Izinkomba Zokusetshenziswa "Metformin": imfundo kanye impendulo

"Metformin" kuyithuluzi elibalulekile kubantu abaphethwe ngifundise ngesifo sikashukela. "Metformin Richter" izinkomba ukusetshenziswa okuyinto efanelekayo iziguli eziningi sikashukela, kusiza ukunciphisa amazinga kashukela egazini, ngaleyo ndlela nokugcina ezingeni ofanele carbohydrate umzimba, kanjalo ngcono izinga lempilo, njengoba kufakazelwa izimpendulo eziningi ezinhle iziguli.

Pharmacodynamics futhi Pharmacokinetics

"Metformin" kubambezela inqubo gluconeogenesis esibindini bese iba isithiyo kokuthola emathunjini iye emzimbeni glucose. Ngakho kukhona nekusita neuropathy glucose cleavage futhi kwandisa isibindi izicubu ukuzwela insulin. Lezi zinqubo kungukuthi ephelezelwa gipoglemicheskimi ukusabela ejenti akuphazamisi ukukhiqizwa engokwemvelo beta amaseli kwamanyikwe insulini, ngokungafani ezinye izidakamizwa analogue "Metformin".

Izinkomba isisindo ukulahleka imithi uvele ngenxa yekhono layo ukuze usimamise noma ngisho kakhulu ukunciphisa isisindo umzimba wesiguli.

Emva kokuthatha "Metformin" kusukela ipheshana emathunjini sebeqala faka ketshezi asebenzayo futhi isenzo ngempumelelo siqala izidakamizwa ngemuva kwamahora 2-2.5. Isici esikhethekile wukuthi kusho unlinkability cishe ephelele plasma amaprotheni.

"Metformin" kungaba buthelela nezinso isibindi, salivary ndlala ezicutshini kwemisipha. Kuboniswa cishe ngokuphelele izinso ngemuva kwamahora 9-12 ngemva kokuphathwa. Uma kwezinso nesineke umsebenzi iphazamiseke izindlela ezingase buthelela emzimbeni isikhathi eside.

Izinkomba kanye contraindications

Izinkomba Zokusetshenziswa "Metformin" ngale ndlela:

• Ngifundise ngesifo sikashukela sohlobo 2, wedlula ngaphandle ukuthambekela ketoacidosis, okuyinto ebaluleke kakhulu abanesifo sikashukela ezikhuluphele ngokweqile emhlabeni.
• Lihambisana insulin abanesifo sikashukela sohlobo 2, ukukhuluphala ukuzimuka, kulandele yesibili insulin.

Naphezu kahle eliphezulu zomuthi, kukhona contraindications ukusetshenziswa "Metformin":

• Ketoacidosis esimweni sikashukela predkomatoznoe noma ikhoma.
• Ukungasebenzi nezinso.
• izifo olunamandla, okuholela ukubukeka izinso ukungasebenzi - ukutheleleka, amanzi emzimbeni nge uhudo olubi noma ukuhlanza, imfiva, izifo umgudu wokuphefumula, hypoxia.
• izifo oyingozi futhi ezingalapheki, okuholela ukubukeka izicubu hypoxia - ukuhluleka inhliziyo noma isimiso sokuphefumula, ama-acute isilethikusebenza.
• Zabhekana kokungenela kuhlinzwa, okwathi ngemva kwalokho okuhleliwe yokwelapha insulini.
• Isibindi ukungasebenzi.
• Acute Ethanol ubuthi, ukuba umlutha wotshwala ezingamahlalakhona.
• Ukukhulelwa.
• Ibele.
• Isici esiyingqayizivele.

Isikali

Isikali "Metformin" wenzeka kanjani kunqunywa okusekelwe kokuqukethwe igazi glucose inikezwa nodokotela nesineke ngayinye. Ngokuvamile kokuqala Isikali amabanga kusuka 0.5 kuya 1 g / usuku. (1-2 amaphilisi), bese, ngokusekelwe ezingeni glucose emva kwezinsuku 10-15 reception kungenzeka ukwanda ekhuphukayo e umthamo.

Ukugcinwa umthamo "Metformin" kuyinto 1.5-2.0 g / usuku. (3-4 amaphilisi), futhi umthamo esiphezulu - 3.0 g / usuku. noma amaphilisi 6. Ezigulini e ukuguga umthamo eliphakeme - hhayi ngaphezulu kuka 1.0 g / usuku. (2 amaphilisi).

Izinkomba Zokusetshenziswa "Metformin" futhi kobufakazi iziguli zisikisela ukuthi izidakamizwa kufanele kuthathwe ngezikhathi zokudla noma ngokushesha ngemva kwalo, ukuphuza amanzi plain. I umthamo wansuku zonke Kunconywa ukuba wahlukanise ngemithamo 2-3 usuku lonke.

Izenzo e ukweqisa izidakamizwa

Overdose kungaholela lactic acidosis, okuyinto okusongelayo ukufa.

lactic acidosis libhekene zimpawu ezilandelayo:

• Isiyezi ephelezelwa isicanucanu nokuhlanza.
• Isifo sohudo.
• Ukwehla elibukhali nezinga lokushisa komzimba.
• ukuphefumula okusheshayo.
• izinhlungu Cijela bemisipha, esiswini.
• Ukulahlekelwa ukwazi ukuqala ikhoma.

Lapho okungenani omnene izimpawu lactic acidosis kufanele ngokushesha ayeke ukuthatha izidakamizwa "Metformin" ukuthatha izinyathelo esibhedlela.

Indlela ephumelela kakhulu umsebenzi zokwelapha lapho hemodialysis kuyinto lactic acidosis, kanye nokwelashwa futhi ephumelelayo izimpawu ngabanye.

Ukusebenzisana neminye imithi

Umuthi 'Metformin "izinkomba ukusetshenziswa okuyinto ngakususi ukusetshenziswa concomitant zomuthi nezinye izidakamizwa ayikwazi ukusetshenziswa kanye dinazolom ngenxa Hyperglycemia umphumela yokugcina. Uma kudingekile, ukusetshenziswa kwemithi yokwelapha dinazolom kudingeka ukulungiswa umthamo "Metformin", okuyinto kumele ubambe udokotela.

"Metformin" Reception kudingeka ayeke ngokuphelele yimuphi ukulungiswa Isikali lihambisana izidakamizwa ezilandelayo:

• "Chlorpromazine".
• Neuroleptics.
• zokuvimbela inzalo Oral, ama-hormone egilo, isisu thiazide futhi loop.
• "Epinephrine".
• "Cimetidine".

Futhi, lapho kuboniswe ukusetshenziswa "Metformin" ezidingekayo ukulishiya ngokuphelele edonsa utshwala, ngaphandle kwalokho, nahlulele by izimpendulo iziguli, umphumela zokwelapha is kakhulu ziyancipha.

"Metformin": impendulo uma isetshenziselwa kwesisindo

nomphumela oqabulayo eyodwa kuphela akugcini ububanzi bokusebenzisa izidakamizwa "Metformin". Izinkomba ukusetshenziswa, kanye nokubuyekeza ubufakazi amakhono ezifana:

• Ukuncishiswa kashukela.
• Ukuncishiswa insulini zemvelo, okuholela ekuncipheni ngesifiso.
• Ukuvimba kumiswa carbohydrate fuel esibindini.
• Ukunciphisa ezingeni nokwenziwa carbohydrate engena emzimbeni ngokudla.

Ukusebenzisa "Metformin" ukuze ulahlekelwe isisindo kuyaqondakala ukuthi umsebenzi wayo oyinhloko Ukwakha isimo lapho kukhona ukusetshenziswa kwezimali fat ezifakwa kunokuba kwemisipha izicubu. Ngoba i ngempumelelo nabangenacala ekulahlekelweni isisindo somzimba, ngokuvumelana izimpendulo eziningi mayelana nokulungiselela kokubili iziguli kanye nodokotela, kufanele ukudala izimo ezikahle:

• Yenqaba ufulawa amnandi futhi, kanye ukudla lula (noodle, okusanhlamvu, amazambane abondiwe).
• Ukuze wehlise edonsa kilojoule.
• Active kanye nokuzivocavoca njalo.

Uma usebenzisa "Metformin" neminye Isikali kumele ushiye 500 mg / ngosuku, futhi engayitholi kumele inikezwe ngaphambi kwasemini kanye dinner. Uphenyo nesineke ukulungiselela show ukusebenza ezanele lapho bephonsa isisindo okweqile, kodwa ukusetshenziswa "Metformin" ngokuqondile ngalezi zinhloso akuvunyelwe ngaphandle kokuxoxisana udokotela isazi.

side effects

Naphezu izinkomba ububanzi ukusetshenziswa, "metformin" kungase kubangele futhi ukubonakaliswa ezinye zezimpawu abuhlungu pheshana emathunjini, okuholela engemihle zomuthi:

• Ukuhlanza nokukhishwa isicanucanu.
• zinenhliziyo emnyama noma ukungezwakali kwawo.
• Ukubuyisa, ukukhishwa isisu, ubuhlungu besisu.

Kaningi lezi zimpawu ekuqaleni ukwelashwa kanye, ngokubona iziguli zinyamalale bebodwa.

Okuningi kakhulu emibi evela kwamanye amasistimu:

• B12 Vitamin lokunemphilo, futhi lactic acidosis.
• anaemia Megaloblastic.
• Kahle kungakhuphula izinga likashukela.
• Ukuqubuka njengoba ukusabela nomzimba.

imiyalelo Special ukusetshenziswa, futhi kobufakazi nesineke

Njenganoma yimuphi esinye isidakamizwa has Izimo yayo futhi izinkomba ukusetshenziswa, "Metformin" kudinga nokuqikelela ukuba umthamo kanye nesikhathi irisidi.

Ikakhulukazi, ngesikhathi idili kumele sihlale njalo siqaphele nokusebenza kwezinso, okuyiwona ubuncane kabili ngonyaka, kanye ukubonakaliswa myalgia kufanele ibone okuqukethwe lactate e-plasma. Ngaphezu kwalokho, njalo ngemva kwezinyanga eziyisithupha kufanele ziqashwe creatinine serum, ikakhulukazi engu iziguli.

Lapho ethola "Metformin" lihambisana sulfonylureas kubalulekile njalo ukuqapha ezingeni glucose egazini.

Lapho izifo kohlelo genitourinary, noma izifo bronchopulmonary kufanele ukubike kudokotela wakho.

Umuthi akuphazamisi ikhono ukushayela imoto futhi akusho aphazamise umsebenzi izindlela.

Inhlanganisela "Metformin" nezinye izidakamizwa hypoglycemic kungaholela ukuthuthukiswa izimo hypoglycemic, elinesimo disorder inkumbulo, okuvimbela ukulawula imoto waxhumana kweminye imisebenzi yingozi futhi zidinga ukunakekelwa okukhulu kanye yokusabela.

Esikhathini esiyiminyaka ukwelashwa akuvunyelwe nakancane utshwala nezidakamizwa equkethe ethanol.

Ngokusho Izibuyekezo zomuthi "Metformin" naphezu eziningi okwesabisayo provleniya side effects zenzeka zisatholakala ezingavamile kakhulu, noma kancane. Futhi ukuthi abathandi bathi amnandi ikakhulukazi, uma uthatha imithi kungenzeka ukukhokhela nocezu ikhekhe noma amnandi, kodwa njalo.

Futhi e amanothi ukubuyekeza patsintov sikashukela kanye amathuba anda yokuba ukhulelwa ngesikhathi ethola "Metformin" ongekho nje kuphela kusiza ukuqeda lesi sifo, kodwa futhi ukuthola injabulo emshadweni.