"Nitrosorbide" - analogue. Umyalelo, ukusetshenziswa, incazelo izidakamizwa

Okungalapheki senhliziyo kuyinkinga enkulu kokubili iziguli esezikhulile futhi abasebasha. Lokubaluleke kakhulu ukwelapha esekelayo. Isiguli kufanele udle njalo amaphilisi impilo evamile. Ukuze linqume Have wenhliziyo oqeqeshiwe. Idumile ochwepheshe kukhona "Nitrosorbid" amaphilisi-mbumbulu. Analogs asetshenziselwa kancane njalo.

Khipha ifomu kanye nokwakheka

Tablets iqembu izidakamizwa antianginal. The main isithako uba isosorbide dinitrate. Njengoba excipients esetshenziswa magnesium stearate, monohydrate lactose, polyvinyl acetate futhi talc. Izibhebhe ayatholakala emhlophe, abe ukuma isiyingi.

Isakhi esiyinhloko esebenzayo, okuyinto i nitrate organic ikhuthaza ukuphumula semithambo bushelelezi imisipha izindonga. Ithonya akuyona kuphela imithambo kodwa futhi ku ngemithambo. sebethule kakhulu ziyancipha wegazi emithambo yegazi, incipha emithambo yegazi ukubuya inhliziyo. ukuchayeka Good emitholampilo has isosorbide dinitrate. Iziyalezo yokusetshenziswa uthi ingxenye main ngokushesha angena egazini. Ngalesi umphumela ukuphola kuza ngokushesha futhi mude.

Pharmacokinetics

Ngemuva kokufaka ithebhulethi esiswini chaza kwamaminithi ambalwa. Amahora ambalwa ungakwazi kakade ukubona imiphumela yokuqala yokwelapha. Izibhebhe esikuthola ngokushesha. Primary izidakamizwa bioavailability kuyinto 22%. Umthelela esiphezulu kufinyelelwe emva 2 amahora ngemva ukungenisa tablet. Okuxhunyanwa isithako nakanjani igazi amaprotheni 30%.

Ngokuphelele eseyiqedile izidakamizwa kusukela umzimba kungakapheli amahora 12. umphumela Okunqwabelanayo akuyona. Isosorbide dinitrate is akheka esibindini. Lokhu kwakha metabolite esebenzayo ye isosorbide mononitrate. Umuthi is excreted ku umchamo cishe ngokuphelele.

ubufakazi

"Nitrosorbid" iphilisi kungenziwa kunqunyiwe ngudokotela wenhliziyo oqeqeshiwe. Analogs nazo esimisiwe izinkomba onguchwepheshe. Umuthi ingasetshenziswa in iziguli isifo senhliziyo, uma ukuphathwa nokunwetshiwe nezinye imithi akakunikanga Chile oqondile. Izibhebhe kungavimbela angina.

I ukwelashwa ingase futhi enikezwa izidakamizwa "Nitrosorbid". Analogs lingasetshenziswa ngendlela elandelayo: "Kardiket" "Of Mick", "Long Dikor". Le mithi kuzoxoxwa ngemva kwesikhashana. Izibhebhe lingasetshenziswa ngokuhlanganyela glycosides inhliziyo, diuretinami noma inhibitor.

Yini enye unamaphilisi "ubufakazi Nitrosorbide '? Umuthi futhi isiza, futhi isilethikusebenza. I nomuthi iqondiswa nangemva kokuqala kokuhlasela esivimba amanzi njengoba prophylaxis. Esikhathini imithi yokwelapha kuhlanganiswe angasetshenziswa ukuze prophylaxis of pectoris angina. Izibhebhe kuleli cala abe isenzo isikhathi eside.

Ukwelashwa nge "Nitrorbid" mhlawumbe phakathi nokukhulelwa kanye lactation. Nokho, kubalulekile ukusebenzisa imithi ngokuqapha. Umuthi inikezwa kuphela uma inzuzo ezingase zisetshenziselwe ukuba umama idlula ingozi ezingase zisetshenziselwe ukuba usana.

Izimo

I nomuthi ikhishwe kuphela kadokotela. Lokhu ugwema reception engalungile amaphilisi iziguli. Iqiniso lokuthi lesi sidakamizwa "Nitrosorbid" ngokuthi "Kardiket kuthiye ukukhula ', anezinye Izimo. Akunakusetshenziswa abakwazi ukusebenzisa izidakamizwa ngesikhathi acute isilethikusebenza, uma kukhona hypotension ezinzima. Kulokhu, izibhebhe kungase kube nomphumela omubi. Hhayi prescribers kanye engela-Ukuvalwa ukufiphala hypovolemia, ukwehluleka oyingozi kwegazi. Akuthathi imithi nge ukulimala kuhlasimulise ingqondo.

Kukhona futhi yobudala. Tablets "Nitrosorbide" noma "Kardiket kuthiye ukukhula" ingase yabelwe kuphela iziguli omdala. Ezinye iziguli kungenzeka hypersensitivity ukuze kwakheke ama-nitrate. Uma kukhona ukusabela iguliswa, uyeka ukuthatha imithi futhi uthintane wenhliziyo.

Izixwayiso

Ukuze esiqoshiwe ukuhlaselwa angina "Nitrosorbid" amaphilisi ayikwazi ukusetshenziswa. I Kungashiwo okufanayo mayelana nemithi 'Of Mick "," Kardiket "futhi" Long Dikor ". Konke lokhu izidakamizwa ingasetshenziswa kuphela for lokuvikela. Uma kuba khona okuhlaselayo kuseduze lokho kuzodinga yokwelapha nezinye izidakamizwa. Phakathi ukusetshenziswa "Nitrosorbid" zithutha kufanele iqaphe njalo ukushaya kwenhliziyo, futhi wegazi. Iziguli ezingamahlalakhona ukwelashwa senhliziyo okunxanelekayo indawo kulungiselelwa esibhedlela.

khansela kakhulu izidakamizwa is hhayi Kunconywa. Reception "Nitrosorbid" ekuqaleni ukwelashwa kungase kwandise isibalo ukuhlaselwa anginal. Umphumela ofanayo kungabuye abona othile ewunikela ngesikhathi yokukhansela abukhali zomuthi. Ukuze cupping nitrate okusheshayo ingasetshenziswa esikhathini ukwelashwa, okuyinto kumele ukhethe wenhliziyo. Ukuzelapha kungaba ukunikeza imiphumela ezingalindelekile.

Musa ukuhlala beshayela imoto, uma lokhu kudingekile ukuze sisebenzise ukulungiselela equkethe isosorbide dinitrate. Imiyalelo isicelo uthi ketshezi uyakwazi ukubangela ukozela nesiyezi. Phatha iyiphi izindlela eziyinkimbinkimbi ngesikhatsi ukwelashwa is hhayi Kunconywa.

Isikali

Izibhebhe abe isenzo isikhathi eside. Iziguli senhliziyo iqondiswa 20 mg kanye ngelanga. Kancane kancane ukwandisa umthamo. Izinga Maximum kumele singeqi 3 amaphilisi ngosuku. Ngo ngaphezulu Ezimweni eziyinkimbinkimbi, kungaba zabelwe eside esebenza izindlela (40 mg). Iziguli ukuthatha isigamu ithebhulethi kabili ngosuku. Ukwandiswa Isikali ngokuqapha futhi kuphela ngaphansi kweso lwezokwelapha.

Ukwelashwa lwaqala ubuncane Isikali izinga futhi kancane kancane ophakanyiswe ngempumelelo enkulu. Njengoba iklanyelwe i-administration eside, amaphilisi "Nitrosorbide". Analogue nazo eyenzelwe yokwelapha eside. ukwelashwa is hhayi Kunconywa ukuba uyaphetha kungazelelwe. Kwangathi ukuthuthukisa engemihle.

ukweqisa izidakamizwa

Strictly ngokuvumelana isincomo udokotela kuyadingeka ukusebenzisa ithebhulethi "Nitrosorbid". Izimpendulo abonisa ukuthi ukweqisa izidakamizwa Ingabangela engemihle. Bavame avele ngendlela isiyezi, isicanucanu, ukuhlanza. Ngaphansi kungenzeka isikhumba ukusabela ezifana ukulunywa, ukuqubuka. uhlelo Cardio-semithambo isiguli uzizwa ukuncipha okukhulu wegazi, palpitations inhliziyo.

Ukwelashwa nokuvikelwa kokudla esiyolandelwa kuphela esibhedlela. Okokuqala wenziwa lavage esiswini. Kamuva babelwe yokwelapha lingaze. Ukuze ngokushesha usimamise isimo lesiguli ingasetshenziswa carbon isebenze.

side effects

Lapho zisetshenziswa kahle, izibhebhe zingase futhi zibe engemihle. Ezimweni eziningi, baze zingezesikhashana futhi asidingi ukuqedwa ukwelashwa. izimpawu ezingemnandi ekuqaleni ukwelashwa futhi kungadala ithebhulethi "Dikor Lorng" "Of Mick", "Kardiket". Ekuqaleni, iziguli zingavela ikhanda, esingenakubalwa bulungiswe noma yimuphi umuthi, amuke ezinsukwini ezimbalwa ngemva Ukuqalwa yokwelapha. kungaba futhi waphawula tachycardia, kunciphisa umfutho wegazi.

Kusukela isimiso sokugaya ukudla bungene side effects ziyabonakala ngesimo ukucanuzela kwenhliziyo, ubuhlungu besisu, uhudo. Lapho ukuhlanza Kufanele ufune izeluleko lwezokwelashwa olusheshayo.

izidakamizwa ekuhlanganyeleni

Isexwayiso kumele kusetshenziswe "Nitrosorbid" ithebhulethi nanoma yimuphi vasodilators. ukuxhumana okunjalo kungaholela side effects. Nge amaphilisi dihydroergotamine ingasetshenziswa kuphela ngemva kokukhuluma nodokotela. Izidakamizwa ekusebenzisaneni kungaholela ukwanda emakamu igazi dihydroergotamine futhi yandise amandla ayo hypotensive.

Uthuthukisa kwegazi kuhlanganiswe nokusetshenziswa amaphilisi "Nitrosorbid" acetylsalicylic acid. Nokho izidakamizwa is hhayi Kunconywa ukuba isetshenziswe ne adsorbents. ukuxhumana okunjalo kuzoholela ukwehla bioavailability zomuthi.

analogs

Idumile ochwepheshe kukhona "Nitrosorbid" amaphilisi-mbumbulu. Intengo Okuphansi zomuthi, futhi libhekene imiphumela emihle emzimbeni. Kodwa ukuthola imithi e-pharmacy akwenzeki ngaso sonke isikhathi. I wenhliziyo kuyohlale ukukusiza ukukhetha nozakwabo eliphezulu. "Kardiket" amaphilisi aphinde abhekane kahle umsebenzi. The main ingxenye esebenzayo zomuthi Usenguyena isosorbide dinitrate. Umuthi ezinqunyiwe ngenjongo prophylaxis of pectoris angina futhi isilethikusebenza.

kumakhophi Okuningi ezibizayo kukhona amaphilisi "Dikor Ezinde." Njengoba izithako asizayo elisetshenziswa amaphilisi corn isitashi, monohydrate lactose, colloidal Silicon dioxide, i-magnesium stearate, ama-titanium dioxide. Izibhebhe ezingahle zinqunywe ukuze izingane nabesifazane abakhulelwe esibhedlela.

Tablets "Of Mick" - elinye ithuluzi adumile Ungashintshanisa imithi "Nitrosordid". The main isithako futhi dinitrate isosorbide. Kuwo wonke la imithi, lokhu eqolo.

Izibuyekezo amaphilisi "Nitrosorbid"

Umuthi inomphumela omuhle ohlelweni senhliziyo nemithambo yegazi. Ngo ukumelwa inhliziyo, ngokulinganisela kwasekuqaleni amaphilisi esimisiwe 'Nitrosorbid ". Inani izidakamizwa iziguli bajabule. Omunye iphakethe angathengwa ruble 15 kuphela. Izibuyekezo omubi angase anemiphumela engemihle ezenzeka ekuqaleni ukwelashwa. Kubalulekile nokukhumbula ukuthi eyesikhashana.

Umuthi kumele isetshenziswe kuphela. Ukwelapha okufanele kwenzeke ngayo ngokuqinile ngaphansi kokuqondisa onguchwepheshe, ezobheka ukuthi umthamo efanele esimweni ngasinye. khansela yokwelapha kakhulu futhi akufanele kube.