"Buspirone": ukubuyekezwa, yokusetshenziswa, analogs

"Buspirone" libhekisela izimali sinomthelela isimiso sezinzwa. Kuyinto anxiolytic, yakhelwe ukuqeda ukukhathazeka nokwesaba, ukuzinza wobuthongo, ngcono inhlalakahle ebukhoneni neurosis. Tablets "Buspirone" ezinye Izimo, futhi kungabangela imiphumela emibi.

Ukwakheka kanye uhlobo "Buspirone" izidakamizwa

Umuthi itholakala ifomu tablet ngesikhathi umthamo 5, 10 no-20 mg. I asebenzayo izidakamizwa izidakamizwa - buspirone. izinto Asizayo zihlanganisa potassium hydroxide, corn isitashi, magnesium stearate.

imiphumela kwemithi

Isenzo we sine izidakamizwa, anxiolytic. Umuthi kususa izimpawu yokwesaba vegetative nempilo yengqondo. kusho lo mshini wezenzo bengayiqondi ngokuphelele, kodwa ukuthi "Buspirone" kuhlukile benzodiazepines nezinye izidakamizwa umphumela anxiolytic ezaziwayo.

Umphumela onamandla inhibitory phezu CNS ngemuva kokuthola okungaxhunyiwe "buspirone" amaphilisi. Yokusetshenziswa kubonisa ukuthi izidakamizwa kunciphisa kwetinhlavu kanye ukukhululwa kwe-serotonin, kubamba serotonergic, ikhuthaza ivimbela Dopamine D2-receptor (ezikhumulweni postsynaptic futhi presynaptic), ngesivinini excitation ka Dopamine izinzwa ise ubuchopho obuphakathi. Ngemva ukuqedwa zomuthi kungukuthi ngilugcinile nesenzakalo kwezimpawu zokuqaleka nokukhathazeka ukubuya.

Umuthi senzelwe abaphathi ngomlomo. Engena phakathi komzimba esifushane ukuthi ukuzigcina egxile ngokuphelele ekufundeni ipheshana wokugaya ukudla. Ngenxa yalokho, umzimba olubanzi bioavailability kuyinto% 4 kuphela. Izinga esiphezulu zomuthi egazini kufinyelelwe cishe ihora ngemva Ukungena ku pheshana emathunjini. Isigamu-ukuphila Kwenziwa amahora 2-3, sesibopho ukuthobisa plasma amaprotheni sifana 95%. Okuqhubekayo nokusebenzisa "buspirone" akuphazamisi ukusebenza yayo.

Phakathi ukuphathwa kwabo, ungayigcini nje ulindele "Buspirone" kusho ukusebenza. Yokusetshenziswa ebonisa ukuthi ukuphumelela izidakamizwa esikhathini kusukela 7th ukuze ngosuku lwe-14 wavuma. Umthelela esiphezulu zomuthi wabonakaliswa emva mayelana 120 izinsuku ukwelashwa.

Izinkomba "buspirone"

Ochwepheshe akunikeze imithi uma uzizwa ingozi, okwembula ukwesaba nokukhathazeka, nangayiphi indlela ukucasuka eyashukumisela okwenzeka omnene neurosis futhi izinkinga zokulala, okuyinto abe umlingisi ehlelekile. Umkhiqizo kufanelekile ekwelapheni izifo ukuphathwa kwabathintwayo, dystonia vegetative nokucindezeleka, ukuqeda ukucindezeleka, utshwala zokuqaleka.

Izimo ethola "Buspirone" izidakamizwa

"Buspirone" (analogue zomuthi kanye) has Izimo. Umuthi yasekuqaleni sinqatshiwe ukuthatha ezimweni ezinjalo:

• glaucoma (uhlobo evaliwe);
• izinqubo sokugembula esindayo okwenzeka isibindi kanye nezinso;
• isithuthwane;
• iziyaluyalu senhliziyo, izinkinga nemithambo yegazi;
• izilonda ipheshana zokuphefumula;
• myasthenia gravis;
• Hypersensitivity kuya izingxenye;
• inkathi abantwana, ukufukamela esifubeni;
• yobudala engaphansi kuka-18 ubudala.

Uma kukhona akuvunyelwe nhlobo ukuba linqume amaphilisi a "Buspirone" nesineke umlando nesimo sokuquleka noma isithuthwane.

Ngaphambi kokuqala ukwelashwa kufanele uhlole ukuzwela lesiguli izidakamizwa.

Ukusetshenziswa kwezimali, umthamo

Phakathi ukwelashwa kusho isicelo "buspirone" ka ezibhebheni ezenziwe ngokuhambisana nezincomo udokotela ekwelapheni. Umhlahlandlela Esemthethweni liqukethe ulwazi oludingekayo ukuze umthamo ngamunye nesineke ezahlukene, isb. K. ukwelashwa ngamunye wesifunda inquma ukusebenza yokwelapha kwenziwa. Umthamo kuncike empilweni yesiguli. izincomo Jikelele zimi kanje:

• Kokuqala esiteji - 3 esenikwe 5 mg zomuthi;
• ukuqhubeka nezinhlelo zokwelashwa ngama-- ukwenyuka kancane umthamo kuhambisana isikhawu izinsuku 2-3 of (uma kunesidingo esinjalo);
• esasikhipha ukuba umthamo sangemihla se-50 mg (ngokungabi bikho umphumela oyifunayo).

Tablets "Buspirone" yokusetshenziswa izimvume kuphela athathe isimo iyonke, abakwazi siyochithwa in uketshezi, gaya futhi ukuhlafuna. Umuthi udakwe amanani ezinkulu yamanzi, kuthathwe nganoma isiphi isikhathi sosuku ngokuzimela ukudla. Isikhathi izinga Kunconywa izinyanga 4. The eside kulesi sikhathi iphathwa "buspirone" is hhayi Kunconywa.

Imiphumela Side "buspirone"

Lapho abanye ukusabela engathandeki umzimba imithi kungatholakala. Ngokwesibonelo, ukozela, jikelele impilo ukuwohloka, ubuthakathaka, ukukhathala, nokunganaki. Uma kukhona imiphumela enjalo idinga ukususwa izidakamizwa. Kufanele uxhumane nodokotela wakho futhi ziyitshela ngale izinguquko ezimbi emzimbeni ngemva kokuthatha iphilisi "Buspirone". Yokusetshenziswa ezimweni ezinjalo kunconywa ukunciphisa umthamo ejenti. Uma side effects musa ukumuka, udokotela kufanele esikhundleni nezinye izidakamizwa imithi ezifanelekayo.

Ezimweni ezingavamile kakhulu, ukusetshenziswa "buspirone" kuholela ukuphazamiseka isimiso sokugaya ukudla bungene. Ngokwesibonelo, kungase kube nesicanucanu isilungulela, kulandele ukuhlanza. ubuhlungu Kunokwenzeka esifundeni epigastric. Kungenzeka kukhona ezinye imiphumela emibi. Zonke lezi zimpawu ukhombise ukungabekezelelani yezingxenye izidakamizwa.

Overdose "Buspirone" izidakamizwa

Uma ithuluzi isetshenziswa ngemithamo ephakeme kunaleyo Kunconywa, umuntu ingase ibe nezimpawu ezithile ukweqisa izidakamizwa. Lezi zihlanganisa isicanucanu nokuhlanza, izinkinga zesisu lomunye hlobo. I isiyezi nesineke, ukuvala abafundi, kungaba ukulahlekelwa emfushane ukwazi. Iziguli shiya isibuyekezo emva kokwelashwa kusho "Buspirone Sandoz", waphawula ukuthi kungenzeka ukudideka, engenhla esitho liqhaqhazela. Phakathi kwezinye izenzo ukweqisa izidakamizwa - ukucasuka, ukucasuka, izinguquko njalo kwemizwa. Overdosing iphathwa ngu lavage esiswini, abaphathi carbon isebenze emzimbeni, yokwelapha lingaze futhi siqhuba ukulawula njalo wegazi, kwenhliziyo, umsebenzi zokuphefumula. isihlungu Specific ngempumuzo izimpawu ukweqisa izidakamizwa "buspirone" alikho nhlobo. Dialysis ezimweni ezinjalo engalethi umphumela oyifunayo.

Ukuxoxa izinto ezihlukahlukene kanye nezinye izidakamizwa

Ngezinye izikhathi lapho inhlanganisela kungavunyelwe kwezidakamizwa ezithile amaphilisi "Buspirone" yokusetshenziswa of analogue incoma ucabangela indawo sikhungo sokuqala. Kuyaziwa ukuthi izidakamizwa akufanele kuthathwe kanye kanye zinhlungu, sedatives ngenxa ukuthuthukisa umphumela izidakamizwa athathwe. Ekwelapheni "buspirone" ezidingekayo ukukhipha ukusebenzisa uphuzo oludakayo. Awukwazi ukuhlanganisa imithi nge Mao inhibitor ngenxa ingozi crisis abanomfutho wegazi ophakeme.

Uma usebenzisa kokubili "Haloperidol" nge "buspirone" egazini kwandisa izinga yalesi izidakamizwa. Ukuhlanganisa imithi nge "trazodone" kuholela nokwanda okuphawulekayo ALT.

Ngenxa yalokho zokuhlolwa okwakuhilela izilwane, ukonakaliswa umzimba awuzange itholwe ngenkathi yokwelapha. Nokho, ukuze sigweme ukusabela engathandeki umzimba ukukwamukela ukunikeza.

"Buspirone" yokusetshenziswa kunjengesipho ithuluzi lakhe umzimba esibindini. Kule nqubo iqhaza CYP3A4, ngokuba isoenzyme iqhaza ukucubungula umzimba nokulungiselela. Ngenxa yalesi sizathu, ukuxhumana kungenzeka "buspirone" nezidakamizwa okuyizinto inducers, noma inhibitor of enzyme.

Izici ukusetshenziswa kwezidakamizwa

Uma, ngesikhathi lactation, kukhona isidingo yokwelapha, esekelwe yokwamukela "buspirone" ibele kumisiwe okwesikhashana.

Kukhona ezinye imikhawulo lapho ukuphazamiseka ukusebenza izitho zangaphakathi. Ngokwesibonelo, uma unezinkinga isibindi kufanele uqaphele ngesikhathi ukwelashwa kanye sihlale njalo siqaphele izinguquko ezenzeka nezempilo. Izimo kuphela kwezinso ezinzima ekusebenzeni emzimbeni. Kuyefana nasendleleni umsebenzi izinso.

Ngokuphathelene aphoyintimenti ejenti ezivela abakhiqizi ezahlukene, e Umq. H. "Buspirone Sandoz" izidakamizwa, ukubuyekezwa yezokwelapha ukuphakamisa isidingo ukuba zihloniphe imithetho yesikhathi esithile. Ukubhala izinto imithi, onguchwepheshe kufanele uqaphele ukuthi leli thuluzi akakwazi ukuqeda izimpawu zokuqaleka okubangelwa benzodiazepine, nenjongo yayo ezimweni okunjalo akunakwenzeka, uma kungekhona sikhipha kwezidakamizwa anxiolytic yadalwa ngaphambi kokwelashwa.

Iziguli kufanele uqaphele ukuthi amaphilisi "Buspirone" ezingase zithinte ukunakekelwa, ikakhulukazi ekuqaleni ukwelashwa, ngakho kungcono uyeke okwesikhashana imisebenzi ezihilela wemfanelo okhethekile okuhlushwa anda. Abanye imisebenzi kungaba yingozi empilweni.

Ngokuphathelene yokwelapha "Buspirone" usho ukuthini, odokotela real mayelana izidakamizwa ikakhulukazi omuhle. Nokho, ochwepheshe aveze ukuthi kubalulekile ukuba nika kahle kuphela izinkomba ezifanele kanye ngemithamo elilungile. Kufanele kuqashelwe ukuthi ukucindezeleka nokukhathazeka ukuthi uvuke umthelela unomphela engakhi ukucindezeleka kwansuku zonke, ukwelashwa nge anxiolytics ngokuvamile akudingekile.

Ukwamukela kusho iziguli "buspirone" nge umthamo ezahlukene, isb izidakamizwa "buspirone 10 mg" Izilinganiso zimelela ukusetshenziswa indlela ephumelelayo. Abantu ababeka babephathwa nale imithi, uqaphele ukuthi udokotela wayebaxwayisile ukuba ukusebenzisa ngokucophelela kunemithi noma amaphilisi owaphuzayo, ezifana nokukhandela imbeleko temlomo, imithi yokwelapha isifo sikashukela, ejenti okukhomba nokwehla kwezinga eliphakeme lomfutho wegazi, izidakamizwa ukuqeda ukucindezeleka futhi izidakamizwa ezifana glycosides inhliziyo , neuroleptics.

ukwehluleka kwezinso futhi ezinzima isibindi sibe sesomile zidinga nokwehlisa umthamo amayunithi. Kulezi zimo, indlela "Buspirone Sandoz" libuyekeza indlela abantu ukuchaza ukwelashwa liyadingeka esizosingathwa ngaphansi kokuqondisa kukadokotela. Okumele kuqashelwe izinguquko kancane sinempilo.

Iziguli imithi isithuthwane neze elibekiwe ngoba ingozi nokuquleka. Ukwelapha okunjalo ngoba kulezi ziguli kuyingozi futhi kufanele kwenziwe nokusetshenziswa neminye imithi. Iziguli awasebenzisa kabi izidakamizwa futhi banomlando sezidakamizwa kufanele aphathwe ngaphansi kokuqondisa esiqinile of onguchwepheshe (izenzeko kuncike "buspirone" wayengekho).

Ucwaningo luye lwabonisa ukuthi "Buspirone" ngemva 3-4 amasonto ukwelashwa lapho alamu akuyona ngempumelelo, ngakho akukho umuzwa sibaphathe isikhathi eside. Ngenxa yokuntuleka ulwazi izidakamizwa ukuphepha kubantwana bakwa-aphoyintimenti yakhe singenziwa abantu abangaphansi kweminyaka engu-18 ubudala.

Ukwelashwa nokuvikelwa ezahlukeneyo ezahlukene zomuthi kanye izidakamizwa "Buspirone hexane" libuyekeza ezinye izazi abonisa indlela yokwelapha ayizwakali ngenxa yokuthi ukulala izinkinga, ukuvela ukucasuka nokukhathazeka ngezinye izikhathi kuwuphawu sina lengqondo iziyaluyalu.

Analogs, ukubuyekezwa mayelana izidakamizwa "Buspirone"

Yomiselela izidakamizwa analog kumele kwenziwe ngemva kokuthola iseluleko kadokotela. Kukhona obambele kuhle imithi, "Buspirone" - "Spitomin". Nobufakazi abonisa ukuthi isenzo bayo ufana isenzo izimali zokuqala. "Spitomin" isetshenziselwa ukwelapha labo izimo ukuthi suppresses futhi "Buspirone". Izibuyekezo zinhle, ngakho uma udinga kungenzeka ukusizakala lokhu esikhundleni, kodwa kuphela emva kokubonisana onguchwepheshe. A nomphumela ofanayo kufinyelelwa ngenxa yokuba khona isithako efanayo esebenzayo. Indlela ephumelela kakhulu "Spitomin" libonisa ku nokwelashwa kweziguli yokukhathazeka.

Ngemva ukwelashwa nge "Buspirone" Nobufakazi angashiya ezahlukene, kodwa ngokuyisisekelo umphumela ukwelashwa okunjalo omuhle. Ingabe waqinisekisa ukusebenza yayo? Izibuyekezo lodokotela abonisa ukuthi umkhiqizo nge esebenzayo isithako buspirone hydrochloride elwa ngempumelelo ngokumelene kuwukubonakaliswa ukukhathazeka ziyehluka kobukhulu kanye nemvelaphi, kodwa umphumela wawo kanye cishe kungaqashelwa, kungabonwa kuphela emva kwesikhathi esithize, okungukuthi - emva amasonto elilodwa noma amabili. Ukuze ubone inani okunokwenzeka nomphumela oqabulayo, kudingeka sihloniphe inyanga eyodwa.

"Buspirone" ithola izimpendulo omuhle iziguli ezimweni lapho kwakungekho imiphumela emibi, kanye izidakamizwa wakhe ababhekana esihle. Ngezikhathi ezithile kuyoba ukusabela okungekuhle umzimba, kodwa kakhulu kuyaqabukela lapho umzimba, ningaze nabonisisa imibuso eyakha lo izidakamizwa. Kusukela izibuyekezo, yabe seyaziwa ezingase ukuphathwa kuhambisane kwengqondo nemisebenzi sotsioterapevticheskimi. Ngezinye izikhathi iziguli emathunjini ukusabela ezingezinhle, isiyezi kanye nobuthakathaka. Overdose - into ezingavamile.

Ngenxa yalokho, ukusetshenziswa kwezidakamizwa "Buspirone" izimpendulo iziguli iphathwa Yiqiniso, akuvamile ukushiya ulwazi mayelana nemiphumela emibi. Inkambo kufanele esekelwe izici ngamunye zomzimba womuntu, impilo yakhe, futhi eliphezulu esimweni ngasinye Ukweqiwa. Naphezu ukulawula njalo udokotela, isiguli liyadingeka ufunde imiyalelo ngaphambi kokuba baqale ukwelashwa.

"Buspirone" - umuthi akavamile kungaholela ekwakhiweni amathuba okuba nemiphumela engemihle futhi ukweqisa izidakamizwa, non-umlutha, ukuphelisa ituthuko engakalungi ngemva yokukhansela yayo, futhi ezimweni eziningi enza umsebenzi walo.