Imijovo "Kokarnit": imfundo. "Kokarnit": ukubuyekezwa, Analogue

Umzimba, noma umzimba libizwa isethi zamakhemikhali ezenzeka emzimbeni ukuze silondoloze ukuphila kwakhe. Lezi zinqubo laba kanjani nesandla ekukhuleni nasekuvezeni izithombo zaso ezintsha.

Umzimba zingahlukaniswa izigaba ezimbili:

• ngesikhathi catabolism izinto eziyinkimbinkimbi organic aguqulwa ku elula;
• ngesikhathi anabolism nge izindleko energy kwemiqondo amaprotheni, amino nucleic, lipids futhi ushukela.

umzimba Lapho aphazamiseke empilweni yomuntu uwohloka ngokuphawulekayo. Kukhona izifo ezihlukahlukene, ukukhathala, ukuwohloka kwempilo jikelele, Ukukhuluphala nokunye.

Ukuze kulesetayelekile umzimba, ochwepheshe batusa ngendlela enempilo, ukudla ngendlela efanele, ngokuvivinya umzimba, nokunye. D. Ngaphezu kwalokho, iziguli izidakamizwa umzimba ezingahle zinqunywe wumgomo. Omunye ethandwa kakhulu kulezi Isidakamizwa "Kokarnit". Yokusetshenziswa, lokhu Izibuyekezo imoto izokwethulwa ngezansi.

nemithi Ukwakheka, ukupakisha kanye nokusungulwa yayo

Ngayiphi yefomu izidakamizwa sithengiswa "Kokarnit"? Umhlahlandlela ibika ukuthi nomuthi ekhiqizwa njengoba lyophilisate isixazululo kanye kuphela (lidocaine) ku ampoules.

Ukwakheka lendlela zihlanganisa nicotinamide, kokarboksilaza, cyanocobalamin, futhi triphosphate adenosine. Njengoba izingxenye ezengeziwe asetshenziswa glycine, methyl parahydroxybenzoate futhi propyl parahydroxybenzoate.

izici pharmacodynamic

Yini kubhekwa indlela yokuxhumana? Yini elikushoyo imfundo? "Kokarnit" kuyinto eziyinkimbinkimbi amavithamini izinto ezithinta umzimba. Anakho neyrometabolicheskie kanye analgesic umphumela, kodwa futhi sithinta ububanzi ngokomzwelo futhi autonomic.

Ukuphumelela lomuthi ngenxa ngezithako zawo. Cabangela izici lomcebo ngamunye kabanzi.

Nicotinamide omuhle kuthinte ama-carbohydrate nitrogen exchange, uthatha iqhaza izinqubo redox, futhi ikhuthaza ukuthuthwa ATP kumaseli. Futhi, lolu ketshezi anezakhi sine. Kule ndaba, kuyaphumelela kakhulu iziyaluyalu Neuro-zengqondo, ukucindezeleka kwengqondo, ukukhathazeka nokunakwa encishisiwe.

Cocarboxylase limelela coenzyme, edlala indima ebalulekile carbohydrate umzimba, inomthelela zamagama of acid nucleic, kuthuthukisa izicubu trophism, lipids namaprotheni, kanye ikhuthaza ukumuncwa glucose.

Ngokuthi adenosine triphosphate adenosine esuselwe. Le ngxenye kuvusa umzimba. Kuyinto enkulu amandla substrate amaseli. Lapho yenhliziyo Umthambo isifo eba namandla kusilela, okuyinto zingancishiswa ngenxa triphosphate adenosine. zokuthutha Its amaseli kwenzeka ngenxa nicotinamide. ATP uyakwazi kunethonya antiarrhythmic, hypotensive futhi vasodilator umphumela.

Kepha cyanocobalamin, ke synthesizes futhi aqoqana amaprotheni, oyenza isebenze umzimba carbohydrate kanye amafutha. Waba yini umphumela walesi senzo ukunciphisa izinga cholesterol, kanye nokuvimbela okunamafutha isibindi.

Kufanele kuphawulwe ukuthi cyanocobalamin regenerator kwandisa ikhono amaseli, esidingeka izitho obumba, kwesibindi nesimiso sezinzwa.

ubufakazi

Ngayiphi izifo kunikezelwe umuthi ngokuthi "Kokarnit"? Yokusetshenziswa (imijovo kufanele sigcwaliswe kuphela umsebenzi wezempilo abanolwazi) lubonisa ukuthi ubufakazi leli thuluzi yilezi:

• neuritis;
• neuralgia zasezindaweni ezihlukahlukene;
• sciatica, sokuqaqanjelwa yiqolo, umfutho sciatica;
• myalgia, tendinitis, bursitis;
• peripheral (kuhlanganise isifo sikashukela);
• zenhliziyo, yenhliziyo Umthambo isifo, myocarditis.

Futhi, kufanele kusho ukuthi ngesikhathi sokukhulelwa, leli thuluzi lisetshenziswa kuphela uma inzuzo omama esizayo kunalelo ingozi embungwini.

Izimo

Lapho hhayi prescribers "Kokarnit"? Ukufundiswa uthi izidakamizwa is contraindicated ku:

• hypersensitivity;
• wegazi vele ophakeme kakhulu futhi hypotension;
• polycythemia, eritremii;
• psoriasis;
• conduction iziyaluyalu futhi senhliziyo ezinzima;
• isilethikusebenza esikhathini oyingozi.

Asinakusho ukuthi kubhekwe ngokuqapha Kunconywa abantu kolwelwesi, isilonda peptic, sifo futhi isifo sesibindi. Idatha ukusetshenziswa kwalesi imithi e melenkih cha fanele ntwana.

Ngaphezu kwalokho, lapho wabela nomuthi wathi kubhekwe Izimo ezilandelayo ukuze uthole uketshezi njengoba 0.5% lidocaine: Stokes-Adams syndrome, ogulayo itheku syndrome, angina, Wolff-Parkinson-White syndrome, myasthenia gravis, epileptiform nokuquleka elihlobene ne yokwamukela lidocaine , ezinzima esingamahlalakhona kwezinso futhi porphyria.

Imijovo "Kokarnit": isitatimende

Amazwana ngalokhu imoto uzobe kuchaziwe ngezansi.

Ngokusho imiyalelo, umuthi kumele kuphethwe ujove esicutshini 1 noma 2 izitsha eziyisikhombisa nsuku zonke. Shots usesikhathini. Ubude yabo incike ngobucayi isifo.

Isixazululo izidakamizwa yasetshenziselwa ngokushesha ngemva nokulungiselela. Kulokhu, kufanele ube umbala obomvu. Uma umbala asishintshi, umuthi akumele zisetshenziswe.

Ukusebenzisa imithi "Kokarnit" imfundo okuyinto linamathele inqwaba amakhadibhodi, kumele njalo ihlolwe abomvu egazi nama-platelet, isikhathi ekunqandeni, uric acid, bilirubin futhi transaminases.

side effects

Yiziphi imiphumela emibi zenzeka ngemuva ukusetshenziswa kwezidakamizwa "Kokarnit"? Yokusetshenziswa ikhomba ukuthi lokhu izidakamizwa kungabangela:

• tachycardia;
• ikhanda;
• isifuba;
• ngenxa yobuthakathaka;
• ajulukayo;
• isiyezi;
• ukuqubuka;
• ukushaqeka anaphylactic;
• ukulunywa;
• isifo sohudo,
• neuropathy thrombosis semithambo;
• edema yamaphaphu.

Kufanele kuphawulwe ukuthi iziguli ezine-hypersensitivity nokuphathwa izidakamizwa Kwenziwa ukuhlolwa intracutaneous.

Overdose kwezidakamizwa

Kuzokwenzekani lapho ngemva kokudla izidakamizwa ngokweqile "Kokarnit"? Yokusetshenziswa (imijovo kufanele sinikezwe kuphela nguchwepheshe) uthi uma ngephutha ukuthatha izidakamizwa ngaphakathi kungenzeka kuwukubonakaliswa ubuthi, okuyinto obonakaliswe isikhumba ngamanzi, ukulunywa, isicanucanu, ikhanda, ukuhlanza kanye isilungulela.

Ukuze imithi ukudakwa ezingamahlalakhona libhekene nenkinga yezinga anda acid kanye glucose amazinga uric, kanye ukubukeka ulcer 12 tiperstnoj emathunjini.

Ukuxhumana nezinye izidakamizwa

Ngingakwazi ukusebenzisa ezinye izidakamizwa imithi "Kokarnit" (isibhamu)? Umhlahlandlela ibika ukuthi kokarboksilaza, ingxenye izidakamizwa uyakwazi ukuthuthukisa imiphumela inhliziyo ka glycosides inhliziyo.

Kepha nicotinamide, ke potentiates sezindawo anticonvulsant izidakamizwa antiepileptic (isib, "Diazepam", "carbamazepine", "valproate").

ATP kanye isisu potassium-engashiyi, i-potassium izidakamizwa ACE inhibitor kwandisa ingozi hyperkalemia. Iphinde sithuthukisa isenzo (antianginal), ama-nitrate nama-beta-blocker.

Lapho ethola nemithi kuthakwe vasodilator yayo senzo "dipyridamole".

Ksantinola nicotinate kunciphisa ukusebenza kwe adenosine triphosphate, futhi "carbamazepine", kunalokho, sithuthukisa umphumela wawo.

Kanye "theophylline", ne-caffeine ibonakala umbango.

Nciphisa ukumuncwa zomuthi potassium izakhamzimba, cyanocobalamin aminoglycosides, antiepileptics, salicylates futhi "Colchicine".

Ukumuncwa cyanocobalamin encishisiwe ngenkathi nedili lomshado nabo "Polymyxin", "Kanamycin", "Neomatsinom" futhi "tetracycline".

Cyanocobalamin aluhambisani ne ascorbic acid "riboflavin" "pyridoxine" futhi elisindayo zensimbi.

Izindlela zokuvimbela inzalo cyanocobalamin temlomo ukunciphisa lokuhlushwa igazi.

Izindleko kanye analogue

Kungakanani buyisidakamizwa "Kokarnit"? Yokusetshenziswa ngeke ukuphendula lo mbuzo. Kungatholakala kubhalwe kuphela ikhemisi. Njengomthetho, intengo imali izitsha eziyisikhombisa ezintathu kuyahlukahluka ngaphakathi ruble 120-150.

Isixazululo kungenziwa indawo umzimba "Kokarnit"? Imiyalelo, ukubuyekezwa bathi analogue kwesakhiwo sale ukulungiselela akekho. Ukuze bavale isikhala salo imikhiqizo efanayo kubalulekile ukubona udokotela (Ngokuvamile zitusa "Ismizhen", "Venogepanol", "Yekani", "Ortsipol", "Sterillium", "Dioflan", "Collomak", "Hondrozamin", "Endofalk", " Seknidoks ").

Izibuyekezo

Manje uyazi isimiso 'Kokarnit "izidakamizwa. Umyalelo, i-analog zomuthi banikezwe ngenhla.

Ezimweni eziningi, lokhu ejenti isetshenziswa esithinta izinzwa, ukuhlinzwa zenhliziyo neurosurgery. Ochwepheshe uqaphele ukuthi le imithi ingazidambisa inani enxebeni ukususa ubuhlungu vertebral.

Kufanele kuphawulwe ukuthi kubhekwe izidakamizwa okuye kungase kutholakale ku nokwelashwa kweziguli sciatica discogenic. Kulokhu, lesi sidakamizwa kufanele usetshenziswe intramuscularly nge 2 ml nsuku zonke kwaze kwaphela amasonto 2-3.

Imiphumela engemihle e iziguli ningagcini leli thuluzi.