Yini "esihlatshelelwayo" ithebhulethi? Ukusetshenziswa intengo

Medicine "isosha esihlatshelelwayo" (amaphilisi), intengo okuyinto ruble 700 kuya 4000, -. Izidakamizwa ngokwanele owaziwa. izidakamizwa Active - pregabalin - analog ye-gamma-aminobutyric (Gaba) acid (Gaba). Kamuva esihlokweni uzonikezwa isichasiselo imithi. Ake sizwe ukuthi yini amaphilisi "esihlatshelelwayo" usebenzisa iziguli.

mshini wezenzo

Pregabalin ubukisa ngempumelelo yayo ekwelapheni peripheral sikashukela kanye neuralgia postherpetic, okuyiwona amaphilisi "isosha esihlatshelelwayo" okunqunyiwe izinga amasonto 13 ne lapho engayitholi yangosuku izikhathi 2 amasonto 8, izikhathi 3 ngosuku. Against isizinda ukuthuthukiswa eshiwo okufanayo engemihle. Iphathelene fibromyalgia kusobala ukunciphisa ezibonakalayo e izimpawu ubuhlungu ikhomba ngenkathi ethatha ngemithamo izidakamizwa 300-600 mg ngosuku. Isikali Daily 450 mg kanye 600 mg ingafaniswa ukuze umsebenzi uhambe kahle, kodwa mithandazo ibekezelelwe kancane kahle. Umuthi kunciphisa kobukhulu zesifo sokuwa, okuyinto amaphilisi "isosha esihlatshelelwayo" litusa khona inkambo ka amasonto 12, 2 noma 3 izikhathi ngosuku. Phakathi reception kwenzeka esibonelweni esifanayo side effects kanye ukuphumelela izidakamizwa ngalesi umthamo. kokuquleka imvamisa iqala ukuba wehlise kakade emasontweni okuqala ukwelashwa. Symptomatology of ukukhathazeka okuvamile sikhombisa ukuthambekela wehlise ezinsukwini zokuqala eziyisikhombisa yokwelashwa. Ngemva kwamasonto ayisishiyagalombili-52% eziguli izidakamizwa ethola pregabalin futhi 38% seziguli ezithola placebo, yabonisa ukuncipha ngamaphesenti angu-50 izimpawu Hamilton isikali (HAM-A).

Pharmacokinetics

I nomuthi "isosha esihlatshelelwayo" (tablet) - Umsebenzisi kuqinisekisa lokhu - ku Kunconywa ngemithamo nsuku zonke nge side pharmacokinetic linearity libhekene, ongaphakeme (<20%) kokuhlukana interindividual. isicelo okuphindiwe kwe- pharmacokinetics zomuthi kungenziwa wabikezela ngesisekelo iyunithi idatha umthamo. Ngakho ukuqapha njalo lokuhlushwa isithako esebenzayo akudingekile. nemingcele Pharmacokinetic zomuthi "esihlatshelelwayo" e amavolontiya aphilile, iziguli isithuthwane abathola ukwelashwa antiepileptic, kanye nokwamukela isidakamizwa for abacindezela ubuhlungu syndromes zifana.

Absorption nokuqeda

Ngemva ngokuthatha pregabalin esiswini esingenalutho amuncwa umzimba ngokushesha okukhulu. Ngemva kwehora, plasma Cmax njengomdwebi uma ufaka okokuqala, futhi ngokuphindaphindiwe. On isizinda pregabalin bioavailability temlomo isezingeni ≥90% futhi izimele of umthamo. Equilibrium kuba yipumelelo lokha ukuthatha eziphindiwe inkathi amahora 24-48. Uma izidakamizwa sisetshenziswa emva kokudla, le Cmax kungenzeka yehliswe ngama-25-30% futhi ukwandisa impumelelo isikhathi yayo 2.5 amahora. Nokho, akukho nomphumela emtholampilo enkulu ukumuncwa zomuthi azange abe ukudla. Ngokuyinhloko lezi izidakamizwa excreted ngu izinso zinjalo. T1 / 2 amahora 6.3.

Pharmacokinetics ezimweni ezikhethekile

Uma ebucayini umsebenzi kwezinso, kubalulekile ukuba acabangele engavamile pregabalin imvume, kuba ngqo wakhona creatinine imvume. Ngokuyinhloko lezi izidakamizwa excreted ngu izinso, ngakho-ke kubalulekile uma ukwephulwa imisebenzi yabo ukunciphisa umthamo. Ngaphandle izinso, nomuthi lingasetshenziswa ngokuphumelelayo asuswe plasma ngu hemodialysis (angu-4 hemodialysis session kunikeza 50% ukwehla lokuhlushwa izidakamizwa e-plasma) nokuqokwa izidakamizwa ke abafiseleka ngokwengeziwe umthamo. Ucwaningo okhethekile pharmacokinetics ejenti "esihlatshelelwayo" in iziguli kahle isibindi umsebenzi ungazange sezenziwe.

Pregabalin akheka cishe bangaveziwe, uboniswa kanye umchamo ngefomu azizange zishintshe, Nokho kahle isibindi umsebenzi akusho kakhulu kuthinte lokuhlushwa izidakamizwa e-plasma. Lapho izidakamizwa inikezwa iziguli ngaphezu kweminyaka engu-65 ubudala, kumele sikhumbule ukuthi ngeminyaka Pregabalin imvume ivame ukuba yehle. Uma umuntu osekhulile ka lehla ekusebenzeni kwezinso, kuba ukuncishiswa adingekayo imithi enqunyiwe umthamo.

Isikali

Inani nsuku zonke ukulungiselela kuhlathululiwe kumThetho-150-600 mg ngosuku. Ukwamukelwa Kwenziwa izikhathi kabili noma ezintathu, kungakhathaliseki ukuthi ukudla. I nomuthi "isosha esihlatshelelwayo" (amaphilisi) imfundo manual uncoma ukuthatha ne ubuhlungu neuropathic -150 mg ngosuku. Uma kungenzeka umphumela lokuzuziwe nekutsi tolerability omuhle iviki elilodwa umthamo wansuku zonke senyukela 300 mg (uqoke "isosha esihlatshelelwayo 300" amaphilisi). Uma kudingeka, umthamo esiphezulu 600 mg ngelanga kungenzeka iqondiswa sekuphele isonto. Ngokufanayo ibalwa umthamo at ekwelapheni isithuthwane. Njengoba kubonisiwe ngenhla, Kunconywa izidakamizwa ekwelapheni fibromyalgia, okuyinto ezibhebheni "isosha esihlatshelelwayo" iqondiswa e umthamo 75 mg ngosuku ngemithamo ezimbili. On okwandisa umthamo ku-300 mg ezithinta umphumela lokuzuziwe nekutsi tolerability. Uma kungekho nomphumela omuhle, okwandisa umthamo 450 mg, futhi uma kudingeka - esingangesonto elilodwa kuya mg 600. Phatha generalized abanenkinga yokukhathazeka ziqale umthamo 150 mg. Futhi ngesonto, abagcina umphumela lokuzuziwe nekutsi tolerability, umthamo wansuku zonke anda 450 mg, futhi ngemva kwezinsuku ezingu-7 - kuze kufinyelele 600 mg (uma kunesidingo).

ukususwa zomuthi

Uma kunesidingo, ukuphathwa ukuqedwa Kunconywa ukukwenza okungenani ngesonto ukuncipha kancane kancane umthamo. Iziguli kahle umsebenzi izinso, eyenziwa Ukukhetha ngazinye Ukweqiwa. Esimeni nemiphumela engemihle e seziguli ezithola izindlela "esihlatshelelwayo" iphilisi-okulingana ukukhethela uchwepheshe. Phakathi izindlela ezivame kakhulu nge nomphumela ofanayo ingashiwo izidakamizwa "Mydocalm" "Apizartron" "Sedavit" "Ambene".

ubufakazi

Imithi Kunconywa zokuqeda ubuhlungu neuropathic, njengoba ukwelashwa adjunctive ngoba nokuquleka olungaphelele yisithuthwane ngokulandelana kwawo, ukuthi ahambisana noma cha ephelezelwa nje okungaqondile yesibili. Kusho kuboniswe ngoba abanenkinga yokukhathazeka generalized imvelo, kanye fibromyalgia.

Izimo

Azikho idatha ukusetshenziswa kwezidakamizwa ezinganeni kanye intsha engu-17, kukonke. Ngokuqondene nalokhu imithi inikezwa kuphela kwabadala. Izimo zihlanganisa izifo lezinceku njengoba galactose ukungabekezelelani, lactase ukuntuleka kwamavithamini, ukungezwani kanye malabsorption glucose / galactose. Ithuluzi aluboniswa ngoba hypersensitivity. Ukuze kulondolozwe ukusebenzisa ngokucophelela izidakamizwa in iziguli ukwehluleka kwezinso futhi inhliziyo.

side effects

Ngokusho isipiliyoni kwesicelo emitholampilo ye nomuthi, e ukozela wawubona nesiyezi njengoba nemiphumela engathandeki. Lesi senzakalo bavame ukwenzeka degree emaphakathi noma omnene. Phakathi kwezinye imiphumela emibi kuholele ukuqedwa imithi, kufanele asthenia, ukudideka, angaboni kahle, incoordination, ataxia, edema neuropathy kuphawulwe. Futhi phakathi imiphumela emibi waphawula ikhanda, nokulahlekelwa ukwazi, ukuquleka, ukuvuvukala ulimi nohudo, ukucanuzela kwenhliziyo, keratitis. Akuvamile isikhumba silume futhi ukusabela angioneurotic. Kukhona nokugcinwa urinary, edema yamaphaphu futhi gynecomastia. Phakathi kwezinye imiphumela emibi ibizwa ngokuthi ukukhathala.