Izitembu zokunciphisa i-cholesterol zingabangela isifo sikashukela futhi zithinte ubuchopho?

Kungani i-cholesterol esabekayo isethusa kuzo zonke izingqikithi? Yini engalungile ngalokhu kuxhumano kwemvelo nokuthi kungani izinkolelo eziningi kangaka ezidalwe kuwo? Mhlawumbe isizathu sokungathandwa kwe-cholesterol esisezingeni elikhulu lokulwa nokukhangisa, okuvela ezinkampanini ezihola imithi. Phela, uma benomkhiqizo, kuyadingeka ukuthola umthengi othembekile. Futhi uma abantu abaningi bakholelwa ezitatimendeni zodokotela, imali eyengeziwe izolethwa kumgcinimafa wabakhiqizi.

Inzuzo ye-Multibillion-dollar

Izitatimende ziyizidakamizwa ezinamazinga aphansi e-cholesterol. Kuphela kwaleli qembu lezinkampani zezokwelapha izidakamizwa zithola izimali eziyizigidi zama-dollar. Kodwa uma uhlaziya izidakamizwa, okuvame ukubekwa odokotela, kukhona umkhuba wokuzibuza: izitembu zikhonjiswe engxenyeni enhle yemigomo ebekiwe. Njengoba ubona, kukhona iphethini ngqo.

Imbonini yezokwelapha ilahlekelwa ukwethenjwa kweziguli

Eminyakeni embalwa eyedlule, abantu abaningi ngokwengeziwe (ngezizathu ezihlukahlukene) abasasekho abathembeli bama-pharmacologists. Lokhu kungenxa yezifundo eziningi ezihloswe ukutadisha imiphumela yezidakamizwa ezithandwayo emzimbeni womuntu. Njengomthetho, ochwepheshe abazimele, bakhuthazele isinqumo esidumazayo. Iningi lamaphilisi ayisimangaliso adluliswayo aliphili, kepha lilimaza abantu.

Amaqiniso amasha ashaqisayo

Akukatholakali kakhulu emlandweni we-American Journal of Physiology wamenyezelwa imiphumela yokutadisha okusha, okusho ukuthi izitembu zingabangela ukuguga kusenesikhathi ngaphambi komzimba. Ukusebenzisa isikhathi eside izidakamizwa ezinciphisa i-cholesterol egazini, ehambisana nemiphumela eminingana yempilo enzima. Isiguli esibheke ngokucophelela imiyalelo yezidakamizwa eziya ezidokotela ukuze zijwayele ukulwa nobuhlungu obuthakathaka, izifo ezithile ze-neurological and diabetes mellitus.

Abalobi besifundo baphumelela ekuboniseni imiphumela emibi emitholampilo

Izitatimende zinomthelela omubi kumaseli we-mesenchymal stem, anesibopho sokwakhiwa kwamathambo namathambo amaningi. Lezi zidakamizwa zenza ushintsho ezingeni lokubonakaliswa kwezakhi zofuzo ze-DNA. Yingesizathu esabizwa ngokuthi yiyona eyinhloko emiphumeleni emitholampilo eyingozi. Kucatshangwa ukuthi izitho zinciphisa inani lamacwecwe eziguli ezinesifo senhliziyo. Kungenxa yalokhu, uhlangothi oluhle futhi uthi izinkampani ezenza imithi.

Uma isiguli sicabanga ukuthi izinga eliphakeme le-cholesterol lizombulala ngokushesha noma ngokuhamba kwesikhathi, uzongena ekudleni njalo kwezidakamizwa ezinomphumela we-hypocholesterolemic. Nokho, ngakolunye uhlangothi, akusizi ukuthi abakhiqizi batshele abantu ngemiphumela emibi eminingi yemikhiqizo yabo. Yingakho ochwepheshe beseluleka ukuba sicabange kathathu ngaphambi kokuvuma izincomo zesidokotela. Kwabanye abantu, imiphumela emibi engenhla ingase ibe yinkinga enkulu.

Iyini ukusetshenziswa kwesikhathi eside kwezimiso?

Abantu abangasazi ukuthi yiziphi izinkinga zesimiso senhliziyo-mzimba akufanele zifake inkinga kulokho okungekho ngempela. Kulesi simo, ukwehliswa kwezinga le-cholesterol (ikakhulukazi ngemuva kokuphathwa kwesikhathi eside) kuhlanganisa ingozi yokubunjwa kwe-cataract. Lezi zidakamizwa azikwazi ukusetshenziswa njengesilinganiso sokuvimbela, ngaphandle kwalokho, zonke izingozi ezingase zibe khona kumele zilinganiswe. Uma izidakamizwa zaleli qembu zinomthelela omubi kuma-stem cells, lokhu kuholela ekunciphiseni ikhono lokuhlukanisa izicubu ezintsha.

Ezinye imiphumela emibi

Okwamanje, ososayensi baye baqhuba izifundo eziningana okuhloswe ngazo ekutadisheni umphumela wama-statins empilweni yabantu. Uma sifingqa iziphetho zaso sonke isayensi, kwenziwa isithombe esicindezelayo. Ngokuphelele, kusukela ekudleni kwezidakamizwa ze-hypocholesterolemic, kutholakala imiphumela engaphezu kuka-300 engathí sina neyingozi yokuphila. Sichaza kuphela izinto eziyinhloko: ingozi yokuba nomdlavuza, i-cataracts, uhlobo lwesifo sikashukela sesi-2, ukukhathazeka kokuvakasha, nokuphazamiseka kwengqondo.

Ukutadisha okunomsoco kwathola ukuthi ukusetshenziswa kweminyaka eyishumi yama-statins ngamaphesenti angu-83 kwandisa ingozi ye-carcinoma. Uma sicabangela izibalo zomdlavuza webele we-invasive, izibalo zicindezela nakakhulu: izidakamizwa ze-hypocholesterolemic zenza ukwanda kwengozi yokuthuthukiswa kwezicubu ezimbi ngamaphesenti angu-97. Njengoba ubona, abesifazane kufanele bahlakaniphe ngokukhethekile.

Ekulweni nokulwa nesifo sofuba

Uma ukhathazekile kakhulu ngokunciphisa izinga le-cholesterol egazini, kufanele wazi igama elibi elithi "i-atherosclerosis". Lesi sifo singapheli, kubangelwa ukwephulwa kwe-lipid metabolism futhi kuthinta imithwalo yegazi nemithambo yegazi. I-cholesterol igcina ifomu ngendlela yama-plaque, okuholela ekuqiniseni izindonga zemikhumbi nokulahlekelwa ukuqina kwazo. Kuvamile ukucabanga ukuthi izitembu zingalwela isimo esibucayi semithwalo yegazi, kodwa ochwepheshe abazimele baphinde bathi okunye. Ngokusho kososayensi, leli qembu lezidakamizwa lishukumisa ukuqina kwe-atherosclerosis futhi kuholela ekuhlulekeni kwenhliziyo ezigulini.

Ovuselela isifo sikashukela

Ngo-2012, kwakukhona ubudlelwane obuqondile phakathi kokuthatha ama-statins nokuqala kwe-type 2 yesifo sikashukela. Ochwepheshe bakhathazeke ngokujulile ngesimo sezindaba futhi banxusa abakhiqizi ukuba bakhulume lokhu kusigaba "semiphumela emibi" ephaketheni. Ilebuli yokuxwayisa iyoba yisihenqo se-alamu kubantu abaseqembu elinesimo esiphezulu sokuqala kwesifo sikashukela.

Ingabe kukhona okunye?

Empeleni, i-cholesterol ibalulekile kumuntu. Iyingxenye ebalulekile emangqamuzaneni weselula futhi ithonya elikhulu ekuqaliseni ama-hormone e-steroid nokukhiqizwa kwe-vitamin D. Nokho, inyama, amaswidi kanye nemikhiqizo equkethe ama-trans aphethe umphumela omubi ekwakheni kwamaseli. Umsebenzi we-cholesterol ukubuyiswa kwezicubu ezonakalisiwe. Ngakho-ke, sidinga ukulwa hhayi nomphumela, kodwa ngesibangela.

Kuyaziwa ukuthi ukudla kwabantu banamuhla ngokuyisisekelo kuqukethe inyama nokudla okucutshungulwayo. Ngeshwa, kancane kancane saqala ukukhohlwa ngokudla kwezitshalo. Kodwa lokhu akulungile, ngisho noma uqala ukuphikisana futhi ucacise ukulinganisa kwabantu abasemaphandleni njengesibonelo. Asikwazi ngokuqinisekile ukuthi yini okhokho bethu ababejwayele ukuyidla, kodwa sikwazi ukubuka imenyu yansuku zonke yezihlobo eziseduzane zamantombazane. Njengoba wazi, izinkawu azidli inyama. Futhi, futhi sinomuthi owanele we-intestine, okusho ukuthi ekuqaleni wajwayela ukudla ukudla okutshala.

Ukudla kwe-vegan kunikeza izinzuzo ezinkulu zezempilo

Ukuhambisana nokudla okutshala izitshalo akuhlinzeki nje ngezinye izinzuzo zezempilo, kepha futhi kuyinto yokuvimbela izifo eziningi ezimbi. Ngakho-ke, ngokudla imifino, ungazivikela ekuhlaselweni kwenhliziyo noma ngesifo sohlangothi, umdlavuza wesifo sikashukela, isifo sikashukela nezinye izifo eziningi. Uma ufuna ngempela ukuvikela izitsha zakho zegazi, vele ubuyekeze isithombe somsoco, futhi ungathengi ezitatimendeni ezilandelayo eziphezulu zama-pharmacologists.

Ungavumeli njalo umzimba wakho emithini, kungakhathaliseki ukuthi zanamuhla. Sayazi isikhathi eside ukuthi yonke imithi inezimo ezimbi, kungukuthi bavame ukubamba iqhaza kuyo. Kodwa uma ngokumelene nesizinda sokuthatha ama-statins awunayo ukusabela okwesikhashana komzimba, kusasho lutho. Imiphumela emibi ingase ivele kamuva, kodwa iyoba yingozi nakakhulu kunokugqama okulula noma isiyezi.