"Bisoprolol": ukubuyekezwa, yokusetshenziswa futhi analogue

Ngokusho odokotela, inhliziyo yomuntu - yisona sakhiwo ebaluleke kakhulu. Kungakhathaliseki ukuthi isimo kuwukuthi, konke kulele ekutheni izinga lempilo kanye nesikhathi salo. Nanoma imikhuhlane noma emathunjini izifo kubantu abaphendukela imitfolamphilo ivame kuphelelwa. Wonke umuntu uyazi ukuthi akuvamile ziholele ekufeni. Ingxenye isizathu ngawo umuntu ongase afe, kukhona isifo senhliziyo. Ososayensi futhi nangodokotela bababhekene nezifo zenhliziyo wadala eziningi zezidakamizwa ezisiza hhayi kuphela isikhathi ekuphileni kwabantu, kodwa futhi kungaba balahle yalesi sifo. futhi lisho "Bisoprolol" libhekisela izidakamizwa ezinjalo. Izibuyekezo okufakiwe odokotela emaphephabhukwini ezokwelapha abonisa ukuthi iziguli isifo senhliziyo, zagcwaliseka emva imithi oyinikiwe nale izidakamizwa iba lula kakhulu.

Main mayelana "bisoprolol" ukulungiselela

Lesi sidakamizwa, okuyinto B-andenoblokiruyuschim kusho. Sekuyisikhathi eside esetshenziswa kwezokwelapha, okungukuthi nezenhliziyo. Khomba hhayi kuphela e umfutho wegazi ophakeme, isifo senhliziyo, kodwa futhi ukwehluleka inhliziyo futhi inhliziyo isigqi iziyaluyalu imithi "bisoprolol". Izibuyekezo iziguli abonisa ukuthi emva kwezinsuku ezimbili kufushane ezilahlekile umoya, ubuhlungu zinyamalale inhliziyo.

Nasi umlando

Umqondo ukukhipha umuthi ezifanayo Wavela in 1967. It yadalwa yinkampani wasebenza "Merck" (wawuyingxenye yezinto ke futhi namuhla iqembu izinkampani "Astra"). Kwaba ngalowo nyaka ngokokuqala, ososayensi baye bathola into ezifana beta1-blocker. Ngaphezu kwalokho, ezimbili subtypes ka-receptor adrenergic etholakala ngesisekelo yalo. Kuyinto ezifana b1-adrenoceptor kanye B2-adrenoceptor. I nomuthi "Bisoprolol" libhekisela eqenjini abakhethayo blocker beta1-adrenergic. Basuke imakwe njengoba kakhulu sokukhohlwa esihlukile nezinye izinto potency.

Ukwakheka izidakamizwa "bisoprolol"

Uma sicabangela izingxenye abamelwe zomuthi, kungabonwa ukuthi isici esiyinhloko - ketshezi kuyinto bisoprolol fumarate uqobo. Iqukethe 5 amagremu efana wonke amaphilisi angiphe wona "bisoprolol". Izibuyekezo iziguli abonisa ukuthi kakade emva ethatha lokuqala izidakamizwa kakhulu kuthuthukisa impilo. Ayikho imithi angeke kwenziwe ngaphandle amalungu asizayo. Futhi izidakamizwa esebenzayo sihlanganisa sodium croscarmellose noma primeloza, povidone noma polivinillirolidon srednemolekurny, isitashi prozhelatininy, Silicon dioxide colloidal kanye talc kancane, microcrystalline cellulose, lactose noma ubisi noshukela magnesium stearate.

izidakamizwa Iningi enamathela bushelelezi amukeleke. Lokhu kusebenza futhi lesi sidakamizwa "bisoprolol". Izibuyekezo zibonisa ukuthi izibhebhe zigwinywa kahle, angahlali ukunambitheka ezingemnandi emlonyeni. Lena konke sibonga izingxenye ezifana Macrogol (polyethylene glycol), ama-titanium dioxide, Opadry 2. zithutha umbala emnandi is etholwe udayi esetshenziswa - yensimbi oxide (2).

Yokusetshenziswa "bisoprolol" izidakamizwa

Sebenzisa le imithi kuphela edinga udokotela. Kukhona njalo ngamunye iphakethe izidakamizwa "bisoprolol" izinkomba. Izibuyekezo abonisa ukuthi ngezinye izikhathi odokotela batusa iziguli zabo inkambo kancane ezihlukene zokwelashwa. It kuncike isifo, ubudala, izici umzimba. Ivame Kunconywa ukuba asebenzise akukho engaphezu kwengu-20 mg ngosuku. Lokhu kuyinto evamile ukuba umuntu omdala. Omunye ithebhulethi ngokuvamile 5 mg. Akumele ezokuhlafunwa futhi kufanele kugwinywe ngokuba namanzi amaningi. Labo izincomo zihlanganisa emuthini "bisoprolol" imfundo manual. Amazwana kwesokunxele abantu belisebenzisa, abonisa ukuthi Yiqiniso ngemva lidlule zempilo ukwelashwa iba ngcono kakhulu.

Uma isiguli kuwufanele ukuxilongwa "umfutho wegazi ophakeme" noma "isifo senhliziyo", kubalulekile ukusebenzisa amaphilisi 2 ngelanga, ngokuvamile ekuseni nakusihlwa. Ngo esigabeni sokuqala umthamo ukwelashwa kungase kube ezincane - 5 mg kuphela ngelanga noma esinye isibhebhe sibonisa. Ngokuzimela idlule kuyinsakavukela noma kunjalo engenakwenzeka. Uma imithi kungasizi, kuzomele uqale bonana nodokotela wakho futhi uthathe isinyathelo izincomo zayo. Ochwepheshe ngaphambi linqume le imithi, hlola umsebenzi nezinye iinhlangano ukunakekelwa okukhethekile ikhokhelwa ukushaya kwenhliziyo. Ngaphambi kokuqala ukuthatha inkambo amaphilisi isiguli kudingeke uhlole inhliziyo yakho ishaya ngamandla.

Izimo

Noma yimuphi nomuthi kubantu bephethwe izifo ezihlukahlukene kungabangela engathandeki engemihle. Lokhu kusebenza futhi "bisoprolol" izidakamizwa. Izinkomba ukusetshenziswa ku iphasela ngalinye. Leli bhukwana libuye lithi lokhu imithi ayidingi ukusebenzisa ukushaqeka, bradycardia (kwenhliziyo uma ushaya imiz ngayinye ngaphansi kuka-50.). Awukwazi ukusebenzisa, futhi ngaphansi ukuvinjelwa atriovenkulyarnoy 2 no-3 degrees, futhi uma kukhona syndrome of uju of itheku node uma hypotension libizwa.

Futhi, izidakamizwa kuyadingeka ukuba ngakususi abantu hypersensitivity noma othambekele bronchospasm. Uma iziguli isihambile esiteji we-peripheral iziyaluyalu kwegazi, umuthi futhi asifanele. Awukwazi ukusebenzisa imithi "bisoprolol" (wentengo yisilinganiso ruble angu-30.) Futhi uma wamukelwe mao inhibitor (kodwa akuyona inhibitor Mao-B).

Ukulinganiselwa reception "Bisoprolol" ukulungiselela

Sebenzisa izidakamizwa esebenzayo kumele kube ngokucophelela abantu abanalo izifo ezifana ngifundise ngesifo sikashukela, kahle kungakhuphula izinga likashukela, lactic umzimba, thyrotoxicosis, atrio-ventricular block 1 degree vazospasmaticheskaya angina. Wena ubuye abakwazi ukusebenzisa lokhu izidakamizwa ukuze iziguli ezingakwazi ukudla okuqinile, futhi labo abaye kwenziwe inkambo ezifana yokwelapha ebulala.

Ngo kokutshelwa ngokukhubazeka kwengane, njengoba ukuhluleka kwenhliziyo ayikwazi ukusetshenziswa ngesikhathi exacerbation izidakamizwa "Bisoprolol". Izibuyekezo abonisa ukuthi kulesi simo ukusetshenziswa kwezidakamizwa, kungaba kubi kakhulu impilo. Futhi nale Ihlahlubo akufanele usebenzise lesi imithi uma kwenhliziyo kuyinto amabhithi angaphansi kuka-60 ngomzuzu. Futhi-ke is contraindicated futhi yehlise systolic blood pressure, ikakhulukazi uma ingaphansi kuka-100 mm HG.

Medicine "bisoprolol" nokukhulelwa

Lesi sidakamizwa noma kunjalo ayikwazi ukusetshenziswa kwabesifazane abakhulelwe kanye lactating. Kukhona okuhlukile, uma kudingekile ukwelapha isiguli nengane esindayo, kodwa kufanele asiyeki ukusebenza uma, ngaphambi kokuzalwa kuyinto amahora mayelana 72. Uma lokhu kungeke kwenzeke, usana ke kufanele igcinwe ngaphansi kweso lodokotela kusukela imizuzu lokuqala lokuzalwa. Ingane, ngemva kwalokhu izidakamizwa angagcina kahle kungakhuphula izinga likashukela, futhi sibonise lesi sifo kakade ezinsukwini ezintathu zokuqala.

side effects

imiphumela emibi babe cishe zonke izidakamizwa. Nomuthi "bisoprolol" kungathinta isimiso sezinzwa. Lokhu kubonakala ukutubeka komzimba, isiyezi, ikhanda njalo izinkinga zokulala. Ukucindezeleka kungandisa zenzeka ezimweni ezingajwayelekile, ukusangana. Kodwa lokhu bonke kwenzekani ngendlela elula, futhi ngemva 1 noma 2 amaviki ngemva Ukuqalwa yokwelashwa senzeka.

Imiphumela engemihle futhi kungathinta izinhlaka umbono ngesimo conjunctivitis noma ukunciphisa Ukubhidliza. akuvamile njengoba iphika kungenzeka, kodwa abantu abanemizimba bronchospasm. Ngezinye izikhathi engaveza kokunikezwa kwe-pheshana emathunjini. Kwangathi ukuzwa isicanucanu noma isifo sohudo, okuncane amajaqamba lesisu. Kodwa izifo ngokuvamile enjalo ezinsukwini ezimbalwa ukudlula.

analogs

Ngu analogue zomuthi "bisoprolol" zihlanganisa izindlela lekartsvennye:

- "Concor".

- "Biprol".

- "Niperten".

- "Bisogamma".

- "bisoprolol-Pramila."

- "bisoprolol-ni" nabanye.