"Fraksiparin": yokusetshenziswa, ngempela

Kungani linqume izidakamizwa ezifana "Fraksiparin"? Iziyalezo ukusetshenziswa kwezidakamizwa wathi ukukhulula ifomu kanye nokwakheka yayo izokwethulwa ngezansi. Futhi, kusuka mathiriyeli lo sihloko uzofunda ukuthi imiphumela izidakamizwa ecaleni kanye contraindications.

Ubujamo, emabhokisini Ukwakheka

Yikuphi iphakethe is imakethwa izidakamizwa "Fraksiparin"? Yokusetshenziswa kusikisela ukuthi leli thuluzi itholakala isipetu, okuyinto ujike ibekwa ibhamuza kanye amakhadibhodi ibhokisi.

ekwakhiweni Slaboopalestsiruyuschy senzelwe imijovo ongama uketshezi kungekho nto enemibala emihle futhi esobala. Kungaqukatha 9500, 5700, 2850, 3800 noma 7600 IU anti-Xa nadroparin calcium. Ngaphezu kwalokho, ukwakheka kufaka nomuthi futhi izinto ezengeziwe ezifana namanzi aziphothula, calcium hydroxide isixazululo, hydrochloric acid.

I kwemithi kanye pharmacokinetic izici

Uyini izidakamizwa "Fraksiparin"? Iziyalezo yokusetshenziswa, exhunywe izidakamizwa, uthi kuba anticoagulant ngempumelelo kakhulu futhi ejenti antithrombotic.

Isithako asebenzayo zomuthi - ongaphakeme yamangqamuzana isisindo heparin. It kuveza depolymerization nemibukiso kuqhathaniswa okusezingeni eliphezulu sesibopho ukuthobisa plasma amaprotheni. ukuchayeka okunjalo kuholela ekuphikeni okusithiyayo okwandisiwe isici Xa.

Emva umjovo ongama ka esiphezulu anti-Xa umsebenzi ebonwe amahora angaba mahlanu. Umuthi is amuncwa 88%.

Uma izidakamizwa saphathwa ngemithambo yegazi, emakamu yayo eliphakeme egazini emva kwemizuzu engaba ngu-10. Kulesi isigamu-ukuphila 2 h.

It is akheka ku desulphation isibindi nomuthi futhi depolymerization.

izinkomba

Kungani usebenzisa izidakamizwa "Fraksiparin"? Yokusetshenziswa (isithombe izidakamizwa ingatholakala kulesi sihloko) uthi le imithi evame ukunikezwa ukuvimbela yezinkinga thromboembolic, kuhlanganise ngemva izinqubo kuhlinzwa wamathambo kuhlinzwa.

ejenti anticoagulant Kunconywa ukuba asebenzise abantu nge ingozi eliphezulu thrombosis, kanye abaphethwe esingamahlalakhona kwemigudu yokuphefumula noma ukumelwa inhliziyo ohlobo oyingozi.

Izimo

Kungaphansi kwaziphi izimo is hhayi Kunconywa ukusebenzisa imithi, "Fraksiparin"? Yokusetshenziswa iqukethe uhlu elandelayo Izimo:

• umonakalo isitho nokuba khona ukopha;
• thrombocytopenia, eba ku ngemuva ukusetshenziswa nadroparin esikhathini esidlule;
• yobudala umuntu ongaphansi kweminyaka engu-18 ubudala;
• ukopha noma ukwanda kwemithwalo nengozi yokuba nesifo somdlavuza elihlobene ne Ukuwohloka hemostasis;
• ukungasebenzi kwezinso, ikakhulukazi ezinzima;
• ukopha intracranial;
• infective endocarditis efomini acute;
• ukuhlinzwa noma ukulimala iso enethiwekhi, ingqondo noma umgogodla;
• hypersensitivity izidakamizwa izinto esigulini.

Asinakusho ukuthi "Fraksiparin", ukubuyekezwa okuyizinto edidayo, kufanele kube ne kuqikelelwe kakhulu in iziguli ukungakhuli kwezinso noma hepatic, izinguquko ukugeleza kwegazi e-retina kanye choroid, umfutho ophakeme wegazi, okwenzeka ezinzima, ngesifo kukhuphuke ingozi ukopha izilonda peptic esikhathini esidlule, kanye lihambisana namanye anticoagulants, ngemuva kokuhlinzwa kanye neziguli nesisindo 40 kg.

Izidakamizwa "Fraksiparin": yokusetshenziswa

imithi IVF "Fraksiparin" okunqunyiwe ukuze sithuthukise nemingcele rheological legazi kalula yenzeka.

Sebenzisa le izidakamizwa kumele udokotela. Kumelwe ufakwe phansi kwesikhumba lapho esiswini, kushintshana izinhlangothi kwesokunxele nakwesokudla. Kulokhu, isiguli kufanele babe sesimweni yizikhukhula. Kwezinye izimo, imithi iqondiswa ethangeni.

Indlela kwabathinta "Fraksiparin"? Inalidi Kufanele ufake perpendicular emphethweni isikhumba esakha khulula esandleni nezinzwani. Kulokhu, abese eyishutheka kufanele igcinwe phakathi nawo wonke umjovo. Ngemva umjovo we bezihlikihla Ukufakwa indawo akuvunyelwe.

Yini okufanele ibe umthamo "Fraksiparin" izidakamizwa? 0.3 ml iqondiswa ukuze kuvinjelwe thromboembolism e kokungenela kuhlinzwa (2850 anti-Xa ME). I nomuthi iqondiswa kungakapheli amahora amane ngaphambi kokuba uhlinzwe, bese - kanye ngosuku. Ukwelashwa kungase baqhubeka okungenani yesonto elilodwa noma inkathi yonke kwengozi thrombus kumiswa (isib ukwedlulisela ngaphansi sinenkonzo yokunakekela iziguli emakhaya observation).

Manje uyazi, kulokho oda lesi sidakamizwa "Fraksiparin" (0.3 ml) angabelwa.

Ngaphezu ukuhlinzwa, ithuluzi ngenkuthalo esetshenziswa nokuvinjelwa thromboembolism e amathambo. Iqondiswa phansi kwesikhumba ukuze 38 anti-Xa IU ngayinye kg isisindo umzimba. Lokhu umthamo kungenziwa lenyuke ngamaphesenti izikhathi 1.5, kodwa ngosuku lwesine emva udokotela wamathambo.

Abantu nengozi enamandla nomuthi thrombotic "Fraksiparin" 1 iqondiswa phansi kwesikhumba kanye ngosuku e isamba, kubalwa njengoba umsebenzi isisindo isiguli (uma esingaphansi 70 kg - 3,800 anti-Xa IU ngelanga, nokuningi - 5.700 anti-Xa IU).

Ekwelapheni thromboembolism, anticoagulation ngesimo amaphilisi kufanele sinikezwe ngokushesha ngangokunokwenzeka. Ukwelashwa "Fraksiparinom" abayeki nje injongo isikhathi prothrombin is ingafinyeleleki.

Izimpawu ze-ukweqisa izidakamizwa

Manje ngoba sewuyazi ukuthi indlela kwabathinta "Fraksiparin". Qaphela ukuthi uma usebenzisa imithamo ephezulu lokhu izidakamizwa e isiguli bangezwa ukopha ka kwasendaweni ezahlukene. Ngesikhathi esifanayo ukopha ababuthakathaka zidinga ukwelashwa esiphuthumayo (kudingekile kuphela ukwehlisa umthamo noma ukubambezeleka elandelayo umjovo).

Ngokuqondene overdoses eqinile, le sulfate protamine kusiza iwukudambisa umphumela anticoagulant ka heparin. Ukusetshenziswa Its liyadingeka kuphela ezimweni ezimbi kakhulu.

side effects

Iziphi izinkinga zokwelashwa kungabangela "Fraksiparin"? Izibuyekezo iziguli ukuthi umuthi onjalo ikhuthaza ukopha izindawo ezihlukahlukene, thrombocytopenia, eosinophilia, amazinga kwenyuke enzyme isibindi, futhi hypersensitivity. Futhi, iziguli zingase akha hematoma encane ongama endaweni yokukhuleka umjovo. Kulezi zimo, ukwelashwa "Fraksiparinom" kufanele inqanyulwe.

izidakamizwa ekuhlanganyeleni

Ingozi hyperkalemia kakhulu anda lapho kubhekwa izidakamizwa lihambisana ACE inhibitor, i-potassium nosawoti, angiotensin yokwamukela blocker, isisu, i-potassium-engashiyi "Tacrolimus" heparins "cyclosporine", futhi ama-NSAID "trimethoprim".

Kufanele ukuthi inhlanganisela ne acetylsalicylic acid, ama-NSAID, anticoagulants ngokungaqondile, "dextran" fibrinolytic noma isenzo synergistic izidakamizwa.

Phakathi nokukhulelwa kanye lactation

Ingabe kungenzeka ngesikhathi ethwele ingane ukuthatha "Fraksiparin"? Yokusetshenziswa ngesikhathi sokukhulelwa (ukubuyekezwa ukulungiswa zizonikezwa ngezansi) uthi nadroparin calcium (asebenzayo izidakamizwa imfuyo) sihamba ngempela kalula ngokusebenzisa placenta. Futhi, ingxenye izidakamizwa ikhishwe kanye nobisi lwebele.

Uma sicabangela lokhu okungenhla, kufanele kuphawulwe ukuthi imijovo "Fraksiparina" nengane esindayo futhi kakhulu hhayi Kunconywa ukuba isetshenziswe ngesikhathi ibele. Nokho, kwezinye izimo, lokhu izidakamizwa nakho elibekelwe iziguli.

Njengoba ukusetshenziswa kwezidakamizwa "Fraksiparin"? Yokusetshenziswa ngesikhathi sokukhulelwa kufanele kuthuthukiswe ulwazi lobuchwepheshe. Kulokhu, lo wesifazane kufanele kube ngaphansi kolawulo njalo nodokotela wakho.

intengo Analogs

Analogs lokhu ukulungiselela yilezi ezilandelayo izidakamizwa: "Heparin-Farmeks", "Atenativ", "Enoksarin", "Isitsha Ngenxa F", "Tsibor", "Heparin", "Fragmin", "Heparin-Biolik", "Flenoks", " heparin-Darnitsa "," Novoparin "," heparin-Indar "," Clexane "" heparin-Novofarm ".

I inani lentengo lomuthi "Fraksiparin" eliphezulu kakhulu. Ngokuhamba imijovo 10 (0.3 ml) kuzodingeka akhokhe ruble mayelana 2,500.

Uphenyo nomuthi

Nobufakazi mayelana imoto abakhona okuxubile. Othile esesizile izidakamizwa kahle, kanti abanye akhononde yokungenzi. Ngaphezu kwalokho, kukhona impela eningi Izibuyekezo ukuthi "Fraksiparin" kubangela inqwaba ukusabela ezingezinhle.

Ochwepheshe batusa sithembele imibono labo uye wawusebenzisa lo izidakamizwa. Kuba semtsetfweni aphoyintimenti zomuthi, ngempumelelo yayo futhi izingozi ezihambisana naso, kungaqondakala kuphela uchwepheshe abanolwazi.

Kufanele kuqashelwe ukuthi azikho izibuyekezo ezimbi ngalokhu thuluzi ekukhulelweni.