"Esomeprazole": yokusetshenziswa, nozakwabo yangempela

"Esomeprazole" - umuthi kungokwalabo Organotropona izidakamizwa emathunjini. Umuthi has antiulcer isinyathelo futhi kuyinto inhibitor proton futha.

Ukwakheka, ifomu ukukhululwa "esomeprazole" izidakamizwa

Umuthi itholakala ngendlela amaphilisi nge umthamo 20 no-40 mg esebenzayo isithako esomeprazole, kanye uhlobo powder senzelwe isixazululo umjovo (40 mg isitsha). amaphilisi Camera, nokonakala ebanjwa emathunjini.

isinyathelo kwemithi "esomeprazole" izidakamizwa

Uyini izidakamizwa "esomeprazole"? Yokusetshenziswa ubonisa ukuthi lokhu ejenti antiulcer, okuyinto, ngokuba isisekelo ababuthakathaka, uthola ifomu asebenzayo ngemva ukungenisa. "Esomeprazole" kuvimbela enzyme H ⁺ -K ⁺ -ATPase umsebenzi, futhi uketshezi of hydrochloric acid (inkanuko yobulili, i-basal). izinyathelo ezidingekayo kwenzeka kungakapheli ihora ngemuva ukungenisa isidakamizwa. Lapho ethola "esomeprazole" wenza zonke, okwensuku ezinhlanu, umthamo ovumelekile nsuku zonke - 20 mg ngemva ukushukuma ngu pentagastrin ileveli enkulu hydrochloric acid kuyehla kakhulu (90%).

Pharmacokinetics

"Esomeprazole" yokusetshenziswa kunjengesipho izidakamizwa lapho, engena ngaphakathi emzimbeni, ngokushesha futhi kahle amuncwa umzimba, sibopha ukuthi amaprotheni cishe 100% (97%). I bioavailability anda ngokusebezisa ngokuphindaphindiwe zomuthi kusukela 64 kuya 89%. I nomuthi uthatha uhlobo metabolites futhi excreted ngokuyinhloko emchamweni, ingxenye encane yawo ekhona indle.

Izinkomba "esomeprazole" ukulungiselela

"Esomeprazole" analogue isetshenziswe ezigulini nge gastroesophageal isifo Reflux ngokwelashwa nokuvimbela kokushelela. Ithuluzi isetshenziswa ekwelapheni izilonda isisu noma duodenum, ukuvimbela isifo ezivukayo ngenxa ama-NSAID.

Umuthi elisetshenziswa isilonda peptic lapho abathintekayo duodenum noma isisu. Kungasetjenziswa iziguli baye belashwa esophagitis, ngesikhathi isikhathi eside lokubuya kwesifo lokuvikela. isicelo OKUVUMELEKILE ezikanye izindlela "esomeprazole" izidakamizwa elwa namagciwane. Amaphilisi kanye umjovo e yokwelapha eyinkimbinkimbi Kulokhu uvumele ukubhubhisa Helicobacter pylori.

Izimo ethola "esomeprazole" izidakamizwa

Izimo zihlanganisa yobudala engaphansi kuka-iminyaka eyishumi nambili, hypersensitivity kuya esomeprazole, kwenkathi ibele. Imiphumela imithi ungazange sezisunguliwe ngesikhathi sokukhulelwa.

izidakamizwa yokusetshenziswa

Umuthi isetshenziswa umthamo wansuku zonke 20-40 mg. Isikhathi yokwelapha kunqunywa izinkomba lwemithi reception kahle nomuthi "esomeprazole". Amaphilisi kanye kanzima isixazululo esilazayo at esingamahlalakhona kwezinso usebenzisa umthamo esiphezulu 20 mg.

Erosive Reflux esophagitis iphathwa amasonto amane nge umthamo zonke izinsuku we-40 mg. Phakathi nokuvinjelwa eside Ukuphinda esekelwe reception kusho isiguli lapho esophagitis owayelaphekile, umthamo wansuku zonke isethwe ku ezahlukene mg 20.

Ngo ekwelapheni Reflux oesophagitis, okuhloswe ngalo ukubhekana ezihleli izimpawu isifo, ukuthatha 20 mg izidakamizwa "esomeprazole". Amalungiselelo ngesimo amaphilisi kanye powder isetshenziswa ukubulala H. Pylori, uma kukhona ukuxhumana isilonda duodenal, ngendlela ukwelashwa - "esomeprazole" (20 mg), "Clarithromycin (500 mg)," amoxicillin "(1 g). Zonke imithi kuthathwe kabili ngosuku.

Izilonda esiswini okubangelwa ama-NSAID, kutuswa ukuba aphathe 20 mg "esomeprazole" ngosuku. Umthamo oyifunayo njalo yabelwe udokotela ikhumbula impilo isiguli, isifo, kobukhulu busebenze, nezinye izinto ezibalulekile.

Imiphumela Side "esomeprazole" izidakamizwa

Iziguli zithatha lezi izidakamizwa isikhathi eside, nivame kumiswa izinhlumba yezindlala esiswini kunezinye iziguli. I njalo kunazo ukubonakaliswa emibi emzimbeni ngesikhatsi ukwelashwa kusho "esomeprazole" imfundo on isicelo inike ikhanda futhi abanye abantu basabele ngendlela embi kusukela ipheshana emathunjini, ezifana: ukuqunjelwa, ukubuyisa, ukukhishwa isisu, isicanucanu, ukuhlanza, khona ubuhlungu esiswini. Ngu lingandile imiphumela emibi ibandakanya omiswe le mucosa emlonyeni, isiyezi, urticaria, ukulunywa, dermatitis. Okunye ukusabela kungenzeka, ngakho ukwelapha kumelwe kwenziwe ngokuqinile ngaphansi kweso onguchwepheshe.

Overdose kuhambisana ubuthakathaka jikelele, okwandisa legciwane yemiphumela emibi, kuhlanganise ingxenye ipheshana wokugaya ukudla. Ezimweni ezinjalo, ukwelashwa wenziwa ekuqedeni izimpawu ukweqisa izidakamizwa kanye therapy yesondlo. Dialysis has cishe awekho siletha imiphumela efiselekayo, lingekho ikhambi.

Izixwayiso

Abesifazane abakhulelwe "esomeprazole" analogs iqondiswa ngokucophelela okukhulu. Ukwelashwa ngesikhathi sokukhulelwa kufanele wawuqondiswa udokotela. isidakamizwa ezinqunyiwe kwabesifazane abakhulelwe kuphela lokhu ikakhulukazi ezimweni lapho igalelo elihle emizimbeni yabo kakhulu lidlula nobungozi ukuba nomntwana ongakazalwa. idatha Esinokwethenjelwa umphumela isidakamizwa umbungu akukafiki ngangokunokwenzeka kufanele bagweme ukuphathwa nale imithi. Ukusebenzisa izidakamizwa "esomeprazole" lapho ukuncelisa ibele akuvunyelwe.

Lapho ukwephula kwesibindi kokweqa umthamo isethi yingozi empilweni (uma lokho kwephula mabi).

Lapho izimpawu isiguli ibhalwe isignali, ezifana hematemesis, dysphagia, isicanucanu, ukunciphisa okuphawulekayo esisindo ngesikhathi ukwelashwa "esomeprazole" ukuze aqede noma isilonda ngenxa ngokuthatha izidakamizwa e nokuba khona isifo kusolwa, umdlavuza kufanele zisuswe. Ukukhomba uhlobo abulalayo izimila kuyadingeka azokuqhubela isifundo.

Iziguli kufanele ukuntula sucrase-isomaltase, lezinceku fructose ukungabekezelelani uhlamvu uvunyelwe ukuba ubeke "esomeprazole" omqondofana.

Ukuxhumana "esomeprazole" nezinye izidakamizwa

With ukusetshenziswa ngesikhathi esisodwa izidakamizwa nge "citalopram", "clomipramine", "imipramine" potentiation kungenzeka kwala magciwane, ngcono we ketshezi esebenzayo egazini. Lapho isetshenziswa ngesikhathi esifanayo ne "esomeprazole" encishisiwe kahle "ketoconazole" "Itraconazole" siba sibi ukumuncwa kwabo.

Lapho ngokuhlanganisa "esomeprazole" nge "ATV" Lo magazini uye waba ukwehla okukhulu exposure yalesi izidakamizwa. "Esomeprazole" imfundo yokusebenza is hhayi Kunconywa ukusebenzisa kanyekanye ne "phenytoin", "clomipramine", "imipramine" nezidakamizwa ezifana "citalopram", "Diazepam", "Nelfinavir" futhi "Atazanavir". Izinga le mithi uyakwazi ukuthi iyophumela igazi, ngakho-ke kungase kube efiselekayo wehlise imithamo yabo. ukusetshenziswa concomitant of «esomeprazole" futhi lisho "clarithromycin" kuholela ushintsho olukhulu ohlotsheni ukuchayeka "esomeprazole" livela okwandisa ahlotshaniswa ne okusithiyayo lokugayeka kokudla izidakamizwa. Yikuphi kufanele kucatjangwe ngako ngekucophelela instrukiyu emuthini futhi uthintane onguchwepheshe.

Izindleko zomuthi, izibuyekezo mayelana izidakamizwa "esomeprazole"

Umuthi ikakhulu labawatfolile esifundvweni nobe ifomu tablet. Amakhemini "esomeprazole" kungatholakala ngaphansi amagama ukuhweba "Nexium" futhi "Emanera". Uma ukuthenga izidakamizwa "esomeprazole" intengo lincike umthamo we ketshezi asebenzayo ngezithako zawo. Lokho okwakudingeka ukuze kukhokhwe izidakamizwa ngesikhathi umthamo 20 mg ( "Emanera") kuyinto ruble mayelana 500. amaphilisi 28 futhi uzimisele ngumkhiqizi. Imithi kanye umthamo we-40 mg isithako esebenzayo ( "Nexium" amaphilisi 28) angathengwa ruble 3000.

"Esomeprazole" has Izibuyekezo ikakhulukazi omuhle. Baphawula impahla izidakamizwa ekuvimbeleni uketshezi acid, kokubili basal inkanuko yobulili. Umuthi luye lwabonisa kusebenta okusezingeni eliphezulu ekwelapheni izimo ezifana izinkomba elicacisiwe imfundo. Phakathi ukwelashwa, lokhu kusho kukhona okungenzeka okuncane amathuba okuba nemiphumela engemihle. Akuwona wonke umuntu kalula ukwazi ukuthola izidakamizwa Pharmacy, ezinye iziguli obamukele "esomeprazole", intengo kubonakala okusezingeni eliphezulu.

Labo ababamba imithi udokotela emva kwencazelo eqondile kwesifo kanye umthamo watusa, ukumaka ekwenteni ncono impilo. Njengoba nokubuyekezwa, "Nexium" zithandwa kakhulu iziguli kuka "Emanera". Lapho "Nexium" esiswini inikeza ukubukeka elamukelekile ngemva inyanga eyodwa ngemuva Ukuqalwa yokwelapha. Ukuthuthukisa isimo, zingaba khona ngemva 1.5 amasonto yokwelashwa. ukungaphathwa kahle imithi kuba ivelakancane. Izidakamizwa "Nexium" ngempumelelo, kuyasiza ne ukuqeda izimo okukhulunywa ngazo imiyalo. Lokho umphumela omuhle, kubalulekile ukuqeda yonke inkambo yokuhle nokubambelela ngokugcwele izincomo udokotela.

Analogs "esomeprazole"

Kuvela okukhethwa kukho okulandelayo ungabahlukanisa kusukela analogue zomuthi:

• "Omeprazole" - ngokuthi "Losek", "Omez", "Ultop" futhi;
• "Rabeprazole" - isilungiselela eyaziwa ngaphansi amagama "Ontaym", "Zulbeks", "Noflyuks" "Pariet", "Hayrabezol";
• "Pantoprazole" ( "Sanpraz", "Kontrolok", "Nolpaza");
• "Lansoprazole" ( "Lanza", "Lanzoptol").

Zonke lezi izidakamizwa nemiphumela efanayo, kodwa ihluke nomunye value abo.

Engaqhathaniswa "esomeprazole" futhi "Omeprazole". Ukungaboni ngaso le mithi zisobala. "Esomeprazole" kuyinto isomer "omeprazole". Lokhu ukulungiselela, kusukela wezokwelapha idatha izincwadi, has a inzuzo enkulu, kodwa isenzo ezifanayo ukuthaka imithi. "Omeprazole" kuyinto ukubaluleka izidakamizwa kwegciwane inani elikhulu amathuba okuba nemiphumela engemihle. Uma sicabanga izakhiwo "esomeprazole", umuthi uvezwa njengoMahluleli inguqulo ethuthukisiwe ye "omeprazole", intengo zazo idonse iziguli eziningi. Nokho, "esomeprazole" mancane amathuba okuthi baxabane okungafunwa, ngakho ukuthenga yayo kubhekwa inzuzo engaphezu kuka-ukuthenga "Omeprazole".

"Rabeprazole" futhi "esomeprazole" efanayo amakhemikhali ukwakheka, abaphatha ngayo isifo esifanayo. Kodwa ochwepheshe bakholelwa ukuthi ezinye izifo, ezifana nesifo gastroesophageal Reflux, "Rabeprazole" aqede ngempumelelo ngaphezulu, it ususa izimpawu kangcono, kunomthelela ukululama ngokushesha imisebenzi emphinjeni. Ukungabi khona nomphumela omuhle ekwelapheni "esomeprazole" kungenzeka ukuthi umataniswe onalezizimpawu ngabanye umzimba.

Uma kudingeka, khetha Analogue kufanele kudokotela. Phatha eyinakekela kahle impilo yabo, futhi baphumelele ekuhlolweni ngesikhathi, bese yokutakula kuyoba ngokushesha futhi ngeke zokugwema izinkinga eziningi.