"L-thyroxine": yokusetshenziswa, ngempela

«L-thyroxine" - hormone zokwenziwa olusekela le ndlala yegilo. A nomuthi ngokufaka izinso futhi isibindi, kancane ibe triiodothyronine, ikhuthaza izicubu ukukhula futhi kuthuthukisa umzimba.

Ifomu mayelana nodaba izidakamizwa, izingxenye zalo

Ukulungiswa senziwa okusekelwe sodium levothyroxine, umthamo okungaba ezahlukene - 50, 75, 100, 125 kanye 150 micrograms. Ungakwazi ukuthenga iphasela 25, 50 no-100 amaphilisi. Excipients ethulwa dextrin, microcrystalline cellulose, sodium isitashi glycolate uhlobo A, dihydrate calcium hydrogen phosphate, eside chain glycerides esinqunyiwe.

Pharmacodynamics "L-thyroxine" izidakamizwa

Ukwakheka izidakamizwa samanje zokwenziwa levothyroxine kokuba isenzo esifanayo njengoba ukukhiqizwa kwama-hormone egilo yemvelo owenziwa ngokuyinhloko indlala yegilo.

Ngenxa ukuguqulwa olulinganiselwe izidakamizwa e -hormone okuthiwa i-T3 ukusatshalaliswa emangqamuzaneni omzimba kuthinta ukuthuthukiswa kanye nokukhula izinqubo, kanye izinqubo umzimba.

Ukubuyiselwa hormone egilo - ngesisekelo ukuzinza lokugayeka kokudla. Isenzo zomuthi ukwehlisa cholesterol i-hypothyroidism.

Pharmacokinetics "L-thyroxine" izidakamizwa

Ukunciphisa akuyona ezingaphezu kuka-80% emva kokungenisa ngokuzila ukudla kusho u- "L-thyroxine". Yokusetshenziswa likhombisa kutsi lizinga ukumuncwa kunqunywa ifomu galenic yomuthi. Le nqubo kwenzeka ogxile emathunjini amancane. Ukudla iyehlisa ukumuncwa yezingxenye.

Izinga plasma eliphakeme ingxenye eyinhloko kutfolakala ngekhatsi cishe amahora amathathu. Umthelela zokwelapha eba eyesithathu usuku lwesihlanu ngemva ekuphathweni lokuqala ngomlomo. Ubuhlobobo plasma amaprotheni kuyinto kakhulu ephelele (ngaphezu kuka-99%), akusiyo nokuxhumana covalent, ngakho phakathi hormone (beboshiwe futhi mahhala) kukhona exchange okusheshayo, okuyinto njalo. Hemoperfusion futhi hemodialysis akazange kuthinte okuqukethwe izidakamizwa yezingxenye umzimba "thyroxine" imfundo manual uthi lokhu kwenzeka ngoba amaprotheni ezinhle esibophezelayo.

ukususwa kwengxenye zomuthi kwenzeka izinsuku eziyisikhombisa, i-hypothyroidism, le nqubo ingathatha izinsuku eziyishumi. Ngo-hyperthyroidism ukususwa olulinganiselwe izidakamizwa kusukela umzimba kwenzeka ngokushesha - ngezinsuku ezintathu noma ezine. Ezinye isithako aqoqana isibindi. izinqubo umzimba zenzeka ikakhulukazi imisipha, izicubu kwengqondo, isibindi nezinso, kuphelile kumiswa metabolites okukhona endleni kanye nomchamo.

Izinkomba "L-thyroxine" izidakamizwa

Izinkomba zincike yokuthi liphansi izinga abakhuthele Ukwakheka nomuthi.

Iphilisi "thyroxine 50" futhi "100 thyroxine" imfundo manual ekhombisa izinkomba ezifana:

• i-hypothyroidism (replacement therapy);
• abanale nkinga imvelo ingozi;
• i-hyperthyroidism (nomuthi isetshenziselwa ekusebenziseni indlela yokwelapha thyreostatic njengoba adjuvant, siyithola lapho obusebenzayo euthyroid);
• goiter (umuthi esetshenziswa njengoba isilinganiso izifo ukuze bangabuyeli emuva kwezifo ezifana efana goiter, ngemva resection).

Ukuze izidakamizwa ngempahla eziyisisekelo lokuhlushwa izinkomba ezengeziwe 100 .mu.g zimi kanje:

• ukuqaliswa kweemboniso;
• umdlavuza yegilo (eyenziwa suppressive yokwelapha esikhundleni futhi, ezimweni eziningi ngemva yegilo).

Ngakolunye esenikwe izidakamizwa esebenzayo «L-thyroxine" yokusetshenziswa bayakhuthazwa ukuba baphakamise kulezi zimo ezilandelayo:

• goitre euthyroid;
• i-hypothyroidism;
• umdlavuza yendlala isimila (ukulungiselela isetshenziswa ngenjongo yokwelapha noma esikhundleni thyreostatic, ngokuvamile ngenxa yegilo);
• isidingo ukuqeda ukuphinda goiter.

Izimo ethola "L-thyroxine" izidakamizwa

I nomuthi akuyona zinikwa hypersensitivity ukuba into ngesisekelo ngalo senziwa, noma izingxenye zalo asizayo. Kunezinye Izimo lokwamukela "thyroxine" ukulungiselela (amaphilisi). Iziyalezo yokusetshenziswa Lezi zihlanganisa:

• acute isilethikusebenza kuyinto kubonakala;
• i-hyperthyroidism;
• yenhliziyo isifo Umthambo;
• acute pancarditis fudlana;
• isifuba somoya noma pituitary esingamahlalakhona we- cortex adrenal;
• myocarditis, ifomu acute;
• i-hyperthyroidism, decompensated umsuka ezahlukene.

Abesifazane abakhulelwe ayikwazi ukusebenzisa "L-thyroxine" nge izindlela tireostaticheskimi - ukuhlanganisa le mithi akwamukeleki nhlobo.

Ukwelashwa "levothyroxine" Isikali ukulungiswa

Iziqondiso banikwa imithamo Kunconywa zomuthi, ukucacisa isilinganiso ezifanele iziguli kufanele udokotela. Uchwepheshe Okokuqala inikeza ongaphakeme umthamo izindlela futhi kancane kancane kwandisa ke, abagcina esingaba izinsuku 14-28 of kuze kube nomphumela oqabulayo. I-Tablet kugwinyiwe ngamanzi, musa ukuhlafuna. Umuthi wenziwa okungenani isigamu sehora ngaphambi kokudla. Uma ungakwazi ukuthatha iphilisi ngesikhathi, ngesikhathi esilandelayo uma izidakamizwa udakwe, njengenjwayelo. Umthamo lomcebo abakhuthele nomuthi kuchazwe, njengoba kuveziwe ngenhla, kungaba ezahlukene.

Umthamo izidakamizwa 50, 100 mcg

Isikimu ukwelashwa incike yobudala lesiguli.

iziguli omdala

Ukuze uvimbele, lapho kubalulekile ukukhipha ingozi kabusha nentuthuko ka goiter, neziyaluyalu ingozi «L-thyroxine 50" imfundo manual incoma yaphathwa imali kusuka 75 kuya 200 mg / usuku. Ezigulini ezine-hypothyroidism ngesikhathi yokwelapha i-hormone belulekwa ukuba azithathele 25 kuya 50 mg, kanye nokuqokwa yokwelapha yesondlo - kusuka 100 g kodwa hhayi ngaphezulu kuka-200-hyperthyroidism, lapho kuhlelwe ukukhiqiza therapy concomitant, aphathe izidakamizwa ngesikhathi umthamo micrograms 50 kuya ku-100. Ngo umdlavuza, lapho kuyadingeka ukwenza esikhundleni noma ukwelashwa suppressive, othathwe micrograms ngelanga 150 kuya ku-300. Ukuze enze kweemboniso liyadingeka zigwinye emini 200 mcg ka nomuthi ngamunye amasonto amabili ngaphambi inqubo.

Izingane ezine-hypothyroidism kwatholakala ukuthi nginesifo (kuzuze, azalwa naso)

yesifo azalwa naso izingane nabancelayo phakathi ukuqaliswa ukwelashwa esikhundleni kuqala iqondiswa 10 micrograms ngamunye eyodwa kilogram esisindo. Okunjalo isamba zomuthi "thyroxine 50" imfundo manual uncoma ukuthi usebenzise izinyanga ezintathu. Esikhathini esizayo, ukushintsha umthamo ngemva nophenyo kunesidingo.

Izingane, i-hypothyroidism abathenge, umuthi iqondiswa i inani 12.5 kuya 50 mcg ukuthola ngaphambi kokudla kwasekuseni. Kancane kancane umthamo, kwathiwa kushintshwe elikhulu ukuqaliswa yokwelapha esikhundleni. Izingane ezineminyaka Eminyakeni engaphansi kwemithathu, ngemithamo ukwanda ukukhiqiza okungenani imizuzu engu-30 ngaphambi kosuku lokuqala ku yokudla. Ngo 10-15 ml amanzi usuhlakazekile ithebhulethi bese ungeze amanzi kancane, cishe 5-10 ml. Usayizi sifana nsuku zonke yesondlo umthamo 100-150 mg ngayinye 1 m ² endaweni umzimba.

ezigulini esezikhulile

"L-thyroxine 50" yokusetshenziswa ngakho weluleka isiguli ukuthatha ukuqaphela lapho kwelashwa ngendlela efanele usaqala, ikakhulukazi khona yenhliziyo Umthambo isifo, ukunciphisa isikhathi eside e umsebenzi yegilo hypofunction noma okunzima. A umthamo ubuncane nsuku kusho, elihambisana 12.5 micrograms. Khulisa umthamo isikhathi eside, kancane kancane. Lapho ukwelashwa lwesondlo ungeze 12.5 g lokulungisela ukunamathela isikhawu izinsuku ezingu-14. Ngaphezu "thyroxine" iziguli ebekiwe nezinye izidakamizwa. Abantu abadala bavamile kudingeka uhlole igazi ku TTG okuqukethwe. Qaphela ukuthi umthamo ukuthi engeyinhle, aliholeli ukulungiswa ledzingekako TSH ezingeni. Umthamo obuncane elanele khona ka goiter nodular, okuyinto unamahlangothi esikhulu, futhi somzimba.

Ukuthola umthamo nomuthi we ketshezi esebenzayo of 75, 125 kanye 150 mcg

Cabangela eminye ukwelashwa lwemithi izingane kanye nabantu abadala izidakamizwa "L-thyroxine", kuncike ekutheni lokuhlushwa izidakamizwa esebenzayo.

abadala

I-hypothyroidism lokuqala iqondiswa kusukela 25 micrograms izidakamizwa, hhayi ngaphezulu kuka 50. Uma lokhu isimo kubhekwa ukusekela umthamo 100 mcg 200, ukukhuliswa wenziwa ngezikhawu izinsuku 14-28 of at 25-50 micrograms. "L-thyroxine Berlin-Chemie" imfundo manual ngakususi goiter lokubuya kwesifo uma kunesidingo uncoma umthamo kusuka 75 micrograms ukuba 200. struma imvelo ingozi futhi euthyroid umthamo letiphakanyisiwe uyefana. Uma i-hyperthyroidism iphathwa tireostatikami futhi kuhlelwe ukukhiqiza ukwelashwa concomitant nge "thyroxine", kufanele kuhambisane umthamo kusuka 50 mcg ukufika ku-100 Ngemva yegilo ebukhoneni isimila umdlavuza reception kudingeka kusho micrograms 150 kuya ku-300.

Izingane ezineminyaka engaphezu kwengu-amathathu

Uma i-hypothyroidism lutholwa, qala ukhuphe kusukela 12.5 mcg ku-50, kancane kancane umthamo njalo ngemva kwamasonto amabili kuya kwamane, ikhumbula imiphumela cwaningo.

abantu abadala

"Thyroxine" yokusetshenziswa kulonyaka lizisho kusetshenziswe ngokuqapha, eziqala umthamo ubuncane 12.5 micrograms. Inani izidakamizwa edingekayo yokwamukela, ukwandisa kancane.

Koze enza ukwelashwa nge "L-thyroxine"?

I-hypothyroidism sebenzisa "L-thyroxine-Acre" imfundo manual incoma ukuthi ngaso sonke isikhathi. Lapho efeza zokuvimbela, okuhloswe ngaso exclusion yokuphindela goiter, ubude bayo ubuncane kwezinyanga ezimbalwa futhi lungaboniswa iminyaka eminingi, kwezinye izimo, iphilisi prophylactic ukuthatha ukuphila. Euthyroid goiter sokuvivinya omnene ihlala izinyanga eziyisithupha, kodwa eminyakeni engaphansi kwemibili uma elamukelekile kungekho, okunye okukhethwa kukho ukwelashwa ekhethiwe. Ngo amafomu kabi izidakamizwa zithatha izinyanga ezimbalwa noma iminyaka embalwa, ngezinye izikhathi kunesidingo for a lifetime. Lapho umuntu ophethwe i-umdlavuza isimila watholakala, benza yegilo ngokuvamile kuyadingeka ukusebenzisa imithi ukuphila. Uma i-hyperthyroidism njengenhlangano ukusetshenziswa kwezidakamizwa asizayo "thyroxine" imfundo manual weluleka ngiyithathe ngendlela efanayo njengoba uma usebenzisa amaphilisi ngesikhathi yokwelapha thyreostatic.

Ukukhulelwa, ubisi lwebele webele

Ngalesi sikhathi, kubaluleke kakhulu ukuba afeze replacement therapy ne-hormone egilo, ungeke uphazamiseke. Ngisho nokusetshenziswa esindayo imithi ingozi embungwini is Nokho, idlule umthamo watusa udokotela akudingekile. Ngo ubisi lwebele impela kancane imithi, ngakho akukho ingozi.

Ngenxa uthwele ingane emzimbeni aphakeme amazinga estrogen, futhi kwandisa isidingo ukusetshenziswa esebenzisa «L-thyroxine". Yokusetshenziswa lubonisa ukuthi lapho yenza kuyadingeka ukuhlola isimo hypofunction we indlala yegilo ekukhulelweni, futhi ngemuva kokuphothulwa le nkathi. Ngaphezu kwalokho, uma kunesidingo, kudingeka ulungise umthamo kuye ngezidingo zomzimba.

Uma ukhulelwe owesifazane tireostatiki esetshenziselwa ukwelapha yegilo hyperfunction, umthamo wabo kufanele kube omncane. iziguli abakhulelwe musa test elihlobene ne nokucindezela umsebenzi yegilo.

Ukulahlekelwa isisindo ne «L-thyroxine"

Ukuze wehlise isisindo, ngalinye 1 kg isisindo ukuthatha 1.8 g zomuthi. Dose kusho kwezinye izimo zingahluka. Inani "thyroxine" kusho incwadi yeziyalezo incoma encishisiwe uma umuntu isifo senhliziyo noma imithambo yegazi. Ezimweni ezinjalo, izindlela kubalwa umthamo kilogram of 0.9 micrograms ngayinye. Ngo ukukhuluphala ke, ngokuphambene nalokho, anda, iziphakamiso kilogram per isicelo 2 mg nomuthi.

Ekuqaleni, lapho kwesisindo akukwazi ubani ukuthatha usuku micrograms ezingaphezu kuka-100. Uma kwamafa ngeviki, futhi yayingawuthinti esabonwa abantu basabele ngendlela embi yomzimba, okwandisa umthamo kungenzeka kuze kube micrograms 300. Njengoba for ekwelapheni, futhi ukuze ukunciphisa isisindo unqabela imali enkulu "L-thyroxine" imfundo manual. Neminye ukulungiswa isetshenziswa equkethe 50 UG esemazweni esebenzayo noma 100. Uma usebenzisa amaphilisi, okuyinto ekhona yokwakheka main isithako 50 mg izinsuku ezine baphuze iphilisi elilodwa for isigamu sehora ngaphambi kokudla kwasekuseni, eyesihlanu ngosuku lwesikhombisa - izibhebhe ezimbili. Esikhathini esizayo, ungakwazi ukuthola kuze kube amaphilisi amane ngosuku, engasekho. Course sinqanyuliwe emva kwezinsuku 21 esebenzisa ukunciphisa kancane kancane umthamo.

Ngezinye umthamo we levothyroxine sodium 100 g kuze kufike usuku lwesikhombisa futhi kubandakanya ukuthatha izidakamizwa ukhiqiza ngendlela efanayo njengoba kwaba njalo endabeni odlule. Ngosuku lwesishiyagalombili njalo baphuze amaphilisi amathathu. Inkambo kufanele amasonto ayisikhombisa. Ngo isimo evamile yegilo eside is hhayi Kunconywa ukuthatha "thyroxine" imfundo manual. Izidakamizwa isisindo ukulahleka okungcono kakhulu esinakho iwukusebenzisa kwehliselwe ku ubuncani ukuthi ingozi umonakalo empilweni. Kodwa ngisho ngaphansi kwalezi zimo zingaphazamisa hormone. Ukuthola ukuncipha, esekelwe yokwamukela "thyroxine", kubalulekile ukuba acabangele ingozi. Ngaphezu kwalokho, kufanele ukuba ubambelele ekudleni.

Odokotela bavame awumuhle ukusetshenziswa imithi nezinye izinjongo. Kubalulekile nokukhumbula ukuthi ukuthatha "thyroxine" nesimo yegilo evamile futhi ngaphandle iseluleko kuchwepheshe kungaba yingozi. Nokho kubalulekile ukuba ulahlekelwe isisindo ngendlela engokwemvelo, nokusetshenziswa lokuvivinya umzimba nokudla, hhayi izidakamizwa.

Imiphumela emibi "L-thyroxine"

Lapho usebenzisa i-50 no-100 UG kusho u- "L-thyroxine" Umsebenzisi Isicelo kungenzeka negative side effects libhekisela kuwukubonakaliswa umsebenzi wenhliziyo sezinzwa, wokugaya ukudla bese izinhlelo zokuzala. iziphazamiso ezazingase zibe khona isimo jikelele umzimba kanye nezinguquko ijwabu ongama kwesikhumba. Ngokuvamile ukusabela engadingeki zenzeka emzimbeni lapho umthamo isethi akuyona imoto efanelekayo noma ukweqisa izidakamizwa elihlobene ne-ukwanda okukhulu kwezincwadi nenani lomuthi kudliwe esigabeni sokuqala ukwelashwa.

Uma izimpawu of ukweqisa izidakamizwa esungulwe izidakamizwa umthamo encishisiwe noma ungathathi imithi kwaphela izinsuku eziningana. Azi nokufa okwenzeka kungazelelwe ngenxa ukuphazamiseka inhliziyo. Ukufa kwenzeka kubantu asebenesikhathi eside kuphuzwa amaphilisi equkethe ebulilini lomcebo asebenzayo.

Uma gone izinguquko ezimbi emzimbeni emva ukuqedwa lesi sidakamizwa "thyroxine Berlin-Chemie", yokusetshenziswa Ungakwazi ukubuyisela ukuphathwa. Nokho, umthamo ingakhetfwa ngokunakekela. Uma komzimba babebhekwa ngaphezulu izidakamizwa alisetshenziswa.

Ukuze Isikali lomcebo asebenzayo 75, 125 kanye 150 UG, iziyaluyalu ezilandelayo:

• izinkinga zabantu besifazane;
• thuthuva ubuthongo;
• ngenxa yobuthakathaka;
• tachycardia;
• sokulungiswa lokushisa lomzimba evamile;
• palpitations inhliziyo;
• ikhanda;
• isifo sohudo,
• isicanucanu, ne ukuhlanza;
• ukukhathazeka;
• isimo convulsive;
• umkhuhlane;
• Brain pseudotumor;
• eliqhaqhazelayo;
• kwesisindo;
• angina;
• arrhythmia;
• ajulukayo;
• komzimba.

ukwenza okufanayo njengoba kwenzeka lwangaphambilini yokweqisa.

imiyalelo ngokukhethekile lesi sidakamizwa "L-thyroxine"

Ayihlobene ne ukwehla kwesisindo emzimbeni eyamukelayo kusho u- "L-thyroxine" imfundo manual. Izidakamizwa isisindo ukulahlekelwa kodwa, naphezu kwalokhu, abantu abaningi basebenzisa, futhi amanye aze ngisho ukubika imiphumela emihle.

Ngaphambi kokuthatha lesi imithi Izimo kuvimbe ukusetshenziswa kwalo kungenzeka emva ukuzinza kwesimiso lesiguli, kodwa hhayi kuzo zonke izimo. Ezinye iziguli kaningi ukuze uhlole isimo indlala yegilo, uma isidingo enjalo, udokotela uzokutshela.

Endabeni ka ekunqanyulweni ngasekuqaleni kokuba khona ukwelapha izimpawu zesifo abuyele, ngakho kuzomele udlule yonke inkambo yokuhle. On kungenzeka ngokuhlanganisa izidakamizwa nezinye izidakamizwa kubalulekile ukuqaphela udokotela. Uma unqabela ukusetshenziswa "thyroxine" Umsebenzisi Isicelo analogs ( "Bagotiroks", "L-Tirok" "Eutiroks" et al.) Ucoca onguchwepheshe futhi ifaniswe ne ngezimo zesiguli, izimpawu, contraindications.

Ukubuyekezwa umkhiqizo zokwelapha "L-thyroxine"

Izibuyekezo lusikisela ukuthi "L-thyroxine" kusiza indlala yegilo ukwenza umsebenzi walo. Abaningi weneliseka intengo, ukuphumelela izidakamizwa. Abantu bathi kulula ukuyisebenzisa. Imithi normalizes amazinga yegilo i-hormone, aqede goiter, iziguli eziningi ngemva Inkambo yokwelashwa ukuze intuthuko enkulu, njengoba kufakazelwa imiphumela yokuhlolwa. Izibuyekezo ukukhombisa ukuthi izidakamizwa kunomthelela ngcono i-hypothyroidism, nge goitre, futhi kwezinye izimo. Iziqondiso zazithi, ukuthola kwemibandela ethile futhi emva imisebenzi ethile ukuthatha imithi ukuphila, kodwa hhayi bonke abantu bazizwe bephephile le yokwelapha esekelwe ukusetshenziswa kwezimali "L-thyroxine". Yokusetshenziswa, izimpendulo ezibonisa ukuthi izidakamizwa kungokwalabo imithi sina kanye nokusebenzisa kwayo ngaphandle izinkomba ezifanele, ezifana elisetshenziselwa ukunciphisa umzimba, akudingekile. Ngokuvamile, akukho izidakamizwa akufanele kuthathwe uma inhloso izidakamizwa isetshenziswa, ingekho ohlwini e ukufundwa futhi engakaze udokotela. Njengoba abaphathi kwezidakamizwa ngabantu enempilo futhi uyiphuze izinkinga ezithile ngaphandle iseluleko kuchwepheshe, ngokuvamile akukho okuhle akuvezi. Kunoma ikuphi, kuyoba usizo ukuvakashela udokotela.

Izibuyekezo ukukhombisa ukuthi ezimweni eziningi, umphumela oyifunayo wayekhona emva kokwelashwa ikhambi "thyroxine". Yokusetshenziswa, izilinganiso libike ukuthi, ngenxa izici ngamunye zisifake ngamunye umphumela nomuthi akuyona into efanayo njalo, ngaphandle kwi yi etholwe emva ukuqaliswa yokwelapha, nethonya elikhulu kobukhulu isimo lesiguli. Ukubuyekezwa wathola ulwazi mayelana imiphumela emibi, okuyinto ngezinye izikhathi kakhulu impela eningi. "Thyroxine" ingase ikhishwe kuphela ngemuva kokuphumelela ukuhlolwa, futhi kuphela lokhu ikakhulukazi ezimweni lapho wamiswa udokotela. Kubalulekile siqambe Izimo, pre-bajwayelane yokwakheka izidakamizwa, ukusabela ezingezinhle, ukuze okungaba umphumela walokho kuphulukisa. Kuyadingeka ukuba afeze izincomo zonke kadokotela futhi ukwandisa umthamo kancane kancane, hhayi ngokuphazima kweso ukulahla amaphilisi.