesi simo akuyona njalo zhizneugrozhayuschi. Ngokwesibonelo, yalokho ezinjalo kungenzeka ngesikhathi exacerbation of yokungezwani komzimba. Kuyinto Dynamics ushintsho ohlwini lwezikhombo ECP esikalini izinga ukuphathwa nempumelelo yayo, umthamo efanele, ukudla.

Kuyaziwa ukuthi eosinophils nomthelela inani Ige, kusukela ku ubuso bayo receptor Site ngale molecule amaprotheni. Kodwa futhi kwenzeka ukuthi amaprotheni eosinophil cationic liphakeme e immunoglobulin evamile E, lapho imbangela amanga hhayi Izifo ukuvuvukala. Ngezinye izikhathi ngenxa yokwephulwa impendulo izinhlelo avikelayo singawathola ukuzwa ngisho ukwehla Ig E ne nokwanda okuphawulekayo EKB.

Ezinye izifo ukuthi kungukuthi ezihlobene komzimba, kodwa futhi ungaqhubeki ikhomponethi ukuvuvukala, isivuno ukwanda eosinophil cationic amaprotheni. Phakathi kwabo, sinusitis webhaktheriya, izimila ku izinso, izifo ezibangelwa amagciwane.

DRESS-syndrome

Lesi sifo libhekene ukungabekezelelani kunoma izidakamizwa. It kubonakala ku ukuqubuka kwesikhumba, izilonda zangaphakathi kanye nezinguquko esithombeni igazi. Ngokuvamile le syndrome ngemuva kokuthola "phenytoin", "Phenobarbital", "Karbmazepina" "Doxycycline", sulfonamides, nabanye. I lokuhlushwa eosinophilic amaprotheni cationic kakhulu anda phakathi DRESS-syndrome.

Injongo yocwaningo

Udokotela wakho angase akunikeze isifundo phezu ECB uma usola ukuthi ukuthuthukiswa nesineke yesifuba somoya atopic, atopic dermatitis noma rhinitis iguliswa. Ngaphezu kwalokho, ngisho izimpawu ukudla yokungezwani komzimba noma poisoning, ezifana ukuvuvukala, ukulunywa, isicanucanu, ukuhlanza, ikhanda elibuhlungu, futhi nokulahlekelwa ukwazi, bangaba sina ngokwanele isizathu injongo yale ukuhlaziywa.

Izindlela sokuhlaziya

Lena ukuhlolwa igazi evamile. Eosinophilic amaprotheni cationic akudingi ukuqeqeshwa othize, kodwa kufanele ulandele imithetho jikelele zokuphetha igazi ukuhlolwa.

1. Biomaterial kudlule ekuseni, kusukela amahora 8 kuya ku-11, esokuba esiswini esingenalutho.
2. Ngolunye usuku ngaphambi kwesifundo ukuze ingafaki utshwala, phys okukhulu. ukulayisha kanye nokuphathwa izidakamizwa.
3. Ukuze umbhangqwana amahora ngaphambi kwesifundo angibhemi, akazange baphuze itiye / ikhofi / juice, ukuqeda ukucindezeleka ngokomzwelo nangokomzimba.
4. izifundo okuphindaphindayo kwenziwe izimo ezifanayo.

okulotshiweyo

Kumelwe ngivume ukuthi lo ngempela indlela ezingavamile ahlolisise - ukuhlaziya eosinophilic amaprotheni cationic. Yini the ECB ezinganeni, bengayiqondi ngokugcwele, wo hlinzeka zenzelwe abadala. Kodwa kuthathwa ngokuthi nesanda yayo (angaphezu kuka-15 ng / ml) izobonisa yisihlungu noma awe ayehlasela helminthic.

Naphezu ngokucacile eliphezulu ukuze kuhlonzwe ngezinye izikhathi akuyona ukuhlaziywa okwanele eosinophilic amaprotheni cationic. abadala Jwayelekile kuyahlukahluka ezahlukahlukene (0 kuya 24 ng / ml), kanye nokuhlaziywa kungase kube yinkohliso-HIV noma amanga-negative kanye nanoma iyiphi enye.

odokotela Modern uzame ukusebenzisa izindlela non-koda ukuxilongwa ukuze emuva lé ngawo ukuthola kungenzeka nokugwema izifo. Ukunqunywa eosinophilic amaprotheni cationic ivumela ukubikezela ukuthuthukiswa izifo ezinzima, njengesifuba somoya noma lomdlavuza wegazi.