"5-NOC" - Izibuyekezo sokulungiselela

Naphezu kweqiniso lokuthi umzimba womuntu sinikezwe amasosha omzimba futhi ukwazi ukubhekana nezifo eziningi iyodwa, amagciwane kanye nezifo ukuthi zinganqotshwa kuphela ngosizo imithi. izidakamizwa ezinjalo singavimbela noma ayeke ukukhula eziphilayo pathogenic, ngaleyo ndlela asuse focus ukuvuvukala. Tablets kukhona "5-NOC" Iqembu izidakamizwa ezinjalo. Nobufakazi ukukhombisa ukusebenza kwazo ngempumelelo okusezingeni eliphezulu ekwelapheni izifo kohlelo genitourinary. Ngaphezu kwalokho, leli thuluzi ephelele ukuze kuvikelwe Ukuphinda ukuvuvukala amafomu ezingamahlalakhona izifo.

izidakamizwa okusebenzayo

Nitroxoline izidakamizwa esebenzayo kuyinto izidakamizwa esebenzayo "NOC-5." Kuyinto kumiswa zokwenziwa, a esuselwe 8-hydroxyquinoline. Ngalesi ingxenye, umuthi ngokufaka umzimba uqala ukubheka amaseli microorganism kanye zivimbela DNA yabo. indlela akhetha ngayo isinyathelo ivumela ukuyeka ekwandeni namagciwane abangela izifo hhayi ukulimaza amaseli enempilo.

Ngaphandle nitroksolin engena ukuphendula esebenzayo acid nucleic kanye enzyme aqukethe insimbi ezinkanjini yabo. Ingqikithi unika inqubo nokuvulwa namagciwane abangela izifo has a action strong amagciwane ngokumelene spectrum ebanzi nezilwanyana ezincane. Ngakho-ke ngempumelelo ethathela namagciwane amelana izidakamizwa kwamanye amaqembu kwama-antibiotic. Medicine "izilinganiso NOC-5 'kuqinisekisiwe ukuba indlela ephumelelayo futhi engabizi ngokumelene izifo ezibangwa isikhunta, amagciwane Amagciwane adala izifo ukumelana nezinye izidakamizwa yesenzo elwa namagciwane kanye isinqandakuvunda.

Khipha ifomu kanye nokwakheka

I nomuthi kukhishelwa ngesimo amaphilisi camera. Sinenkosi esawolintshi noma ephuzi, ngesimo round, we-lenticular wangakwesokunxele, kukhona isici ayebuthaka. The main isithako - nitroksolin. izingxenye Asizayo sokuqanjwa: sucrose, E110 colorant, carboxymethylcellulose, ne-lactose.

Yini nezilwanyana ezincane elwa izidakamizwa

Qaphela ukuthi ekwakhiweni kunomphumela ohlangothini futhi impela ngokumelene ezinye amagciwane Amagciwane:

• Aerobic kanye anaerobic Gram-HIV eziphilayo - Enterococcus faecalis, Streptococcus SPP. (Pneumoniae zamagciwane, pyogenes).
• Staphylococcus SPP., Haka aureus, Bacillus subtilis, Corynebacterium SPP.
• Anaerobic nezinto ezincane eziphilayo aerobic (igremu) - Klebsiella SPP, Proteus SPP, Shigella SPP, Salmonella SPP, haemophilus influenzae, Enterobacter SPP, Escherichia coli, Neisseria gonorrhoeae ......
• Ezithathelana kubangelwa isifo sofuba Mycobacterium, ka Mycoplasma hominis, Trichomonas vaginalis, ka Ureaplasma urealyticum.

Isikhunta, dermatophytes, isikhunta of Candida, abanye eziphilayo okubangela izifo ngokujulile fungal - lezi zifo nazo ngempumelelo ekunciphiseni izidakamizwa "5-NOC". Uphenyo odokotela khombisa ikhono zomuthi ukunciphisa adhesion eziphilayo uropathogenic odongeni ipayipi (sokukhipha umchamo ezigulini) kanye pheshana urinary EPITHELIAL ungqimba.

lapho zaphathwa

Ngenxa ezahlukene kunalokho ububanzi kwezicelo izidakamizwa ukuze ubhekane ngokuphumelelayo nalesi izifo elandelayo:

• Ezingalapheki, sibi, isifo yansukuzonke (ezithathelwanayo omsakazo) ngomgudu womchamo ezibangelwa amagciwane Gram-negative futhi Gram-HIV kanye nesikhunta.
• Epididymitis.
• Pyelonephritis: ifomu chronic oyingozi.
• Urethritis.
• Cystitis.
• Adenoma futhi carcinoma (positive) we wendlala.
• izifo Ukuvimbela (yansukuzonke) ngomgudu womchamo.
• Faka emva izindlela zokuxilonga kuhlinzwa e ngomgudu womchamo: ukuhlinzwa izinso, cystoscopy, catheterization.

Kuyaphawuleka ukuthi ezibekiwe ukwelashwa okufanele kuncike ngobucayi isifo kungaba udokotela. Tablets "5-NOC" ochwepheshe beyibuyekeza kuqinisekisiwe ukuba bioavailability okusezingeni eliphezulu - 90%. Basuke ngokushesha ugxile pheshana emathunjini bese ukufinyelela eliphakeme plasma lokuhlushwa kungakapheli amahora 1.5-2.

Pharmacokinetics

Ukulungiswa has a ikhono ongaphakeme ukuhlanganisa plasma amaprotheni. Ubuningi eliphakeme lomcebo asebenzayo kukhonjisiwe umchamo isiguli. Umuthi is akheka ikakhulukazi sesibindi excreted ngu nezinso. Inani ezithile zomuthi esuswa umzimba Bile - inkathi of 2 amahora Kumele kuqashelwe ukuthi idatha pharmacokinetics zomuthi ezinganeni, abantu lapho usukhulile futhi in iziguli esingamahlalakhona kwezinso nesibindi ezingazange wafunda .. Ngakho-ke, kufanele uthole udokotela kokubonisana afanelekayo phambi enquma amaphilisi "5-NOC". Izibuyekezo Ochwepheshe uqaphele ukuthi izingane ibekezelelwe kahle imithi uma kutfotjelwa umthamo kanye nokwelashwa zemithi. ukunakekelwa ngokukhethekile kufanele kuholele okwashiwo ingane, okuyinto kungazange kufinyelele eminyakeni emi-3 ubudala.

Indlela

Kunconywa ukuthatha izidakamizwa ngezikhathi zokudla noma ngemva kwalo. Tablets musa ukuhlafuna, ukugwinya lonke, wageza phansi ngamanzi ahlanzekile. Ukweqiwa ngalokwenetisako:

• iziguli Adult - 100 kuya ku-200 mg, kuze kube izikhathi ezingamashumi 4 ngosuku. Qaphela ukuthi ngaphansi isimo ukusetshenziswa okuqhubekayo kwe-Izinga amaphilisi ayikwazi ukudlula izinsuku ezingu-30. Nokho, izifundo kungenzeka yokwelapha nge alternation: izinsuku ezingu-14 baphuze amaphilisi, izinsuku ezingu-14 akalithabathanga izidakamizwa. Le ndlela kwenza kube nokwenzeka ukuba babanikeze ukwelashwa izinyanga eziningana.
• Ukuvimbela isifo esithathelwanayo ngemva izinqubo zokuhlinza, izindlela zokuxilonga - mg 100 kuze kube izikhathi 4 ngosuku. Okunjalo nomuthi reception imodi ihlala kufika 3 amaviki. Ezigulini ezine-kahle isibindi umsebenzi nezinso umthamo kokuqala 50% we Kunconywa.

Kufanele kuqashelwe ukuthi umuthi "5-NOC" cystitis, kobufakazi nesineke uqinisekise lesi, ngokushesha kunciphisa ukuvuvukala futhi aqede ubuhlungu obuhlabayo. Nokho, ngisho uma kwenzeka kuba nomphumela omuhle ukwelashwa is hhayi Kunconywa ukuba uphazamisa Yiqiniso udokotela, kungenjalo kukhona ingozi Ukuphinda.

Umthamo izingane

Khumbula ukuthi sokuphuza isilinganiso esengeziwe somuthi ezanele ingane ukuhlonza udokotela kuphela ngesisekelo inhlolovo. izidakamizwa ngokuvamile ebekiwe kanje:

• Babe kusukela 2 izinyanga ezingu-12 ukubala senziwa, esekelwe isisindo isidumbu sengane: 25 mg / kg ngosuku. Zonke imithi kufanele ihlukaniswe 4 ngemithamo njalo ngezikhathi ezithile. Isikhathi yokuyelapha kusukela izinsuku ezingu-10 ukuba 3 amaviki. Uma ukutheleleka ezinzima - up 1 inyanga.
• Lapho ngineminyaka engu-engu-12 izinyanga 14 enqunyiwe edonsa mg 50 kuya ku-100 kuze kube izikhathi 4 ngosuku. Inkambo kunqunywa nguchwepheshe, kodwa reception okuqhubekayo akunakuba idlule izinsuku ezingu-30. Lapho imodi esikukhompiyutha 2 amaviki - reception, futhi 2 amaviki - ikhefu kuvunyelwe ukusetshenziswa isikhathi eside zomuthi "5-NOC". Izingane, odokotela Izibuyekezo mayelana nalo mdlalo izindlela kufanele libekwe kuphela ezimweni ezimbi kakhulu uma imishanguzo neminye imithi wazibonakalisa ayizwakali.

Imiphumela engemihle

Qaphela ukuthi imiphumela emibi e iziguli ezingavamile, kodwa kuyadingeka uma kwenzeka nesenzakalo yabo ngokushesha uxhumane udokotela. Ukuze ukhansele izidakamizwa nokuziphatha ukwelashwa lingaze emva kokwelashwa "5-NOC". Ukufundiswa libuyekeza odokotela basikisela izinto ezilandelayo ezibonisa omubi ekwelashweni kwe-:

• Ukuhlanza, ukuqothuka kwezinwele okungavamile kuphelile kokusebenza kwesibindi, isicanucanu, sokuzincisha, ezimweni ezingajwayelekile.
• Tachycardia.
• Paresthesia, polyneuropathy.
• kusebentisana kahle, isiyezi, ubuhlungu bekhanda, ngezinye izikhathi nokulahlekelwa ukwazi.
• neuritis optic (amaphilisi ukusetshenziswa isikhathi eside).
• Urticaria, amawala, uyaxebuka isikhumba.
• Thrombocytopenia, ngezinye izikhathi umchamo staining e ezijulile luhlaza ophuzi, ukwanda uric acid Inkomba e oketshezini olungenambala lwegazi.

Njengomthetho, zonke izigameko ezingezinhle ezavela sishesha emva ukuqedwa ngokuphelele izidakamizwa, "5-NOC". Nobufakazi ukukhombisa ungazizwa kahle, kuphela uma ukweqisa izidakamizwa noma ukuhambisana abampofu.

Izimo

Uma isiguli ukusabela iguliswa noma ukuzwela ukuba kwenye yezingxenye of the ukwakheka, kwenqatshelwe ukwabela izidakamizwa. It is hhayi Kunconywa ukusebenzisa nomuthi at ibele, ale nkinga, ukuqothuka kwezinwele okungavamile kuphelile isibindi umsebenzi nezinso.

Kuyaphawuleka ukuthi umuthi "5-NOC" abesifazane impendulo mayelana nalo mdlalo ngokuvamile ebekiwe ngesikhathi sokukhulelwa. Akukona ukusungula amacala ukulinyazwa impilo kokubili umama esizayo futhi ingane. Ngokuvamile, izidakamizwa ezinqunyiwe cystitis oyingozi, izifo lwesitho sangasese sowesifazane kanye ukubonakaliswa fungal (thrush).

Akubalulekile ukuthatha imithi ngesikhathi esifanayo ngemithi eziqukethe hydroxyquinoline. ubuthi anobuthi singenzeka kusukela babutha ketshezi asebenzayo emzimbeni.