I-Pentoxifylline: izifaniso, imiyalelo yokusetshenziswa, izibuyekezo, amanani

Yini engingayenza esikhundleni se-Pentoxifylline? I-analogue yalesi sidakamizwa izonikezwa esihlokweni. Kuzo uzothola ukuthi yini le mithi ehloswe ngayo, yiziphi izinhlobo ezithengiswa ngazo, ukuthi kufanele isetshenziswe kanjani, njalonjalo.

Ukwakhiwa, ukuma, ukupakisha

Ngamuphi uhlobo umkhiqizo wokwelapha u-Pentoxifylline uthengisiwe? Imiyalo yokusetshenziswa (okufana nale mithi ingatholakala kunoma iyiphi ikhemisi) ikhombisa ukuthi le mithi ikhishwa ngamafomu ahlukene, okungukuthi:

• Emaphilisi (400 no-100 mg), ahlanganiswe negobolondo lombala obomvana. I-carton eyodwa ingaqukatha izingcezu ezingu-60 noma ezingu-20.
• Emaphilisi (400 no-100 mg). Emphakathini owodwa wekhadibhodi ingaba izingcezu ezingu-60 noma ezingu-20.
• Emaphilisi amasha asetshenziswe isikhathi eside (600 no-400 mg), aphethwe ngengubo ye-enteric futhi abe nomugqa wokwahlukana. Emaphaketheni ekhadibhodi ngokuvamile iqukethe izingcezu ezingu-50.
• Ku-ampoules ngesisombululo somjovo. Ukwakhiwa kwalesi sidakamizwa kubandakanya pentoxifylline, kanye ne-sodium chloride namanzi.

Izici zezemvelo

Yiziphi izindawo zomuthi Pentoxifylline? Isifaniso salolu remedy sinemisebenzi efanayo nemithi ngokwayo. Ubhekiselwa eqenjini elisha lama-pharmacy of hemorheological agents. Iyakwazi ukubuyisela i-plasticity ye-erythrocyte iphinde inciphise ukukhishwa kwayo. Lokhu kwandisa ukukhishwa kwemikhumbi, ene-lumen encane.

Izakhiwo ezinjalo zezidakamizwa ziholela ekunciphiseni ama-microcirculation okungcono, ezithinta kahle izicubu ngesikhathi se-hypoxia.

Pentoxifylline isebenza kanjani? Ama-analogs angenisiwe kanye nesiRashiya anethonya elifanayo lokwelapha njengoba imithi ngokwayo. Ngemuva kokusebenzisa lesi sidakamizwa, kunciphisa ukuhlanganiswa kwama-erythrocyte, okwandisa kalula ukunikezwa kwegazi kwezitho bese ufaka umbhede ongavamile.

Umuntu akanakusiza ukusho ukuthi lesi sidakamizwa sinciphisa i-viscosity yegazi, ngaleyo ndlela ibe negalelo ekuhlukaniseni amaplatelet. Ngenxa yalokhu kuvezwa, imizuzu yamaminithi kanye nokushaqeka kwegazi iyanda, kodwa izinga lenhliziyo alishintshi.

Ngakho-ke, ukwandiswa kwemikhumbi ye-pulmonary kuthuthukisa ukugcwaliswa kwegazi le-O ₂ , futhi ukwandiswa kwemithambo ye-coronary kwandisa ukuhanjiswa kwe-O ₂ emkhatsini we-myocardium.

Isidakamizwa esibuzwayo singakwazi ukwandisa ithoni ye-diaphragm kanye nomswakama wokuphefumula. Ngaphansi kwethonya laso, inani legazi eligeleza ngezibambiso liyakhula, futhi ukuhamba kwegazi kuyanda kuzo.

Yiziphi ezinye izinto eziphawulekayo yimithi Pentoxifylline? Isifanekiso salesi sidakamizwa kanye nomuthi ngokwawo ukwandisa ukuhlushwa kwe-ATP ebuchosheni, futhi kuthuthukise nokunikezwa kwegazi ezindaweni eziphazamisekile (isibonelo, ngesifo socwaningo lwe-ischemic).

Kumele kuqashelwe ukuthi le mithi imithinta kahle isimiso sezinzwa zomphakathi kanye nomsebenzi wayo. Ngokunqotshwa kwemithambo ye-peripheral, ukusetshenziswa kwalesi sikhungo kuholela ekwandeni kwamakhilomitha okuhamba, kufaka nesifo njengesifo sokuphela kwe-endarteritis.

Imingcele ye-Pharmacokinetic

Isidakamizwa "Pentoxifylline" sithatha isikhathi esingakanani? Imiyalo yokusetshenziswa (izifanisi zalo muthi zibalwe ngezansi) zisitshela ukuthi le mithi inegunya elihle kakhulu elingaphumelela, kuhlanganise nendawo yokuvimbela igazi.

I-half-life of the drug with administration of intravenous is 30 minutes. Uma uthatha imithi ngaphakathi, i-adsorbed ngokuphelele kusuka kumgudu wokugaya.

Umuthi esibindiwe uguqulwa, lapho udala ama-metabolites we-dimethylxanthine. Egazini, ukuhlushwa okukhulu komuthi kufinyelelwa kungakapheli amahora amane emva kokusetshenziswa. Kulesi simo, uhlala ezingeni lokwelapha cishe usuku.

Isidakamizwa sithandwa kakhulu yizinso (cishe amaphesenti angu-95). Ngomuthi, umuthi uphuma kancane.

Abamele abesilisa ababuthakathaka, abancancisayo, izidakamizwa zingase zivele kanye nobisi. Kumele kuqashelwe ukuthi ukuhoxiswa kwalesi sidakamizwa kuphuza kwiziguli ezinesifo esinzima sezinso, izifo zesibindi kanye nasebekhulile.

Izinkomba zokusetshenziswa

Ngabe iziphi izizathu isiguli esingabekwa sona ngemithi yePentoxifylline? Ama-analogues kanye nezikhundla zezidakamizwa anemibono efanayo yokusetshenziswa.

Njengamanje, izidakamizwa eziphumelelayo zisetshenziselwa ukuphatha izifo eziningi. Ake sibhale kuhlu njengamanje:

• Insufficiency ye-cerebrovascular;
• Isifo se-Urolithic;
• Encephalopathy i-atherosclerotic;
• Isihlungu sakwaSikemikhali;
• Nephroangiopathy yesifo sikashukela;
• Isifo somfutho wegazi ophezulu;
• I-bronchitis yokuvimbela;
• I-asthma ye-brronchial;
• Ukuphulwa komshini wokujikeleza kwe-peripheral ;
• Ukuxilongwa kwe-discirculatory;
• I-Algodismenorea;
• Sepsis;
• Cholecystitis;
• I-Dyskinesia yamathumbu ;
• Pilorospasm;
• I-spasms yemisipha ebushelelezi;
• I-Postthrombophlebitic syndrome;
• I-Dysmenorrhea;
• I-Angioneuropathy (isifo sikaRaynaud) ;
• Ukuphazamiseka kwegazi kwegazi;
• Ukuphulwa kwezicubu ze-trophic;
• Izilonda zeTrophic;
• Isongela ukukhulelwa kwesisu;
• Ukuphazamiseka okusebenzayo kwendlebe ephakathi nangaphakathi;
• Ukungabi namandla kwe-Vascular;
• I-dystrophy yama-muscular;
• I-gangrene, i-frostbite.

Ukungafani kokusetshenziswa

Kuziphi izifo okuvunyelwe ukusebenzisa umuthi Pentoxifylline? I-analogue yalo muthi kanye nezidakamizwa ngokwazo azikwazi ukuthathwa kubantu abangeneliswano kwezingxenye eziyinhloko, kanye nabanye abamele iqembu le-xanthine.

Ngaphezu kwalokho, lesi sidakamizwa siyaphikisana neziguli ezisanda kuhlaselwa isifo esibi kakhulu noma i-infarction ephawulekayo ye-myocardial, kanye nokuhlushwa kwe-atherosclerosis enkulu ye-heart and artery arteries, porphyria.

Ukusebenzisa imithi ngaphakathi kungavunyelwe ukuhleleka, ukuphuma kwegazi, ukucindezela kwegazi okuphansi, ukubola kwe-retina kweso. Futhi, lesi sidakamizwa sithinteka ekulaleni futhi sithela izithelo, izingane ezingaphansi kweminyaka engu-18.

Ngokunakekelwa okukhethekile, le nqubo imiselwe abantu abaqhutshwayo (ukuvimbela ukuphuma kwamagundane emangcwabeni kanye nezitho zangaphakathi), kanye neziguli ezinesifo esinzima sezinso nezinso zesibindi, isilonda esiswini, isisu sofuba nesifo senhliziyo.

Izindlela zokusebenzisa

I-Pentoxifylline isetshenziswa kanjani? Imiyalo yokusetshenziswa, ukubuyekezwa (izilinganiso zalesi sidakamizwa zingase zibe nezinye izilinganiso) odokotela abanolwazi bathi le mithi ithathwa ngomlomo nangokwesilisa (kuxhomeke ebukhulu besifo).

Ukuphatha ngomlomo izidakamizwa kuqala ngomthamo we-200 mg (ie amaphilisi amabili izikhathi ezintathu ngosuku, emva kokudla). Ngemuva kokufinyelela umphumela wokwelapha, inani elibonisiwe liyancipha ngesigamu. Inkambo yokwelashwa ngamathebulethi akumele iphele ngaphezu kwenyanga.

Ngezifo ezinzima neziyingozi zamalungu angaphakathi, imithi inqunywe kuma-ampoules. Kunezindlela ezimbili zokulawulwa kwezidakamizwa: ezithintekayo kanye nezibhedlela. Inqubo yokuqala yenziwa nge-dropper. Ukuze wenze lokhu, sebenzisa i-ampoule engu-250 ml ngesisombululo se-glucose noma i-sodium chloride. Leli lilinganiso lilawulwa amahora amabili.

Ngokuphathelene nokuphathwa kwe-intra-arterial of the drug, kunqunywe ngomthamo we-0.1 g ngomzuzu 50ml wekhambi le-sodium chloride.

Imiphumela emibi

Phakathi kwemiphumela emibi kakhulu yilezi ezilandelayo:

• Usizi, ukukhathazeka, ukuphazamiseka kokulala, ukuxubana, ukushintsha kwemizwelo, ukuphathwa ikhanda;
• Ukwandiswa kwe-cholecystitis, ukunyuka komsebenzi we-transaminase yesibindi, ukuthuthukiswa kwesifo sofuba se-cholestatic;
• Ukuvuthwa, umuzwa wokuchichima esiswini, isicashu, uhudo, ukunciphisa ukudla;
• U-urticaria, ukushaqeka kwe-anaphylactic, ukubheka, i- angioedema, ukubomvu kwesikhumba sobuso;
• Ukwenzeka kwe-arrhythmia, ubuhlungu enhliziyweni, ukwehla kwengcindezi yegazi, i-angina pectoris;
• I-Thrombocytopenia, i-leukopenia;
• Ukuhlala, ukukhubazeka okubukwayo;
• Ukweqisa kwe-asthma ye-bronchial, i-bronchospasm, ukwehluleka kokuphefumula;
• Ukukhipha ama-etiologies ehlukene.

Ukulungiselela "Pentoxifylline": okufanayo, intengo

Izidakamizwa ezilandelayo zifana nomuthi obabuzwayo:

• I-agapurin yehla (100 mg), kanye nesisombululo sejoza ku-ampoules (100 mg);
• Amathebulethi "Vasonite", agqoke ukugqoka (600 mg);
• Amathebulethi kanye nesisombululo sezijovo "Trental".

Kumele kuqatshelwe ngokukhethekile ukuthi "i-Trental" iyisidakamizwa sokuqala. Inqunyelwe iziguli ezine-encephalopathies zemvelaphi ehlukile.

Ngokuqondene nenani, ke kuzo zonke izidakamizwa ezibalwe kuhlukile. I-Analog "Trental" "Pentoxifylline" ingathengwa ngamaruble angu-120, imithi yokuqala - ama-ruble angu-520, i- "Agapurin" - ama-ruble angu-300, ne-"Vazonit" - ama-ruble angu-400.

Ukubuyekeza

Ukubuyekeza mayelana nalesi sidakamizwa kuningi kakhulu. Imithi iphumelela ezifweni ezinesisulu zezinhlelo eziningi nezitho. Ukubuyekezwa okuningi ekusetshenzisweni kwe- "Pentoxifylline" bashiywe ngamadoda ahlupheka ngokuqeda i-endarteritis nge- claudication ephakathi. Le mithi iyisiluleko sabo esingu-1, njengoba lesi sifo sinendawo yokuqhubeka.