"Agapurin": yokusetshenziswa, ngempela

Uyini izidakamizwa "Agapurin"? Yokusetshenziswa, ifomu ukukhululwa kwaba nabantu bezizwe ezixubile izimali izokwethulwa kancane okunye. Ngaphezu kwalokho, kulesi sihloko uzofunda mayelana amacala lapho izidakamizwa inikezwa lapho ukusetshenziswa kwalo akuvumelekile ukuthi unakho side effects kanye nokunye.

Ukwakheka kanye ifomu zomuthi

Ingabe kukhona igama ngamazwe ku "Agapurin" izidakamizwa? "Pentoxifylline" - Yileli igama lakhe lesibili.

Okwamanje izidakamizwa itholakala amafomu ezimbili ezihlukene:

1. amaphilisi Biconvex camera (omhlophe) nokuba kukhanye ecwebezelayo. Lesi sidakamizwa iqukethe ingxenye esebenzayo pentoxifylline futhi izinto ezengeziwe (monohydrate lactose, isitashi ummbila, colloidal Silica anhydrous, talc kanye magnesium stearate). Mayelana igobolondo, sifaka izakhi ezifana sodium carmellose, crystalline sucrose, sucrose oluyimpuphu, talc, methylparaben, ama-titanium dioxide, Silica colloidal anhydrous lomtholo.
2. Isixazululo (ecacile, kungekho nto enemibala emihle) ngoba umjovo. Lokhu nomuthi kuhlanganisa pentoxifylline, i-sodium chloride namanzi umjovo.

Ngizothanda futhi ukubalula Iqiniso lokuthi enjalo Analogue izidakamizwa ingatholakala ekhemisi amaketanga ngokuthi "Agapurin kuthiye ukukhula". Ukufundiswa zomuthi uthi iba i-ejenti isenzo isikhathi eside. Itholakala in amaphilisi, okuyinto camera nge enamathela ifilimu. Lo muthi iqukethe pentoxifylline futhi izakhi ezengeziwe ezifana hypromellose, povidone, talc, futhi magnesium stearate.

izakhiwo kwemithi

Uyini izidakamizwa "Agapurin"? Iziyalezo yokusetshenziswa uthi lokhu ejenti kuyinto antispasmodic futhi kungokwalabo iqembu purine. It kakhulu ngcono kwegazi, kanye nezakhi zawo rheological. Isimiso yokusebenza nomuthi wathi iwukuba phosphodiesterase okusithiyayo, nokukhuphula okuqukethwe ATP e erythrocyte bamisa amatende platelet ne bullet ukugcwaliswa amandla ezingaba khona. Lokhu kuphumela vasodilation uphinde wehlise ukumelana Imininingwane semithambo (neuropathy), kanye ngomzuzu futhi ukwandisa unhlangothi ivolumu ngaphandle ukushintsha okuphawulekayo endleleni kwenhliziyo.

Lo mshini wezenzo zomuthi

Uyini lo mshini wezenzo "Agapurin" izidakamizwa? Yokusetshenziswa akunika impendulo oluphelele kulo mbuzo. Ngemuva kokufaka isicelo uvuleke nomuthi nemithambo yegazi yenhliziyo, bese okwandisa ukulethwa oxygen ukuze izitsha yamaphaphu futhi myocardium, kuba nomphumela antianginal futhi kuthuthukisa oxygenation yegazi.

Kufanele kuphawulwe ukuthi ekwakhiweni ethulwa uyakwazi okwandisa ithoni ezicutshini zokuphefumula, ikakhulukazi diaphragm futhi intercostal imisipha.

Lapho emthanjeni umjovo ke kuholela eseduze kwegazi, kanye uphakamise izwi igazi eligeleza ngokusebenzisa 1-tsu-sigaba. Ngaphezu kwalokho, lokhu izidakamizwa kubangela ukwenyuka okuqukethwe adenosine asebuchosheni has imiphumela ezuzisayo kumsebenzi bioelectrical isimiso sezinzwa.

Ngokusho imfundo, wathi nomuthi uyakwazi ukunciphisa viscosity igazi, ukwandisa kuyaqina we ulwelwesi erythrocyte futhi sithuthukise microcirculation nge kwegazi kahle.

Iziphi izici has umuthi "Agapurin"? Yokusetshenziswa lithi lwemithambo isifo occlusive (neuropathy) izidakamizwa esebenzayo kungaholela ukuqedwa ebusuku amajaqamba amathole, nokunwebeka ibanga ukuhamba kanye nobuhlungu endaweni ukuphumula.

Pharmacokinetics

Medicine "Agapurin" ngokushesha akheka esibindini. Lokhu kukhipha metabolites asebenzayo. okuhlushwa zabo egazini izikhathi eziningana ephakeme ukwedlula lokuhlushwa izidakamizwa eziyisisekelo.

Ekhombisa ethulwa nomuthi njengoba metabolites in inani 94%, bese kuthi ezisele - ngokusebenzisa emathunjini. Phakathi neminyaka yokuqala 4 amahora emva ukungenisa isidakamizwa eyakhishwa ngo isamba ka 90% of the imithamo esetshenziswa. Ngo ifomu unmodified, uboniswa volume of 2%. Kufanele kuqashelwe ukuthi le ketshezi asebenzayo futhi metabolites ka pentoxifylline asisho abophe ukuze Amaprotheni egazi.

Lapho kahle izinso umsebenzi decelerates okukhipha metabolites. Uma umsebenzi sesibindi kwezinso waphawula kwelulwa isigamu-nokuphila, futhi bioavailability anda.

Izidakamizwa "Agapurin" (amaphilisi): yokusetshenziswa

Ngokusho imiyalelo exhunywe nomuthi, kumele kuthathwe kwelinye futhi ngesikhathi esifanayo sosuku emva kokudla ukudla, ukuphuza amanzi plain. Umuthi noma kunjalo engenakwenzeka ukuhlafuna.

Isikali kokuqala umuthi 200 mg kathathu ngosuku. Uma isiguli kube impatho eside noma wayekade ukubekezelelana abampofu izidakamizwa, umthamo owodwa ke zingancishiswa ncamashi kabili, kodwa ugcine inani reception.

Kusho umthamo nsuku zonke akufanele budlule 1200 mg.

Manje uyazi ukuthi ukusebenzisa izidakamizwa "Agapurin" (amaphilisi). izindlela ezifanayo ukuze imiyalelo isicelo ekukhishweni enwetshiwe liqukethe ulwazi mayelana imithamo efanayo. Nokho, lapho usebenzisa kungenzeka ukunciphisa kaningi reception.

Yokusetshenziswa yesixazululo ngoba umjovo

Indlela yokusebenzisa lesi sidakamizwa "Agapurin"? Tablets kuyabekwa kanengi ukudlula izixazululo nemijovo. Uma nganoma isiphi isizathu isiguli abakwazi ukuthatha imithi ngomlomo, wagunyaza imijovo.

Lokhu ukulungiselela edayiswa ifomu isixazululo umjovo angase kuphethwe eyodwa yezindlela ezilandelayo:

1. Iv. Okuqukethwe ampoule kufanele buhlanjululwe in 5% isixazululo glucose noma ml 250-500 chloride (0.9%) sodium chloride. Umuthi kufanele sinikezwe kancane, hhayi ngaphezulu kuka-150 ml ngehora. Uma isiguli uyazibekezelela umuthi, umthamo wansuku zonke avunyelwe ukwandisa kuze kube ampoules ezimbili, okusho ukuthi 200 mg.
2. Intramuscularly. Umuthi iqondiswa at mg 100 kabili ngosuku. Akukona alulaze okuqukethwe isitsha.
3. Intraarterially. Ukwelashwa isiguli kufanele uqale nesimiso sokuqondisa a ampoule olulodwa, okumele ibe-pre-buhlanjululwe in 20-50 ml isotonic isixazululo sodium chloride. Uma ufuna ukwelashwa isikhathi eside, umthamo kungase kukhule ku 2-3 ampoules. Bayobizwa buhlanjululwe ukuba 30-50 ml.

Kumele kuqashelwe ukuthi isamba elikhulu nomuthi ethulwa kunqunywa kuphela udokotela, futhi kuphela lapho kwenziwa iseluleko ngabanye nesineke.

Nomuthi "Agapurin": izinkomba ukusetshenziswa

Ngaphambi kokusebenzisa lo imithi, kufanele uxhumane nodokotela wakho futhi uhlolwe. Phela, imithi inikezwa kuphela ngaphansi ngeziphambeko ezithile. Uhlu sizoqhubeka sihlola.

1. iziyaluyalu trophic kwezicubu ukuthi kwavela ngaphansi kwesimo emithambo yegazi abampofu noma microcirculation lwemithambo (ezifana nezilonda ezingapholi, varicose izilonda, frostbite, nokunye.).
2. iziyaluyalu kwegazi (neuropathy) kwakheka ngenxa izinqubo ukuvuvukala, atherosclerotic futhi sikashukela okuyinto. imithi ebekiwe claudication "ngakanye", okuyinto kubangelwa isifo sokuqina kwemithambo yegazi, lwemithambo isifo occlusive, futhi angiopathy sikashukela.
3. Okungalapheki ne-acute unhlangothi ischemic, okuyinto imvelaphi ischemic. Futhi, izidakamizwa isetshenziswa cerebral ukuqina kwemithambo yegazi, paresthesia, angioneyropatii, isifo Raynaud futhi akrozianoz.
4. ukuzungeza Ukuphazamiseka izitsha izitho ezibukwayo (ukwehluleka oyingozi futhi ezingalapheki kwegazi, imithambo yegazi kanye anezikhala ulwelwesi samehlo).
5. State ezivukayo ngemva ischemic noma oluhambisana unhlangothi.
6. Ukungasebenzi indlebe phakathi imvelaphi semithambo, okuyinto ahambisana ukulahlekelwa kukuzwa.

Izimo ukusetshenziswa

Uma ungeke ukwazi ukusebenzisa imithi "Agapurin"? Ukusetshenziswa kwalesi izidakamizwa kungavunyelwe ngaphansi kwezimo ezilandelayo kanye ngeziphambeko:

• acute isilethikusebenza;
• uzwakalise ukuqina kwemithambo yegazi yenhliziyo noma i-cerebral;
• uzwakalise ukwephula inhliziyo isigqi;
• porphyria;
• engalawuliwe lwemithambo hypotension;
• ukopha okukhulu;
• acute oluhambisana unhlangothi;
• ukopha ngwengwzi;
• sokukhulelwa, ukuncelisa;
• kweminyaka eyi-18 (ukuphepha nokusebenza ngempumelelo ungazange sezisunguliwe);
• hypersensitivity kuya pentoxifylline, futhi izakhi eqenjini xanthine nemikhiqizo.

ukusetshenziswa Ohlakaniphile imithi

Ngokunakekela okukhulu ithuluzi ozofakwa iziguli ukuthambekela lwemithambo hypotension, labile blood pressure, ukuhluleka kwenhliziyo (ezingamahlalakhona), ukuthambekela ukopha, esingamahlalakhona kwezinso futhi hepatic, futhi esimweni ngemva kokuhlinzwa.

side effects

Zikhona yini imiphumela emibi evela izidakamizwa, "Agapurin"? Tablets Umhlahlandlela okuyinto uvezwa ngenhla, kanye isixazululo umjovo kungabangela eziningi nemiphumela enqabayo. Ake sixoxe ngazo ngokuningiliziwe.

• wokugaya ukudla: i-hepatitis cholestatic, atony emathunjini, okubi kakhulu cholecystitis, nomlomo owomile futhi angafuni kudla.
• isimiso sezinzwa: izinkathazo, ukuqwasha, isiyezi, amajaqamba nekhanda.
• imithambo yegazi kanye isikhumba: ukuvuvukala, izinzipho ziyaqothuka, ngamanzi ebusweni, siwasebenzise phezulu ebusweni nasesifubeni.
• Isimiso senhliziyo nemithambo yegazi: arrhythmia, angina zamanga, lesichubekako angina pectoris, tachycardia futhi umfutho ophansi wegazi.
• Amachibi hematopoiesis futhi hemostasis uhlelo: thrombocytopenia, leukopenia, pancytopenia, gipofibrinogenemia kusuka ukopha emathunjini, esiswini, ama-capillary ongama futhi nolwelwesi lwamafinyila.
• izitho Ukudideka: angaboni kahle futhi scotoma.
• komzimba: pruritus, urticaria, angioedema futhi anaphylaxis.

amacala ukweqisa izidakamizwa

Kwenzekani uma usebenzisa ebulilini lesi sidakamizwa "Agapurin" (400 mg, 600 mg, 1200 mg)? Kulokhu, isiguli ingase ibe nezimpawu ezifana sokugembula njengoba ubuthakathaka, imakwe ukunciphisa umfutho wabo wegazi, isiyezi, tachycardia, nakwisyncope, somnolence, generalized nokuquleka tonic-clonic, nokulahlekelwa ukwazi, komzimba, ukucasuka, emathunjini izimpawu ukopha (isib, ukuhlanza " ngezizathu ikhofi ") futhi areflexia.

Kulokhu zidinga ukwelashwa esiphuthumayo lingaze okuyinto sibhekiswe nokugcina evamile blood pressure kanye umsebenzi zokuphefumula.

iziyalo ezikhethekile ngokuqondene ukusetshenziswa kwezidakamizwa

Okufanele ukwazi ngaphambi kokuba usebenzise izidakamizwa "Agapurin"? Uphenyo odokotela bathi umuthi muhle at lo msebenzi, kodwa ukwelashwa badinga ukuba ngaphansi kolawulo esiqinile wegazi. Kulokhu, in iziguli senhliziyo (ezingamahlalakhona) iyadingeka ukufeza isinxephezelo kwegazi.

Kufanele kuphawulwe ukuthi iziguli kwathiwa unesifo "isifo sikashukela" Ungcono kunokudla izidakamizwa hypoglycemic, ukusetshenziswa kwalesi ejenti ngemithamo ezinkulu ebangela kahle kungakhuphula izinga likashukela evelele. Ngakho-ke ukulungiswa umthamo kuyadingeka kubo.

With ukusetshenziswa ngesikhathi esisodwa izidakamizwa ne anticoagulants kufanele ukuqapha ngokucophelela isimo kohlelo igazi coagulation.

Ezigulini usanda wahlinzwa udinga sihlale njalo siqaphele lokuhlushwa i-hemoglobin futhi hematocrit.

Umthamo iqondiswa kumele encishisiwe in iziguli engazinzile noma umfutho ophansi wegazi.

Abantu abadala kungase kudingeke umthamo ezincane.

Ngokocwaningo olwenziwa, ukubhema iyehlisa kusebenta zokwelapha zomuthi.

pentoxifylline kwedivayisi nezinye izixazululo ukumnika kufanele kuhlolwe ngamunye icala ngabanye.

Ukuxhumana nezinye izindlela

I asebenzayo izidakamizwa pentoxifylline ngokuvamile sithuthukisa isenzo ejenti ezithinta igazi ekunqandeni. izidakamizwa ezinjalo zihlanganisa anticoagulants nenkhulumombiko, valproic acid, thrombolytics, futhi anitibiotiki (isib izidakamizwa "Tsefamandol", "Cefoperazone", "tsefotetan").

Kusho umphenyi kwandisa ukuphumelela kwezindlela hypoglycemic temlomo na izidakamizwa antihypertensive, kanye nge-insulini.

Asinakusho ukuthi izidakamizwa "cimetidine" Ngokuphawulekayo kwandisa lokuhlushwa pentoxifylline egazini. Lokhu kwandisa ingozi nemiphumela emibi.

Co-isimiso sokuqondisa 'Agapurin "izidakamizwa, ukubuyekezwa zazo kukhonjisiwe ngezansi, nabanye xanthines kuholela ngokweqile injabulo kwemizwa.

Izindlela yokugcina ukulungiselela, ukubuyekezwa ke, intengo

Izidakamizwa "Agapurin" okuthengiswa cishe njalo ikhemisi. Thenga amaphilisi 60 (100 mg), uzokwazi besilinganiso nje kuka-250 ama-ruble angu-Russian.

Nobufakazi lokhu nomuthi kuyinto oqondile. Yingakho ngokuvamile neminye imithi egunyaziwe iziguli abanezinkinga nemithambo yegazi.

Kufanele kuphawulwe ukuthi umuthi kahle esikhulu ethandwa "Agapurin" sawo esiningi. Izibuyekezo bodybuilders bathi leli thuluzi kufanele kubhekwe ngokuhlukile nezinye izidakamizwa ukuthi ngcono ukugeleza kwegazi. Phela, nguye ephumelela kunazo kodwa engabizi.

nomuthi Active okuyinto ukuthatha abasubathi, njengoba kuveza hhayi kuphela ngesimo i solution nemijovo, kodwa futhi ifomu tablet. Amakhemini leli thuluzi kungatholakala ngaphansi amanye amagama ukuthi kuzwakale "Pentoxifylline" noma "Trental".

Umsebenzi oyinhloko emelelwa izenzo izidakamizwa anda ithoni imithambo yegazi, ukunciphisa igazi viscosity nokukhuphula ukugeleza kwegazi. Konke lokhu kuyindlela enhle kakhulu ukufeza uzotshala ku ukuqeqeshwa ezemidlalo, uma kukhona umuzwa imisipha ukusebenza uzotshala.

Sebenzisa le imithi bodybuilders wazibonela kufanele niqaphele kakhulu, ngoba kalula nje ingabangela ukweqisa izidakamizwa kanye nenombolo okuba nemiphumela engemihle.

Gcina "Agapurin" okungcono emnyama, endaweni eyomile lapho kungekho ukufinyelela izingane ezincane. Ngakho izinga lokushisa isitoreji umuthi degrees 10-15 kuphela. Usuku lokuphela kuboniswe kwi isembozo futhi iminyaka emibili. Emva kwalesi sikhathi, ukusetshenziswa kwezidakamizwa akuvunyelwe.

Ekuphetheni, siphawula waphinda ukuthi akufanele kube self-ukhombe bona ukuthatha lo muthi. Ubude besikhathi sokwelashwa Isikali kumele kunqunywe kudokotela nesineke ethile.