"Klarotadin": yokusetshenziswa. Lapho ukuthenga "Klarotadin"? Kusukela lokho amaphilisi "Klarotadin"? Analogs "Klarotadina"

komzimba - isihloko sizobe sithi ngempela olufanele, ikakhulu kubazali. Phela, inani okuthiwa "yokungezwani komzimba" liyakhula njalo ngonyaka. Ngakho-ke, manje sicabangela ngokuningiliziwe ukulungiswa "Klarotadin". Yokusetshenziswa uzoqala Ukubukeza kwethu izidakamizwa. Worth ukubona ngaphambi ukusetshenziswa. Thenga "Klarotadin" nganoma yisiphi ekhemisi edolobheni lakho, futhi ngaphandle kadokotela.

lapho ukusebenzisa

I nomuthi ingasetshenziswa conjunctivitis nomzimba, angioedema, nge urticaria (acute chronic idiopathic). Umuthi 'Klarotadin "ubuye ngempumelelo ngesikhathi unyaka wonke noma rhinitis ezithile zonyaka; pseudoallergic lapho ukusabela zibangelwa histamine ikhishwe; indlela esisabela ngayo lapho isinambuzane eluma ezahlukene; kanye ukulunywa dermatoses. Uhlu angase kulekelelwa.

Yini ikhiqizwa

Cabanga kuqala umkhiqizo "Klarotadin" -sirop. ku isicelo iziyalezo zakhe uzonikezwa ngezansi. Isikali - 5 mg / 5 ml. Loratodina (isithako esebenzayo) omunye milligram ngemililitha isiraphu ngalinye. Excipients: propylene glycol, ushukela, benzoic acid, ETHYL utshwala, citric acid, tropeolin, amanzi ahlanzekile, flavorings ukudla.

Edayiswa ibhodlela ingilazi amnyama, amandla awo eziyikhulu namamililitha. Lokhu bubble ebhokisini amakhadibhodi. Le kit sihlanganisa wokulinganisa spoon ekhethekile.

Manje cabanga iphilisi "Klarotadin". ithebhulethi ngamunye has angu eziyishumi loratodina. Kusukela nezinsizasenzo - MCC, i-lactose, calcium stearate, glycolate, isitashi sodium. Ibekwe amashashaza, ngasinye izingcezu eziyisikhombisa noma eziyishumi. La mabhokisi kungenzeka kusuka eyodwa kuya kwemithathu-amaphakethe yezingqimba zomhlaba.

pharmacodynamics

Lesi sidakamizwa kungokwalabo H1-antihistamine, abangenalo anticholinergic futhi isenzo emaphakathi. Iqala isigamu sehora ngemva ukuphuza izenzo usuku lonke. Kubalulekile ukuthi ekuphathweni ezingamahlalakhona zomuthi akusho ziba namandla okumelana nalo. Kufanele kuqashelwe ukuthi loratodin izidakamizwa futhi metabolites zayo akuzona ezikwazi ukuhlaba zingene Bbb.

Pharmacokinetics

Ngokuqondene eyanele, ngesikhathi edonsa kule ngemithamo Kunconywa ngumkhiqizi, ingxenye eyinhloko loratodin ngokushesha futhi ngokugcwele angena egazini ngokusebenzisa pheshana emathunjini. I lokuhlushwa ezingasetshenziswa kakade ukunquma, avele ukubunjwa oketshezini olungenambala lwegazi imizuzu eyishumi nanhlanu ngemuva kokudla. Njengoba isikhathi ukufinyelela Cmax e-plasma loratodina, ke kuhluka ihora elilodwa imizuzu engamashumi amane emahoreni amabili imizuzu engamashumi amathathu.

Kodwa isikhathi ukuze nifinyelele Cmax metabolite yayo esebenzayo ngamahola amathathu kwedlule. Vele khumbula ukuthi ukusetshenziswa ngesikhathi esisodwa ukudla kanye imithi okwaziyo ukubambezela yonke impumelelo Cmax loratodina futhi metabolite yayo asebenzayo plasma ngehora elilodwa. Ngesikhathi esifanayo Cmax yalezi izinto kuyoba azizange zishintshe, futhi ukudla ayikwazi nganoma iyiphi indlela ukuthonya umphumela.

Manje asebekhulile. "Klarotadin" (afundiswe amanothi isicelo), angase ayiswe ngaphandle ukubhuka ekhethekile mayelana ubudala. Vele khumbula ukuthi isikhathi ukufinyelela Cmax luyanda amahora eyodwa nengxenye, ngokungafani kuya intsha. Mayelana ukulimala kwesibindi oludakayo, kuye ngobucayi izifo kanti futhi ekufezeni okhushuliwe Cmax.

Esikhathini plasma okuqukethwe loratodina metabolite yayo asebenzayo ifinyelela iningi iziguli ezingeni umile kakhulu ngosuku lwesihlanu ngemva ukungenisa. Kwakheka isibopho ne-plasma amaprotheni - 97%.

umzimba

Isibindi loratodin izidakamizwa esebenzayo akheka esebumba asebenzayo metabolite dezkarboetoksiloratadina. Lokhu kwenzeka ngenxa ithonya cytochrome P450 isoenzyme CYP3A4. Umthelela cytochrome P450 isoenzyme CYP2D6 sithinta, nakuba ngezinga elincane. Kektonazol samanje, kuyinto inhibitor ka CYP3A4, kuvumela loratodinu ibe dezkarboetoksiloratadin. Lokhu kungenxa imithelela CYP2D6.

zizalela

Ukuhoxiswa lesi sidakamizwa "Klarotadin" (yokusetshenziswa futhi okukhulunywa) nge izinso, kanye kanye Bile. Isilinganiso T1 / 2 loratadine ketshezi kuyinto amahora ayisishiyagalombili nemizuzu ematjhumi amabili (ububanzi kungenzeka kusukela amahora amathathu kuya kwangamashumi amabili). Ngokuphathelene metabolite asebenzayo, isilinganiso salo amahora amabili nesishiyagalombili (ububanzi kungaba amahora ayisithupha imizuzu engamashumi amane amahora amathathu nesikhombisa).

I dezkaboetoksiloratadina lesemkhatsini kuyinto amahora nesikhombisa futhi imizuzu engamashumi amathathu (ububanzi, nanye ukuze amathathu nesishiyagalombili amahora). Uma kuba utshwala isibindi lesion, le T1 / 2 kuzokhulisa nge okwandisa kobukhulu isifo. Kodwa ezigulini abe nokwehluleka ukusebenza kwezinso futhi othola hemodialysis, pharmacokinetics abangekho washintsha.

sokukhulelwa

Ngeke ezithathwe kwabesifazane abakhulelwe lesi izidakamizwa, ngoba "Klarotadin" izingane ezimbili usesibelethweni, kungabangela umonakalo. Uma-ke kwadingeka ukuba usebenzise lesi umama izidakamizwa ubuhlengikazi, khona-ke kuyadingeka ukuba ayeke ibele nje ekwelapheni usuphothuliwe.

Izimo

Njengezinye izidakamizwa has contraindications "Klarotadin". Imiyalelo isicelo uthi isidakamizwa akumelwe lisetshenziswe uma isiguli sine-hypersensitivity kunoma sezakhi zalokhu nokulungiselela. Nokukhulelwa kanye lactation nazo izimo lapho thuluzi alinikeziwe noma wathola. Iziguli kufanele yokwehluleka kwesibindi, kufanele athathe lesi sidakamizwa "Klarotadin" ngokuqapha.

side effects

Manje kubalulekile ukutshela mayelana nendlela lokhu kungase zibulale izidakamizwa emzimbeni womuntu. izimpawu olungenzeka kwemizwa uhlelo neziyaluyalu, okungukuthi, ukukhathazeka asthenia, hyperkinesia, ukuyaluza wengane, somnolence, liqhaqhazela, paresthesias, ukucindezeleka futhi ukulahlekelwa amandla okukhumbula. amafutha Ongama nesikhumba angaphendula izingxenye imithi dermatitis.

Uma sikhuluma uhlelo genitourinary ke ukumshumayeza kungaba ushintsho umbala umchamo, isiguli singase yini oyozizwa efuna ukuchamela, okuyinto uzobe ephelezelwa ubuhlungu. Kungase futhi ukuthuthukisa lezinkinobho, dysmenorrhea futhi menorrhagia.

On the yesimiso endocrine kanye ukwephulwa. Isisindo zingandiswa, isiguli ngeke Ngilambile, futhi kungase kwandise ukujuluka. uhlelo zemisipha ingase futhi ibhekane ezinye ukushayisana umsebenzi wabo. Lokhu umlenze amajaqamba futhi myalgia, futhi arthralgia.

Isimiso sokugaya ukudla bungene Ungase futhi ahlupheke. Ukuhlanekezela ukunambitheka, ukuqunjelwa noma isifo sohudo, ukudla, ukudla kolwelwesi, ukuqunjelwa, isifiso sokudla kakhulu, stomatitis kanye ukubuyisa - konke lokhu nge okungenzeka ezithile kungenzeka uma usebenzisa "Klarotadina".

Buvame ukwehluleka futhi umgudu wokuphefumula. Ukwephulwa babonakalise njengoba bronchoconstriction, ukukhwehlela, sinusitis, futhi kome ulwelwesi lwamafinyila ku ekhaleni. Ingase futhi ukuthuthukisa conjunctivitis, umbono siyabhubha, ubuhlungu izindlebe namehlo. Isimiso senhliziyo nemithambo yegazi futhi kuncike side imiphumela bangase balwisane njengoba palpitations, kukhuphuke blood pressure, futhi kuncishiswe it.

Cases komzimba nezinto, ebonakaliswa ifomu angioedema, pruritus, urticaria futhi photosensitivity. Ungase wamukele iqolo, imfiva, hoarseness, ubuhlungu besifuba, Ukugodola, blepharospasm, futhi ubuhlungu webele.

Njengoba ubona, imiphumela engemihle ingase ibe mibi kakhulu, ngakho-ke ungakhohlwa ngakho. Ukubonisana edingekayo kokubili ngaphambi ekuphathweni lokuqala izidakamizwa futhi esimweni ukuthola izinkinga ngenhla.

Sebenzisa umthamo

Isiraphu kanye amaphilisi "Klarotadin" kuyiphi - ukuqonda. Manje ake sixoxe okufanele zithathwe kanjani. Le mithi zenzelwe ukusetshenziswa yangaphakathi. Izingane eziba abaneminyaka engaphezu kuka-nambili, kanye kutuswa umuntu omdala ngosuku kuba angu eziyishumi. Lokhu akhe amabili isiraphu liquid noma esinye isibhebhe sibonisa. Kodwa izingane kusukela eminyakeni emibili kuya kwabayishumi nambili ubudala, isisindo somzimba esingaphansi amathathu amakhilogramu, kutuswa ukuthatha angu ezinhlanu. Lena ngenye Ketha noma isigamu ithebhulethi. I umthamo wansuku zonke kumele singeqi lesi sibalo. Uma isisindo engaphezu kuka amathathu amakhilogramu, umthamo kuyoba okufanayo njengoba abadala.

ukweqisa izidakamizwa

Uma ungalaleli iseluleko futhi ukuthatha izidakamizwa eziningi ezinkulu, kungabangela izimpawu e abadala, okuzokwenza manje efakwe ohlwini. Lokhu tachycardia, ikhanda futhi ukozela. Futhi izingane zabo isisindo lingaphansi kuka amathathu amakhilogramu, ukweqisa izidakamizwa kungadala palpitations, futhi izimpawu extrapyramidal.

Uma isiguli wavuma ukweqisa izidakamizwa, kufanele axhumane ngokushesha ne-udokotela. Kuyadingeka ukuba athathe izinyathelo zokuqinisekisa ukuthi izidakamizwa lasuswa kusukela pheshana emathunjini bese ukumuncwa lancipha. Lokhu kwenziwa ngokuyenga emesis, lavage esiswini, kanye nokusetshenziswa kwe-carbon isebenze. Endabeni yokwelapha lingaze kungaba kwenziwe kuphakama isidingo. Kufanele kukhunjulwe ukuthi imfuyo esebenzayo loratadine ayikwazi yekhalenda kusuka emzimbeni by hemodialysis. Futhi, azikho idatha excretion kwalesi sakhi ngesikhathi isebenzisa umshini wezinso peritoneal.

Ukuxhumana nezinye izidakamizwa

Uma sisebenzisa "Klarotadin" in umthamo zokwelapha, umphumela potentiating of utshwala atholakele. Futhi isicelo zomuthi nemithi ezifana "Cimetidine", "Erythromycin" futhi "ketoconazole" kuzokhulisa lokuhlushwa loratodina plasma yegazi. Lesi simo esiyingqayizivele sibangelwa akusho sibonakalise emtholampilo, futhi akunamthelela le electrocardiogram.

Kunobufakazi bokuthi i-inductors ka microsomal namachibi, okuyinto zihlanganisa ethanol, phenytoin, barbiturates, rifampicin, ziksorin, tricyclic antidepressant, Phenylbutazone, kunganciphisa ukusebenza kwalesi izidakamizwa.

Izixwayiso

Iziguli abaphethwe kahle umsebenzi hepatic, futhi ezithinta ukuphathwa izinso (filtration glomerular has a Isivinini esingaphansi amathathu ml / iminithi), Kunconywa umthamo kokuqala "Klarotadin" kumele singeqi angu eziyishumi (lokhu ingenye ithebhulethi, noma spoon ezimbili yokulinganisa isiraphu) e ezimbili usuku. Singeke sikunikeza lokhu izidakamizwa ezinganeni, ogama yobudala engaphansi kuka-iminyaka emibili.

Bonke labo waqala ukuphuza lokhu imithi kumele kunqanyulwe isikhathi ngezikhathi ukwelashwa noma yiluphi uhlobo imisebenzi engase ibe yingozi ezidinga emakamu eliphezulu nesivinini lengqondo ukusabela.

analogs

Kuyinto kungalungile ukusho ukuthi kwakungekho ngisho noyedwa uhlobo buyisidakamizwa "Klarotadin". Analogue benomthwalo phakathi izidakamizwa ezifuywayo amazwe. Ngiphephile efanayo yokusebenzelana namazwe angaphandle "nabo" ingumuthi "Claritin". Amandla ayo cishe kuyafana nalokho zomuthi ngenhla kubhekwe "Klarotadin". Inani - lokho umehluko oyinhloko. ukulungiselela Overseas kakhulu ngaphezulu ezibizayo. Intengo yasekhaya kuyafana, kuncike ukumisa. Ngakho, ukupakisha 7 PC. Izokubiza ruble mayelana 100 lokugoqa metering nentaba 10 x 3 -. Cishe 270 ruble, futhi 100 ml isiraphu -. Ruble mayelana 135.

Ngeke lapha ukukhuluma ngalokho ukusebenzisa kangcono - "Klarotadin" noma "Claritin". Lena indaba yangasese, futhi kuyomelwe ukuba uzinqumela, ukuthenga ezishibhile womkhiqizo wakuleli, noma makudle angaphandle ezibizayo. Kodwa-ke Kuyaphawuleka ukuthi eminyakeni kakhulu kahle kungase kutholakale umkhiqizo "Klarotadin". ngaleyo ndlela Analogs avele nsuku zonke.

Kunoma ikuphi, ngaphambi kokuba uqale ukuthatha le mithi nokuningi ukuze lokuqoka izingane zabo, qiniseka bonana nodokotela wakho kuqala. Lokhu kuzokwenza ukukuvikela kungenzeka imiphumela engemihle engase ivele ngenxa ukungabekezelelani izidakamizwa, nokusebenzisa kabi ukweqisa izidakamizwa zakhe noma. Kufanele ngaso sonke isikhathi zikhunjulwe imiphumela enjalo singaba usongo enkulu empilweni yakho, impilo izingane zakho, futhi ukuphila kwenu.