Calcitonin - kuyini? Ukuhlaziya i-calcitonin. Calcitonin: abesifazane evamile

Thyroxine futhi triiodothyronine - la ama-hormone egilo ezivezwa indlala yegilo. Ngaphezu kwalokho C-emangqamuzaneni omzimba ayakwazi secreting calcitonin. Kuyini lokhu? Lokhu hormone kube inkomba yokuthi calcium umzimba futhi zingaba hhayi kuphela e indlala yegilo, kodwa futhi nezinye izitho. Ikakhulukazi yimpumelelo emaphashini kanye thymus. Calcitonin ehilelekile ukulawulwa amaminerali umzimba futhi eziyinkimbinkimbi zamakhemikhali isakhiwo ehlanganisa neketanga amino acid. Noma ikuphi ukwephulwa lokhu ukulandelana kuholela ukuthi hormone ilahlekelwa umsebenzi wayo begazi.

Calcitonin - kuyini?

Uma kwenzeke ukuba izinkinga emzimbeni, odokotela bacelwa ukuba kutholakale imbangela yokushona ukuhlolwa igazi. Ngezinye izikhathi wambula okuqukethwe semali into ezifana calcitonin. Kuyini lokhu? Lokhu i-hormone yegilo akhiqizwa yayo C-cells. He is oncomarker ukuxilonga umdlavuza yegilo kanye ukuhlola umzimba calcium emzimbeni.

Uyini umsebenzi calcitonin?

Umsebenzi oyinhloko calcitonin kuyinto ukuqaliswa isenzo abasiphikisayo mayelana hormone parathyroid, okuyinto kuveza nezindlala parathyroid alawule calcium umzimba kwandisa okuqukethwe kwayo egazini. Calcitonin ikhuthaza ukulawulwa calcium ne phosphorus amazinga. Receptor kulolu ketshezi atholakala egazini (monocytes), yi-placenta, iphaphu, isibindi, umnkantsha amaseli isimiso sezinzwa esiyinhloko, Izitho zokuzala, nezinso.

Uhlaka lwamathambo kwale hormone ivimbela leaching calcium, kangangokuba akusekho usekelo isakhiwo amathambo. Calcitonin kubaluleke kakhulu ezimweni lapho namaminerali babambeke izinto eziningi ezinkulu. Leso simo kwenzeka ngesikhathi ukukhula asebenzayo wengane, nokukhulelwa kanye lactation.

Igazi, le hormone esithile nawo abalulekile futhi kunomphumela hypocalcemic. Calcitonin ikhuthaza ukukhululwa kwe nosawoti umchamo futhi kwehlisa bamba yabo emathunjini. Iphinde kwehlisa amazinga egazi phosphorus, okuyinto kuba nethonya ipheshana wokugaya ukudla kanye nezinso.

Indlala yegilo ikhiqiza hormone eziningi ezincane, nokuqukethwe egazini neze kakhulu. It zingaba esiswini, kodwa endaweni ngemithamo miniscule kakhulu.

Calcitonin egazini

Kuqakatheke ngani ukuba afeze ukuhlaziywa calcitonin? C-amaseli, ezikhiqiza le hormone, umdlavuza ikhula yegilo - carcinoma medullary, noma C-cell carcinoma. Ukwanda izimila enjalo uyephuza, kodwa kunzima kakhulu, esakaza metastases ukuba izindlala zamanzi entanyeni, kanye nezinye izitho eziningi. Kunzima kakhulu ukuba imiphumela emibi yokwelashwa ngamakhemikhali.

Njengoba C-cell akhiqiza i-hormone okuthiwa i-calcitonin, enzeke abukhali egazini kungase kubonise khona medullary umdlavuza yegilo. ekuhlonzweni yalesi sifo lukusindisile inqwaba izimpilo zabantu.

Ngaphansi kwaziphi izimo igazi le-calcitonin?

Isimila cells ngokuvamile sitholwa njengefa. Zonke izihlobo zalo isiguli kumele banikele njalo igazi le hormone. Ngaphandle ukuhlola okunjalo asetjentiselwa kukhomba ukuphinda isimila esibulalayo. Uma ngesikhathi Histology ukusebenza waqinisekisa khona umdlavuza medullary ke kamuva igazi calcitonin uzodinga ukuthatha njalo ezinyangeni ezingu-3 noma izinyanga eziyisithupha.

Zikhona nezinye izizathu ezenza ezidlulisela lokhu kuhlolwa:

• ukuhlonza izifo ezivukayo ngenxa normal calcium umzimba;
• ukuze kuhlonzwe kwamathambo;
• ukucacisa esikhiqiza izimila;
• nge waphuka njalo futhi izimpawu izifo zabo.

Norma calcitonin

Kufanele kukhunjulwe ukuthi ayikho into efana eboshiwe engezansi amazinga ama-hormone ngesikhathi ukuhlolwa igazi ukuze calcitonin. Norma kuzoba umcimbi ukuthi zero ezingeni egazini. Kubalulekile ukuthi ayidluli umkhawulo ophezulu evamile.

Laboratories ezahlukene ngesilinganiso calcitonin egazini zingahluka. Lokhu kuchazwe iqiniso lokuthi reagents ezahlukene futhi asebenzise imishini ethize esetshenziselwa isifundo. Ngaphezu kwalokho, umphumela incike yobudala kanye ocansini. Ucwaningo olwenziwa izindlela ezimbili: by immunoassay enzyme kanye immunohemilyuminestsentnym.

Immunoassay indlela has okulandelayo inkomba amagugu i-hormone onjalo afana ngazo calcitonin:

• Izinga kwabesifazane - 0,07-12,97 pg / ml;
• Izinga lamadoda - 0,68-32,26 pg / ml;
• uthola izingane - kufike ku-79 pg / ml.

Norm at immunohemilyuminestsentnom indlela:

• Abesifazane - 1.46 pmol / L;
• wesilisa - 2,46 pmol / l.

Umphumela yokuhlaziya zingase abesifazane ngesikhathi sokukhulelwa futhi ngenkathi ibele.

Yini uthi izinga eliphezulu le-hormone?

Uma isiguli calcitonin yanda, futhi kungakhathaliseki ukuthi, noma kunjalo kodwa kuyinkinga enkulu kakhulu okudinga more ngokujulile ukuhlola ochwepheshe kakhulu professional nabanekhono. Uma Inkomba calcitonin egazini ezingaphezu kuka-100-pg / ml, cishe ngo-100% iqiniso angakhuluma umdlavuza. I okujulile kunemithetho-hormone okuthiwa i Ileveli, kulapho dengwane kuyinto isimila nendlala okuthiwa i aba maningi amathuba ukuthola e-lymph kanye nezinye izitho metastases yayo.

Uma isiguli sine-thyroid Izigaxana, futhi wamiswa njengomqondisi inaliti biopsy kwezinto, eyabonisa ukuthi awayona ingozi, futhi igazi calcitonin-hormone okuthiwa i anda, kubalulekile ukuba bakholwe ngaphezulu umphumela ukuhlaziya, ngoba cishe njalo kweqiniso. Lapho ukwanda kakhulu i-hormone igazi ngempela bahlinza ukuze ususe ngokuphelele indlala yegilo kanye ezizungezile zamanzi.

Ngaphezu kwalokho amazinga ama-hormone umdlavuza medullary ongama lapho lezi zifo ezilandelayo:

• C-cell Hyperplasia;
• ; Ellison - Zollinger
• isifo sokusha utshwala;
• umdlavuza neuroendocrine nemvelo;
• anaemia eziyingozi;
• psevdogipoparatireoidizm;
• syndrome carcinoid;
• thyroiditis ne pancreatitis;
• isifo samaphaphu uhlamvu ingozi;
• ezingamahlalakhona ukwehluleka kwezinso.

Lapho isiqinisekiso lezi zifo kufanele siqiniseke abaziphatha ngayo.

isiphetho

Iziguli eziningi, odokotela linqume kwegazi kwezidingo calcitonin. Kuyini lokhu? Lokhu i-hormone yegilo, okuyinto ukwandisa amazinga kungase kubonise khona isimila esibulalayo zomzimba. Nge ukuthola esifike umdlavuza medullary nokwelashwa kuhlinzwa ngokuqiniseka sithi lokhu inkinga alusekho. Ngaphezu kwalokho, lesi sifo kubangela amazinga ama-hormone ukwanda nezinye izizathu ukuthi ukwelashwa esifike ngesikhathi udokotela ingelapheka ngempumelelo.