"Ramipril": analogue, impendulo nokulaywa. "Ramipril-C3"

Ezinye zezifo ezingaba kakhulu ukunciphisa isikhathi sokuphila futhi kuthinte izinga layo, eceleni emi nomfutho wegazi ophezulu. Kutfutfukisa kancane kancane futhi kancane kancane kuthinta imithambo yegazi, ubuchopho, ezinsweni myocardium. Ezigabeni zokuqala isiguli kunzima bathola lesi sifo, ngoba kubonakala sengathi izikhalazo ezincane noma engenazo nhlobo.

Kamuva zivela, kanti isiguli ukuthi umfutho wegazi yakhe iphakeme kakhulu kunokuvamile. Lesi simo sidinga ukuqala ukwelashwa kwemithi, okuyinto kungenzeka nokusetshenziswa 5 amakilasi izidakamizwa. Futhi "Ramipril" njengomgijimi ophelele iningi labo, eqinisekisa umphumela monotherapy noma njengengxenye kuhlanganiswe ukuphathwa multicomponent.

Isimiso Sokuthungatha izici umkhiqizo

"Ramipril" analogue zomuthi, kanye uphulukisa ephelele zingabameleli antihypertensive. Ramipril ngokwayo - isithako esebenzayo ukuthi kuqukethwe amalungiselelo amaningi. Lokhu inhibitor ACE uyakwazi ivimbela enzyme futhi kuncishiswe blood pressure. It ikuvumela ukuba kakhulu ngcono Izibikezelo inkambo isifo kwasebekhulile.

Ngo izifundo zokwelapha luye lwabonisa ukuthi ramiprilat, le metabolite ngenkuthalo 'Ramipril "Sinemandla kuvimbela enzyme angiotensin-kokuguqula. Ngenxa yalokhu "Ramipril" analogue kanye nemikhiqizo eziyinkimbinkimbi kukhona kukhethwa izindlela nge kunzima ukulawula umfutho wegazi ophakeme.

analogs

Kusukela izidakamizwa ungakwazi kanzima ukuvimba ACE futhi kusiza ukulawula umfutho wegazi ophakeme, ilungiselela "Ramipril" eziningi analogue. Bonke asetshenziswa ukwelapha umfutho ophakeme wegazi ngempumelelo. Ngaphezu kwalokho, lo original izidakamizwa ramipril kuyinto "Tritatse". Zonke ukuphumula - izidakamizwa zalo ejwayelekile, ogama ukusebenza kufanele kuqhathaniswa kuye. Ukwamukelwa ukudayiswa kufanele kuqinisekiswe izidakamizwa bioequivalence "Tritatse".

Okwamanje, uhlu analogue kokulandelayo: "Amprilan", "Vazolong", "Dilaprel", "Korpril", "bukisisa", "Ramepress", "Ramigamma", "Ramikardiya", "Tritatse," "Hart". "Ramipril" futhi kukhiqizwa yizinkampani Russian "Tatkhimpharmpreparaty" "Biocom" futhi "North Star". Imikhiqizo zokugcina ibizwa ngokuthi "Ramipril NW".

imithamo esezingeni amalungiselelo eziyinkimbinkimbi

Antihypertensive imithi "Ramipril" Kulula ukuba ikhiphe futhi wamukele. umsebenzi layo lizisho ezintathu iyunithi imithamo zomuthi. Lokhu 2.5 mg, 10 mg kanye 5 mg. Tablets uquqaba leyo mibono kabili ngosuku. imithi okuhlangene futhi zikhona equkethe ramipril futhi hydrochlorothiazide: "Amprilan ND", "Amprilan NL", "Vazolong H", "Remazid", "Triapin", "Tritatse Plus", "Hart D", "Egipress". Lapha, inani ramipril zokhahlamba kusuka 2.5 kuya ku-10 mg, futhi umthamo hydrochlorothiazide - kusuka 12.5 kuya 25 mg iphilisi ngalinye.

Eyesibili isigaba kwemikhiqizo eziyinkimbinkimbi - inhlanganisela "Ramipril" kanye omelene calcium - "Amlodipine". Isibonelo umuthi "Egipress" elitholakala ejwayelekile imithamo ezimbili: 10 mg kanye ramipril 5 mg amlodipine futhi ngineminyaka engu-10 \ 10 mg. Ngaphezu le nhlanganisela, kunolunye uhlobo ka ekwakhiweni equkethe inhibitor ACE "Ramipril" ne-calcium omelene "Felodipine". Lokhu "Triapin", eyayinekheli 2.5 mg ramipril futhi felodipine 2.5 mg.

Izinhlinzeko yokusetshenziswa

Ngaphezu izincomo isiguli udokotela kufanele bacabangele yokusetshenziswa. Liqukethe ulwazi mayelana izinkomba, side effects, umthamo futhi wamukele izindlela, contraindications izinyathelo zokuphepha. Futhi exhunywe izidakamizwa "Ramipril" yokusetshenziswa uchaza isidingo ukwenqaba utshwala ekwelapheni nomfutho wegazi ophezulu.

ubufakazi

"Ramipril" analogue zomuthi kanye ejwayelekile "Tritatse" show at:

• nomfutho wegazi ophezulu kubalulekile ;
• ku eziyinkimbinkimbi ukuphathwa multi-class of ezingamahlalakhona ukuhluleka kwenhliziyo;
• nephropathy sikashukela nezinye emtholampilo noma subclinical, ongakaphathelani kwezinso Umthambo stenosis ;
• e nomfutho wegazi ophezulu lingaze;
• nokuvimbela isilethikusebenza, ukunciphisa ukufa kwezingane iziguli isifo senhliziyo, kanye ukwelapha umfutho ophakeme wegazi kanye okusezingeni eliphezulu ingozi Imininingwane zenhliziyo.

Inkomba esemqoka iwukuthi nomfutho wegazi ophezulu. Lona isifo njalo iningi yobudala emaphakathi futhi ubudala, ezidinga ukulungiswa. "Ramipril" Futhi, izidakamizwa noma ezinye ACE inhibitor kufanele sinikezwe iziguli phakathi nezinsuku zokuqala 2-9 ka-acute esivimba amanzi infarction isikhathi. umthamo izidakamizwa kufanele kube esiphezulu ibekezelelwe ngisho nalapho isiguli akusho uhlushwa nomfutho wegazi ophezulu. Lokhu kungenxa imiphumela enamandla cardioprotective ka ACE inhibitor.

Izimo

Ukulungiselela "Ramipril SOC" akufanele kusetshenziswe ne umlando edema angioneurotic yimuphi izidakamizwa Analogue, kanye nanoma yikuphi ukusabela iguliswa, okuyinto ithuthukiswe reception yayo. aphoyintimenti contraindicated ebukhoneni hemodynamically stenosis abalulekile kwemithambo yegazi nhlangothi zombili. Uma stenosis kuyinto sohlangothi olulodwa futhi nesineke umsebenzi ovame nezinso zombili, ukuqokwa kungenzeka ngokuqapha futhi ngaphansi kokuqondisa GFR.

Ukulungiselela "Ramipril" (5 mg, noma liphakamisa noma yiluphi olunye umthamo) awusebenzi uma hypotension ngezansi 90 mmHg. Art. Futhi, izidakamizwa akumelwe lisetshenziswe hemodynamically abalulekile stenosis ka yomthambo i-aorta ne-valve noma mitral, nge hypertrophic zenhliziyo obstructive, hyperaldosteronism eyinhloko, ezingamahlalakhona ukwehluleka kwezinso nge inkomba creatinine imvume (GFR) engaphansi kuka-20 ml / imiz.

Attached manual izidakamizwa "Ramipril" imfundo (dokhumenti kungekho analogue) iqukethe inkomba ukungakwazi ukusebenzisa izidakamizwa phakathi nokukhulelwa kanye lactation. Akwamukeleki nalapho kufaka ukusebenzisa imithi izingane. Lapho ngineminyaka engu-iminyaka engu-18 isipiliyoni emitholampilo alwanele futhi asikwazi ukuqinisekisa ukuphepha.

Umthamo zemithi

Le mfundiso eyasungulwa ethi eziyisisekelo lesi sidakamizwa "Ramipril" - amaphilisi. Amaphilisi kunethemba elincane ezivamile. Kulesi simo Kunconywa sokuqala umthamo kuyinto 1.25 mg. Umthamo owesincane izidakamizwa - 2.5 mg, ephoqa ukuhlukana ezimbili. Ukuba khona umugqa kwithebhulethi kukuvumela wenze lokhu kalula.

Lapho ngananoma ngiyiphi nomfutho wegazi ophezulu umthamo kokuqala kwaba 1.25 mg kanye nsuku zonke. Khona-ke umthamo kancane kancane kabili ngesikhathi tolerability ezinhle. Dose Titration Kwenziwa kuze kube isikhathi lapho ingcindezi igazi uhlaliseke. Umbandela of ukwelashwa okuphumelelayo nomfutho wegazi ophezulu - blood pressure njalo, okuyinto akuvamile liphuma wedwa.

izinyathelo zokuqapha

Umuthi kumele kuthathwe ngaphansi kolawulo ingcindezi, ikakhulukazi ngesikhathi aphoyintimenti kokuqala. Kubalulekile ukuthi systolic blood pressure lancipha hhayi ngaphansana 90 mm. HG. Art. Lapho umfutho wegazi lize liba ngaphansi kwe alolu Kunconywa abasebenzi Sokuzivikela. Ukuze uvimbele amathonsi wegazi is hhayi Kunconywa ukusebenzisa "Ramipril" kanye nitrate, ikilasi mina izidakamizwa antiarrhythmic ( "Procainamide") futhi-alpha 1-blocker ( "Alfuzosin," Tamsulosin ").

Umuthi kumele athathwe njalo futhi okungcono ngalelohola. Lokhu kwenza kube nokwenzeka ukujwayela uhlelo renin-angiotensin-aldosterone, elawula umfutho wegazi. Futhi, ungaphuthelwa imithi singawathola ezinzima abanomfutho wegazi ophakeme crisis. ukwenqatshwa Cijela reception kungabangela unhlangothi, izingozi zazo anda le nkathi.

Uphenyo iziguli imithi

"Tritatse" futhi imithi ejwayelekile yayo - imikhiqizo ephezulu ukuthi kahle-elawulwa blood pressure. Kuze kube manje, lo izidakamizwa iyona enamandla kakhulu ejenti antihypertensive. Nale kobufakazi nesineke ngako ku lonke omuhle. Zichaza kuye njengoba izidakamizwa okuthembekile uqine kahle elawulwa blood pressure. Okwakubaluleke ngokukhethekile kukhona izimpendulo walabo ezigulini eziye ngaphambilini ezithathwe nezinye izidakamizwa kuleli qembu.

Iziguli waphawula esincane ukusabela ezingezinhle elihlobene ne ubuthi. ziyezwana ePhakeme ACE, kanye umthamo encane izidakamizwa negate eziningana imiphumela umzimba, engase engathandeki uma esetshenziswa njalo. Kubalulekile ukuthi isibalo zinhlekelele nokusetshenziswa njalo "Ramipril" ziyancipha kakhulu. Nokho, ukuqedwa kwabo okuphelele akunakwenzeka monotherapy.

Uphenyo odokotela mayelana izidakamizwa

nomfutho wegazi ophezulu izibalo kucindezele ngendlela efanayo. Liqinisekisa ukubaluleka kwalesi sifo imithi yesimanje. Kubalulekile futhi ukuthi zokugula kakhulu linciphisa ukuphila okulindelekile. Kwegazi eba ngenxa ukukhiqiza ngokwedlulele ka renin, okuyinto kwandisa umthamo wegazi angiotensin. Okusithiyayo lokhu enzyme kuholela Ukwehliswa ingcindezi. Kuyadingeka ukuvimbela semithambo sclerosis udonga futhi ukuvela yezinkinga ezinzima nomfutho wegazi ophezulu.

Njengoba izifundo zokwelapha zokuhlola, izimo eziningi fibrillation atrial futhi ischemic isifo senhliziyo eba ngemva isiguli isikhathi esithile agelezé nomfutho wegazi ophezulu. Ngenxa ukubaluleka ukwelashwa yayo nawo njengomnyango mkhulu kakhulu. Futhi okubaluleke, ngakho yikhono ukuqeda khona isifo ngokusebenzisa izidakamizwa ACEI iqembu. Phakathi kwabo, "Ramipril" kusese enamandla kakhulu futhi ephumelelayo.

Odokotela mayelana kubonisa izinzuzo zayo. Ukulungiswa Kulula ukusebenzisa Imbalwa ohlangothini ukusabela futhi ngempumelelo ngokwanele. Nokho, naphezu kwalezi izimfanelo, kungase kungabi ngokwanele ukwelapha umfutho ophakeme wegazi ezinzima. Cishe 40-50% of amacala zokwelapha.

Ukuze ukwelashwa kwabo kudinga inhlanganisela wesifunda ehlanganisa i inhibitor ACE, isisu, a omelene calcium ne-beta blocker ngezinye izikhathi. Njengoba i angiotensin ukuguqulela enzyme inhibitor "Ramipril" awunankinga. Ngoba endaweni yayo ekwelapheni nomfutho wegazi ophezulu kungathatha, noma nini lokhu kuyamukeleka. Nakuba iziguli eziningi ukuthole ngenxa yokuntula izindleko ngobuhle okusezingeni eliphezulu.