"Fosfomycin": analogue, imfundo kanye impendulo

Nakuba ama-ejenti elwa namagciwane abe inombolo enkulu yemiphumela emibi, akusiyo njalo kungenzeka ukuba senqabe isicelo sabo. Into esemqoka ukuthi izidakamizwa likhethwe kahle futhi ikunikeze imiphumela oyifunayo.

ukusebenza kahle High ekwelapheni izifo kuyahluka nomuthi "Fosfomycin". Izidakamizwa analogue nomphumela ofanayo. "Fosfomycin" ikhishwa ngesimo granules kanye powder amanzi-encibilikayo senzelwe isixazululo, it has a ububanzi spectrum umsebenzi elwa namagciwane.

Lo mshini wezenzo zomuthi

Imithi elwa namagciwane ngempumelelo yezifo kabani ukuthuthukiswa kungenxa imiphumela phezu komzimba amagciwane ayingozi (Gram omuhle futhi Gram-negative). Umthelela elwa namagciwane kufinyelelwa ngezithukuthuku esebenzayo izidakamizwa fosfomycin trometamol. isenzo elwa namagciwane Kwenziwa ukwephulwa kwetinhlavu webhaktheriya iseli izindonga.

Pharmacokinetics

Lapho lokuhlushwa enkulu isithako esebenzayo, esiphezulu waphawula izidakamizwa umsebenzi "Fosfomycin" elikhona oketshezini olungenambala lwegazi. Umhlahlandlela libonisa ukuthi lokhu amahora 2-2,5 ngemva Ukungena zomuthi emzimbeni. "Fosfomycin" efanelekayo ekuphathweni parenteral futhi ngomlomo. Izidakamizwa kokungenisa, ugxile ngokushesha kusukela ipheshana emathunjini, abuye ahlahlele ku trometamol fosfomycin. Absorption ku ekupha 34% kuya ku-65% (ukudla kunciphisa Inkomba, kangcono ngakho imithi isiphuzo esiswini esingenalutho). Kwaphela isigamu-izimpilo edingekayo 4 ihora. Fosfomycin trometamol excreted ngokuphelele indle kanye nomchamo, ngokuyinhloko izinso (cishe 90%).

izinkomba

Ngokuvamile "Fosfomycin" analogs nomuthi esithathwayo ngomlomo izifo ezithathelwanayo kohlelo urinary. Izidakamizwa ngempumelelo aphathe cystitis kanye urethritis omsakazo webhaktheriya, bacteriuria ezinde kakhulu, ezingase ngezinye izikhathi kwenzeka kwabesifazane abakhulelwe futhi kungaba akusho ukuzibonakalisa. Esikhathini esiyiminyaka nasezinkingeni ezilandela ngemva kokuhlinzwa, lo ejenti elwa namagciwane ukuvimbela ukuvela pathologies ezithathelwanayo.

Ukujova kuboniswe ekwelapheni inqwaba izifo eziwumphumela ekubhujisweni ngemagciwane zomzimba:

• ubovu pleurisy;
• cystitis oyingozi;
• pyelonephritis;
• adnexitis;
• septicemia;
• i-pneumonia,
• bronchiectasis;
• ukutheleleka okhalo.

Ezimweni ezimbi kakhulu ekwelapheni inhlanganisela kungenzeka, ngaphandle uma "Fosfomycin" nezinye esetshenziswa antibiotic. Ngokuyinhloko "Fosfomycin" (analogs) isetshenziswa ngesikhathi esifanayo ne-beta-lactam antibiotic.

Izimo kanye nemikhawulo

Umuthi akuyona iqondiswa at ezwela ephakeme ukuze isithako esebenzayo kanye izingxenye asizayo. Umuthi is contraindicated iziguli kutholakala ukwehluleka kwezinso (creatinine imvume ngaphansi kuka 10 ml / imiz.).

Lapho ukwephula "Fosfomycin" nemisebenzi isibindi kanye nezinso kusetshenziswe ngokuqapha phakathi nokukhulelwa kanye lactation - kuphela ngaphansi kokuqondisa onguchwepheshe.

Asebenzisa iyadingeka nokwelashwa kweziguli ngaphansi kweminyaka engu-5 no-engu-75 ubudala (izingane ezingaphansi kweminyaka engu-5 "Fosfomycin" okunqunyiwe ezingavamile).

Ukusetshenziswa "Fosfomycin"

Ngaphakathi ukusetshenziswa zithutha ngaphambilini ziyoncibilika emanzini imijovo ukuthatha ikhambi komjovo okulungiselelwe kusukela powder "Fosfomycin" ukulungiselela. Analogs, futhi leli thuluzi lisetshenziswa ngemithamo ezinconywe udokotela ukuba khona. Umthamo kuncike isifo namandla aso.

Kusukela endulo, iziqondiso kusho umthamo esiphezulu esibekiwe lapho zokungenisa: izingane - 2 amagremu ngosuku, abadala - 3 amagremu ngosuku. Ingane ingasatshenziswa ngemithambo yegazi kungekho zinesisindo kakhudlwana kunezinye 100-200 mg / kg emzimbeni, omdala - hhayi ngaphezulu kuka 2-4 g Granules kanye ezithathwe, esiswini esingenalutho noma 2 amahora ngemva kokudla. Kulokhu isidlo esilandelayo kungenzeka ngaphambili kuka emva 2 amahora. Kungcono ukuthatha imithi ngaphambi kokulala ngemva bethulula esinyeni.

side effects

Umkhiqizo equkethe trometamol fosfomycin, analogs ithuluzi, kanye nanoma yimuphi omunye imithi elwa namagciwane kungaholela ukuthuthukiswa ukusabela engadingeki. Thuthuva elandelayo pheshana emathunjini:

• ukushintsha e sezinyawo;
• ukubuyisa;
• isicanucanu, kulandele ukuhlanza.

Isimiso sezinzwa ngezinye izikhathi waphawula uvalo anda, isiyezi, ubuhlungu bekhanda, umuntu njalo ufuna ukulala.

Imijovo kungabangela ubuhlungu ngesikhathi indawo umjovo, umuzwa ukoma. Ngemva kokuphathwa zomuthi ngale ndlela ezinye iziguli thrombocytopenia, leukopenia, kusukela komzimba - ukushaqeka anaphylactic, isikhumba ukulunywa, ukuqubuka, urticaria. Imiphumela engemihle futhi zihlanganisa ukubukeka edema neuropathy, futhi nokuquleka. It is hhayi ngaphandle ukubonakaliswa nezinye imiphumela emibi.

Ngo ukweqisa izidakamizwa ukusabela engadingeki kukhona evelele. Kubalulekile siphuza neziphuzo kakhudlwana, ngaphezu, kubalulekile ukuba afeze ukuphathwa lingaze.

Ngemva kokuchaza imiphumela emibi izidakamizwa "Fosfomycin" imfundo iyakwenqabela ukusetshenziswa kwaso phambili. Doctor izidakamizwa esikhundleni kumele kwenziwe.

Izixwayiso

Kufanele kucatshangelwe nokuxhumana zomuthi nezinye izinto. It is hhayi Kunconywa ukuthatha nge "metoclopramide" usho ukuthini, isb. Ukuze. Waba yini umphumela ukusetshenziswa kwabo ngokuhlanganyela ukunciphisa ukusebenza kwe "Fosfomycin".

Musa thatha imithi ezigulini zithambekele ukubonakaliswa nomzimba. Njengoba izidakamizwa ludlulele ngaphakathi ubisi lwebele, ukwelashwa ngesikhathi ibele kufanele inqanyulwe noma kwenziwe ngokuqapha.

"Fosfomycin" analogue, omqondofana zomuthi zithatha izifundo. Phakathi ukwelashwa, imithi angeke ezingabanjwanga, kubalulekile ukusebenzisa abagcina ngezikhawu alinganayo. Uma kwakuba khona pass umthamo edingekayo kufanele kuthathwe njengendawo (kuphela uma kwenzeka ukuthi akudingekile ukuthatha umthamo olandelayo esikhathini esizayo esiseduze) ngokushesha ngangokunokwenzeka.

Izibuyekezo Analogs

Kunalokho, lesi sidakamizwa "Fosfomycin" singasebenza izidakamizwa, analogs nezidakamizwa-omqondofana. Kodwa kufanele akhethe udokotela ekwelapheni. Kuyaphawuleka ukuthi "Urofosfabol" futhi "Monural" ngokuvamile lisetshenziswa esikhundleni sokubika amathuluzi. Zingaba ngempela ngempumelelo esikhundleni "Fosfomycin". Analogue e-Ukraine eyethulwe le mithi. Le mithi kahle ukubhekana kangcono nale imisebenzi ingasetshenziswa aphathe izifo ezifanayo njengoba "Fosfomycin". Njengezinye ejenti elwa namagciwane, banayo ezinye imiphumela emibi. "Urofosfabol", "Monural" kuthathwe ngokucophelela okukhulu, into efanayo kusebenza izidakamizwa "Fosfomycin". Uzakwabo eRussia, okuyinto ethandwa kakhulu - "Monural", kodwa futhi "Urofosfabol" futhi babe Pharmacy.

"Monural" ngokuvamile ezinqunyiwe ekwelapheni ngomgudu womchamo izifo sibi ezithathelwanayo okuyinto zenzeka ngaphandle yobunzima obabangelwa nezilwanyana ezincane ekuthonyweni izidakamizwa. Umuthi asetshenziswe imisebenzi kanye nezinqubo kusebenta kwahulumende. "Urofosfabolom" ukwelapha izifo ezithathelwanayo kanye ukuvuvukala, kodwa yilabo kuphela nozwelo izinto zalo ephilayo. Kunezindlela ongakhetha ambalwa Ungashintshanisa "Fosfomycin". Analogue of Ukraine neRussia usebenzise ubuchwepheshe obufanayo.

Izibuyekezo abonisa ukuthi "Fosfomycin" Ngeke uhlale kungatholakala Pharmacy, futhi izindleko kuphakeme, hhayi wonke umuntu angakwazi ukuthenga. Kodwa "Monural" ihlale ikhona. Kuyinto ushibhile, kodwa akenzi okubi nakakhulu. Ngokufanayo, labo abamukela "Fosfomycin" isaziso ukuthi unakho nomphumela ofiselekayo ngokushesha ngokwanele. Nokho, akubona bonke uyalibona ngesikhathi ushintsho oluhle. Ngezinye izikhathi, ukuze lesi sifo, kubalulekile ukuba amise enye izidakamizwa. Kwezinye izimo, ohlangothini ukusabela zenzeka, isb. K. Umzimba lomuntu ngamunye uhlukile futhi esabela izinto ekhona amalungiselelo ehlukile.