"Pipekuroniyu bromide": yokusetshenziswa

Imithi eziphumulele imisipha yohlaka, kabanzi hhayi kuphela phakathi nezinqubo kuhlinzwa adlulayo kanye nephakathi nendawo, kodwa futhi umkhuba ukuhlukumezeka ngenhloso ekuhleleni kabusha noma amalunga omzimba zokufakelwa. "Pipekuroniyu bromide" libhekisela relaxants iqembu antidepolyarizuyuschih futhi ubude besikhathi yesenzo imizuzu 50-70 kuncike izici umzimba ka. Ake sicabangele yokusetshenziswa zomuthi, futhi ikakhulukazi elisetshenziswa umkhuba wokubulala izinzwa.

kwebalingisi kwemithi

Lo mshini wezenzo zomuthi elihlobene ne ivimbela ukudluliselwa kwe-zokuxhumana zobuchopho ngesikhathi synapse kwamanyuroni. Ngenxa yalokhu, kukhona okusithiyayo we nesenzakalo isenzo engaba e ulwelwesi imisipha fibre, futhi ngaleyo ndlela, iseli imisipha ilahlekelwa ikhono lawo ukwenza inkontileka.

Nge ukuvezwa kwesikhathi eside izidakamizwa ngokwemibandela "pipekuroniyu bromide" ezicutshini lwamathambo ephumula. Njengoba sazi ukuthi receptor nicotinic cholinergic yohlobo elise hhayi kuphela endaweni contact efferent Imicu yotshani ukuphathwa kwabathintwayo isimiso sezinzwa ne kwemisipha amaseli imisipha yohlaka kanye ganglia e autonomic nesimiso sezinzwa, ukwethulwa amazinga okukhishwa esikhulu nomuthi okubangelwa umphumela ganglioblokiruyuschimi ababuthakathaka. Lokhu kungenxa ukumisa ukudluliswa kwe-nerve nesifiso nolwelwesi postsynaptic sezinzwa, okuholela ukwehla kokubili imiphumela nozwela futhi parasympathetic.

izinkomba

Ukulungiselela "pipekuroniyu bromide" kuboniswa ngenxa ukuphumula imisipha yohlaka phakathi nokuhlinzwa. Ukuphumelela izidakamizwa ngenjongo tracheal intubation umoya lokukhanda.

Izimo

Njengoba umuthi "pipekuroniyu bromide" mfundo, isidakamizwa ngokuphelele contraindicated ebukhoneni hypersensitivity futhi khona myasthenia (ezingavamile, isifo kunqunywa zofuzo, okuyinto ephula excitation ngesikhathi kwamanyuroni ukuthuthukiswa synapse futhi ukuba buthakathaka kwezicubu).

Umuthi is contraindicated in iziguli kusaqalwa yokukhulelwa. Ezigabeni kamuva zomuthi lingasetshenziswa, njengoba kweqa isithiyo esinomhlapho imali ezincane.

side effects

Umuthi singavimbela umsebenzi isimiso sezinzwa esiyinhloko, kubangele hypersensitivity imihlola.

Kusukela eceleni senhliziyo side effects kubangelwa okusithiyayo yokudlulisela cholinergic ngesikhathi synapse. Ukwenza kanjalo kungehlisa izinga lokushaya kwenhliziyo, ephansi blood pressure, ischemic ukulimala esivimba amanzi, ukulimala kobuchopho elihlobene ne kwehle perfusion.

Lapho edalulwa ukucindezeleka okungenzeka umgudu wokuphefumula umsebenzi zokuphefumula, okuvela yokuphelelwa umoya noma zokuphelelwa umoya (ikakhulukazi phakathi Imiphumela zomuthi).

Umuthi sithinta umzimba futhi uyakwazi kubangele ukwanda egazini potassium ezingeni, okwandisa ezingeni creatinine endogenous plasma namazinga kashukela egazini eliphansi.

Izidakamizwa "pipekuroniyu bromide" - yokusetshenziswa

Umuthi iqondiswa kuphela ngaphansi kokuqondisa onguchwepheshe. Ngaphambi izidakamizwa Abaphathi kumele benze ukuhlola ukutholakala anticholinesterases ( "Neostegmina" noma "Pyridostigmine") noma anticholinergics ( "Atropine").

Ngemva zokukhwabanisa okuqhubekayo zokuqapha nesineke Kwenziwa ngesikhathi yokutakula ngemva kokubulawa izinzwa kanye nesineke kulesetayelekile imisipha ithoni.

Umthamo nomuthi ngesisekelo luhlolo eziyinkimbinkimbi amasu ukuhlaziya laboratory nesineke kanye nedatha ucwaningo. Ephambi kwezinduna ukwehluleka kwezinso excretory umsebenzi, yokwehluleka kwesibindi ukusebenza, ukukhuluphala - umthamo kufanele kube nomuthi aphansi.

Isixazululo ibhalwe ngokushesha ngaphambi izidakamizwa isimiso sokuqondisa 'pipekuroniyu bromide. " Ifomu izidakamizwa Ukukhululwa - izitsha eziyisikhombisa powder lyophilized equkethe 0.004 g lomcebo asebenzayo.

Ezigulini ezine-kahle igazi electrolyte ukulinganisela acid-base silinganisele nasekufezeni edingekayo umthamo ukulungiswa. ukunciphisa i-Preferential ion lokuhlushwa i-plasma, hypothermia kanye nokusetshenziswa ka glycosides inhliziyo (ngesikhathi digitalization) bayakwazi ukuba zinde isikhathi kwezidakamizwa. Endabeni muscle kuleli qembu iziguli ekuqaleni kudingeka kulesetayelekile electrolyte wegazi, bese lokufeza muscle. Endabeni iziguli nesifo senhliziyo, kwegazi kungase kukwenze wephuze ukwelulwa kwesikhathi esicashile kwezidakamizwa umphumela (ukwanda esikhathini phakathi kokuphathwa kanye ukuqala ukusebenza).

Ungasebenzisa izidakamizwa ezinganeni kusukela ngonyaka 1. Kulokhu-ke kumelwe kukhunjulwe ukuthi umzimba somntwana akanandaba imiphumela relaxant imisipha, futhi ngokufanelekile, ukufeza umphumela oyifunayo, umthamo we izidakamizwa kumele lenyuke.

Iholide izidakamizwa

Libeke kwezidakamizwa "pipekuroniyu bromide" iresiphi ngesiLatini awukwazi ngisho nokuya kudokotela. isikhungo Medical uthola izinto ezinamandla kusukela uhlu A kuphela uma ecelwa ngesisekelo isimo. Kwesinye isehlakalo esehlukile, "pipekuroniyu bromide" iresiphi angabeka uchwepheshe ngokusebenzisa ifomu "red" Nokho, akubona bonke inethiwekhi esibhedlela anelungelo ukugcwaliseka izidakamizwa nezidakamizwa kanzima, kuhlanganise imisipha relaxants.

amagama akho okuhweba

Ezimakethe ezithaka imithi izidakamizwa iyatholakala ngaphansi ezifana amagama akho okuhweba ngokuthi "Arduan" "Vero pipekuroniyu", "Aperamid", "pipekuroniyu bromide." egameni lendawo yokuhweba noma izidakamizwa luncike umakhi, ezidayisa umuthi emakethe ezithaka imithi.

ukweqisa izidakamizwa

Ukweqisa izidakamizwa zomuthi futhi umphumela ukunciphisa kungenzeka ngenxa ukwethulwa anticholinesterases. Le mithi basize ukwandisa lokuhlushwa acetylcholine neurotransmitter, kanjalo ukuncintisana kwemisipha relaxant ngoba ngibopha amasayithi yokwamukela.

Futhi, izinyathelo zokwelapha e ukweqisa izidakamizwa eklanyelwe umfutho wegazi, ukugcina ezibalulekile umzimba imisebenzi, kuhlanganise ngezithukuthuku ukupholisa lokukhanda.

ekusebenzisaneni izidakamizwa

Umuthi ayikwazi exutshwe ezahlukene ukumnika izixazululo, ngaphandle izixazululo isotonic of sodium chloride futhi dextrose. Ukuthuthukiswa izidakamizwa umphumela kubambezela, umthamo ngempumelelo zokwelapha luyanda ngaphansi kombandela yokuphathwa preoperative isiguli le cholinesterase inhibitor.

Ngo isicelo ezikanye imisipha relaxant analgesics kwezidakamizwa ukucindezeleka okungenzeka isikhungo zokuphefumula nge ukuthuthukiswa ukuphelelwa umoya lapho belele.

Ukusebenzisa izidakamizwa ne depolarizing imisipha relaxants uhlobo senzo kokubili ukuthuthukisa ona jikelele imisipha relaxant umphumela. Lokhu isimo kungenxa Isikali izidakamizwa, isikhathi ukuphatha, kanye nokuzwela ngakunye izidakamizwa.

isiphetho

Ethwele muscle phakathi nokuhlinzwa - kuyingxenye ebalulekile i izinzwa ehlangene. Izidakamizwa "pipekuroniyu bromide" isetshenziswa kwezokwelapha ngalezi zinhloso ngempumelelo.

Kumele kukhunjulwe ukuthi ukwethulwa izidakamizwa kubangela ukuphumula imisipha yohlaka obhekene ukunyakaza kokuzithandela hhayi kuphela, kodwa futhi kubangela ukukhubazeka kwemisipha yokuphefumula. Ukucabangela lesi, umuthi isetshenziswa kuphela ngaphansi kwezimo kanye kuhlinzwa olunzulu ukunakekelwa amayunithi.