Prostaglandin - ke ... Prostaglandins (izidakamizwa): igama intengo

Iningi izinqubo emzimbeni wethu incike prostaglandins, okuyinto akhiqizwa cishe yizo zonke izicubu. Avame kubhekwe nama-hormone, Nokho, akuzona. Zenza ngokuncanyelwayo endaweni zamagama bese beshushisa ekubhujisweni. Ama-hormone futhi nethonya yabo buqamama zihlukaniswa kuphela nezindlala endocrine nezicubu akuzona ingxenye enkulu.

synthesis prostaglandins

Ake sibheke ukwakheka yalolu ketshezi emzimbeni. Prostaglandin - ikhemikhali imiswe phakathi umzimba arachidonic acid, zingabantu Eicosanoids. acid Fatty ayingxenye phospholipids, okuyinto atholakala kuwo wonke izicubu. Ngaphansi isenzo phospholipase A2 onakala arachidonic acid, ngemva kwalokho liyophuma phezu cyclooxygenase noma lipoxygenase izindlela. Prostaglandins siwumkhiqizo wokuziphendukela ngowokuqala.

Iyini indima emzimbeni?

Eicosanoids zenza imisebenzi. Prostaglandin - ikhemikhali bahileleke kakhulu izinqubo ezenzeka emzimbeni wethu. Ngokwesibonelo, prostaglandin E has a depressor umphumela, isb kunciphisa umfutho wegazi ngu ezithinta ithoni semithambo. Ngaphezu kwalokho, prostaglandins (izidakamizwa zemvelo) ukwenza kusebenze umsebenzi contractile we myometrium, ngenxa lapho zisetshenziselwa lokungeniswa zomsebenzi. Lezi izinto ukwandisa synthesis isikhwehlela akhiqizwa amaseli goblet isisu. Amafinyila eyenza umsebenzi zokuzivikela, ukuvimbela isenzo yezici okumayelana mucosa. Ngaphezu kwalokho, ngenxa yalezi izinto is bebengaphuzile kumiswa pepsin futhi hydrochloric acid, okuyinto wayisebenzisa ekwelapheni izifo esiswini elihlobene ne uketshezi lelitfutfukile lezi izinto. Futhi kuthinte izakhiwo rheological wegazi, ezivimbela platelet wokuhlanganisa. Prostaglandin E kuthinte bushelelezi imisipha amaseli kuqhoqhoqho kanye bronchi, lwenza ukuphumula zabo, futhi ngenxa yalokho, ukunwetshwa yomoya. Indima ebalulekile prostaglandins e ukuvuvukala ubuhlungu. Lezi izinto hhayi kuphela ngokuqondile kuthinte eziyimpumelelo emsipheni kanye imicu, kodwa futhi bahileleke ukubukeka nezinye izimpawu ukuvuvukala. Izinguquko kule ithoni semithambo ngaphansi isenzo prostaglandins okuholela ukuminyana, nokwenyuka permeability odongeni - imbangela kumiswa edema. Prostaglandins, ngaphezu umthelela kungenzeka emsipheni vagus, okubangela isicanucanu nokuhlanza. Nge side effect ezinjalo kaningi iziguli. Prostaglandins - izidakamizwa (amagama ngezansi) zisebenza kuphela ngaphansi izinkomba esiqinile.

Ukuxhumana ka prostaglandins nezidakamizwa eqeda ukuvuvukala

Prostaglandin - kuba umhlanganyeli oqondile e ukuvuvukala. Isenzo of ama-NSAID kusekelwe zokunciphisa zamagama (cyclooxygenase enzyme ivinjelwe). ukusetshenziswa kwesikhathi eside ama-NSAID kuholela ukuntula prostaglandins, okuholela kahle isithiyo umsebenzi esiswini - ukwehla uketshezi of isikhwehlela. Lena ezinkulu side effect le mithi.

Prostaglandins - amalungiselelo: igama

Le mithi asetshenziswa ngokuyinhloko izifo ze-isisu kanye isilonda duodenum, nemvelo erosive. Ngaphezu kwalokho, iphathwa ukuze sikhuthaze ukusikwa we myometrium futhi sithuthukise igazi rheology.

"Misoprostol"

Prostaglandins (izidakamizwa) kuthiwa asakazwa kakhulu ekwelapheni izilonda esiswini kanye duodenal ngenxa yomsebenzi walo anti-secretory. Lesi senzo sihlotshaniswa nomthelela receptor prostaglandin, okuyinto zitholakala esiswini parietal amaseli. Ngakho, "Misoprostol" izenzo njengoba prostaglandin zemvelo. Ukukhuthazwa zokukhiqiza isikhwehlela kusiza ukuvikela ulwelwesi lwamafinyila iphinde ivimbele ukwakheka izilonda entsha. Konke lokhu kudala isimo esihle angawokuphulukisa izilonda futhi erosions.

"Alprostadil"

Umuthi iyona prostaglandin izidakamizwa E. Ivame iqondiswa ezimweni lapho ukwanda kuyadingeka wokwehla myometrium - lokungeniswa zomsebenzi. Futhi, izidakamizwa esetshenziswa ukwenza ngcono kwegazi - okusithiyayo of platelet wokuhlanganisa futhi vasodilation (isifo sokuqina kwemithambo yegazi). Itholakala in vials kwezokuphatha emthanjeni.

Izimo

Kokubili izidakamizwa akuyona iqondiswa, uma kukhona hypersensitivity kuya prostaglandins futhi analogs yalo. Phakathi Izimo - yobudala 18, bekhulelwe nangenkathi bencelisa. Futhi bathathe ngokuqapha yabo in iziguli esingamahlalakhona kwezinso futhi hepatic, pathologies we endocrine uhlelo, enterocolitis, ukuntuleka kwegazi emzimbeni.

Self-nokuphathwa prostaglandin izidakamizwa ngaphandle kokukhuluma onguchwepheshe akuvunyelwe. udokotela kuphela ungathola umthamo kwesokudla futhi ulungise isu ukwelashwa, kucatshangelwa izici ngamunye isiguli. Kuye yakini zizoshintsha intengo. Prostaglandin itholakala amafomu ahlukahlukene kanye ngaphansi ezihlukahlukene amagama brand, sithinta izindleko.

side effects

Ngokuvamile, lapho izidakamizwa kuholele kwezinso wokugaya ukudla - isicanucanu, ukuhlanza, ukukhishwa isisu kanye iziyaluyalu dyspeptic. Uma umzimba uxabane nawo, imakwe pruritus, amawala, ububomvu nokuvuvukala, futhi kungenzeka ukusabela anaphylactic. Administration izidakamizwa kungenzeka ehlangane nokuya esikhathini okungajwayelekile, dysmenorrhea. Ukunciphisa myometrium ngokuvamile it libhekene ubuhlungu esiswini. Phakathi kwezinye side effects - isiyezi, ubuhlungu bekhanda, isisindo somzimba iyehla iyenyuka.

I degree of ingozi nemiphumela engemihle kuba ngamanye esigulini ngasinye. Lapho sigcina izenzakalo ezinjalo kufanele uxhumane nodokotela wakho futhi ushintshe uhlelo ukwelashwa.

Prostaglandin - into edingekayo ekwelapheni peptic isilonda isifo kanye nezinye pathologies. Zivame kuhlangene nezinye izidakamizwa ukuze kuzuzwe nomphumela ofiselekayo. Kukhethwa imithi umthamo yayo incike esimweni emitholampilo izici ngamunye nesineke.