Hormone hypothalamic ukukhulula

hormone Ukukhipha kukhona neurohormone wesintu kwemiqondo nucleus hypothalamic. Bona zivimbela (ama-statin) noma ukugqugquzela (liberiny) ukukhiqizwa kwama-hormone utho pituitary. Owenza usebenze nezindlala endocrine, futhi kukhona ukulawulwa ukukhishwa kwama-hormone. Izingxenye ephakeme we isimiso sezinzwa esiyinhloko futhi endocrine uhlelo zihlobene ngenxa hormone lokukhululwa.

umsebenzi hypothalamic

Enye yezingxenye ezibaluleke kohlelo endocrine obhekene ekukhiqizweni kwama-hormone - hypothalamus. Ikhishwa izinto ngxenye kukhona hormone ehilelekile izinqubo umzimba emzimbeni.

Ngo hypothalamus kukhona amangqamuzana ezinzwa ukuqinisekisa ukuthi ukukhiqizwa izinto ezidingekayo umzimba udinga ukusebenza evamile. La mangqamuzana abizwa ngokuthi neurosecretory. Umsebenti wabo - ukuthola pulses adlulisa ezingxenyeni ezahlukene isimiso sezinzwa. izakhi Ukuba Wedwa kwenzeka ngokusebenzisa aksovazalnye synapse.

Ikhishwa hormone hypothalamic ukukhulula, noma njengoba bebizwa kanjalo ngokuhlukile, statin futhi liberiny, kubalulekile ukuze ukusebenza evamile indlala pituitary. Ngokwemvelo yabo zamakhemikhali, zingabantu peptides. Ngenxa amaza chemical futhi izinzwa kuyinto zamagama abo, basuke uthuthwa igazi yi pituitary uhlelo hypothalamic-pituitary.

Ukwahlukaniswa hormone

Cabanga hormone ukukhulula kunazo owaziwa:

• Ezivimbela uketshezi of pituitary umsebenzi - kuba somatostatin melanostatin, prolaktostatine.
• Ivuselela - sikhuluma melanoliberine, prolaktoliberine, folliberine, lyuliberine, somatoliberin, i-hormone thyrotropin-ukukhulula, i-hormone gonadotropin-ukukhululwa corticotropin.

Lezi izinto, noma kunalokho ezinye zazo, kungenziwa cishe ezivezwa nezinye izindikimba, hhayi kuphela hypothalamus (isb, amanyikwe).

Statin futhi liberiny

Ukusebenza indlala pituitary kuyinto encike ngqo kwi kubo. nazo ziba nomthelela ekusebenzeni neuropathy endocrine nezindlala:

• yegilo;
• amaqanda e amantombazane;
• testes kwabesilisa.

Statin futhi liberiny okuyinto enhle eyaziwa kakhulu yilezi:

• Dopamine;
• GnRH (lyuliberin, folliberin);
• melonostatin;
• somatostatin;
• tireoliberin.

I uketshezi of luteinizing kwama-hormone hormone follicle-inkanuko we pituitary GnRH ukunikeza.

On umsebenzi androgen ezingabantu futhi kungathinta GnRH, neqhaza ekwandeni womsebenzi isidoda kanye nezinga libido.

Futhi abesifazane neurohormone obhekene nomjikelezo wokuya esikhathini, inani lama-hormone siyahlukahluka esigabeni lomjikelezo ke.

ukukhiqizwa ezinganele lokukhululwa hormone ngokuvamile kubangela ukungazali nokuvusa induku.

Izimpawu hormone

i-hormone Corticotropin obhekene imizwa yokukhathazeka, ekhishwa le ngxenye. Lena enye ukukhulula esibalulekile, esebenza ngokuhlanganyela amahomoni pituitary nemiphumela yabo phezu nezindlala adrenal. Abantu ngenxa yokuntula le hormone ngokuvamile uhlushwa umfutho wegazi ophakeme, futhi esingamahlalakhona adrenal.

GnRH - hormone sithuthukisa ukukhiqizwa gonadotropins - futhi umkhiqizo hypothalamus. Ibizwa nangokuthi i-hormone gonadotropin-lokukhululwa.

Ukusebenza evamile Izitho zokuzala ngeke akwenze ngaphandle GnRH. Kuyinto le hormone obangela Yiqiniso engokwemvelo umjikelezo wokuya esikhathini kwabesifazane. With iqhaza lakhe isifika inqubo nokuvuthwa kanye ukukhululwa kwe-amaqanda. Lokhu i-hormone unesibopho libido (ubulili drive). Lapho kukhona ukukhiqizwa enganele hormone ngu hypothalamus e abesifazane esikhathini esinengi ithuthukisa nenzalo. Yini enye kuthiwa ukukhulula hormone?

somatoliberin

Iningi ngokushesha adedelwa esakhula. Sici Its main yinqubo ukuzinza of isitho ukukhula izinhlelo zomzimba. Kusukela ukukhiqizwa kwawo kuxhomeke kulokho ukuthuthukiswa okugcwele ukwakheka ingane. ukukhiqizwa ezinganele le-hormone kusukela hypothalamus kungaholela ukubhasha komzimba (ukubhasha komzimba).

Prolaktoliberin

ukuthuthukiswa yakhe ezimatasa kwenzeka ngesikhathi sokukhulelwa futhi phakathi nayo yonke inkathi ukunikeza umama wengane. Lokhu isici ukukhulula normalizes ukukhiqizwa kwe prolactin, ukwakha Amapayipi we nezindlala mammary.

Prolaktostatin

Prolaktostatin kubhekisela esenzakalweni esiyisimangaliso subclass ka-statin ezivezwa hypothalamus, obangela okusithiyayo of prolactin.

Ngu prolaktostatinam zihlanganisa:

· Dopamine;

· Somatostatin;

· Melanostatin.

Isenzo sabo esiyinhloko kuhloswe abacindezela hormone ifasitelana le pituitary futhi ngxenye.

Melanotropin-ukukhulula ama-hormone

Ngo inqubo sombala i-melanin nokuhlukaniswa amaseli kuthinta melanoliberin. Wabuye enza izinto izakhi DWP pituitary.

Zithonye nokuziphatha neurophysiological. Isetshenziselwa kokukhipha ekwelapheni uthi bacindezeleke futhi parkinsonism.

Thyrotropin-ukukhulula ama-hormone (TRH)

Ngu-hormone thyrotropin-ukukhululwa hypothalamus kusebenza thyroliberine. Ukhuthaza ekukhiqizweni kwama-hormone we anterior pituitary thyritropic.

Ngokwezinga elithileko encane inomthelela inqubo prolactin. Thyroliberine sithuthukisa lokuhlushwa thyroxine egazini.

CNS kunethonya elikhulu ku izinqubo ekukhiqizweni kwama-hormone. Ukuze kukhiqizwe neurohormones banesibopho iseli neurosecretory uhlelo lokulawula lolu hlelo.

Imisebenzi Basic liberinov

Lokhu hypothalamic ukukhulula hormone. Yenza imisebenzi zokulawula. GnRH kujwayeleke ukusebenza kwesimiso sokuzala besifazane nebesilisa.

Bazi ukuthi banesibophezelo ukukhiqizwa hormone follicle-kuqabula futhi kuthinte ukusebenza kwe-testes futhi ezikhiqiza amaqanda.

isakhi okunjalo njengoba lyuliberin, ihumusha lehlukanisa nomthelela nge-ovulation, ukwakha kungenzeka ukuba akhulelwe fetus.

Abantu besifazane abane-qakala ukuphila obuseduze, futhi lyuliberin folliberin akhiqizwa izinto eziningi enganele.

Kukhona futhi kukhishwa izici eziphathelene share isilinganiso hypothalamus, kodwa uxhumano yabo kuze pituitary anterior pituitary amaseli bese ezingazange wafunda.

Agonists ukukhulula ama-hormone: izidakamizwa

Njengoba sekuphawuliwe kakade, la ma-hormone ekhiqizwa ngxenye. Lapho ibizwa oyifunayo ukuze sikhuthaze amaqanda, isibonelo ngaphambi inqubo IVF, wasebenzisa agonists noma corticotropin ukukhulula ama-hormone analogs. Okungukuthi, banayo emzimbeni nomphumela ofanayo njengoba i-hormone ayo.

Kodwa amathuba ukusabela ezingezinhle phezu ingxenye yomzimba zesifazane. Lokhu kwenzeka ngenxa amazinga estrogen aphansi. Imiphumela ezivamile zihlanganisa:

• ikhanda;
• ukujuluka ngokweqile;
• komzimba;
• isitho sowesifazane somile;
• kwemizwelo;
• ukucindezeleka.

Izidakamizwa asetshenziswa ngale ndlela:

• "Diferelin" kuyinto yokufakelwa decapeptide Analogue of hormone zemvelo lokukhululwa.
• "Dekapeptil" njengengxenye triptorelin, i Analogue yokufakelwa of GnRH. Ingxenye-ukuphila isikhathi eside. Ngokuvamile esetshenziselwa insemination yokufakelwa.
• "Lyukrin edepho" - leuprorelin. It has anti-estrogen, umphumela anti-androgenic, uphulukisa endometriosis, izimila ama-hormone engaphansi - umdlavuza wendlala yabesilisa, lesizalo fibroids. "Lyukrin edepho" kunciphisa lokuhlushwa testosterone amadoda, estradiol kwabesifazane, ngaphezu, kuvimbela pituitary incretia FSH, LH.
• Effect zomuthi kancane kancane, elikhishiwe kwezinye izinguqulo uketshezi bokuphila hormone.
• 'Zoladex' - Analogue zokwenziwa of engokwemvelo-hormone okuthiwa i-hormone okuthiwa i-ukukhulula (LH). Ngokuvamile esetshenziswa IVF. Yehlisa lokuhlushwa estradiol egazini, lokhu kwenzeka ngenxa nokucindezela LH uketshezi of anterior pituitary.
  

Saxoxa amalungiselelo agonists ukukhulula hormone.

abamelene

Kusukela lapho ithola ukukhulula ama-hormone agonists inyuka ngokudlulele estradiol kungenzeka ukukhululwa ngokushesha luteinizing hormone. Lokhu kuholela nge-ovulation ngaphambi kwesikhathi futhi ukubhujiswa amaqanda. Ukuze ugweme lokhu, abamelene ukukhulula ukusetshenziswa hormone. Ngenxa yalokho yezenzo zabo kusukumisa indlala pituitary futhi. Wesibeletho hyperstimulation syndrome akusho ukuzibonakalisa, kodwa kaningi kwenzeka ngenxa ukusetshenziswa eside GnRH agonists. Iphathwa zingakapheli izinsuku ezinhlanu kusukela kuqale isicelo of follicle eqabulayo hormone.

Ukuze ukwelashwa kuphumelela, zonke izinjongo amalungiselelo kufanele kuphela onguchwepheshe.