"Estrozhel": yokusetshenziswa, incazelo ukulungiselela, analogs, side effects

Kuyinto imfihlo ukuthi i- syndrome climacteric libhekene autonomic-semithambo, engokwengqondo umzimba kanye endocrine iziyaluyalu ukuthi uvuke ubulili bubuhle nge Imininingwane yobudala involution umzimba, kanye ngemuva ukushabalala kancane kancane hormone umsebenzi wesibeletho.

Kulesi sikhathi esinzima ukuze abesifazane babevame uzizwe ukufikelwa ukushisa kuya ekhanda, emzimbeni elingaphezulu nezingalo.

Ngaphezu kwalokho, izimpawu ze-menopause zihlanganisa ukucasuka ngokweqile, ukuqwasha, ukucindezeleka, ubuthakathaka kanye umuzwa kokuphila ngokwesaba njalo. Ngokuvamile, abantu bobulili bubuhle eshintsha esesuthi ukuphazamisa migraine, inzululwane, kanye kokuba ukujuluka ngokweqile, edema kanye vasospasm.

Ukuze ungangihluphi kakhulu isimo sowesifazane, izinkampani zemithi eseqala ukuveza protivoklimaktericheskie izidakamizwa. Indlela ephumelela kakhulu zalezi zinhlobo zihlanganisa imithi efana "Estrozhel". Ukubuyekezwa (ngesikhathi menopause iyindlela ebekiwe ngokuvamile kakhulu) abasebenzisi izokwethulwa ngezansi. Uyofunda indlela ukusebenzisa izidakamizwa wathi, ukuthi kubiza malini, nokunye.

Incazelo, ukubunjwa, iphakeji ifomu ukukhululwa

ithengiswe imithi "Estrozhel" ngayiphi indlela? Uphenyo abesifazane asho ukuthi umuthi zingatholakala ngesimo ijeli transdermal. Ayinambala, okusobala, futhi iphunga ethanol.

Isithako asebenzayo lokhu ejenti izenzo estradiol. Njengoba izithako asizayo nomuthi iqukethe carbomer, ethanol, trolamine namanzi ahlanzekile.

Ukulungiselela "Estrozhel" (gel) okuthengiswa amashubhu aluminium. Okunye okufakiwe nokokuyifaka ekhethekile ukuba ulungiselele.

izici kwemithi

Kuyini ijeli "Estrozhel"? Imiyalelo isicelo ibonisa ukuthi kuba ejenti hormone, okwenza i-bikho estrogen yomzimba wowesifazane.

Ngenxa izithako zako asebenzayo lo muthi has umsebenzi estrogenic. Kuhloswe kuphela isicelo yangaphandle noma baqonde izinto ezenzekayo.

Ekwelapheni lesi sakhiwo kwabobulili bubuhle kakhulu ziyancipha izimpawu of syndrome menopausal, kuhlanganise nokucindezeleka amawala, ukufikelwa ukushisa kanye isitho sowesifazane somile.

Ngo ukusebenza kahle yayo ngeziguli ekwelapheni izimpawu postmenopausal imithi kubhekwe akusho sokudedela ukwelashwa nge ngomlomo yokwelapha i-estrogen. Ngaphezu kwalokho, uma usebenzisa leli thuluzi ezigulini menopausal imakwe okwehlisa izinqubo ezinciphisa kwabantu nezicubu namathambo.

Futhi ukwelashwa wachitha kusiza ekwehliseni cholesterol Imininingwane.

Asinakusho ukuthi izidakamizwa "Estrozhel", intengo oboniswe ngezansi, has procoagulant kahle. Kunciphisa inani antithrombin III futhi kwandisa hepatic synthesis K-engaphansi igazi ekunqandeni ejenti.

izakhiwo pharmacokinetic

Kungakhathaliseki imithi ugxile "Estrozhel"? Izibuyekezo ochwepheshe bathi emva isicelo se-ijeli kwenzeka ngokushesha ngempela ahwamukayo le-ethanol, lapho estradiol ngokushesha ingena esikhunjeni. Ingxenye enkulu izidakamizwa ngokushesha ingena kwegazi, futhi ezincane - egcinwa amanoni ongama, okuyilona elisebenzayo futhi kalusilili.

Ngemva ukusetshenziswa endawo emakamu gel esiphezulu estradiol egazini waphawula emva kwemizuzu 180-240. I bioavailability zomuthi kuyinto 82%.

nomuthi Okubukwe akuyona ngaphansi umphumela "pass kuqala", esihlinzeka plasma lokuhlushwa ephakeme ka estradiol uma ziqhathaniswa temlomo analogue.

Ukuhoxiswa estradiol kanye nenguquko yayo umzimba efana neyalabo ngokuba estrogen zemvelo efanayo.

Izinkomba isicelo i nokulungiselela yangaphandle

Lokhu kwakwenziwa ngayiphi injongo izidakamizwa "Estrozhel" ingasetshenziswa? Yokusetshenziswa ibonisa ukuthi lokhu remedy Kunconywa ukunciphisa noma kuqede izimpawu ze-syndrome climacteric, kuhlanganise menopause eyayenziwe ngamabomu. Ngaphezu kwalokho, izidakamizwa okukhulunywa livame ukusetshenziswa nokwelashwa kwamathambo phakathi kwabadala.

Izimo

Ingabe uyasazi uma akufanele sisebenzise ijeli "Estrozhel"? Yokusetshenziswa ibika ukuthi kuya Izimo eliphelele leli thuluzi zihlanganisa izimo elandelayo:

• Rotor syndrome;
• ischemic noma haemorrhagic unhlangothi;
• thrombophlebitis oyingozi noma thromboembolism;
• ngesikhathi sokukhulelwa;
• lesizalo ukopha Lokudabuka esingacaciswanga;
• ukwehluleka kwezinso;
• ibele;

• ; Johnson - syndrome Dubin
• komdlavuza estrogen ancike noma izinsolo yobukhona babo;
• hypersensitivity;
• izimila ingozi noma abulalayo we pituitary;
• Serious isifo sesibindi esigabeni oyingozi, izimila isibindi, futhi i-jaundice.

Ukusetshenziswa kwesivuno ngokuqikelela nomuthi

Kunini lapho kufanele ngithinte ukusebenzisa ijeli "Estrozhel" ngokucophelela okukhulu? ochwepheshe lezivakashi bathini mayelana kwale mibandela elandelayo:

• leiomyoma;
• yenhliziyo isifo Umthambo;
• endometriosis;
• thuthuva umsebenzi sesibindi;
• pancreatitis;
• sikashukela;
• migraine;
• isithuthwane;
• somoya;
• hyperlipoproteinemia umndeni;
• porphyria hepatic;
• isifo ukuvuvukala kwesimiso sokuzala kwabobulili bubuhle;
• waphawula ngaphambi jaundice, kuhlanganise ukubonakaliswa yayo ngokuhamba sokukhulelwa zokugcina;
• trombozay, thrombophlebitis noma thromboembolism (kuqhathaniswa ukwelashwa estrogen);
• nomfutho wegazi ophakeme ezinzima;
• zokugula gallbladder futhi cholelithiasis (umlando);
• hypercalcemia ezihlobene ne amathambo metastases webele asesibelethweni izimila;
• iziyaluyalu kwegazi.

Gel "Estrozhel": yokusetshenziswa

ukulungiselela Okubukwe isetshenziswa ihlelwe ngokulandelana kwezihloko kuphela. Kulesi simo isetshenziselwa ngokuqhubekayo noma cyclically. Ubude besikhathi sokwelashwa Isikali zomuthi akhethiwe ngamunye.

Umthamo owodwa we-ijeli "Estrozhel" (2.5 g) iqukethe 1.5 mg estradiol.

Ekwelapheni izimpawu menopause kuboniswe alahlwayo ukusebenzisa izidakamizwa ngosuku e isamba umthamo ngamunye. Ijeli ukuthi thinly ukusakaza phezu kwesikhumba endaweni ye lumbar esifundeni, ibhodi lemisindo, esiswini noma ehlombe, futhi silindele ukuncela yayo ngokuphelele.

Isayithi kwesikhumba lapho izidakamizwa lasetshenziswa, ngeke ibe ngaphansi endaweni kokubili izandla isiguli.

Ukuze ukusebenza efanele izinhlelo zokusebenza ngolwazi lokuphequlula umphumela ephumelela kunazo libhekene ukumuncwa izidakamizwa imizuzu 3. Ngesikhathi esifanayo kulondolozwe stickiness emva isicelo isilinganiso esisodwa zomuthi imizuzu 5 kubonisa ukuntula isikhala esetshenziswa isikhumba.

Sebenzisa imithi kufanele isiguli (ekuseni nobe ntsambama). Sebenzisa gel kuyinto efiselekayo nesembozo ngaphambilini bahlanza.

side effects

Yimiphi imiphumela engadingeki zenzeka ngemuva ukusetshenziswa ijeli "Estrozhel"? Uphenyo abesifazane ukubika imiphumela emibi:

• isikhumba ukucasuka, isikhumba ngamanzi, ikhanda kanye migraines;
• ukushintshashintsha kwemizwelo, amehlo nesiyezi;
• ukuzwela nokwanda ubukhulu nezindlala mammary, ubuhlungu babo, menorrhagia, amenorrhea, ukufohla ukopha;
• izimila kule nezindlala mammary, libido yanda, smearing osenyameni lwesitho sangasese sowesifazane, kuhlanganise nezikhathi intermenstrual;
• ukuqunjelwa, nenyongo sesinye isimiso, isicanucanu, ukuhlanza, isifo sokusha kwesibindi, ubuhlungu epigastric, ukudla, ukudla pancreatitis;
• cholelithiasis, jaundice cholestatic, uhudo, amajaqamba esiswini, ukuvuvukala;
• thromboembolism, contact lens ukungabekezelelani, izinguquko isisindo, edema neuropathy;
• anda blood pressure, nokungezwani komzimba nezinto (kuhlanganise urticaria futhi ukulunywa kwesikhumba), contact dermatitis.

Zonke yale miphumela engemihle kuvetwa kunalokho wavuma. Ngokuvamile kwenzeka eqala ukwelashwa futhi cishe akasoze adinga ukuqedwa imithi.

Izimpawu ze-ukweqisa izidakamizwa

Kuzokwenzekani uma semali lesi sidakamizwa "Estrozhel" (indlela ukusebenzisa leli thuluzi, we thasisela ngenhla)? Endabeni ngemithamo ephakeme nomuthi e isicanucanu nesineke futhi ukuhlanza, kanye nokuthuthukisa lesizalo ukopha. Ngo ukwakheka lezi zimpawu zisebenzisa ijeli ngayeka.

Ukuxhumana nezinye izidakamizwa

Kungenzeka yini ukuba zihlangana kanjani nezinye izidakamizwa izidakamizwa "Estrozhel" (gel)?

• Ngo isicelo parallel ejenti antihypertensive futhi hypoglycemic, futhi anticoagulants kungehlisa impumelelo yabo, okudinga ukubuyekeza umbuso sokuphuzisa.
• Inhlanganisela "Estrozhelya" nezidakamizwa lipid-ukwehlisa kuholela umphumela kakhudlwana yokugcina.
• Ngekusetjentiswa kanyekanye ne izidakamizwa okuyizinto inducers enzyme isibindi microsomal (isb, "rifamycins", "Carbamazepine", "griseofulvin" futhi barbiturates), ekhishwe oketshezini olungenambala olusegazini estradiol kungehlisa izinga.
• Ukusetshenziswa ijeli kunciphisa ukusebenza kwe-isisu futhi hormone ocansini besilisa.
• Ukusetshenziswa ngesikhathi esisodwa izidakamizwa, analgesics opioid nezidakamizwa ezisetshenziselwa ukubulawa kwezinzwa okuvamile, ngesivinini umzimba estradiol.
• Inhlanganisela nge nemithi ethile elwa namagciwane (kuhlanganise "rifampicin" futhi "ampicillin"), kanye "Phenylbutazone" kunciphisa plasma lokuhlala estradiol.
• ukwelashwa kanye kanye nge-folic acid futhi hormone yegilo kwandisa estradiol imiphumela izindlela.

izincomo ezithile

Izidakamizwa "Estrozhel" ukusetshenziswa akuvunyelwe nakancane ngesikhathi sokukhulelwa. Kufanele kuphawulwe ukuthi ngaphambi isicelo wabesifazane gel kufanele aqiniseke ukuthola luhlolo ephelele izifo zabesifazane. Ngekusetjentiswa eside zomuthi, lezo zinqubo kufanele kwenziwe okungenani kanye ngonyaka.

Ngokusho izincomo ukwelashwa onguchwepheshe is advantageously eyenziwa lihambisana estradiol, ukwelashwa progestin. inhlanganisela enjalo uzovikela endometrium.

Kufanele ukuvikela mucosa we ngemomozi futhi sangasese, kanye isikhumba ebeleni zingangeni kubo kubhekwe izidakamizwa.

ukusetshenziswa isikhathi eside zomuthi, kuhlanganise ebulilini, wandise nengozi yokuba webele futhi umdlavuza endometrial.

Uma ufuna yokuqokwa ukuhlinzwa, therapy estrogen kufanele inqanyulwe amasonto 4-6 ngaphambi.

"Estrozhel" akumele zisetshenziswe ngesikhathi ukuhlela sokukhulelwa. Kufanele kuqashelwe ukuthi le nomuthi asebenzayo akusho umuthi izakhiwo kanye akuvimbeli ukukhulelwa.

Izidakamizwa "Estrozhel" futhi "Utrozhestan" - inhlanganisela ephelele. Ngenxa yaleli lungiselelo izinga lempilo lesiguli ngesikhathi menopause ngcono kakhulu.

Izindleko kanye efanayo amalungiselelo

Yeka ukuthi kuyinto ijeli "Estrozhel"? Intengo yale ejenti kuyinto ruble angu-700. Uma kudingeka, kungase kuthathelwe indawo nezinye izidakamizwa ezifana "Estrokad", "Esterlan", "Estrovagin", "Ovestin", "Sinestrol", "Kolpotrofin", "ethinylestradiol", "Elvagin", "Ovipol Clio", "Pauzogest "," Klim "nabanye.

Izibuyekezo abesifazane

I ubulili bubuhle usebenzisa indlela ngempumuzo izimpawu zokunqamuka wamshiya okubuyayo kuphela. Bona wazi kahle yaso ephezulu imvamisa encane nobukhali side effects kuqhathaniswa nabalingani ngomlomo.

Okunye ezimfanelweni ezinhle izidakamizwa ahlanganisa elula nokushintsha kokudla nokufakwa indlela yayo, ukuntuleka tackiness emva inqubo kanye ukumuncwa okusheshayo esikhunjeni.