"Dekapeptil": yokusetshenziswa, ukwakheka, izinkomba kanye contraindications

Indlela ukusebenzisa imithi "Dekapeptil"? Iziyalezo ukusetshenziswa kwalesi izidakamizwa izokwethulwa ngezansi. Uyofunda mayelana izinkomba ukusetshenziswa zomuthi, analogs lwalo kanye nezinye izigigaba ezingezinhle.

"Dekapeptil": incazelo izidakamizwa, ukubunjwa yayo futhi ifomu

nomuthi Okubukwe udayiswa umjovo ecacile futhi kungekho nto enemibala emihle ngaphandle kokuba kungekho iphunga amanyela.

Isakhi esiyinhloko lokhu umuthi triptorelin acetate. Ngaphezu kwalokho, kuhlanganisa izithako ezifana glacial acetic acid, i-sodium chloride namanzi umjovo.

Thenga isixazululo "Dekapeptil" isithombe sokuthi ubizwa okwethulwa kulesi sihloko kungaba imijovo, izitsha eziyisikhombisa, ephelele inaliti, okuyinto tihlelwe e nentaba amaseli bese amakhadibhodi amabhokisi, ngokulandelana.

Isenzo zomuthi (kwemithi)

Liyini ikhambi "Dekapeptil"? Yokusetshenziswa ibika ukuthi Analogue zokwenziwa of GnRH, noma okuthiwa i-hormone gonadotropin-lokukhululwa.

Ngemva kokuphathwa zomuthi izidakamizwa esebenzayo kudala ukwanda ezingeni LH futhi FSH egazini, eyagcina kuholela ukwanda lezivakashi e lokuhlushwa hormone ocansini. ukushukuma okuqhubekayo we pituitary (isib at isicelo njalo kwezidakamizwa) kunomthelela ekusebenzeni ukuvinjelwa gonadotropic. Waba yini umphumela wesibindi imiphumela enjalo kuyinto ukwehla inani hormone (ubulili) ukuze menopausal noma postcastration. Lezi emuva.

Izifundo izilwane zokucwaninga Akabonisanga mutagenic noma imiphumela teratogenic kubhekwe izidakamizwa.

I pharmacokinetics lomjovo izidakamizwa

Yini izakhiwo pharmacokinetic isici "Dekapeptil" isixazululo? Iziyalezo yokusetshenziswa uthi ngemaminithi ekucala 50-90 emva nokuphathwa izidakamizwa egazini ifinyelela isiqongo sayo triptorelin. okuhlushwa Eminye yalolu ketshezi abahlukene encishisiwe (emini).

Isikhathi isigamu-nokuphila we Isakhi esiyinhloko kuba imizuzu 18,7. Mayelana 4% triptorelin ivela umchamo ngefomu zinjalo.

Kufanele kuqashelwe ukuthi pharmacokinetics we ukuhlolwa kwezidakamizwa emzimbeni zazenziwa abantu unesifo ukuqinisekisile of lesizalo fibroids noma i-endometriosis, kanye amavolontiya aphilile besilisa iziguli ezine carcinoma we wendlala.

Izinkomba kwezokuphatha i isixazululo komjovo

Ukuze lokho prescribers "Dekapeptil" injongo? Izinkomba ukusetshenziswa yesixazululo kwabesifazane yilezi:

• lesizalo fibroids;
• ukwelashwa ukungazali usebenzisa ubuchwepheshe zokuzala (isb, ukudluliswa embryo yoke, IVF);
• i-endometriosis.

Ngokuqondene namadoda, iyithuluzi Kunconywa for ekwelapheni lingaze hormone ancike carcinoma ethuthukile wendlala.

Uvala ukwethulwa izidakamizwa kwabesilisa nabesifazane

Kwezinye izimo, awukwazi ukungena isixazululo "Dekapeptil"? Yokusetshenziswa ibonisa ukuthi lokhu izidakamizwa is contraindicated abesifazane:

• ngenkathi ibele;
• ukhulelwe;
• ukubonakaliswa emitholampilo ingozi kwamathambo.

Kufanele kuphawulwe ukuthi ngokuqapha izidakamizwa esetshenziswa ekuqhubeni uhlelo in iziguli IVF nge amaqanda polycystic (ngamanye amazwi, uma isibalo follicle, okuyinto kunqunywa ultrasound, ingaphezu kuka-10).

Ukuze wobulili namandla izidakamizwa kubhekwe is contraindicated ku:

• nge castration kuhlinzwa (ngaphambi);
• wendlala carcinoma (i-hormone ezimele).

mthetho Jikelele indawo ye-thuluzi hypersensitivity kuya triptorelin nesineke noma kwezinye izingxenye ze-izidakamizwa.

Isixazululo "Dekapeptil": yokusetshenziswa

Lo muthi senzelwe abaphathi ongama. Ngo endometriosis, umdlavuza wesinye kanye nomdlavuza lesizalo izidakamizwa iqondiswa e isamba 0.5 mg / ml kanye ngosuku isonto lonke. Ngosuku 8th kudlule umthamo nokugcinwa 0.1 mg / ml kanye ngosuku.

Ekwelapheni le-ejenti liyadingeka ukuqhuba ultrasound futhi qapha osayizi fibroids futhi endometriosis foci.

Lapho nomuthi Uhlelo IVF iqondiswa ngokuvumelana yezifiso (kungaba esifushane noma ultrashort). Ukuze uvimbele umjovo indawo ukusabela post-umjovo isikhathi ngasinye ushintsho.

Lapho ukusebenzisa isixazululo "Dekapeptil Depot"? Iziyalezo yokusetshenziswa uthi leli thuluzi uvezwa phakathi Yiqiniso isikhathi eside yokwelapha. Liphinde iqondiswa phansi kwesikhumba esifundeni besisu, noma intramuscularly 1 isikhathi ezinsukwini ezingu-30.

Isixazululo ukulungele yasetshenziselwa ngokushesha. ukwelashwa endometriosis futhi lesizalo myoma iqala ezinsukwini zokuqala lomjikelezo. Lokhu kwelashwa kufanele tinyanga mayelana 3-6. Lapho ukwelashwa umdlavuza wendlala nakho kwenziwe isikhathi eside.

Lapho IVF izidakamizwa "Dekapeptil Depot" iqondiswa kanye ngezinsuku ezithile umjikelezo.

Phenomena ngu-uhlamvu

Elibangela ukusabela ezingezinhle "Dekapeptil" isixazululo? Imiyalelo, ukubuyekezwa babike ukuthi imiphumela emibi, eyabonakala ku ngemuva kwesicelo yaleli izidakamizwa ngenxa ukwehla kwenani hormone ocansini egazini, okungase luholele ukuthuthukiswa izimpawu ezinjengokucindezeleka, isimo lability, ngiphathwa ikhanda njalo buthakathaka libido, ubuthongo thuthuva , ukushisa komzimba, isisindo somzimba, futhi ukujuluka anda. Ngaphezu kwalokho, izinguquko ezilandelayo aye abonakala kwezinye iziguli:

• ukuvimbela ngomgudu womchamo, paresthesia, ubuhlungu ngesikhathi sokuya ocansini;
• angaboni kahle, ubuhlungu emuva, ukuba buthakathaka kwezicubu;
• abesifazane - ukopha lesizalo futhi isitho sowesifazane somile;
• amadoda - gynecomastia, ziyancipha potency ukunciphisa usayizi emasendeni;
• isicanucanu, siwasebenzise, ukungakuthandi ukudla, ukulunywa;
• imfiva, hypercholesterolemia, ithambo nobuhlungu obubangelwa metastases;
• myalgia, umgogodla intambo kokucindezelwa, anaphylaxis;
• arthralgia, ubuhlungu ngesikhathi izidakamizwa umjovo site, ithambo demineralization (ngokusebezisa isikhathi eside);
• lymph ukwandisa node, thrombophlebitis, ukuvuvukala kwezinyawo;
• iqothukile phezu imilenze, esifubeni kanye izingalo, ukunciphisa umkhawulo wentshebe ukukhula.

Kufanele kuqashelwe ukuthi zonke yale miphumela engemihle zinyamalale ngokushesha ngemuva kokuphela yokwelapha.

ekusebenzisaneni Izidakamizwa, overdoses

Nokwenza kubhekwe izidakamizwa uyalandelwa. With ukuthuthukiswa izimpawu omubi isizinda ngemithamo okweqa imithi kumele kwenziwe ukwelashwa lingaze.

Izidakamizwa ekuhlanganyeleni "Dekapeptil" engakaze iqiniswe namanye amanxusa.

ulwazi oluthile ukuze iziguli

ukwelashwa izidakamizwa "Dekapeptil" kufanele kube ngaphansi kolawulo okuqinile izinga lama-hormone ocansini egazini.

Abesifazane Kufanele nifeze isifundo ukuze ugweme ukukhulelwa kungenzeka. Phakathi ukusetshenziswa kwezidakamizwa Akwamukelekile basebenzise izinto zokuvimbela inzalo hormone, kanye amalungiselelo equkethe estrogens ngokwako.

Isiguli kufanele baziswe ukuthi ngesikhathi Inkambo yokwelashwa kubhekwe kokuya esikhathini izidakamizwa kuyoba lingekho.

Ukusetshenziswa leli thuluzi ngo amadoda kungaholela ziwohloke zesikhashana esimweni sayo. kufanele ngokushesha ubone udokotela ngesikhathi okuvela izimpawu ezingezinhle.

izidakamizwa ezifanayo

Yini esikhundleni isixazululo zokwelapha "Dekapeptil"? Analogue kule izidakamizwa kunzima ngempela ukuthola, ngakho inqubo efanayo kufanele ukubhekana kuphela udokotela abanolwazi.

Ngokusho kwemibiko kwezinye izazi, imithi kungenziwa babhekwa Limiselelwe izindlela ezilandelayo:. 'Zoladex', 'Buserelin Depot "," Diferelin "," triptorelin "

Izibuyekezo solution umjovo

Okwamanje, i-therapy ye endometriosis, uhlelo zokuzala kanye nezinye izifo lekahle futsi abaphumelelayo agonists hormone gonadotropin-lokukhululwa. Lezi zihlanganisa izidakamizwa ezifana "Dekapeptil", "Diferelin ',' Zoladex 'nabanye. Nokho, kufanele kuphawulwe ukuthi zibiza kakhulu lezo zimali ayikuvumeli ukuba kabanzi zokwelapha. Kule ndaba, amazwana isicelo sabo, akukho kakhulu.

Ngokusho imibiko wezazi, lesi sidakamizwa "Dekapeptil" avame engabelwe ekwelapheni lesizalo fibroids (ubude izinyanga 5-6). Ukusetshenziswa okunjalo le nomuthi okuholela ukuncipha lesizalo umthamo kanye osayizi ISIZINDA. Okulandelayo bahlinza. Ngakho, ukwelashwa "Dekapeptilom" esasibekelwe njengoba kulungiselelwa preoperative.

Iziguli eziningi bathi ngemva nokwethulwa kwesixazululo avame amqaphela umjovo indawo ubuhlungu, ukulunywa futhi ububomvu. Futhi ikhanda, ukushisa komzimba, ukuqwasha kanye nokukhathala.

imibiko emihle mayelana leli thuluzi ngokuvamile ashiye abesifazane besebenzisa "Dekapeptil" IVF olandelwayo. Ngenxa yalesi izidakamizwa ezimweni eziningi inqubo ukuqaliswa umbungu esibelethweni uphela ngempumelelo. Ka ohlangothini imiphumela esaphatha bubuhle ubulili ukufikelwa ukushisa futhi ukujuluka.