Isimila umaka HE4: okulotshiweyo. Izimpawu ze-umdlavuza wesibeletho kwabesifazane

Minyaka yonke, abathile abanomdlavuza ziyanda. Lokhu kuhlasela akusho onga ubani. Ososayensi nodokotela basazama ukubhekana ne nesenzakalo we izimbangela umdlavuza futhi uthole izindlela eziphumelelayo zokwelapha. Ngeshwa, ngo-kusaqalwa lesi sifo asymptomatic. Iziguli eziningi beze kudokotela nezikhalazo, thola ukuthi they fanele kwedlulela sokuhlupheka ngawo ukulwa kwesikhathi. Ngakho-ke, izinga lokufa ngenxa yomdlavuza kuphezulu. Nokho, ososayensi baye bakwazi ukuba abhekane nenkinga. Izinhlobo eziningi zama-umdlavuza kungatholakala at kusaqalwa, ngaso kanye isikhathi kodokotela futhi ngegazi ekuhlolweni. amasu laboratory Special vumela behlukene igazi "amabhikhoni" womuntu -onkomarkery, inkinga iphutha. Lokhu kukuvumela ukuthola lesi sifo zisaqala, okuyinto kuzokwanda izikhathi eziningana amathuba alulame.

Kuze kube manje, omunye wayemesaba kakhulu umdlavuza zesifazane - umdlavuza wesibeletho. Nokufa kuwo likhulu kunawo wonke phakathi kwezinye komdlavuza ezithweni zangasese zesifazane. Ungethuki. Phela, ukucacisa kuqala lesi sifo kungase kube kusaqalwa sokuthuthuka ukunciphisa izingozi ezingase zibe yingozi. cwaningo ezikhethekile ngegazi khona isimila umaka HE4 ugcine engozini.

Izimbangela umdlavuza wesibeletho

Nikeza izizathu eqondile izimila wesibeletho kwabesifazane, akunakwenzeka. Kunezindlela eziningana zici ukuthi kumkhathaze ukuthuthukiswa izimila:

• Izinguquko ngemuva kwama-hormone. Ngokuvamile, ukungalingani hormone kwenzeka kwabesifazane ngesikhathi nambili kuya kwabadala. Phakathi nale nkathi, kwandziswa kwelinani letikhungo hormone ocansini owesifazane emzimbeni. Ngenxa yalokho, kunomthelela ukuvela umdlavuza izimila, kuhlanganise wesibeletho. yokwanda kwama-hormone futhi kungenzeka, futhi emantfombatana nebafati labasebasha. Ngakho-ke, abantu nge okungajwayelekile imijikelezo kokuya esikhathini kudingeka sinake ekhethekile empilweni.
• Izejwayezi ezimbi. Wonke umuntu Sane uyazi ukuthi ukubhema, ukuphuza utshwala, ukudla okungenamsoco - abasizi izifo ezihlukahlukene. Ayikho ngaphandle, futhi umdlavuza wesibeletho. Ngokwesibonelo, abesifazane labahlukumeta imikhiqizo equkethe amafutha trans, carcinogens, udayi kanye nezinye izithasiselo ezilimazayo waphawula engozini onkovracha.
• ushintsho Permanent labantu ozibandakanya nabo kwezocansi, isisu. Uma amadoda bashintshe njengomphumela amagilavu, hhayi ukunakekela impilo yabo, khona-ke ukubamba izifo, izifo ezidluliselwa ngocansi, kulula. Ngokuzayo lokhu kuzonciphisa izivikeli mzimba wendawo, futhi ngenxa yalokho, okuvela kuyo umdlavuza. ukukhulelwa okungafunwa kungaba umphumela okuxekethile. Abesifazane abaningi, ngibona ingekho enye indlela ngaphandle isisu. Lesi sinyathelo kuhlinzwa - a ukucindezeleka enkulu umzimba female, eshintsha ibhalansi hormone. Umphumela - ukungazali, nomdlavuza.
• Nemisebenzi ezikhiqiza amaqanda, okuyinto ukukhuthaza ukwakheka kwamaseli atypical EPITHELIAL isitho.
• Ufuzo. Ososayensi baye babonisa ezimweni lapho khona izakhi zofuzo ezifanele iketango DNA ikhuthaza ukubukeka izimila abulalayo kubantu.
• Isimila we esibelethweni besifazane ngezinye izikhathi ithuthukisa ngenxa ezinye izifo oncological.

Izimpawu zesifo

Ngo kusaqalwa umdlavuza wesibeletho ukucacisa cishe engenakwenzeka. Izimpawu avele lapho isifo lashaya umzimba ezijulile. Izibonakaliso eyinhloko umdlavuza wesibeletho kwabesifazane:

• iziyaluyalu kokuya esikhathini;
• ukuchama kaningi;
• ngokucindezela ukuzwa esiswini aphansi;
• ezidabukile ubuhlungu esibelethweni;
• izinkinga nge sokuzikhulula;
• ukungakhululeki, ubuhlungu ngesikhathi kocansi.

Lezi kubonakaliswa isifo asikwazi kubhekwe ethize umdlavuza wesibeletho. Ngakho-ke, ukuze sigweme inhlekelele, kuba ukuvakashelwa kuphoqelekile udokotela wezifo zabesifazane.

ukuhlola

Ukuhlolwa evamile esitulweni izifo zabesifazane ziyonquma izinguquko isakhiwo wesibeletho. Ukuze uqinisekise uphethwe kokuqala isiguli siqondiswe wenze inani lezifundo wezinsimbi:

• ultrasound ukuhlola izitho zangasese;
• izicubu biopsies ukunquma isakhiwo anomdlavuza;
• MRI - indlela lapho kwasendaweni futhi imingcele izimila wazibona ngokuningiliziwe;
• X-ray kanye isixazululo Ngokuphambene kuzovumela ukubona indawo yesimila.

Futhi, i-sitholakele wesibeletho umdlavuza iziguli wathumela ukuba ukuhlolwa igazi, okuyinto ukuthola ubukhona isimila iziphambano. Ngo ingqondo wahlulele khona lesi sifo. Ukuze sithole wesibeletho igazi umdlavuza pass at ekuboneni isimila nakomaka ezimbili - CA125 futhi HE4. Uhlobo yokugcina umaka esanda kuqalile ukuchaza, kodwa iningi ngokunembile likhombisa ukuqhubeka kwesifo.

Kuyini HE4?

Isimila - into ethize, lapho uqala ukukhiqiza i umzimba nge izilonda iyiphi unesimila isitho. Futhi, kungenziwa izimpawu ekhiqizwa kuleli evamile umuntu enempilo, kodwa ukwandisa lokuhlushwa Ochwepheshe umdlavuza babona bese uyibuka agobhoze.

HE4 - isimila umaki umdlavuza wesibeletho kwabesifazane, ikhiqizwa eziningi ezincane emzimbeni ukulondoloza umsebenzi okunempilo bokuphila. Uma epithelium ethintekile umdlavuza wesibeletho, othize amaprotheni lokuhlushwa liphuma khona.

Ngaphambili, ukuqinisekisa ukuxilongwa, "umdlavuza wesibeletho" wasebenzisa CA-125 umaka, okwakubekelwa kunqunywa ukuhlolwa okukhethekile kwegazi. Kodwa le ndlela asivumelekile, ngoba lokuhlushwa lalomaka ukwandisa izifo ze-non-neoplastic noma izimila nezinye izitho. Ukwandiswa amazinga serum of CA-125 kungase kube mhlaka 3 noma isigaba 4th lesi sifo. Ezigabeni zokuqala zesifo ukunquma esebenzisa lalomaka cishe akunakwenzeka. Ngokuvamile, lizinga "beacon" buyaqina lapho ukukhombisa izimpawu zokwelashwa umdlavuza wesibeletho kwabesifazane.

HE4 has a ngokucacile ephakeme (95%) kanye nokuzwela (76%) uma kuqhathaniswa CA-125. Sekube izifundo ukuthi kuye kwabonisa ukuthi abantu besifazane abaningi abasuka ephakeme ka HE4 umaka CA-125 igazi uhlala evamile. Ngakho-ke, ekutholweni umdlavuza wesibeletho ngendlela efanele usaqala kungcono ukusebenzisa, ebheka indlela HE4.

Ukuze uthole imiphumela emihle ukuba amaphesenti enkulu ukunemba, ochwepheshe ichaze ezimbili nje isimila umaka (CA-125 futhi HE4). Khona-ke sebenzisa i-algorithm akhethekile zezibalo ukuthi kungenzeka ukuvumela ukukhuluma mayelana nokuthuthukiswa izinqubo oncological e ezikhiqiza amaqanda. Ngokucacile futhi nozwela le ndlela kwandisa ezikhathini eziningana (kufika ku-96%).

Isimila umaka HE4: abesifazane evamile

Xilonga, singagxili kuphela umphumela ukuhlaziya, okuyinto inquma HE4 akwamukeleki. Ukuze uthole ukusebenziswa zokuxilonga kuphela oluphelele indlela ukuhlolwa amathuluzi nezindlela sokunquma vivinyo isimila iziphambano. Ekuhlaziyeni, ekutholweni marker for umdlavuza wesibeletho kufanele kukhonjiswe, kwenzeke abesifazane menopause noma cha, njengoba Ibanga yamanani abesifazane ukunqamuka kokuya esikhathini ngaphambi ngenhla.

Ngo abesifazane ngaphambi menopause HE4 Inkomba Kufanele ibe ngaphansi kuka-70 pmoles / ml.

Owesifazane labetibambile menopause HE4 ezingeni kuvamile lapho zabonisa 140 pmol / ml.

Isimila umaka HE4: okulotshiweyo

Asivume. Uma HE4 isimila umaka liphakeme, kubonisa okuvela EPITHELIAL umdlavuza wesibeletho. Vele uqaphele ukuthi ezinye izinhlobo umdlavuza ezikhiqiza amaqanda (isib, mucinous) nenani HE4 serum is ukhulise.

I lokuhlushwa eliphezulu HE4 akuyona njalo kukhombisa umdlavuza wesibeletho. Ngezinye izikhathi izinga lezakhi lalomaka kwaphakanyiswa ukwehluleka kwezinso, umdlavuza wamaphaphu endometrial, izinso cystic.

ukulungiselela Esifanele ukuhlaziywa sithinta ezingeni umaka egazini.

Ukulungiselela i-ukuhlaziywa

Ukuze ubone ukuthi isimila umaka HE4 egazi losana umthambo ka bazila ukudla. Ngakho-ke, ngaphambi isandla kuwe phezu ukuhlaziywa, amahora angu-12 ngaphambi kokuba inqubo akakwazi ukudla ukudla okunamafutha, utshwala, amaswidi, inyama, awukwazi ubheme. Ngosuku ukuhlaziywa ziphuze amanzi kuphela nengcosana.

isiphetho

Ukubeka okuyikona kungenziwa kuphela ube udokotela, sithembele idatha kusuka izinhlobo eziningana ukuhlola. Ukuze ugweme izinkinga zezempilo, ukuthola umkhuba kanye ngonyaka bayohlolwa. Phela, ukuze nazi ukuthi liyini enempilo - abunakuqhathaniswa.